Inhibit cancer. Medical search. Frequent questions

Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
it inhibits cell migration, reduces the ability to form colonies and induces apoptosis or programmed cell death through the modulation of other key genes (p53, caspase-3, c-PARP) and various apoptotic factors," says Maurizio Battino, coordinator of the research. (agenciasinc.es)
It also suppresses the receptor of the epidermal growth factor called EGFR/HER2 and its signalling pathways, which could be an attractive target in cancer therapies because of their important role in the processes of cell survival and proliferation, as well as in those of apoptosis and metastasis. (agenciasinc.es)
Here, we explored whether sesamin activates p53, which is widely inhibited in cervical cancer cells, thereby inducing p53-mediated apoptosis. (medsci.org)
These findings indicate that sesamin inhibits cervical cancer cell proliferation, and its mechanism may be attributed to the induction of p53/PTEN-mediated apoptosis. (medsci.org)
Panobinostat inhibits one or more of the histone deacetylase (HDAC) enzymes, a mechanism leading to apoptosis of malignant cells via multiple pathways. (addiandcassi.com)
In addition, compared to the mono-treatment, combination of Polo-like kinase 1 inhibition with anti-mitotic or DNA damaging agents boosts more severe mitotic defects, effectually triggers apoptosis and strongly inhibits proliferation of cancer cells with functional p53. (oncotarget.com)
SCARA5 overexpression significantly inhibited cell proliferation and induced apoptosis of CAL-27 and SCC-9 cells. (degruyter.com)
In conclusion, SCARA5 inhibited the proliferation and EMT and induced the apoptosis of OSCC cells through the inhibition of STAT3 and PI3K/AKT signaling pathways, thereby exerting a tumor suppressor effect. (degruyter.com)
Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. (greenmedinfo.com)
In this study, we investigated the effects of Ganoderma lucidum on cell proliferation, cell cycle, and apoptosis in human prostate cancer cells PC-3. (greenmedinfo.com)
UCN-01, a protein kinase C (PKC) inhibitor, induces growth arrest and apoptosis in cancer cells and was recently introduced in a phase I clinical trial. (karger.com)

however, its effects on metastasis‑related phenotypes in ovarian cancer models are unclear. (spandidos-publications.com)
Correspondingly, most cancer signaling pathways seem to converge on one or more TFs, termed "master regulators" (MRs) [ 4 ], which direct tumor development, progression, and metastasis through hierarchical control of gene expression patterns. (aging-us.com)
Researchers have reduced breast cancer metastasis to bone by using an experimental agent to inhibit ROCK (Rho-associated kinase), a protein that was found to be over-expressed in metastatic breast cancer. (bioquicknews.com)
In a study in mice, a team of researchers from Tufts University reported that inhibiting ROCK in the earliest stages of breast cancer decreased metastatic tumor mass in bone by 77 percent and overall frequency of metastasis by 36 percent. (bioquicknews.com)
The results suggest that ROCK may be a target for new drug therapies to reduce breast cancer metastasis. (bioquicknews.com)
While the primary tumor causes significant illness and requires treatment, metastasis accounts for over 90 percent of breast cancer-related deaths. (bioquicknews.com)
Establishing ROCK's role in the spread of breast cancer and identifying agents to inhibit ROCK brings us one step closer to an approach that might reduce metastasis in the future," said senior author Dr. Michael Rosenblatt. (bioquicknews.com)
Bone is the most common site of breast cancer metastasis, affected three times more often than the lungs or liver. (bioquicknews.com)
We further provided evidence that IL-37 inhibited effectively tumor metastasis in vitro and in vivo . (nature.com)
In this regard, restoration of p53 in tumor cells with loss or mutation of p53 will reinforce the cytotoxicity of combined Polo-like kinase 1 therapy and provide a proficient strategy for combating relapse and metastasis of cancer. (oncotarget.com)
Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach. (medscape.com)

The aim of our study was to find whether DAB2 and DAB2IP were mutated in gastric (GCs) and colorectal cancers (CRCs) by DNA sequencing. (nih.gov)
Colorectal cancer (CRC) is a severe threat to human health. (hindawi.com)
According to the World Cancer Report, colorectal cancer (CRC) is one of the most dangerous malignant tumors in humans. (hindawi.com)
Colorectal cancer (CRC) is one of the leading malignancies, which is expected to account for 2.2 million new cases and 1.1 million deaths worldwide in 2030 [ 1 ]. (hindawi.com)
Although these therapeutic regimens achieve somewhat satisfactory local disease control, effective regimens for metastatic CRC patients with liver metastases from colorectal cancer are limited. (hindawi.com)
It is of interest to explore the inhibitory effect of adenine on the growth of colorectal cancer cells and to determine the underlying mechanism. (hindawi.com)
We explored the possible mechanisms underlying the anticancer activity of adenine in colorectal cancer cells. (hindawi.com)
With these data it is not yet possible to speak of a cure or safe prevention of colorectal cancer thanks to strawberry tree honey," emphasizes Battino, who adds: "This work constitutes a starting point in the effort to evaluate its possible biological and anti-cancer effects and indicates the main molecular mechanisms through which it exerts its effect, reinforcing the interest in the study and production of this Mediterranean foodstuff. (agenciasinc.es)
American Indian (AI) men have some of the highest rates of colorectal cancer (CRC) in the United States but among the lowest screening rates. (cdc.gov)
Our goal was to better understand awareness and discourse about colorectal cancer in a heterogeneous group of AI men in the Midwestern United States. (cdc.gov)
Men in the study felt that awareness about colorectal cancer was low, and people were interested in learning more. (cdc.gov)
Our objective was to identify barriers to colorectal cancer (CRC) screening so that we could develop a culturally sensitive intervention for AI men. (cdc.gov)
METHODS: Male colorectal cancer (CRC) screenees were recruited to undergo upper endoscopy, identifying newly diagnosed cases of Barrett's esophagus. (who.int)
This anti-inflammatory property has turned aspirin into a potential drug for inflammation-related cancers such as colorectal cancer (CRC). (lu.se)

However, the mechanism by which adenine inhibits the proliferation of cancer cells is sketchy. (hindawi.com)

Previous studies identified that both DAB2 and DAB2IP genes were inactivated by promoter hypermethylation in human cancers, but their mutational alterations in cancers remain largely unknown. (nih.gov)

Thus, downregulation of RNF168 protein expression is a mechanism for providing BRCA1-null cancer cell lines with a residual level of HR that is essential for viability. (nih.gov)
Adenine significantly inhibited the viability of colon cancer cells, HT29 and Caco-2 cells, in a dose-dependent manner. (hindawi.com)
LPS effectively inhibited cell viability and LC3B I expression and enhanced LC3B II, Beclin-1 and atg5 expressions in MLE-12 cells. (karger.com)

Cannabinoids, the active ingredients in marijuana, restrict the sprouting of blood vessels to brain tumors by inhibiting the expression of genes needed for the production of vascular endothelial growth factor (VEGF). (innovations-report.com)
The intracellular domain of TbRI (TbRI-ICD) is released from the cell membrane, soluble and is transported to the nucleus in some specific forms of cancer to promote expression of genes causing invasion and metastatic growth. (ki.se)

This so-called cancer cachexia is accompanied by a poor prognosis with regard to disease progression, quality of life, and mortality. (genengnews.com)
The findings suggest resveratrol can counteract the malignant progression since it inhibits the proliferation of hormone resistant breast cancer cells. (naturalproductsinsider.com)
However, one recent intervention study conducted in Italy revealed that men with a precursor to prostate cancer called prostatic intraepithelial neoplasia (PIN) who consumed a green tea extract reduced their risk for progression to prostate cancer. (lesliebeck.com)
Previous studies have demonstrated that microRNAs (miRs) serve important roles in the progression of human cancer types, including pancreatic cancer (PC), a highly lethal malignancy. (spandidos-publications.com)
I just read on PNAS that the Novartis cancer drug Panobinostat (LBH-589), a Phase 3 drug developed for the treatment of cancer, may be able to halt the progression of Niemann Pick Type C disease, a fatal genetic cholesterol metabolism disorder that affects my twins. (addiandcassi.com)

Furthermore, sesamin induced p53 phosphorylation at serine-46 and serine-15 and upregulated the levels of PUMA, Bax, and PTEN, while inhibiting AKT phosphorylation at serine-473. (medsci.org)

Therefore, this study proves that Rh4 inhibits cancer cell proliferation by activating the ROS/p53 signaling pathway and activating autophagy to induce ferroptosis, which provides necessary scientific evidence of the great anticancer potential of Rh4. (hindawi.com)

After we inhibited the galectin1 protein, the brain tumors simply didn't grow for several months. (news-medical.net)

Hepatocellular carcinoma (HCC) is one of the five leading causes of cancer-related death worldwide. (aging-us.com)

McGill University researchers identify proteins that drive cancer stem cells. (news-medical.net)
While treatments such as surgery, radiation, and chemotherapy can help ease symptoms for a few months, in most cases tumor cells regrow after treatment and the cancer recurs. (news-medical.net)
Among all cancerous cells, some act as stem cells that reproduce themselves and sustain the cancer, much like normal stem cells typically renew and sustain our organs and tissues, say the researchers. (news-medical.net)
To improve patient response to therapy, we must exploit these newly identified vulnerabilities in cancer stem cells. (news-medical.net)
The discovery sheds light on the mechanisms that regulate cancer stem cells. (news-medical.net)
The critical challenge in cancer treatment is how to effectively kill cancer cells without affecting healthy cells. (hindawi.com)
Many cancers re-emerge after treatment, despite the sensitivity of the bulk of tumor cells to treatments. (mdpi.com)
This observation has led to the 'cancer stem cell' (CSCs) hypothesis, stating that a subpopulation of cancer cells survive therapy and lead to tumor relapse. (mdpi.com)
In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)
In the present study, we investigated the anticancer effects of adenine and the underlying mechanism in colon cancer cells. (hindawi.com)
Our findings suggest that adenine inhibits the growth of colon cancer cells. (hindawi.com)
Anticancer activity of adenine in colon cancer cells is attributable to the activation of apoptotic signaling and in turn the AMPK/mTOR pathway. (hindawi.com)
Adenine has been suggested to induce cell cycle arrest in cancer cells, leading to cell death [ 9 , 10 ]. (hindawi.com)
In this study, we investigated the effects of adenine against the proliferation of colon cancer cells. (hindawi.com)
Spanish and Italian researchers have proven that when honey from strawberry trees, a product typical of Mediterranean areas, is added to colon cancer cells grown in the laboratory, cell proliferation is stopped. (agenciasinc.es)
The results, published in the Journal of Functional Foods, show that strawberry tree honey is capable of inhibiting the proliferation of tumour cells cultivated in laboratory plates - more specifically, those of a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo), widely used to investigate this type of tumour. (agenciasinc.es)
Strawberry tree honey is capable of inhibiting the proliferation of tumour cells on a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo). (agenciasinc.es)
Zhang et al ( 9 ) revealed that expression of miR-205 was significantly decreased in radioresistant subpopulations of breast cancer cells and loss of miR-205 expression was associated with poor distant relapse-free survival in patients with breast cancer. (spandidos-publications.com)
Human HeLa and SiHa cervical cancer cells and normal Hs68 dermal cells were used as cell models. (medsci.org)
Sesamin (75 and 150 μM) clearly inhibited SiHa and HeLa cell proliferation in a dose-dependent fashion, but did not affect the proliferation of Hs68 cells. (medsci.org)
In the current study, the anti‑invasive activities and associated signaling pathways of celastrol were determined in ovarian cancer cells. (spandidos-publications.com)
This study aimed to investigate the relationship between miR-506 and proliferation and migration of breast cancer cells. (medscimonit.com)
MiR-506 mimics, inhibitor, and negative control (NC) were transfected into MDA-MB-231 breast cancer cells. (medscimonit.com)
Cell proliferation, cell counting, colony formation assay, and Transwell assay were applied to evaluate the proliferation and migration of breast cancer cells. (medscimonit.com)
miR-506 over-expression may thus be able to improve the malignant phenotype of breast cancer cells. (medscimonit.com)
Our HCC signature covered well-established liver cancer hallmarks, and network analyses revealed coordinated interaction between several MRs. One novel MR, SEC14L2 , exerted an anti-proliferative effect in HCC cells and strongly suppressed tumor growth in a mouse model. (aging-us.com)
Moreover, all compounds not only can reduce the expression of JAK2 and STAT3 mRNA but also inhibit the p -JAK2 and p -STAT3 protein expression levels in a dose‐dependent manner in the HepG-2 cells. (researchsquare.com)
In conclusion, three sesquiterpene lactone compounds inhibited the proliferation of HepG-2 cells via suppressing the JAK2/STAT3 signaling pathway. (researchsquare.com)
Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells. (hotzehwc.com)
Intracellular mature form of IL-37, but not its extracellular form, markedly inhibited migration of multiple kinds of tumor cells through inhibiting Rac1 activation. (nature.com)
Background/Aim: Demethoxycurcumin (DMC), a derivate of curcumin from natural plants, exerts antitumor effects on various human cancer cells in vitro and in vivo. (iiarjournals.org)
Nevertheless, no reports have disclosed whether DMC can affect the growth of human cervical cancer cells in vivo. (iiarjournals.org)
To evaluate in vivo activity of BMS-911543, we used a genetically engineered PCa model with conditional expression of mutant KrasG12D, tp53R270H , and Brca1 alleles in pancreatic cancer cells (Brca1-KPC mice). (bmj.com)
Signaling by the androgen-induced androgen receptor (AR) promotes cell growth of prostate cancer (PC) cells. (oncotarget.com)
p53 represses the promoter of Polo-like kinase 1, whereas Polo-like kinase 1 inhibits p53 and its family members p63 and p73 in cancer cells lacking functional p53. (oncotarget.com)
Reishi inhibits proliferation and induces programmed cell death in human prostate cancer cells. (greenmedinfo.com)
However, the mechanism(s) responsible for the effects of Ganoderma lucidum on cancer cells remain to be elucidated. (greenmedinfo.com)
We have previously demonstrated that Ganoderma lucidum down-regulated the expression of NF-kappaB-regulated urokinase plasminogen activator (uPA) and uPA receptor (uPAR), which resulted in suppression of cell migration of highly invasive human breast and prostate cancer cells. (greenmedinfo.com)
Thus, Ganoderma lucidum exerts its effect on cancer cells by multiple mechanisms and may have potential therapeutic use for the prevention and treatment of cancer. (greenmedinfo.com)
We demonstrate that UCN-01, at concentrations lower than those necessary to inhibit cancer cell growth, inhibit proliferation of human endothelial cells in vitro. (karger.com)
Since hypoxia activates hypoxia-inducible factor (HIF-1)-dependent transcription in cancer cells that, in a paracrine fashion, drive tumor angiogenesis, we investigated the effects of UCN-01 on HIF-1-responsive promoter constructs. (karger.com)
We conclude that UCN-01, at clinically relevant concentrations, exerts an anti-neovascularization effect by blocking two important steps in vessel formation: (1) the response of cancer cells to hypoxia, and (2) endothelial cell proliferation. (karger.com)
We have found that the TbRI undergoes proteolytic cleavage in cancer cells in a manner dependent on the ubiquitin-ligase tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6). (ki.se)
Aquaporins are central to many mechanisms in our cells , and also play a crucial role in several health conditions such as cancer and type 2 diabetes. (lu.se)
It seems that cancer cells may increase the number of aquaporins to enhance their own survival and increase their spreading ability, says Karin Lindkvist, professor of cell biology at Lund University and structural biology researcher. (lu.se)
By understanding the structure of the protein , and how drugs attach to it, we are trying to comprehend how cancer cells respond to new drug candidates. (lu.se)
Gastric cancer mesenchymal stem cells inhibit natural killer cell function by up-regulating FBP1. (bvsalud.org)
Gastric cancer mesenchymal stem cells (GCMSCs) are one of the vital elements of stromal cells in the tumour environment (TME) which possess immunosuppressive activity. (bvsalud.org)
GCMSCs inhibited the degranulation capacity, perforin production and cytotoxicity of NK cells . (bvsalud.org)
breast cancer cells by competitively binding to and blocking and the NIH Medical Scientist Training Program (L.H. Saal). (lu.se)
Breast Cancer Breast cancer occurs when cells in the breast become abnormal and divide into more cells uncontrollably. (msdmanuals.com)
Galiellalactone Inhibits Stem Cell-Like ALDH-Positive Prostate Cancer Cells. (lu.se)

By contrast, miR-205 expression has been identified to be significantly increased in several human cancer types, including ovarian cancer, endometrial cancer and laryngeal squamous cell carcinoma, in which it was identified to function as an oncoprotein ( 10 , 11 , 13 ). (spandidos-publications.com)
According to a new study published in the August 15, 2004 issue of the journal Cancer Research, administration of cannabinoids significantly lowered VEGF activity in laboratory mice and two patients with late-stage glioblastoma. (innovations-report.com)
For the new study, the Huntsman Cancer Institute team deleted the DGK iota gene in these mice and found that they developed few tumors, while mice with an intact DGK iota gene and an activated Ras gene exhibited significantly more tumors. (utah.edu)

Now, scientists at the Institute for Diabetes and Cancer (IDC) at Helmholtz Zentrum München say they have identified the adenosine monophosphate (AMP)-activated protein kinase (AMPK) as the central enzyme in cancer cachexia. (genengnews.com)
Their study ("An AMP-Activated Protein Kinase-Stabilizing Peptide Ameliorates Adipose Tissue Wasting in Cancer Cachexia in Mice") appears in Nature Medicine. (genengnews.com)
Here, we found multiple BRCA1 -mutant cancer cell lines and primary tumors with low levels of RNF168 protein expression. (nih.gov)
The researchers discovered that a protein called galectin1 interacts with another protein called HOXA5 to control the genetic programs that drive cancer stem cell behavior. (news-medical.net)
The data showed that adenine activated AMP-activated protein kinase (AMPK) signaling contributing to autophagic cell death through mTOR in both colon cancer cell lines. (hindawi.com)
For this ex vivo study, blood samples were obtained from 11 patients with B cell-CLL to determine whether inhibiting the CDC-protective protein with or without a negative control monoclonal antibody would affect rituximab resistance. (cancertherapyadvisor.com)
The enhanced anti-cancer effect of the combined use of dipyridamole with aspirin was found to rely on the induction of an overwhelmed endoplasmic reticulum (ER) stress and subsequent pro-apoptotic unfolded protein response (UPR), which was different from the anti-platelet effect. (lu.se)

We focus on the role of HPV in the increased incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer in which HPV is most commonly found ( 4 ). (cdc.gov)
Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)

In addition, TMZ effectively inhibited EndMT in ISO-treated rat hearts and TGF-β-treated HUVECs, as manifested by increased CD31 expression, decreased α-SMA expression, and suppressed cell migration. (dovepress.com)
SCR-6852, an oral and highly brain-penetrating estrogen receptor degrader (SERD), effectively shrinks tumors both in intracranial and subcutaneous ER + breast cancer models. (medscape.com)
Nevertheless, it is one of the most preventable and cancer prevention services through advocacy and curable forms of cancer if diagnosed early and effectively providing information about cervical cancer prevention managed. (who.int)
The STAT3 Inhibitor Galiellalactone Effectively Reduces Tumor Growth and Metastatic Spread in an Orthotopic Xenograft Mouse Model of Prostate Cancer. (lu.se)

This has important implications for the treatment of women with breast cancer whose tumors eventually develop resistance to hormonal therapy. (naturalproductsinsider.com)
With regard to cancer treatment, celastrol has been shown to exert considerable cell-killing effects and to shrink xenografted tumors in tissue and animal models of various malignancies including cancers of the prostate ( 16 - 18 ), breast ( 19 ), liver ( 20 , 21 ) and lung ( 22 , 23 ). (spandidos-publications.com)
May 9, 2005 - By studying mice with skin cancer, researchers at the Huntsman Cancer Institute at the University of Utah discovered a way to inhibit a mutant gene found in up to 30 percent of human tumors. (utah.edu)
Attempts to inhibit activated Ras have had limited success until now, but the Huntsman Cancer Institute researchers explain that they have discovered an enzyme that, when inhibited, appears to reduce the incidence of Ras-induced tumors in mice. (utah.edu)
The introduction of HPV vaccines has also drawn more attention to the fact that HPV is associated not only with cervical cancer and genital warts but also with other tumors, such as head neck and anogenital cancers ( 3 ). (cdc.gov)
Requests for reprints: Sofia K. Gruvberger-Saal, Institute for Cancer Genetics, tumors in the adjuvant or metastatic setting. (lu.se)

a promising chemopreventive agent, enhances the antitumor effect of 5-FU against breast cancer and inhibits tumor growth and angiogenesis in Ehrlich solid tumor. (physiciansweekly.com)
In this study, the investigators chose to work with cannabinoids which, in previous studies, have been shown to inhibit the growth of blood vessels, or angiogenesis, in laboratory mice. (innovations-report.com)
Our initial results highlight 22 new lead compounds that inhibit S100P-RAGE interaction, some of which have shown an ability to decrease pancreatic cell line growth. (brighton.ac.uk)
The androgen receptor (AR) is a ligand-dependent transcription factor that promotes prostate cancer (PC) cell growth through control of target gene expression. (oncotarget.com)
We report that, in addition to direct inhibitory effects on endothelial cell growth, UCN-01 abrogates hypoxia-mediated transactivation of HIF-1-responsive promoters in a prostate cancer cell line. (karger.com)
Transforming growth factor beta (TGFb) is frequently overexpressed in several forms of cancer including prostate cancer and this has been shown to correlate with poor prognosis. (ki.se)
When mutated, however, Ras is an "oncogene" or cancer-causing gene that has been shown to promote the growth of cancers in the pancreas, colon and lung, as well as thyroid cancer and leukemia. (utah.edu)

Expression of the suppressor of cytokine signaling-1 (SOCS1) is inactivated in hematopoietic and solid cancers by promoter methylation, miRNA-mediated silencing, and mutations. (aacrjournals.org)
Mechanistically, intracellular mature IL-37 directly bound to the CAAX motif in the C-terminal hypervariable region of Rac1, and then inhibited Rac1 membrane translocation and subsequent downstream signaling. (nature.com)
Silibinin Preferentially Radiosensitizes Prostate Cancer by Inhibiting DNA Repair Signaling. (wakehealth.edu)

Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical, China. (bvsalud.org)

Here we show that methanolic extracts of Sapota fruit (MESF) induces cytotoxicity in a dose-dependent manner in cancer cell lines. (nature.com)

In 2014, the American Cancer Society reported 21,550 cases of epithelial ovarian carcinoma and 14,600 disease-related mortalities, indicating that 69% percent of all patients with ovarian carcinoma succumbed to their disease. (spandidos-publications.com)

Preclinical and clinical studies have established plant derived dietary substances as suitable candidates for treating various types of cancers due to their broad chemical diversity. (nature.com)
In this regard, Baicalin (BA) is the dominant natural flavonoid extracted from the roots of Scutellaria baicalensis showed fascinating antitumor activity in many types of cancers, including breast cancer. (physiciansweekly.com)

mSIRK inhibited Epac1-induced melanoma cell migration. (biomedcentral.com)
mSIRK, but not L9A, inhibited 8-pMeOPT-induced cell migration. (biomedcentral.com)
Co-overexpression of Gβ1 and Gγ2 inhibited Epac1-induced cell migration. (biomedcentral.com)
f) Ablation of Epac1 inhibits GPCR-induced cell migration in melanoma. (biomedcentral.com)
Ablation of Epac1 inhibits both basal and ISO-induced cell migration. (biomedcentral.com)

Therefore, BRCA1-deficient cancers require adaptations that prevent excessive genomic alterations from triggering cell death. (nih.gov)
Researchers at the University of Calabria in Italy used several breast cancer cell lines expressing the estrogen receptor to test the effects of resveratrol. (naturalproductsinsider.com)
Recently, adenine has been explored for its anticancer property in several types of cancer cell lines. (hindawi.com)
None of these effects was observed when honey was applied to healthy cell lines," the authors point out, noting the anticarcinogenic potential of this natural product, but insisting on the need for new studies with colon cancer in vivo models to confirm its chemopreventive effects. (agenciasinc.es)
A number of studies have demonstrated that altered expression of miRs serves critical roles in human cancers by directly regulating cell behaviors ( 5 - 7 ). (spandidos-publications.com)
BA is a promising preventive or adjuvant therapy in breast cancer treatment with 5-FU mainly via cooperative inhibition of inflammation, angiogenesis, and triggering apoptotic cell death. (physiciansweekly.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Our data demonstrate that Ganoderma lucidum inhibits cell proliferation in a dose- and time-dependent manner by the down-regulation of expression of cyclin B and Cdc2 and by the up-regulation of p21 expression. (greenmedinfo.com)
The researchers found that a CFH-targeted monoclonal antibody conferred cancer cell sensitivity to rituximab. (cancertherapyadvisor.com)
miR-203 drives breast cancer cell differentiation. (medscape.com)
Cancer Cell. (lu.se)

Factor Inhibiting HIF (FIH) Asparaginyl Hydroxylase Inhibitors inhibit the FIH pathway also catalyzed by Asparaginyl Hydroxylase inhibition. (wikipedia.org)
inhibition of angiogenesis is a promising new approach in cancer therapy. (karger.com)
Publisher Correction: RAGE inhibition blunts insulin-induced oncogenic signals in breast cancer. (medscape.com)

NF-κB controls the expression of an array of genes involved in multiple features of cancer, including proliferation, survival angiogenesis and invasion. (spandidos-publications.com)

It is one more piece of evidence that a healthy, balanced and natural diet can provide bioactive compounds with possible interesting effects on the control and development of diseases as critical as this type of cancer," concludes the researcher. (agenciasinc.es)
Three sesquiterpene lactone compounds, 2 α ,5 α -dihydroxy-11 α H-eudesma-4(15)-en-12,8 β -olide ( 1 ), telekin ( 2 ), oxoeudesm-11(13)-eno-12,8 α -lactone ( 3 ) were obtained. (researchsquare.com)
Therefore, many studies have focused on finding and seeking new compounds from natural products for treating cervical cancer. (iiarjournals.org)
Mercury compounds reacting with sulfhydryl groups inhibit a variety of enzymes. (cdc.gov)

Metastatic ovarian cancer is a major clinical challenge with poor prognosis and high mortality. (spandidos-publications.com)
Ovarian cancer is one of the most lethal gynecological malignancies with a high case-to-mortality ratio ( 1 ). (spandidos-publications.com)
In addition, conventional treatment strategies such as chemotherapy and radiation are unlikely to reduce the metastatic frequency in ovarian cancer ( 3 ). (spandidos-publications.com)
Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)

A better understanding of the potential risks of developing second primary malignancies among survivors of breast cancer could lead to better prevention and management strategies for these patients. (medscape.com)

Glioblastoma multiforme, the most aggressive form of glioma, strikes more than 7,000 Americans each year and is considered one of the most malignant and deadliest forms of cancer, generally resulting in death within one to two years following diagnosis. (innovations-report.com)

A ) hTS (in cartoon with the A and B subunits colored white and grey, respectively) inhibited by the cofactor analogue pemetrexed (PMX, in sticks, purple carbons), which occupies the cofactor binding pocket by establishing a π-π interaction with the dUMP substrate (in sticks, green carbons) (PDB ID: 1JU6). (elifesciences.org)

Accessible Version: www.cdc.gov/pcd/issues/2022/21_0450.htm dress public problems in rural areas, despite an excess burden of risk factors for cancer morbidity and mortality. (cdc.gov)

Pancreatic cancer (PC) is one of the most lethal malignancy types, with a 5-year survival rate of ~8% ( 1 ). (spandidos-publications.com)
Pancreatic cancer (PCa) is resistant to cytotoxic therapies, and the profound immune suppressive nature of this disease renders patients non-responsive to immunologic therapies. (bmj.com)

Our data suggest that the preservation of 'healthy' adipose tissue can promote not only the quality of life, but also the response to treatment and the survival of cancer patients," says Prof. Stephan Herzig, IDC Director. (genengnews.com)
The cytotoxicity and anti-tumour effects of strawberry tree honey in relation to colon cancer lines increased with the amount and time of treatment. (agenciasinc.es)
Led by Paola Massi, PhD from the University of Milan, the team concludes that CBD could offer an effective treatment for brain cancer - without side effects. (hippocrates.com.au)
Traditional herbal medicines have demonstrated great potential in cancer treatment. (spandidos-publications.com)
So it is of great significance to find new safe and effective drugs for the treatment of liver cancer. (researchsquare.com)
Despite considerable advances in cancer treatment, chemotherapy remains a cornerstone in breast cancer therapy. (physiciansweekly.com)
however, the treatment of patients with cervical cancer depends on the cancer stage and tumor location according to diagnosis and characteristics of the patients ( 7 , 8 ). (iiarjournals.org)
However, cancer may develop resistance to chemotherapies and lead to treatment failure ( 9 , 10 ). (iiarjournals.org)
Other side-effects of the current chemotherapy treatment of patients with cervical cancer are fatigue, nausea, vomiting, and diarrhea ( 11 ). (iiarjournals.org)
Is the Subject Area "Cancer treatment" applicable to this article? (plos.org)
Effectiveness of palbociclib with aromatase inhibitors for the treatment of advanced breast cancer in an exposure retrospective cohort study: implications for clinical practice. (medscape.com)
Finding factors facilitating early detection of breast breast cancer as early as possible greatly cancer among Iranian women, as part of a improves the likelihood that treatment will more comprehensive study of the factors be successful. (who.int)
Conclusion: Expression of ERh is an independent marker for favorable prognosis after adjuvant tamoxifen treatment in ERa-negative breast cancer patients and involves a gene expression program distinct from ERa. (lu.se)
Swedish Research Council frequently prescribed drug for treatment of breast cancer. (lu.se)
METHODS: Population-based clinical data analysis was conducted to assess a possible therapeutic effect of combined dipyridamole and aspirin treatment in inhibiting CRC compared with either monotherapy. (lu.se)
The treatment of cervical cancer has a good prognosis if diagnosed early. (who.int)

LBH589 (panobinostat) is an orally available HDAC inhibitor that crosses the blood-brain barrier and is currently in phase III clinical trials for several types of cancer. (addiandcassi.com)

The incidence of cervical cancer is increasing worldwide. (iiarjournals.org)
A continued increase in the incidence of decisions about preventive and protective breast cancer death among Iranian women care, this study focused on the experiences, is due, in part, to low screening rates and views and perceptions of Iranian women late detection of breast cancer [8]. (who.int)
On the basis of these data and reports indicating that patients with HPV-positive cancer have their first sexual experience at a young age and have multiple partners, we postulate that increased incidence of OSCC in the United States and some countries in northern Europe is because of a new, primarily sexually transmitted HPV epidemic. (cdc.gov)
It is the most common form of cancer in India, and incidence is higher in countries in Latin America than in the United States and northern Europe. (cdc.gov)

In this study, we tested the feasibility of inhibiting activation of proMMP-2 by exogenous inhibitors, which block the binding between PEX and TIMP-2. (amrita.edu)
and that HIF prolyl-hydroxylase inhibitors may only minimally inhibit FIH. (wikipedia.org)

Phytochemicals have been considered as conducive for cancer prevention. (nature.com)
Men with prostate cancer who consumed green tea prior to undergoing prostatectomy had reductions in markers of inflammation, according to data presented at the 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research, held in Anaheim, California this month. (lesliebeck.com)
For example, curcumin shows considerable prevention effects when used before chemotherapy in Phase I trials in colon cancer patients ( 12 ). (spandidos-publications.com)
Its mission is to understand cancer from its beginnings, to use that knowledge in the creation and improvement of cancer treatments, to relieve the suffering of cancer patients, and to provide education about cancer risk, prevention, and care. (utah.edu)
10]. It is hoped that the findings of this women, comprising 21.4% of all cancer ma- research will be useful for health admin- lignancies among Iranian females [3] and istrators, health providers and educators affects women at least one decade earlier to consider when designing strategies and than their counterparts in developed coun- educational practices in cancer prevention. (who.int)
To develop these guidelines, CDC staff convened meetings of experts from the fields of tobacco-use prevention and education, reviewed published research, and considered the conclusions of the National Cancer Institute Expert Advisory Panel on School-Based Smoking Prevention Programs (4) and the findings of the 1994 Surgeon General's Report, Preventing Tobacco Use Among Young People (8). (cdc.gov)
Existing strengths found in rural areas, including long-standing relation- themes: commitment to address community needs, mutual willing- ships and approaches to leveraging limited resources, can facilitate multi- ness to collaborate, long-standing relationships, smaller com- sector collaborations for cancer prevention and control. (cdc.gov)
2019). According prevention, infuence social norms, and facilitate behavior to The Global Cancer Observatory (2021), cervical change among selected individuals or sub-populations to cancer is the second most prevalent cancer among prevent cervical cancer (Abraham et. (who.int)

Nuclear factor (NF)-κB is a major transcription factor that is essential for the development of inflammation and cancer ( 4 ). (spandidos-publications.com)

The high mortality rate of this cancer is largely due to the fact that many patients present with advanced or metastatic disease ( 2 ). (spandidos-publications.com)

Hence, the present study aimed to find the main active components of this plant against liver cancer and clarify its mechanism of action. (researchsquare.com)
Chronic arsenic poisoning is associated with skin, nervous system, liver, and other body systems as well as occurrence of cancer. (cdc.gov)

Cachexia is the most frequent cause of death in cancer patients. (genengnews.com)
Cancer is a major disease with millions of patients diagnosed each year with high mortality around the world. (nature.com)
One reason for the extensive application of traditional medicine in modern cancer therapy is that, in comparison with chemotherapy, natural agents are less toxic to normal tissues and, therefore, patients maintain tolerance to them ( 13 ). (spandidos-publications.com)
Furthermore, positive correlation of expression levels between CNPY2 and AR/AR target genes was observed in tissue samples from human prostate cancer patients. (oncotarget.com)
Most OSCC patients are found in the late stage of OSCC, mainly because there are no early molecular markers when cancer occurs. (degruyter.com)
Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)
Tumor markers are not elevated in all cancer patients, particularly patients with early-stage cancer. (medscape.com)
Purpose: Endocrine therapies, such as tamoxifen, are commonly given to most patients with estrogen receptor (ERa) ^ positive breast carcinoma but are not indicated for persons with ERa-negative cancer. (lu.se)

Now, scientists from the universities of Vigo and Granada (Spain) and from the Polytechnic University of Marche (Italy) have analysed for the first time the potential of this Mediterranean product to fight colon cancer. (agenciasinc.es)

Thus, the International Agency for Research against Cancer has acknowledged HPV as a risk factor for OSCC, in addition to smoking and alcohol consumption. (cdc.gov)
HPV infection, with dominance of HPV16 infection, has therefore been acknowledged by the International Agency for Research against Cancer as a risk factor for OSCC ( 10 ). (cdc.gov)
Tonsillar cancer is the most common OSCC, followed by base of tongue cancer. (cdc.gov)

The present study aimed to explore the chemopreventive and antitumor action of baicalin alone and in combination with 5-FU in addition to its ability to enhance the antitumor effect of 5-FU on breast cancer using the Ehrlich solid tumor-mice model. (physiciansweekly.com)

Several natural materials used in Chinese medicines, including green tea polyphenols, curcumin and triptolide, have been intensively studied and exhibit antitumor efficacy in preclinical models of various cancer types ( 11 ). (spandidos-publications.com)
In collaboration with SciLifeLab DDD we have generated potential therapeutic antibodies to target this pathway which we are investigating the function of, in our established preclinical models for prostate cancer. (ki.se)

Topham says his team will now examine more closely the mechanism behind how DGK iota works to inhibit tumor formation. (utah.edu)

Its therapeutic use for managing cancer is of great interest. (hindawi.com)

Breast cancer is the second leading fatal cancer in women, and affects just under one in eight women in the United States. (bioquicknews.com)
These results suggest a strong link between ovulatory menstrual cycles and the risk of developing breast cancer, with progesterone playing an important role. (medscape.com)
How do these two imaging modalities compare in terms of diagnostic accuracy for breast cancer detection? (medscape.com)
Certain modifiable factors may affect the risk for developing breast cancer. (medscape.com)
Circulating 27-hydroxycholesterol, lipids, and steroid hormones in breast cancer risk: a nested case-control study of the Multiethnic Cohort Study. (medscape.com)
A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. (medscape.com)
Examination of fully automated mammographic density measures using LIBRA and breast cancer risk in a cohort of 21,000 non-Hispanic white women. (medscape.com)
Association of air pollution with postmenopausal breast cancer risk in UK Biobank. (medscape.com)
MRI-based breast cancer radiogenomics using RNA profiling: association with subtypes in a single-center prospective study. (medscape.com)
Correction to: National and subnational burden of female and male breast cancer and risk factors in Iran from 1990 to 2019: results from the Global Burden of Disease study 2019. (medscape.com)
Studying the association between longitudinal mammographic density measurements and breast cancer risk: a joint modelling approach. (medscape.com)
Correction: Expression of hormone receptors is associated with specific immunological profiles of the breast cancer microenvironment. (medscape.com)
Correction: Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy. (medscape.com)
Correction: A prospective case-cohort analysis of plasma metabolites and breast cancer risk. (medscape.com)
Correction: Multimorbidity and overall survival among women with breast cancer: results from the South African Breast Cancer and HIV Outcomes Study. (medscape.com)
Clinical and biological heterogeneities in triple-negative breast cancer reveals a non-negligible role of HER2-low. (medscape.com)
Breast cancer is the most common cancer that 1 in 4 women with breast cancer in the among women worldwide. (who.int)
cerning breast cancer screening. (who.int)
6]. In Tehran, the capital city, breast cancer theory emerging from this type of work is is the most common cancer among women grounded in the data [11]. (who.int)
Efforts about breast cancer screening. (who.int)
The data directed at increasing the early breast cancer were collected and analysed during a 6- detection rate in women are important in month period in 2004-05. (who.int)
municipal culture house (Misagh) and the Iranian Centre for Breast Cancer and then was extended to the participants' home or workplace. (who.int)
In contrast, breast cancer can mean. (msdmanuals.com)
For severe pain during menstrual periods, danazol (a synthetic hormone related to testosterone ) or tamoxifen (a drug used to treat breast cancer) may be used. (msdmanuals.com)

Pancreatic adenocarcinoma (PDAC) is one of the most lethal human cancers with a 5-year survival of less than 5% due mostly to the lack of effective therapy and difficulty of detection at an early stage of development. (brighton.ac.uk)

Cancer often results in weight loss due to unwanted metabolic complications. (genengnews.com)

This suggests that sesamin might be useful as an adjuvant in promoting anti-cervical cancer treatments. (medsci.org)
Conclusion: These effects and findings might provide evidence for investigating the potential use of DMC as an anti-cervical cancer drug in the future. (iiarjournals.org)

CONCLUSIONS: Our data indicate that the anti-cancer effect of aspirin against CRC may be enhanced by combined administration with dipyridamole. (lu.se)

Anatomy12

Organisms3

Diseases57

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment68

Psychiatry and Psychology1

Phenomena and Processes50

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena3

Humanities1

Information Science7

Named Groups2

Health Care31

Geographicals4

Apoptosis12

Metastasis11

Colorectal14

Proliferation of cancer cells1

Inactivated by pr1

Viability3

Expression of ge2

Progression5

Phosphorylation1

Autophagy1

Brain tumors1

Hepatocellular carcinoma1

Cells52

Significantly3

Protein7

Squamous2

Effectively4

Tumors6

Growth7

Signaling3

Oncology1

Induces1

Epithelial1

Types of cancers2

Migration5

Cell11

Inhibition3

Angiogenesis1

Compounds4

Ovarian cancer5

Malignancies1

Malignant1

Subunits1

20221

Pancreatic cancer2

Treatment16

Inhibitor1

Incidence4

Inhibitors2

Prevention8

Inflammation1

Metastatic1

Liver2

Patients8

Colon1

OSCC3

Mice1

Preclinical models2

Mechanism1

Therapeutic1

Breast24

Survival1

Metabolic1

Anti-cervical cancer2

Conclusions1