Inhibit breast cancer growth arrest. Medical search. Frequent questions

Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. (hindawi.com)
Other studies have shown that blueberries inhibit melanoma metastasis and proliferation. (newsmax.com)
2008). New steroidal aromatase inhibitors: Suppression of estrogen-dependent breast cancer cell proliferation and induction of cell death . (up.pt)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-test was used to observe the proliferation of human breast cancer MCF-7 and MDA-MB-231 cells induced on VALD-3. (researchsquare.com)
The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. (mdpi.com)
Reishi inhibits proliferation and induces programmed cell death in human prostate cancer cells. (greenmedinfo.com)
Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. (greenmedinfo.com)
In this study, we investigated the effects of Ganoderma lucidum on cell proliferation, cell cycle, and apoptosis in human prostate cancer cells PC-3. (greenmedinfo.com)
Our data demonstrate that Ganoderma lucidum inhibits cell proliferation in a dose- and time-dependent manner by the down-regulation of expression of cyclin B and Cdc2 and by the up-regulation of p21 expression. (greenmedinfo.com)
The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
In cellular and animal models of breast cancer, tranilast induces G1/S phase cell cycle arrest, decreases levels of TGF-β1 and endoglin, increases levels of p53 and activation of caspase 3 and PARP, and inhibits cell migration, cell proliferation, and tumor growth. (lktlabs.com)
In vitro, tranilast inhibits VEGF- and FGF-induced cell proliferation, migration, and tube formation. (lktlabs.com)
Tranilast inhibits cell proliferation and migration and promotes apoptosis in murine breast cancer. (lktlabs.com)
Emerging evidence has demonstrated that WISP2 is critically involved in cell proliferation, migration, invasion and metastasis in cancers. (biomedcentral.com)
One study further identified that WISP2 expression was enhanced by serum and correlated with serum-induced cell proliferation in breast cancer cells, demonstrating that WISP2 could enhance cell proliferation in breast cancer [ 8 ]. (biomedcentral.com)
In this study, I investigated the proliferation signaling pathway in triple negative breast cancer (TNBC) cells with respect to the presence of functional BRCA1 and whether this signaling can be inhibited by genistein. (snu.ac.kr)
BRCA1 deficient breast cancer cells showed increased cell proliferation compared to breast cancer cells harboring wild-type BRCA1. (snu.ac.kr)
These results indicate that deficiency in BRCA1 promotes aggressive proliferation of breast cancer. (snu.ac.kr)
Genistein was chosen to be tested as a representative phytochemical that might inhibit aggressive proliferation of BRCA1 deficient TNBC cells by inactivating GPR30. (snu.ac.kr)
I examined the effects of genistein on proliferation and growth of TNBC cells, and how these effects differ depending on the presence or absence of functionally active BRCA1. (snu.ac.kr)
Estrogen causes proliferation of ovarian cancer cells. (biomedcentral.com)
Intra-tumoral estrogens derived from in situ aromatization act as an autocrine growth factor that promotes cancer cell proliferation independent of circulating estrogen [ 11 ]. (biomedcentral.com)
PGM1 knockdown stimulated both cell proliferation and colony formation, and inhibited cell cycle arrest and apoptosis, while overexpression of PGM1 produced the opposite effects in CRC cells both in vivo and in vitro. (biomedcentral.com)
PGM1 inhibits hepatocellular carcinoma cell (HCC) proliferation and growth by utilizing sufficient extracellular glucose to convert glycogen, while deletion of the PGM1 gene inhibits glycogen synthesis and leads to glycolysis of additional glucose, thus promoting tumor cell proliferation and growth [ 15 ]. (biomedcentral.com)
2015). Therefore, effective che- motherapeutic drugs require multiple molecular/cellular tar- gets/pathways to control cancer cell survival/proliferation. (pi3k-inhibitors.com)

1993] Inhibition of lysine acetyltransferase by anacardic acid was shown to make cancer cells using alternative lengthening of telomeres more sensitive to radiation. (wikipedia.org)
2013). Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: Aromatase inhibition and autophagy . (up.pt)
In cancer progression, FOXO3a inhibition stimulates cell transformation and angiogenesis ( 9 ). (spandidos-publications.com)
consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
Activation of TRPV1 by capsaicin caused significant inhibition of cancer cell growth and induced apoptosis and necrosis. (dovepress.com)
The inhibition of cell growth was also demonstrated by cell cycle arrest at G2/M phase. (greenmedinfo.com)
1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)
Inhibition of calcitriol metabolism by 24-hydroxylase promotes growth inhibition effect of calcitriol. (jcancer.org)
Likewise, MDA-MB-231 cells that were transfected with BRCA1-siRNA were more susceptible to genistein-mediated growth inhibition. (snu.ac.kr)
GSE (25-200 micro g/ml) treatment of cells resulted in 16-72% growth inhibition and 9-33% cell death, in a dose- and a time-dependent manner. (nih.gov)
In other studies, Dox (10-100 nM) treatment showed 23-96% growth inhibition and 10-55% cell death. (nih.gov)
Based on these results, several combinations of GSE (25-100 micro g/ml) with Dox (10-75 nM) were next assessed for their synergistic, additive and/or antagonistic efficacy towards cell growth inhibition and death. (nih.gov)
0.5] in cell growth inhibition, but mostly an additive effect (CI approximately 1) in cell death. (nih.gov)
In a preclinical study, Acalisib (GS-9820) resulted in tumor growth inhibition in xenograft models of breast adenocarcinoma harboring a PIK3CA mutation (Mol Cancer Ther 2009;8(12 Suppl):B136). (jax.org)
ERBB1 and ERBB2 inhibition rapidly (within 3 h) inhibits both tumor cell motility and intravasation. (aacrjournals.org)
Using gefitinib, ERBB1 inhibition rapidly inhibits tumor cell motility and invasion but not intravasation, whereas ERBB2 inhibition by AG825 rapidly blocks intravasation. (aacrjournals.org)
These results indicate that ERBB inhibition should be considered for blocking other tumor cell malignant properties besides growth. (aacrjournals.org)
There is increasing interest in the effect of natural compounds, especially food extracts, on the resident oral microflora, both in terms of their ability to promote the growth of beneficial organisms and by their inhibition of the growth and metabolism of species associated with disease 60 . (bvsalud.org)

Breast cancer stem cells (BCSCs) play a critical role in chemoresistance, metastasis, and poor prognosis of breast cancer. (hindawi.com)
is known to exert anticancer effects, such as inducing cell cycle arrest, inhibiting metastasis, and overcoming immunotherapy resistance in breast cancer cells. (hindawi.com)
As the most common endocrine tumor, PTC has a tendency to occur lymph node metastasis in the early stages of cancer, and 20%-30% of PTC patients already have cancerous lymph node involvement at the time of diagnosis [ 3 , 4 ]. (jcancer.org)
It is designed to treat micrometastatic disease (or breast cancer cells that have escaped the breast and regional lymph nodes but which have not yet had an established identifiable metastasis). (medscape.com)

There is also a suspicion that inhibiting anacardic acids may arrest the growth of cancer tumors such as breast cancer. (wikipedia.org)
In most cases, the testing has been conducted using either animal models with chemically induced cancers or animals that have had human tumors implanted in them. (newsmax.com)
1975 Munson shows anti cancer effects of cannabis in Lewis Lung Tumors. (greenmedinfo.com)
This review article focuses on the role of honey in modulating the development and progression of tumors or cancers. (mdpi.com)
p53's ability to inhibit tumors can be considered as a specific outcome of its stress-responsive effects. (nature.com)
Using in vivo mouse models of breast cancer, we test the effects of ERBB1 and ERBB2 inhibitors AC480 and lapatinib, ERBB1 inhibitor gefitinib, and ERBB2 inhibitor AG825 on in vivo tumor cell invasive properties in mammary fat pad tumors. (aacrjournals.org)
Using existing datasets containing super-enhancer-associated genes identified in breast tumors and public databases comprising genomic and clinical information for breast cancer patients, we investigated whether highly expressed super-enhancer-associated genes correlate to breast cancer patients' poor prognosis and to patients' poor response to therapy. (biomedcentral.com)
We bioinformatically identified two novel super-enhancer-associated genes - NSMCE2 and MAL2 - highly upregulated in breast tumors, for which high RNA levels significantly and specifically correlate with breast cancer patients' poor prognosis. (biomedcentral.com)
Breast tumors can be divided into subtypes using two parameters: (I) At the molecular level based on the protein expression of three receptors: estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) [ 2 ]. (biomedcentral.com)
Finally, the Normal-like classified tumors show high expression levels of many genes expressed by adipose tissue and other nonepithelial cell types and are characterized by gene expression patterns that are similar to those of normal breast tissue. (biomedcentral.com)

Casticin, a natural polymethoxyflavone isolated from A. annua, V. trifolia, and V. agnus‑castus induces apoptosis in cancer cells by activating FoxO3a. (spandidos-publications.com)
Conversely, FOXO3a overexpression suppresses cancer cell growth, induces apoptosis, and reduces tumor size by regulating downstream effectors ( 10 ). (spandidos-publications.com)
This study is the first to show that VALD-3 induces apoptosis and cell cycle arrest in human breast cancer cells by suppressing Wnt/β-catenin signaling, indicating that it could be a potential drug for the treatment of breast cancer. (researchsquare.com)
In other animal models, this compound decreases allograft rejection and induces T cell anergy by increasing expression of p21 and p51, decreasing levels of IL-2, and stimulating cell cycle arrest. (lktlabs.com)
Genistein induces G2/M phase arrest by down-regulating Cyclin B1 expression through suppression of Akt phosphorylation and GPR30 activation in BRCA1 deficient breast cancer cells. (snu.ac.kr)
In this study, we observed that BME treatment induces autophagosome-bound Long chain 3 (LC3)-B and accumulates protein p62/SQSTM1 (p62) in breast cancer cells. (oncotarget.com)
Exemestane also induces apoptosis, arrests cell cycle progression at the G2/M phase and dramatically inhibits the growth of human breast cancer cells in vitro. (steroidscanada.is)

In our previous studies, we showed that bitter melon extract (BME) exerts a strong anti-proliferative effect by inducing caspase-dependent apoptosis in breast cancer cells [ 6 ], although the in vivo effect of BME was not examined in breast cancer model. (oncotarget.com)
CAPE Analogs Induce Growth Arrest and Apoptosis in Breast Cancer Cells. (propolisscience.org)
With the objective of developing stronger anticancer compounds, we studied 18 recently described CAPE derivatives for their ability to induce apoptosis in breast cancer cell lines. (propolisscience.org)

The aim of the present investigation was to elucidate the cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads to cell cycle arrest and apoptosis in vitro in keratinocytes, the target cells in psoriasis. (hindawi.com)
However, whether casticin inhibits in vitro carcinogenesis and cancer stem cell (CSC) characteristics, and whether casticin activates FoxO3a in small cell lung cancer (SCLC) cells remain unclear. (spandidos-publications.com)
Emerging evidence suggests that cancer stem cells (CSCs), a subpopulation of tumor cells, have the properties of self-renewal, heterogeneous progeny, drug-resistance, and carcinogenesis in vitro and in vivo ( 4 , 5 ). (spandidos-publications.com)
However, whether casticin inhibits in vitro carcinogenesis and CSC characteristics in the SCLC H446 cell line, and activates FoxO3a remains unclear. (spandidos-publications.com)
To better mimic the TNBC microenvironment in vitro, we established a 3D co-culture by combining the human TNBC cell line MDA-MB-231 with primary murine cancer-associated fibroblasts (CAF) and type I collagen. (bath.ac.uk)
To identify the vitamins and dietary micronutrients that exert protective effects against breast cancer and define their mechanism of action, we performed a literature review of in vitro, animal and epidemiological studies and selected the in vitro and animal studies with robust molecular evidence and the epidemiological studies reporting statistically significant inverse associations for a breast cancer-specific protective effect. (vitamindwiki.com)
In vitro and animal studies investigating the effects of such micronutrients and vitamins on breast tumours and breast cancer cells were also included in our search. (vitamindwiki.com)

VALD-3 also regulated the Wnt/β-catenin signaling pathway in breast cancer cells, inhibiting the activation of downstream molecules. (researchsquare.com)
Ferroptosis acts as an independent pathway for suppressing tumor growth and is tightly connected with metabolism and oxidative stress responses. (nature.com)
Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells. (lktlabs.com)
There is evidence that at the clinically relevant doses, itraconazole has potent anti-angiogenic activity, and that it can inhibit the Hedgehog signalling pathway and may also induce autophagic growth arrest. (ecancer.org)
Additionally, we observed that BME treatment in breast cancer cells increases phospho-AMPK expression and inhibits the mTOR/Akt signaling pathway. (oncotarget.com)
Taken together, our results demonstrate that BME treatment inhibits breast tumor growth, and this anti-tumor activity in breast cancer is, in part, mediated by induction of autophagy and modulation of the AMPK/mTOR pathway. (oncotarget.com)
In a preclinical study, CUDC-907 inhibited PIK3CA, blocked downstream AKT pathway activation, and induced apoptosis and cell cycle arrest in both PIK3CA wild-type and PIK3CA mutant human cancer cell lines and xenograft models of multiple tumor types ( PMID: 22693356 ). (jax.org)
In a preclinical study, MSC2363318A demonstrated anti-proliferative activity against many solid tumor cell lines with PI3K pathway genomic alterations, and inhibited tumor growth in several human cancer xenograft models of breast, pancreatic, glioblastoma and ovarian cancers (Mol Cancer Ther 2013;12(11 Suppl):A162). (jax.org)
PI3K inhibitors block the PI3K/AKT/mTOR pathway and thus slow down cancer growth. (pi3k-inhibitors.com)

In fact, these compounds can inhibit cancer in all of its stages - initiation, promotion, and progression. (newsmax.com)
The tumor microenvironment (TME) promotes BCSC survival and cancer progression, and targeting the TME can aid in successful immunotherapy. (hindawi.com)
The anti-proliferative effect of (1s) is distinct from paclitaxel in that it arrests the cell cycle at the G0/G1 state, thereby mediating a time-dependent delay in cell cycle progression. (bath.ac.uk)
2 - 4 Expression profiling on a genomic scale led to the classification of the intrinsic subtypes of breast cancer, thus allowing for the prediction of disease progression and patient stratification. (dovepress.com)
Absence or mutation of BRCA1 has been associated with development and progression of breast cancer. (snu.ac.kr)
In cell-cycle progression studies, GSE plus Dox combination resulted in a moderate increase in G1 arrest in MCF-7 cells compared to each agent alone. (nih.gov)
Breast cancer is a heterogeneous disease, but the identification of shared mechanisms that drive tumor progression has significantly improved patients' treatment in the last decades. (biomedcentral.com)
The approval of palbociclib for ER+/HER2- advanced breast cancer in combination with fulvestrant in women (regardless of menopausal status) with disease progression following endocrine therapy was based on the PALOMA-3 trial (n=521). (medscape.com)

HNK controls various intracellular signaling pathways involved in cancer, including those related to nuclear factor kappa B (NF- B), signal transducers and activators of transcription 3 (STAT3), epidermal growth factor receptor (EGFR), and mammalian targets of rapamycin (mTOR) [ 12 ]. (hindawi.com)
whereas human epidermal growth factor receptor 2 (HER2)-positive breast cancers can be targeted by specific drugs, the triple-negative breast cancer phenotype is defined by chromosomal instability and low expression levels of estrogen receptor (ER) alpha, progesterone receptor (PR), and HER2, rendering treatment rather difficult. (dovepress.com)
The epidermal growth factor receptor (ERBB1) and related family member HER-2/ neu (ERBB2) are often overexpressed in aggressive breast cancers and their overexpression is correlated with poor prognosis. (aacrjournals.org)
The epidermal growth factor receptor family (ERBB) is overexpressed in a wide variety of tumor types and is correlated with poor prognosis. (aacrjournals.org)
Palbociclib and ribociclib are cyclin-dependent kinases (CDK) 4, 6 inhibitors indicated in combination with an aromatase inhibitor as initial endocrine-based therapy for postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. (medscape.com)

This study aimed to explore the potential targets and molecular mechanisms of HNK on metastatic BCSC (mBCSC)-cell cycle arrest and the impact of the TME. (hindawi.com)
Multiple SCLC characteristics, such as aggressiveness and high metastatic potential, suggest that this cancer could be enriched in CSCs ( 6 ). (spandidos-publications.com)
Due to the metastatic incidence at diagnosis, drug resistance after chemotherapy and recurrence after surgery, long-term survival is still low in patients with esophageal cancer [ 5 ]. (biomedcentral.com)
Ryan Haumschild, PharmD, MS, MBA, leads drives a conversation surrounding the impact of CDK4/6 inhibitors in treatment of metastatic breast cancer. (pharmacytimes.com)
Can you review the chemotherapy regimens that have been conventionally used in these patients [with] HR+/HER2- metastatic breast cancer? (pharmacytimes.com)
Letrozole is an oral non-steroidal AI and used for the treatment of local or metastatic breast cancer that is ER positive. (biomedcentral.com)
Although surgery and certain chemotherapy drugs reduce the risk of breast cancer recurrence in some women who are at risk of developing the metastatic disease or a recurrence, the adverse side effects limits their use [ 2 ]. (oncotarget.com)
On January 30, 2023, the U.S. FDA approved ORSERDU™ (elacestrant) by Radius Health (Waltham, MA) for the treatment of postmenopausal women or adult men with ER+, HER2-, ESR1-mutated advanced or metastatic breast cancer that has progressed after at least one line of endocrine therapy. (biotechprimer.com)
Bevacizumab, a humanized monoclonal antibody that inhibits angiogenesis, had been approved for use in combination therapy for metastatic breast cancer. (medscape.com)
Fulvestrant (Faslodex) was approved by the FDA for hormone receptor (HR)-positive, HER2-negative locally-advanced or metastatic breast cancer in postmenopausal women not previously treated with endocrine therapy. (medscape.com)

10 TRPV1 agonist, capsaicin, is capable of inducing apoptosis 11 , 12 and inhibiting cancer cell growth by cell cycle arrest in many different types of cancer, for example, osteosarcoma, colon, and pancreatic cancer cells, while normal cells remained unharmed. (dovepress.com)
Clinical trials have shown that patients with prostate, lung, and basal cell carcinoma have benefited from treatment with itraconazole, and there are additional reports of activity in leukaemia, ovarian, breast, and pancreatic cancers. (ecancer.org)

One of the most important processes involved in a cancer's growth, invasion, and spread is angiogenesis, or development of new blood vessels. (newsmax.com)
Inhibiting angiogenesis has been shown to powerfully impede cancer growth, and can even lead to the death of cancers. (newsmax.com)
All of the berries exhibited this property, but the most powerful were bilberries and blueberries, which inhibited two compounds that drive angiogenesis - vascular endothelial growth factor (VEGF) and TNF-alpha. (newsmax.com)

Anthocyanins from blueberry and black currant juices have also been shown to inhibit the growth of ovarian and cervical cancer, as well as melanomas. (newsmax.com)
Allicin and ajoene, the major sulfur containing compounds of garlic, were shown to inhibit inducible nitric oxide synthetase (iNOS), by reducing the protein and mRNA, and thus to promote vasodilatation. (healthbenefitstimes.com)

Chemoresistance, or the insensitivity of cancer cells to drug therapy, is a major factor in the failure of chemotherapy against breast cancer. (hindawi.com)
Adjuvant chemotherapy has become the main treatment for breast cancer in China, and about 81.4% of patients with invasive breast cancer begin chemotherapy treatment [5]. (researchsquare.com)
With an approach to enhance the efficacy of chemotherapy agents against breast cancer treatment, here, we investigated the anti-cancer effects of grape seed extract (GSE) and doxorubicin (Dox), either alone or in combination, in estrogen receptor-positive MCF-7 and receptor-negative MDA-MB468 human breast carcinoma cells. (nih.gov)
It may also be used to treat advanced breast cancer in postmenopausal women with hormone-receptor positive, HER2-negative breast cancer who have received at least one chemotherapy treatment.It may also be used to treat hormone-receptor positive, HER2-negative advanced breast cancer in postmenopausal women who have received at least two chemotherapy treatments. (steroidscanada.is)
Finally, we showed that decreasing NSMCE2 gene expression increases breast cancer cells' sensitivity to chemotherapy treatment. (biomedcentral.com)
The Monarch 1 trial studied the safety and efficacy of abemaciclib as a stand-alone treatment in a single-arm trial of 132 patients with HR-positive, HER2-negative breast cancer that had progressed after treatment with endocrine therapy and chemotherapy after the cancer metastasized. (medscape.com)

For instance, overexpression of cyclins or the elimination of CDK inhibitors or pRB due to genetic mutation are common cause in human cancer. (ukessays.com)
WISP2 overexpression inhibited cell growth and induced cell apoptosis, suppressed cell migration and invasion in ESCC cells. (biomedcentral.com)
Moreover, WISP overexpression retarded tumor growth in mouse model. (biomedcentral.com)
Sakashita K et al investigated the relationship between APOE and gastric cancer by immunohistochemistry and RT-PCR, and APOE overexpression in gastric cancer tissues exhibited stronger malignant invasiveness compared to cancer tissues with low APOE expression [ 10 ]. (jcancer.org)

Subsequently, we demonstrated that BME feeding effectively inhibited breast cancer growth in syngeneic and xenograft mouse models. (oncotarget.com)
In a preclinical study, Sapanisertib (MLN0128) demonstrated efficacy in PIK3CA mutant breast cancer xenograft models ( PMID: 23085766 ). (jax.org)
In a preclinical study, CCT128930 induced growth arrest and inhibited tumor growth in a xenograft model of a ERBB2 (HER2)-positive human breast cancer cell line harboring a PIK3CA mutation ( PMID: 21191045 ). (jax.org)

Utilization of potential synergistic interactions among different bioactive agents is a promising approach to inhibit complex diseases such as cancer. (umass.edu)
Ganoderma lucidum (Reishi), an oriental medical mushroom, has been widely used in Asian countries for centuries to prevent or treat different diseases, including cancer. (greenmedinfo.com)
1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
Besides cancer, some miRNAs genes cause or contribute in many inherited and genetic based diseases. (ukessays.com)
We also discuss the possibility of targeting p53-mediated ferroptotic responses for the treatment of human cancers and potentially, other diseases. (nature.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Natural products play a critical role in the discovery and the development of numerous drugs for the treatment of various types of deadly diseases including cancer [ 3 , 4 ]. (oncotarget.com)
Clinical trials have also been conducted to evaluate the safety and efficacy of J Acid Urea in treating various diseases, such as cancer and inflammatory disorders. (thebiotek.com)
Flavonoids have been chronicles of the history of a long way journey in the cure of physiological or pathophysiological conditions in various diseases including cancer. (pi3k-inhibitors.com)
According to a hypothesis, polyphenol (PP) activity against several forms of cancer, proliferative diseases, inflammation and neurodegeneration is mainly exerted through the inhibiting and modulating activities against a wide range of receptors, enzymes and transcription molecules 88 . (bvsalud.org)

Zionova Aromasin may be used to treat advanced breast cancer in postmenopausal women. (steroidscanada.is)
Approval of ribociclib was based on interim analysis results from the pivotal phase 3 MONALEESA-2 trial in postmenopausal women who received no prior systemic therapy for their advanced breast cancer. (medscape.com)

6-pentadecyl salicylic acid (6-PDSA), a potent HAT inhibitor from cashew nut shell liquid, and sensitizer of cancer cells to ionizing radiation. (wikipedia.org)
Therefore, based on clinical experience as well as cytotoxic activity against multiple human cancer cells, we hypothesized that induction of apoptosis is the underlying mechanism for the treatment of psoriasis. (hindawi.com)
Blueberry, currant, cranberry, and a few others significantly reduced the growth of these cancers by inhibiting the reproduction of the cancer cells (a process called cell-cycle arrest). (newsmax.com)
In one study, researchers examined the ability of red raspberries to inhibit inflammatory immune cells (called macrophages) taken from colitis-affected animals. (newsmax.com)
2012). Apoptosis and autophagy in breast cancer cells following exemestane treatment . (up.pt)
Breast cancer stem cells (BCSCs) are one of the main factors driving chemoresistance, thereby contributing to poor prognosis and clinical outcomes [ 3 - 5 ]. (hindawi.com)
Herein, we studied NBT and TAN in combination with atorvastatin (ATST, Lipitor, a cholesterol-lowering drug) in MDAMB231 and MCF-7 human breast cancer cells. (umass.edu)
Flow cytometry analysis showed that both NBT/ATST and TAN/ATST combinations caused significant cell cycle arrest at G0/G1 phase in MDAMB231 cells (ER+). (umass.edu)
We here demonstrated that casticin decreased sphere‑ and colony‑formation capabilities, and downregulated uPAR and CD133 in second‑generation spheres, which were considered as lung cancer stem‑like cells (LCSLCs), from SCLC H446 cells, in a concentration‑dependent manner. (spandidos-publications.com)
These findings reveal a novel mechanism for regulating AMPK/FoxO3a signaling in response to casticin, suggesting a new strategy for SCLC therapy by targeting cancer stem‑like cells. (spandidos-publications.com)
In this study, we investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms. (researchsquare.com)
Flow cytometry analysis showed that VALD-3 triggered cell cycle arrest and induced apoptosis of breast cancer cells. (researchsquare.com)
By xenografting human breast cancer cells into nude mice, we found that VALD-3 significantly suppressed tumor cell growth while showing low toxicity against major organs. (researchsquare.com)
One such peptide, Lunasin , has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. (weeksmd.com)
Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
Gene therapy has attracted attention for its potential to specifically and efficiently target cancer cells with minimal toxicity to normal cells. (weeksmd.com)
Numerous vectors have been engineered for the sole purpose of killing cancer cells, and some have successfully suppressed malignant tumours. (weeksmd.com)
In this study, stimulation by the TRPV1 agonist, capsaicin, of SUM149PT cells, a model system for the most aggressive breast cancer subtype, triple-negative breast cancer, led to intracellular calcium signals that were diminished by the specific TRPV1 antagonist, capsazepin. (dovepress.com)
However, the mechanism(s) responsible for the effects of Ganoderma lucidum on cancer cells remain to be elucidated. (greenmedinfo.com)
We have previously demonstrated that Ganoderma lucidum down-regulated the expression of NF-kappaB-regulated urokinase plasminogen activator (uPA) and uPA receptor (uPAR), which resulted in suppression of cell migration of highly invasive human breast and prostate cancer cells. (greenmedinfo.com)
Thus, Ganoderma lucidum exerts its effect on cancer cells by multiple mechanisms and may have potential therapeutic use for the prevention and treatment of cancer. (greenmedinfo.com)
Additionally, poha isolates compounds were evaluated for their growth inhibitory effects with U251MG glioblastoma and MDA-MB-231 breast cancer cells that harbor aberrantly-active signal transducer and activation of transcription 3 (STAT3), compared to normal NIH-3T3 mouse fibroblasts. (nih.gov)
In particular, emerging evidence suggests that agonists of cannabinoid receptors expressed by tumor cells may offer a novel strategy to treat cancer. (aacrjournals.org)
Prodrugs generated up to about 95% cell killing at 2.5 µM when administered with hexyl-aminolevulinate (HAL) to produce Protoporphyrin IX in cancer cells in both 2D monolayer and 3D spheroids model. (bvsalud.org)
Genistein caused cell cycle arrest at the G2/M phase in BRCA1 mutant cells, leading to down-regulation of Cyclin B1. (snu.ac.kr)
Genistein treatment also decreased the level of phosphorylated Akt, an upstream kinase of Cyclin B1, more prominently in BRCA1 mutated breast cancer cells. (snu.ac.kr)
Significance This study provides a new insight to better understand the mechanism of action of Salinomycin, at least in breast cancer cells. (uaeu.ac.ae)
Does insulin make breast cancer cells resistant to doxorubicin toxicity? (foodforbreastcancer.com)
In tumor necrosis factor (TNF)-alpha-stimulated human aortic endothelial cells, beta-sitosterol was found to significantly inhibit vascular adhesion molecule 1 and intracellular adhesion molecule 1 expression. (drugs.com)
We have previously shown the anti-proliferative activity of bitter melon extract (BME) in breast cancer cells. (oncotarget.com)
GSE plus Dox combination showed a very strong and significant G1 arrest in MDA-MB468 cells when compared with Dox alone, however, it was less than that observed with GSE alone. (nih.gov)
HER2+ cancer cells produce, and therefore present, larger than normal numbers of the HER2 receptors on their cell surface. (biotechprimer.com)
Genentech's (South San Francisco, CA) Herceptin is a monoclonal antibody that binds to and blocks the activity of the HER2 receptor on cancer cells. (biotechprimer.com)
When the HER2 receptor is blocked, the HER2 growth factor can no longer bind and send a growth signal to the cell, so the cancer cells stop dividing. (biotechprimer.com)
The presence of an antibody on the surface of HER2+ breast cancer cells also signals the patient's immune system to attack that cell. (biotechprimer.com)
Kadcyla, also made by Genentech, is an antibody-drug conjugate - a monoclonal antibody that delivers a highly toxic drug directly to HER2+ breast cancer cells. (biotechprimer.com)
Fewer estrogen receptors mean that the cells receive growth signals from estrogen. (biotechprimer.com)
In a preclinical study, PIK3CA mutant breast cancer cells showed increased sensitivity to VS-5584 compared to PIK3CA wild-type cells in culture ( PMID: 23270925 ). (jax.org)
In a preclinical study, BEZ235 demonstrated efficacy in promoting apoptosis of colon cancer cells harboring a PIK3CA mutation in culture ( PMID: 22543857 ). (jax.org)
J Acid Urea has also been reported to target specific biological molecules, such as DNA and RNA, and induce cell cycle arrest and apoptosis in cancer cells. (thebiotek.com)
For instance, a study reported that J Acid Urea inhibited the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis. (thebiotek.com)
Targeting specific pathways which are aberrant in cancer cells relative to normal cells is ideally a good approach at therapeu- tic dosages. (pi3k-inhibitors.com)
All of the mice also received injections with breast cancer cells for 3 weeks after the start of the experiment. (crsociety.org)
Our computational findings were experimentally confirmed in breast cancer cells by pharmacological SE disruption and gene silencing techniques. (biomedcentral.com)
Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). (medscape.com)

Compounds from all of the berries reduced growth of these cancers, but the most effective were strawberries and black raspberries, especially against colon cancer. (newsmax.com)
In another study, researchers found that dried black raspberries inhibited oral, esophageal, and colon cancers in rodents. (newsmax.com)
Even more impressive was the fact that they inhibited colon cancer by 80 percent. (newsmax.com)
Chronic inflammation of the colon, called colitis, is a common cause of colon cancer. (newsmax.com)
Compounds that inhibit this inflammation have been shown to prevent colon cancer from developing. (newsmax.com)
Additional studies were performed with models of colon cancer. (nih.gov)
Specifically, 4β-hydroxywithanolide E (4HWE) inhibited the growth of colon cancer monolayer and spheroid cultures. (nih.gov)
These data suggest the ingestion of poha berries may have some effect on the prevalence of colon cancer. (nih.gov)
Combinatorial effect of QUE and resveratrol has been found to be antiproliferative via suppression of oncogenic microRNA-27a and induction of zinc finger protein ZBTB10 against HT-29 colon cancer (Del Follo-Martinez et al. (pi3k-inhibitors.com)

Numerous epidemiological and preclinical studies support a role of vitamin D compounds in cancer prevention and treatment in colorectal, breast, prostate, ovarian, bladder, lung and skin cancers and leukemia ( 1 , 5 , 6 ). (jcancer.org)

HR+ cancers may respond positively to treatments that block either the action or the production of estrogen. (biotechprimer.com)
Tamoxifen works by inhibiting the estrogen receptor and was originally discovered by AstraZeneca (London, U.K.). On the other hand, aromatase inhibitors block the production of estrogen by inhibiting an enzyme whose activity is required for estrogen production. (biotechprimer.com)
Zionova Aromasin works by inhibiting the aromatase enzyme, which is responsible for the production of estrogen. (steroidscanada.is)

Low levels of plasma 25(OH)D 3 are associated with higher cancer incidence and mortality in men in colorectal, breast, lung and prostate cancers ( 7 - 10 ). (jcancer.org)

HER2-positive (HER2+) breast cancer patients - about 20% of all breast cancer cases - have the most highly effective therapies available on the market. (biotechprimer.com)
These HER2 receptors capture growth factors, which trigger the cell to grow and reproduce more rapidly than normal. (biotechprimer.com)

These results suggest that our new CAPE analog compounds may display the capacity to induce breast cancer apoptosis in a p53-dependent and/or independent manner. (propolisscience.org)
The resulting oxidative stress leads to slower growth and can induce apoptosis. (deuteriumdepletion.org)

Berries contain a number of compounds that have been shown to prevent cancer development. (newsmax.com)
These compounds can treat developed cancers as well. (newsmax.com)

Women with T1DM had significantly lower risk for breast cancer, melanoma, and Hodgkin's lymphoma ( 7 , 10 ). (frontiersin.org)

Interestingly, treatment with low concentrations of Salinomycin induced a transient G1 arrest at earlier time point and G2 arrest at later point and senescence associatedwith enlarged cellmorphology, upregulation of p21 protein, increase in histone H3 and H4 hyperacetylation and expression of SA-β-Gal activity. (uaeu.ac.ae)
The functions of APOE co-expressed genes were mainly enriched in adaptive immune response, protein-lipid complex subunit organization, actin cytoskeleton reorganization, cell chemotaxis, protein activation cascade and transcriptional misregulation in cancer. (jcancer.org)

According to the World Health Organization, breast cancer has the highest incidence rate in Indonesia, with a mortality rate of 22,692 cases per year [ 1 ]. (hindawi.com)
Age-standardized incidence rates for breast cancer in Chinese women showed a significant upward trend during the period 2000 to 2011[2]. (researchsquare.com)
Of note, breast cancer incidence in China continues to rise at a rate of 3% to 4% per year, which is twice the world average for the same period [3,4]. (researchsquare.com)
Breast cancer remains a very common disease among women, with an annual global incidence of over 2 million cases per year and one of the highest numbers of cancer- related deaths among women (1, 2). (vitamindwiki.com)
Jordt N, Kjærgaard KA, Thomsen RW, Borgquist S, Cronin-Fenton D. Breast cancer and incidence of type 2 diabetes mellitus: a systematic review and meta-analysis. (foodforbreastcancer.com)
Thyroid Papillary Carcinoma (PTC) is the most common subtype of thyroid cancer, accounting for about 80% and its incidence and mortality rate have increased significantly in recent years [ 1 , 2 ]. (jcancer.org)

We here examine the efficacy of an aromatase inhibitor (AI) for peritonitis carcinomatosa, the late stage of ovarian cancer. (biomedcentral.com)
Estrogen receptor (ER)α was assayed in four ovarian cancer cell lines by the RT-PCR method. (biomedcentral.com)
Ovarian cancer is still the most lethal of all gynecologic cancers. (biomedcentral.com)
The American Cancer Society estimated that about 22,240 new cases of ovarian cancer will be diagnosed and 14,030 women will die of ovarian cancer in the United States in 2013 [ 1 ]. (biomedcentral.com)
There are various methods for treating of recurrent ovarian cancer and chemotherapeutic regimen is chosen based on platinum susceptibility but there is no established second-line therapy. (biomedcentral.com)
In the National Comprehensive Cancer Network (NCCN) guidelines (version 3, 2012), hormone therapy is classified under "other drugs that are potentially effective" as "approved treatment for recurrent forms" of epithelial ovarian cancer. (biomedcentral.com)
In a Phase I clinical trial, Torisel (temsirolimus) demonstrated limited efficacy in ovarian cancer patients with PIK3CA mutations ( PMID: 22271473 ). (jax.org)

A five-country study of cancers in patients with T1DM has reported that T1DM was correlated with the risk of several common cancers. (frontiersin.org)
Breast cancer is one of the most common cancers affecting women worldwide. (dovepress.com)

About 69,500 women died of breast cancer in China in 2015, and the mortality in urban and rural areas was 43.8 and 25.7 per thousand, respectively [2]. (researchsquare.com)
Further, previous studies have suggested that diabetes is associated with increased risk of cancer mortality ( 5 , 6 ). (frontiersin.org)
Previous cohort studies also reported an overall increased standardized mortality ratio for cancers among patients with T1DM compared with the general population ( 14 ). (frontiersin.org)
Previous large cohort studies conducted in the UK suggested that neither the risk of urinary bladder cancer nor mortality from urinary bladder cancer was increased in patients with T1DM or T2DM ( 11 , 16 ). (frontiersin.org)
In addition, cohort studies undertaken in the UK ( 11 , 18 ) and the USA ( 19 ) reported that no significantly increased all-cause cancer mortality was found in patients with T1DM when compared to the general population. (frontiersin.org)
Breast cancer is the predominant cancer among women in the world-wide and the leading cause of cancer-related mortality [ 1 ]. (oncotarget.com)
Despite today's advances in the treatment of cancer, breast cancer-related mortality remains high, in part due to the lack of effective targeted therapies against breast tumor types that do not respond to standard treatments. (biomedcentral.com)
Treatment is aimed at reducing the risk of future recurrence, thereby reducing breast cancer−related morbidity and mortality. (medscape.com)

Numerous dietary components and vitamins have been found to inhibit the molecular events and signalling pathways associated with various stages of breast cancer development. (vitamindwiki.com)
In fact, CAPE is well documented as inducing cell death by inhibiting NFκB and by inducing pro-apoptotic pathways (i.e., p53). (propolisscience.org)

This finding was confirmed by another study that used freeze-dried black raspberries, which inhibited esophageal cancer in rodents by 30 to 60 percent. (newsmax.com)
Esophageal cancer is the common malignant neoplasm, which arises from the mucosa or gland of the esophagus. (biomedcentral.com)
An estimated 17,290 patients will be diagnosed with esophageal cancer, and 15,850 people will die due to this disease in 2018 in the United States [ 1 ]. (biomedcentral.com)
The reasons of esophageal cancer development are unclear. (biomedcentral.com)
Early detection and treatment of esophageal cancer is a promising strategy to improve the survival rate in esophageal cancer patients. (biomedcentral.com)
However, esophageal cancer patients often exhibit the onset of symptoms at diagnosis, which leads to poor prognosis. (biomedcentral.com)
Alternatively, identification of molecular mechanism underlying esophageal tumorigenesis could be helpful for the better treatment of esophageal cancer patients. (biomedcentral.com)

They even isolated ferulic acid and beta-sitosterol as the active ingredients in the berries that inhibited the cancers. (newsmax.com)

These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)

Small cell lung cancer (SCLC), a poorly differentiated and highly aggressive tumor, constitutes approximately 15% of all lung cancers ( 1 ). (spandidos-publications.com)
Triple-negative breast cancer (TNBC), representing the most aggressive form of breast cancer with currently no targeted therapy available, is characterized by an inflammatory and hypoxic tumor microenvironment. (bath.ac.uk)

It reviews available evidence (some of which is very recent) with regards to the antimetastatic, antiproliferative and anticancer effects of honey in various forms of cancer. (mdpi.com)

Immunostimulatory cytokines can enhance anti-tumor immunity and are part of the therapeutic armamentarium for cancer treatment. (weeksmd.com)

Two common types of medication for HR-positive breast cancers are Tamoxifen and aromatase inhibitors. (biotechprimer.com)
Steroids Canada is proud to offer Zionova Aromasin, an aromatase inhibitor that is highly effective at preventing gynecomastia, or the development of breasts in men. (steroidscanada.is)
In patients receiving adjuvant aromatase inhibitor therapy for breast cancer who are at high risk for fracture, the monoclonal antibody denosumab or either of the bisphosphonates zoledronic acid and pamidronate may be added to the treatment regimen to increase bone mass. (medscape.com)

Although the survival rate for breast cancer in China has greatly improved, the five-year survival rate is still significantly lower than in Western developed countries. (researchsquare.com)
On the contrary, incidences of prostate cancer and testis cancer significantly decreased in men with T1DM in comparison with the general population ( 7 , 13 ). (frontiersin.org)

Here, we aimed to identify novel super-enhancer dysregulated genes highly associated with breast cancer patients' poor prognosis and negative response to treatment. (biomedcentral.com)

This review summarized the associations between various types of diabetes and cancers and updated available evidence of underlying mechanisms between diabetes and cancers. (frontiersin.org)
However, the underlying mechanisms between various types of diabetes and cancers have not yet been summarized. (frontiersin.org)
Transient receptor potential (TRP) channels contribute to the regulation of intracellular calcium, which can promote cancer hallmarks in cases of dysregulation of gene transcription and calcium-dependent pro-proliferative or anti-apoptotic mechanisms. (dovepress.com)
Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
To date, various mechanisms have been suggested to explain the powerful tumor-suppressive effect of p53, including the induction of cell cycle arrest, senescence, and apoptosis. (nature.com)
Therefore, there remains a need to identify reliable biomarkers and cancer-related molecular mechanisms that can assist with making decisions regarding a patient's prognosis and developing suitable therapeutic strategies. (biomedcentral.com)
Although some mechanisms have been clarified, including growth factors, ionizing radiation, iodine intake, gender and genetic factors, these factors have not yet specifically clarified the mechanisms of PTC occurrence and cannot be used as specific targets for clinical treatment for PTC. (jcancer.org)

Adjuvant treatment for breast cancer involves radiation therapy and a variety of chemotherapeutic and biologic agents. (medscape.com)

The identified potential therapeutic targets of HNK (PTTH) included CCND1 , SIRT2 , AURKB , VEGFA , HDAC1 , CASP9 , HSP90AA1 , and HSP90AB1 , which can potentially inhibit the cell cycle of mBCSCs. (hindawi.com)
Compound (1) demonstrates superiority against the therapeutic gold standard paclitaxel by diminishing spheroid growth by 40% at 100 nM. (bath.ac.uk)
Understanding Lunasin 's biology and potential as a cancer therapeutic by utilizing Drosophila genetics. (weeksmd.com)
The therapeutic effect of AIs has been shown to be superior to that of tamoxifen as adjuvant therapy for breast cancer [ 14 ]. (biomedcentral.com)
Breast cancer is a major public health problem worldwide in women and current therapeutic strategies are not adequately effective for this deadly disease. (oncotarget.com)

In conclusion, our result demonstrated strong synergy between two major citrus PMFs (NBT and TAN) and ATST in inhibiting human breast cancer cell growth. (umass.edu)
Two human breast cancer cell lines, MDA-MB-231 (wild-type BRCA1) and HCC1937 (mutated BRCA1), were compared to ascertain the difference in growth signaling depending on the presence of functional BRCA1. (snu.ac.kr)
Background In the present study, we investigated the effect of Salinomycin on the survival of three human breast cancer cell lines MCF-7, T47D and MDA-MB-231 grown in adherent culture conditions. (uaeu.ac.ae)

Anatomy13

Organisms3

Diseases46

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment77

Psychiatry and Psychology2

Phenomena and Processes50

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science7

Named Groups3

Health Care31

Geographicals2

Proliferation25

Inhibition19

Metastasis4

Tumors10

Induces7

Apoptosis in breast cancer3

Vitro7

Pathway9

Progression8

Epidermal growth f5

Metastatic10

Pancreatic2

Angiogenesis3

Shown to inhibit2

Chemotherapy6

Overexpression4

Xenograft3

Diseases10

Postmenopausal2

Cells45

Colon9

Preclinical1

Production of estrogen3

Prostate cancers1

HER22

Induce2

Compounds2

Melanoma1

Protein2

Incidence6

Ovarian cancer7

Common cancers2

Mortality8

Pathways2

Esophageal7

Beta-sitosterol1

Colorectal cancer cell1

Aggressive2

Anticancer effects1

Anti-tumor1

Aromatase3

Significantly2

Poor prognosis1

Mechanisms7

Adjuvant Treatment1

Therapeutic5

Human breast cancer3