• The discovered mechanosensitive pathway is conserved in other pathogens, allowing this strategy to be exploited for developing unique antibiotics to combat multiple types of bacterial infections. (technologypublisher.com)
  • Furthermore, indole and its derivatives are viewed as potential antivirulence compounds against antibiotic-resistant pathogens because of their ability to inhibit quorum sensing and virulence factor production. (nih.gov)
  • Achaogen in San Francisco, CA is working on "preclinical development of novel therapeutics that reduce the virulence of, and inhibit resistance in, Class A Bacterial Pathogens. (defenseindustrydaily.com)
  • So, just what are "Class A bacterial pathogens? (defenseindustrydaily.com)
  • Achaogen in San Francisco, CA won a $24.6 million cost-reimbursement contract for preclinical development of novel broad-spectrum small-molecule therapeutics that reduce the virulence of, and inhibit resistance in, Class A Bacterial Pathogens. (defenseindustrydaily.com)
  • My laboratory is interested in understanding, treating, and preventing diarrheal disease caused by bacterial pathogens. (k-state.edu)
  • The goal of this study was to define how bacterial pathogens exploit eukaryotic secretory pathways. (k-state.edu)
  • Regulation of type III secretion hierarchy of translocators and effectors in attaching and effacing bacterial pathogens. (k-state.edu)
  • We have previously identified a panel of inhibitors targeting bacterial histidine kinases in bacteria that inhibit targets involved in the regulation of virulence and stress response pathways in bacterial pathogens (Velikova et al. (wur.nl)
  • These pathogens express a type III secretion system molecular syringe that injects bacterial effectors into the target cells, subverting host pathways and allowing successful colonisation, thus making C. rodentium an invaluable tool to investigate virulence mechanisms, mucosal immunity and host adaptation. (imperial.ac.uk)
  • There is a growing interest in studying the effect of nanoparticles on quorum sensing signaling mechanisms in bacterial pathogens at sub-inhibitory concentrations to develop alternative therapeutics. (taylorfrancis.com)
  • Targeting QS can attenuate the virulence of pathogens without inhibiting their growth. (taylorfrancis.com)
  • Therefore, inhibiting the growth of oral pathogens, as well as effectively preventing biofilm formation contribute to reducing these risks. (biomedcentral.com)
  • Finally, we discuss the opportunities and challenges of autophagy manipulation in improving therapeutics and vaccines against bacterial pathogens. (frontiersin.org)
  • Here, we review the many functions of autophagy in bacterial infections with a focus on macrophages, the first line of host defenses, and the replicative niche of numerous pathogens. (frontiersin.org)
  • As a novel antibacterial agent against foodborne pathogens, endolysins are peptidoglycan hydrolases encoded by bacteriophages that lyse bacterial cells by targeting their cell wall, notably in Gram-positive bacteria due to their naturally exposed peptidoglycan layer. (usda.gov)
  • Given the conservation of T6SS in several human bacterial pathogens, the discovery of an effective broad-spectrum T6SS virulence blocker represents an attractive target for development of antivirulence therapies. (crcm-marseille.fr)
  • In contrast to antibiotics that inhibit the growth pathways of bacteria, the antivirulence strategy is a promising approach to disarm pathogens by interfering with bacterial virulence factors without exerting evolutionary pressure. (crcm-marseille.fr)
  • Homologs of CsrA and related regulatory RNAs have been implicated in the regulation of gluconeogenesis, biofilm formation, and virulence factor expression in plant and human pathogens. (illinois.edu)
  • The ability of bacteria to cause disease is described in terms of the number of infecting bacteria, the route of entry into the body, the effects of host defense mechanisms, and intrinsic characteristics of the bacteria called virulence factors. (wikipedia.org)
  • The virulence factors of bacteria are typically proteins or other molecules that are synthesized by enzymes. (wikipedia.org)
  • Many bacterial and host molecules that are involved in the adhesion of bacteria to host cells have been identified. (wikipedia.org)
  • These virulence factors allow the bacteria to enter host cells and facilitate entry into the body across epithelial tissue layers at the body surface. (wikipedia.org)
  • Immune response inhibitors Many bacteria produce virulence factors that inhibit the host's immune system defenses. (wikipedia.org)
  • Toxins Many virulence factors are proteins made by bacteria that poison host cells and cause tissue damage. (wikipedia.org)
  • We currently focus on three protein targets involved in difference aspects of virulence expression in pathogenic bacteria. (luc.edu)
  • Overall, a variety of approaches including protein engineering, inhibitor design and discovery of super agonistic ligands will be used to exploit the potential of reducing virulence, to bring about novel treatments that overcome antibiotic resistance in bacteria, and to improve the quality of life of patients who suffer from these life-long infections. (luc.edu)
  • 2016 Sci Rep ). Inhibiting virulence mechanisms in disease-causing bacteria would disarm the pathogen, enabling the host innate immune system to eradicate the pathogen from the body and reduce selection for emergence and spread of drug-resistance in host-associated microbiota. (wur.nl)
  • Quorum sensing (QS) modulates biofilm formation and virulence factor production in most of the pathogenic bacteria. (taylorfrancis.com)
  • Several earlier studies have shown that honey inhibits the formation of biofilms or disease-causing bacteria. (ndtv.com)
  • It is important to develop functional transmucosal implant surfaces that reduce the number of initially adhering bacteria and they need to be modified to improve the anti-bacterial performance. (hindawi.com)
  • The first method is to inhibit the initial adhesion of oral bacteria. (hindawi.com)
  • The second method is to inhibit the colonization of the oral bacteria, which involves surface antibacterial activity [ 7 ]. (hindawi.com)
  • Princeton Docket # 15-3109-1Researchers in the Departments of Molecular Biology and Mechanical and Aerospace Engineering at Princeton University have designed new methods to effectively inhibit the entry, spread and growth of bacteria. (technologypublisher.com)
  • In this study, we evaluated the ability of two types of biosurfactants (rhamnolipids and surfactin) to inhibit growth and biofilm formation ability of oral pathogenic bacteria such as Aggregatibacter actinomycetemcomitans , Streptococcus mutans , and Streptococcus sanguinis . (biomedcentral.com)
  • Rhamnolipids inhibited the growth and biofilm formation ability of all examined oral bacteria. (biomedcentral.com)
  • Anti-bacterial agents and disinfectants are effective against planktonic bacteria (bacteria suspended in liquid), however, they are not effective against biofilm-forming bacteria due to the difficulty of chemicals penetrating the biofilm. (biomedcentral.com)
  • The development of antibiotic resistance in periodontopathogens is a major issue given that these bacteria may migrate from the oral cavity to other organs where they may cause infections or transfer their antibiotic resistances to other bacterial species. (nature.com)
  • Most studies focus on the bacterial response to lethal antibiotic concentrations, yet bacteria often encounter lower antibiotic doses that still allow their growth. (fems-microbiology.org)
  • The study " Non-essential tRNA and rRNA modifications impact the bacterial response to sub-MIC antibiotic stress " in microLife looks at new mechanisms of how bacteria adapt to sub-inhibitory concentrations of antibiotics. (fems-microbiology.org)
  • Quorum sensing (QS) is a phenomenon in bacteria where the accumulation of extracellular signaling molecules (autoinducers, AIs), which enable bacterial cells to sense neighboring cells (population density), reaches certain threshold and triggers group behaviors of bacteria including virulence production and biofilm formation. (umd.edu)
  • The inhibition of QS and hence toxin production or biofilm formation by pathogenic bacteria has been suggested as an alternative strategy to deal with the problem of bacterial resistance to traditional antibiotics. (umd.edu)
  • Inhibiting QS will not kill bacteria, however the expectation is that resistance to a QS antagonist will not be as widespread as it is for traditional cytotoxic antibiotics. (umd.edu)
  • [1] [2] They may either kill or inhibit the growth of bacteria. (wikipedia.org)
  • In current usage, the term "antibiotic" is applied to any medication that kills bacteria or inhibits their growth, regardless of whether that medication is produced by a microorganism or not. (wikipedia.org)
  • A recently emerged strategy consists of disarming pathogenic bacteria by targeting and blocking their virulence factors. (crcm-marseille.fr)
  • Conversely to antibiotics and biocides, VesuBACT does not alter the survival of bacteria but targets the communication system they use to regulate the virulence process. (directindustry.com)
  • In addition to its role in protein degradation ClpP is also a global regulator in the production of bacterial toxins - termed virulence factors - that are mainly responsible for the disease-causing effect of bacteria. (mpg.de)
  • The antimicrobial resistance (AMR) and/or virulence determinants possessed by the associated bacteria are generally found on mobile genetic elements (MGEs) that transmit between K . pneumoniae cells via horizontal gene transfer (HGT) [ 4 ]. (biomedcentral.com)
  • Role of serotype and virulence determinants of Streptococcus pyogenes biofilm bacteria in internalization and persistence in epithelial cells in vitro. (lu.se)
  • Here, live respiratory epithelial cells were inoculated with broth-grown or biofilm bacteria of different M-types, as well as with isogenic mutants lacking common virulence factors. (lu.se)
  • Microscopy of internalized bacteria showed that planktonic bacteria were internalized in lower numbers as individual or small clumps of bacteria in the cytoplasm, whereas GAS biofilm bacteria displayed a pattern of perinuclear localization of bacterial aggregates that affected actin structure. (lu.se)
  • Dive into the research topics of 'Role of serotype and virulence determinants of Streptococcus pyogenes biofilm bacteria in internalization and persistence in epithelial cells in vitro. (lu.se)
  • Antimicrobial proteins and peptides offer a multifaceted mechanism suitable to fight bacterial resistance. (frontiersin.org)
  • Many virulence factors are so-called effector proteins that are injected into the host cells by specialized secretion apparati, such as the type three secretion system. (wikipedia.org)
  • For example, a common bacterial strategy is to produce proteins that bind host antibodies. (wikipedia.org)
  • Dr. Liu's research group primarily employs X-ray crystallography in combination with mechanistic, biological and computational methods to study proteins involved in bacterial infections and other human diseases. (luc.edu)
  • Additionally, bacterial virulence proteins utilize many molecular mechanisms that are also conserved among viruses of importance to biosecurity. (k-state.edu)
  • My research team has discovered several mechanisms by which bacterial proteins subvert the host innate immune system to promote bacterial colonization and transmission. (k-state.edu)
  • The goal of this study is to characterize E. coli virulence proteins that disrupt the host immune response. (k-state.edu)
  • The goal of this study was to identify E. coli virulence proteins that inhibit innate immunity. (k-state.edu)
  • Oregon State University scientists have identified proteins that prevent a bacterial cell from becoming misguided by its own messaging, allowing it to instead wait for collective communication from its group. (news-medical.net)
  • The composition, configuration, and density of the proteins in the pellicle derived from the saliva and gingival crevicular fluid are largely dependent on the physical and chemical nature of the underlying surface and thus the properties of the surface influence bacterial adhesion through the pellicle [ 2 ]. (hindawi.com)
  • These results could be the basis for future studies to develop antibiotics that inhibit the translation of specific proteins, for example, virulence factors or antibiotic resistance genes. (fems-microbiology.org)
  • It plays an important role in bacterial metabolism by ensuring the controlled degradation of defective proteins. (mpg.de)
  • The class of RNAs that modify activity of proteins is exemplified by CsrB and CsrC of E. coli, two RNAs that bind to and inhibit CsrA, a protein translational regulator. (illinois.edu)
  • Researchers in the Department of Molecular Biology at Princeton University and the School of Medicine at Dartmouth College have identified a novel strategy for inhibiting the pathogenesis of the human pathogen Pseudomonas aeruginosa by regulating its virulence factors upon surface contact instead of inhibiting its growth. (technologypublisher.com)
  • The pathogenicity of an organism-its ability to cause disease-is determined by its virulence factors. (wikipedia.org)
  • Therefore, strategies to combat certain bacterial infections by targeting these specific virulence factors and mobile genetic elements have been proposed. (wikipedia.org)
  • Virus virulence factors allow it to replicate, modify host defenses, and spread within the host, and they are toxic to the host. (wikipedia.org)
  • Some viral virulence factors confer ability to replicate during the defensive inflammation responses of the host such as during virus-induced fever. (wikipedia.org)
  • Genetic and functional analysis of these variants provides insight into the potential contribution of specific bacterial virulence factors to these emerging GBS clinical syndromes. (cdc.gov)
  • Of GBS virulence factors, 2 of the best characterized are its exopolysaccharide capsule and the surface-associated toxin, β-hemolysin/cytolysin (β-h/c). (cdc.gov)
  • It is an uncommon cause of adult bacterial meningitis, mainly causing disease in those with predisposing factors. (medscape.com)
  • The gene expression level of virulence factors of S. mutans was detected by qRT- PCR . (bvsalud.org)
  • Two bacterial virulence factors are required for effective induction of apoptosis by extracellular GAS: (i) hyaluronic acid capsule that inhibits bacterial internalization and (ii) secreted cytolysin, streptolysin O (SLO), that forms. (lu.se)
  • Two bacterial virulence factors are required for effective induction of apoptosis by extracellular GAS: (i) hyaluronic acid capsule that inhibits bacterial internalization and (ii) secreted cytolysin, streptolysin O (SLO), that forms transmembrane pores that permit extracellular calcium influx into the cytosol. (lu.se)
  • Shigellosis, an acute bacterial infection of the intestine, is caused by the gram-negative Shigella bacterium whose pathogenicity is reliant on virulence factors (VirF) required to invade epithelial cells. (uni-marburg.de)
  • Strategies developed to inhibit TGT include potent active-site inhibitors to block the binding of tRNA, thereby preventing the transcription of the virulence factors. (uni-marburg.de)
  • Moreover, these tea components also attenuated F. nucleatum -mediated hemolysis and hydrogen sulfide production, two other virulence factors expressed by this bacterium. (nature.com)
  • Additionally, it seems that the resulting variations in translation and codon recognition could be critical factors in the bacterial stress response. (fems-microbiology.org)
  • Proteus mirabilis are Gram negative rods, show a wide range of pathogenesis based on arsenal of diverse virulence factors. (academicjournals.org)
  • Associated Risk Factors and Diagnostic Value of Fiberoptic Bronchoscopy for Protracted Bacterial Bronchitis in Children. (medscape.com)
  • The capsule contributes to immune resistance by inhibiting complement deposition and activation on the bacterial surface, thereby reducing opsonophagocytic clearance ( 4 ). (cdc.gov)
  • Their approach focuses on small molecules that inhibit the emergence of bacterial resistance to antibiotics. (defenseindustrydaily.com)
  • Sub-objective 4.1: Analysis of ExPEC isolated from chickens and humans: biofilm assays, virulence gene profiles, antimicrobial resistance profiles, whole genome comparison of ExPEC strains isolated from chicken and human infections. (usda.gov)
  • Now add battling bacterial resistance to the list. (ndtv.com)
  • UAB researchers, based on a collection of clinical isolates from several countries, have established a link between the cell-to-cell communication system (the quorum sensing) and the virulence and resistance phenotypes in Stenotrophomonas maltophilia. (news-medical.net)
  • Additionally, these two analogues were found to inhibit penicillin resistance in two strains of MRSA. (purdue.edu)
  • In contrast to classic antibiotic treatment, an anti-virulence strategy should lead to lower resistance rates," the scientist explained. (regenerativemedicine.net)
  • Resistance designates the ability of a bacterial cell to withstand and grow during antibiotic treatment. (fems-microbiology.org)
  • Yet, characterizing the bacterial responses to such stress and its impact on resistance and tolerance needs to be comprehensively clarified. (fems-microbiology.org)
  • VesuBACT aims at inhibiting bacterial virulence and biofilm formation while not selecting for resistance. (directindustry.com)
  • moreover, these isolates showed an increase resistance and more aggressive virulence behavior. (academicjournals.org)
  • Any drug impairing crucial processes for bacterial life will inevitably lead to the development of drug-resistant strains, whereas the inhibition of biofilm formation might prevent the onset of bacterial resistance. (intechopen.com)
  • Resistance to the lytic effects of serum complement confers virulence. (msdmanuals.com)
  • Antimicrobial peptide temporin derivatives inhibit biofilm formation and virulence factor expression of Streptococcus mutans . (bvsalud.org)
  • The virulence of various strains of Helicobacter pylori tends to correlate with the level of production of urease. (wikipedia.org)
  • Encapsulated strains (also known as typeable) are surrounded by a polysaccharide capsule that plays an important role in the determination of virulence of the organism. (medscape.com)
  • We will examine poultry and swine as reservoirs for food-borne infections linked to ExPEC and STEC, respectively, and characterize isolated strains to determine their virulence. (usda.gov)
  • The type VI secretion system (T6SS) is a widespread secretion nanomachine encoded and employed by pathogenic strains to establish their virulence process during host invasion. (crcm-marseille.fr)
  • A disc that contains 0.04U of bacitracin inhibits the growth of more than 95% of group A strains, whereas 80-90% of non-group A strains are resistant to this antibiotic. (medscape.com)
  • however, individual strains vary in their virulence potential due to the presence of mobile accessory genes. (biomedcentral.com)
  • Concerningly, iuc has also been reported in MDR strains in the hospital setting, where it was associated with increased mortality, highlighting the need to understand, detect and track the mobility of these virulence loci in the K . pneumoniae population. (biomedcentral.com)
  • This study provides a framework for identifying and tracking these important virulence loci, which will be important for genomic surveillance efforts including monitoring for the emergence of hypervirulent MDR K . pneumoniae strains. (biomedcentral.com)
  • His work discovered new components of the bacterial cytoskeleton, new functions for bacterial polymers in metabolism, compartmentalization, and chromosome dynamics, and established the importance of protein assembly for unexpected processes like metabolism and pathogenesis. (technologypublisher.com)
  • In the traditional clinical view of invasive GBS pathogenesis, a bacterial isolate enters a normally sterile site from a focus of mucosal colonization or recent acquisition of the pathogen. (cdc.gov)
  • Thus, in vivo pathogenesis from a bacterial perspective is likely more dynamic. (cdc.gov)
  • Indole, as an interspecies and interkingdom signaling molecule, plays important roles in bacterial pathogenesis and eukaryotic immunity. (nih.gov)
  • Although the T6SS is undoubtedly involved in pathogenesis, strategies targeting this virulence factor are crucially lacking. (crcm-marseille.fr)
  • These targets are critical for different biological functions but converge on virulence expression in persistent infections such as the lung infection in patients with cystic fibrosis. (luc.edu)
  • This article is about treatment of bacterial infection. (wikipedia.org)
  • Improved Zn status may also reduce the risk of bacterial co‑infection by improving mucociliary clearance and barrier function of the respiratory epithelium, as well as direct antibacterial effects against S. pneumoniae. (spandidos-publications.com)
  • The objectives of the proposed Transnational Network are to bring together scientists from academia and industry working in relevant multidisciplinary fields to develop integrated strategies to overcome the permeability barrier of Gram-negative cell envelopes and further develop newly discovered histidine kinase inhibitors as anti-virulence therapies. (wur.nl)
  • The group of Stephan Sieber (TU Munich) has been successfully investigating the protease ClpP for years and has already developed a variety of potent inhibitors against ClpP that can stop the production of bacterial toxins. (mpg.de)
  • The polysaccharide capsule of Streptococcus pneumoniae inhibits phagocytosis of the bacterium by host immune cells. (wikipedia.org)
  • [ 1 ] The other two causes of bacterial meningitis in adolescents are Neisseria meningitidis and Streptococcus pneumoniae . (medscape.com)
  • Moreover, the high expression of capsule and SLO inhibited cellular uptake and capsule expression was required for intracellular survival. (lu.se)
  • We have proposed that this effect stems from a reduction in the essential bacterial carotenoid staphyloxanthin which is necessary to the maturation of penicillin binding protein PBP2a and an important virulence factor in S. aureus. (purdue.edu)
  • on-going studies aim to employ lactonase as a protein therapeutic to disrupt bacterial cell-to-cell communication, quorum-quenching. (luc.edu)
  • On Target 2, on-going studies aim to inhibit acylase to disrupt bacterial iron acquisition. (luc.edu)
  • Several studies have recently shown that features such as its high infectivity, slow growth, and complex cell-wall structure, make M. tuberculosis a major challenge to be faced, since the specific mechanisms that reinforce the high virulence of Mtb remain largely unknown ( 4 , 7 ). (frontiersin.org)
  • Synthesis of acquired siderophores contributes to K . pneumoniae virulence via multiple mechanisms. (biomedcentral.com)
  • Endotoxin triggers humoral enzymatic mechanisms involving the complement, clotting, fibrinolytic, and kinin pathways and causes much of the morbidity in gram-negative bacterial sepsis. (msdmanuals.com)
  • Many microorganisms have mechanisms that impair antibody production by inducing suppressor cells, blocking antigen processing, and inhibiting lymphocyte mitogenesis. (msdmanuals.com)
  • QS inhibition can be achieved by inhibiting signal synthesis, disrupting signal reception, and degradation of signal molecules. (taylorfrancis.com)
  • Testing the susceptibility of Staphylococcus aureus to antibiotics by the Kirby-Bauer disk diffusion method - antibiotics diffuse from antibiotic-containing disks and inhibit growth of S. aureus , resulting in a zone of inhibition. (wikipedia.org)
  • Abstract Background: Bacterial populations communicate through the cell density-dependent mechanism of quorum sensing (QS). (huji.ac.il)
  • The newly licensed parenteral vaccine (Vi capsular polysaccharide {ViCPS}) is composed of purified Vi ('virulence') antigen, the capsular polysaccharide elaborated by S. typhi isolated from blood cultures (16). (cdc.gov)
  • Also it could change anti-bacterial lipids and prolong survival of MRSA in wound. (powershow.com)
  • Conclusion: First evidence is being provided for interference of bacterial signal-transduction systems by a synthetic cannabinoid. (huji.ac.il)
  • The enzymes in these studies include bacterial Sucrose Synthase and bacterial ADP-Glucose Pyrophosphorylase, which are important in biofuel production. (luc.edu)
  • Trouw L., Nilsson S., Goncalvez I., Landberg G. and Blom A. M. (2005) C4b-binding protein binds to necrotic cells and DNA, which limits DNA release and inhibits complement activation. (lu.se)
  • An ideal transmucosal implant surface exposed to the oral cavity is recommended to be highly polished to resist bacterial colonization and it is expected to allow the formation of an epithelial seal that prevents plaque accumulation leading to peri-implantitis [ 5 , 6 ]. (hindawi.com)
  • The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function. (k-state.edu)
  • HU-210 inhibited QS-mediated virulence factor production without any inhibitory effect on bacterial growth. (huji.ac.il)
  • We report that modifications to the native AI-2 molecule affords analogs that can potently inhibit QS processes in E. coli and Salmonella. (umd.edu)
  • While all common antibiotics work by inhibiting vital processes, in this new approach an antibacterial effect is achieved by activating a process. (mpg.de)
  • According to her, honey uses a combination of weapons, including hydrogen peroxide, acidity, osmotic effect, high sugar concentration and polyphenols -- all of which actively kill bacterial cells. (ndtv.com)
  • For instance, the osmotic effect, which is the result of the high sugar concentration in honey, draws water from the bacterial cells, dehydrating and killing them. (ndtv.com)
  • Petidoglycan-Used for osmotic stability so bacterial cell wall does not burst due to hypertonic states. (powershow.com)
  • The goal of this study was to define the role of the NleF protein in enterohemorrhagic E. coli virulence. (k-state.edu)
  • Research on pathogenic E. coli will focus on examining the association between acid tolerance in STEC and virulence potential, curli expression, biofilm formation, and persistence. (usda.gov)
  • Since 1973 in the US, five bacterial illness outbreaks have been attributed to berries [ 8, 10 ] and most of them were related to strawberries contaminated with Staphylococcus aureus (1985), Salmonella Group B (2003), and enterohemorragic E. coli O26 (2006). (iospress.com)
  • Achaogen, Inc. in South San Francisco, CA receives an $8.9 million cost-plus-fixed-fee contract modification to research novel broad spectrum therapeutics against gram-negative bacterial threat agents, for the US Defense Threat Reduction Agency's R&D enteprise. (defenseindustrydaily.com)
  • Achaogen in San Francisco, CA won an $18.8 million cost-plus-fixed-fee contract to Perform Research on Novel Broad-Spectrum Therapeutics Against Gram-Negative Bacterial Threat Agents. (defenseindustrydaily.com)
  • Bacterial effector binding to ribosomal protein S3 subverts NF-B function. (k-state.edu)
  • Such modifications of the tRNA or rRNA further influence the protein translation rate, fidelity, precision of codon decoding and, therefore, the composition of the bacterial proteome. (fems-microbiology.org)
  • Zinc possesses anti‑inflammatory activity by inhibiting NF‑κB signaling and modulation of regulatory T‑cell functions that may limit the cytokine storm in COVID‑19. (spandidos-publications.com)
  • Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex. (crcm-marseille.fr)
  • On the other hand, tolerance - also associated with antibiotic treatment failure - refers to the extension of the period during which a bacterial population can survive the transient exposure to antibiotics. (fems-microbiology.org)
  • A ubiquitous organism, S pyogenes is the most common bacterial cause of acute pharyngitis , accounting for 15-30% of cases in children and 5-10% of cases in adults. (medscape.com)
  • In the absence of voltage, aminoglycosides are taken into cells and exert bacteriostatic effects by inhibiting translation. (elifesciences.org)
  • The results clearly demonstrated that rhamnolipids inhibit biofilm formation after the initiation process, however, they do not affect attachment or maturation. (biomedcentral.com)
  • On Target 3 , on-going studies aim to modulate GabR-dependent transcription regulation to weaken bacterial stress response. (luc.edu)
  • Rhamnolipids inhibit oral bacterial growth and biofilm formation by A. actinomycetemcomitans Y4, and may serve as novel oral drug against localized invasive periodontitis. (biomedcentral.com)
  • BACKGROUND: Descriptions of changes in invasive bacterial disease (IBD) epidemiology during the COVID-19 pandemic in the United States are limited. (cdc.gov)
  • Bacterial survival assay, fluorescent staining assay and transmission electron microscopy observation were applied to explore how the peptides inhibited and killed S. mutans. (bvsalud.org)
  • It has been shown that the peptides inhibited biofilm rapid accumulation by weakening the initial adhesion of S. mutans and reducing the production of EPS. (bvsalud.org)
  • Bacterial death against the as-annealed Ag doped TiO 2 nanotubes were detected against A. actinomycetemcomitans , T. forsythia , and C. rectus indicating antibacterial efficacy. (hindawi.com)
  • The tea extracts and components displayed various degrees of antibacterial activity that may involve damage to the bacterial cell membrane and the chelation of iron. (nature.com)
  • The antibiofilm efficacy was assayed by examining exopolysaccharide (EPS) and lactic acid production , bacterial adhesion and cell surface hydrophobicity . (bvsalud.org)
  • Lactic acid was more effective inhibiting bacterial growth compared to malic acid. (iospress.com)
  • GBS production of β-h/c is encoded by the genes of the cyl operon ( 5 , 6 ) and is associated with direct lysis of a variety of eukaryotic cell types ( 7 - 9 ), inflammatory activation ( 10 - 12 ), and virulence in animal models ( 10 , 13 , 14 ). (cdc.gov)
  • Because the bacterial cell is not killed off or inhibited in its growth, it is subject to less evolutionary pressure. (regenerativemedicine.net)
  • As originally described by Lancefield, beta-hemolytic streptococci can be divided into many groups based on the antigenic differences in group-specific polysaccharides located in the bacterial cell wall. (medscape.com)
  • He identified periodic acid-Schiff (PAS)-staining granules, most likely representing degenerating bacterial forms, within macrophages isolated from the small bowel as well as other tissue and fluid specimens (eg, pericardium, endocardium, lymph nodes, synovia, lung, brain, meninges) obtained from patients in whom Whipple disease was suspected. (medscape.com)
  • Bacterial morphology was examined using an SEM. (hindawi.com)
  • Techniques to inhibit biofilm formation are essential and have wide applications. (biomedcentral.com)
  • We also attempted to determine the step in the biofilm formation process that was inhibited by biosurfactants. (biomedcentral.com)
  • Thus, there is a requirement for the development of a simpler and more effective oral care capable of inhibiting oral bacterial growth and biofilm formation. (biomedcentral.com)
  • They also prevented biofilm formation by F. nucleatum at concentrations that did not interfere with bacterial growth. (nature.com)
  • The goal of this study was to determine how bacterial effectors inhibit type I interferon production. (k-state.edu)