Inhibit autonomic agents. Medical search. Frequent questions

Adrenergic blocking agents are a class of drugs that exhibit its pharmacological action through inhibiting the action of the sympathetic nervous system in the body. (wikipedia.org)
The sympathetic nervous system(SNS) is an autonomic nervous system that we cannot control by will. (wikipedia.org)
The autonomic nervous system (ANS) is to a large extent responsible for automatically and subconsciously regulating the cardiovascular, renal, gastrointestinal, thermoregulatory, and other systems, in order to enable the body to meet the continual and ever-changing stresses to which it is exposed. (blogspot.com)
Anatomically and functionally, the autonomic nervous system is made up of two subdivisions: the sympathetic system with long-lasting and diffuse effects, and the parasympathetic system with more transient and specific effects. (blogspot.com)
It also has a balancing effect on the autonomic nervous system, which controls blood pressure. (shivaexportsindia.com)
Multiple System Atrophy (MSA) is a rare, neurodegenerative disease characterized by failure of the autonomic nervous system and impaired movement. (yahoo.com)
Because these chemical weapons affect the autonomic nervous system, they are sometimes referred to as "nerve agents. (mhmedical.com)
What is important to consider is that the vagus nerve is part of the circuit that is the human nervous system and responsible for the transmission of the chemical agent responsible for inflammation: tumor necrosis factor (TNF). (chienergytraining.com)
The bladder and urethra are innervated by 3 sets of peripheral nerves arising from the autonomic nervous system (ANS) and somatic nervous system. (medscape.com)

autonomic ganglia, which likely increases peripheral vasoconstriction sympathetic nerve fiber transmission. (medscape.com)
It exerts little effects on the actions of ACh at nicotinic receptor sites such as autonomic ganglia. (wellingtonicu.com)

Nerve agents inhibit the enzyme acetylcholinesterase (AChE), which hydrolyzes the neurotransmitter acetylcholine (ACh) once ACh has finished activating receptors in neurons, muscles, and glands. (msdmanuals.com)
Neuromuscular blocking drugs act on acetylcholine receptors and fall into two distinct groups: nondepolarizing (competitive) and depolarizing blocking agents. (britannica.com)
Hyoscine hydrobromide is one of the major antimuscarinic agents that inhibit the action of acetylcholine (ACh) on autonomic effectors innervated by postganglionic cholinergic nerves as well as on smooth muscles that lack cholinergic innervation. (wellingtonicu.com)
Flavoxate (flay vox' ate) is a synthetic quaternary ammonium anticholinergic which inhibits the muscarinic actions of acetylcholine on autonomic nerve endings, decreasing the smooth muscle tone of bladder and gastrointestinal tract. (nih.gov)
Blockade of AChE is the most clinically significant effect of OPs and carbamates because this leads to the accumulation of excessive amounts of acetylcholine at muscarinic receptors (found on various cholinergic secretory cells), at nicotinic receptors (located on skeletal neuromuscular junctions and autonomic ganglia), and in the CNS. (mhmedical.com)
Excess acetylcholine produces a predictable cholinergic syndrome consisting of copious respiratory and oral secretions, diarrhea and vomiting, sweating, altered mental status, autonomic instability, and generalized weakness that can progress to paralysis and respiratory arrest. (cdc.gov)

With central neural blockade these changes may be attributable to block of autonomic fibers, a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system, and/or the beta-adrenergic receptor stimulating action of epinephrine when present. (nih.gov)
Autonomic nerve fibers innervate cardiac muscle, smooth muscle, and glands. (blogspot.com)
A muscle or gland innervated by autonomic fibers is called an effector organ. (blogspot.com)
If the autonomic nerve fibers to an effector organ are cut, the organ may continue to function, but will lack the capability of adjusting to changing conditions. (blogspot.com)
If the autonomic nerve fibers to the heart are cut, the heart will continue to beat and pump blood normally, but its ability to increase cardiac output under stress will be seriously limited. (blogspot.com)
It contains motor, sensory and autonomic (parasympathetic) fibers. (chienergytraining.com)

Organophosphate Poisoning and Carbamate Poisoning Organophosphates and carbamates are common insecticide ingredients that inhibit cholinesterase activity, causing acute muscarinic manifestations (eg, salivation, lacrimation, urination, diarrhea. (msdmanuals.com)
Nerve agents inhibit both muscarinic and nicotinic ACh receptors. (msdmanuals.com)

Suicide Risk: All patients being treated with drugs inhibiting the reuptake of norepinephrine and/or serotonin for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of treatment and when increasing or decreasing the dose. (savellahcp.com)
Families and caregivers of patients being treated with drugs that inhibit the reuptake of norepinephrine and/or serotonin should be alerted about the need to monitor patients daily. (savellahcp.com)

Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects. (hhs.gov)

MSA is a Parkinsonian disorder characterized by a variable combination of slowed movement and/or rigidity, autonomic instability that affects involuntary functions such as blood pressure maintenance and bladder control, and impaired balance and/or coordination that predisposes to falls. (yahoo.com)

This activity describes the indications, actions, adverse effects, and contraindications of sildenafil as an agent in the clinical setting. (nih.gov)
Contraindications Contraindications A condition or factor associated with a recipient that makes the use of a drug, procedure, or physical agent improper or inadvisable. (lecturio.com)

Organophosphorus compounds inhibit two enzymes: acetylcholinesterase (AChE), found in synaptic junctions and in red blood cells (RBCs), and butyrylcholinesterase, also known as pseudocholinesterase (PChE) or plasma cholinesterase, found in the blood. (mhmedical.com)

Xylocaine (lidocaine HCl) Injections are sterile, nonpyrogenic, aqueous solutions that contain a local anesthetic agent with or without epinephrine and are administered parenterally by injection. (nih.gov)
Although the incidence of side effects with lidocaine HCl is quite low, caution should be exercised when employing large volumes and concentrations, since the incidence of side effects is directly proportional to the total dose of local anesthetic agent injected. (pfizermedicalinformation.com)

To describe cardiac autonomic behavior in a child using biological medication in order to understand the neurological influence of autoimmunity in this type of case. (bvsalud.org)
The authors described a case report of an 8-year-old male child diagnosed with JIA - oligoarticular form, using etanercept (biological medication) through laboratory and imaging exams, kinetic-functional evaluation and cardiac autonomic modulation examination. (bvsalud.org)

In the 1950s, the US Army began to consider the development of binary nerve agent weapons to provide increased safety during storage and handling. (medscape.com)
At that time, unitary nerve agent weapons were the only ones in existence. (medscape.com)
Once deployed, the precursors mix and develop the nerve agent. (medscape.com)
Novichok agent ("Newcomer"): a series of nerve agents developed by the Soviet Union in the 1970s and 1990s, all in the "third generation nerve agent" category. (medscape.com)
Persons whose skin or clothing is contaminated with nerve agent can contaminate rescuers by direct contact or through off-gassing vapor. (cdc.gov)
It is the least volatile nerve agent. (cdc.gov)
Nerve agent vapors are heavier than air. (cdc.gov)
Nerve agent liquids are readily absorbed from the skin and eyes. (cdc.gov)
The purpose of this document is to enable health care workers and public health officials to recognize an unknown or suspected exposure to a nerve agent or an organophosphate (OP) pesticide. (cdc.gov)
The amount and route of exposure to the nerve agent or OP pesticide, the type of nerve agent or pesticide, and the premorbid condition of the person exposed person will contribute to the time of onset and the severity of illness. (cdc.gov)
For example, inhalation of a nerve agent or an OP pesticide leads to a quicker onset of poisoning with more severe symptoms when compared to with dermal exposure s, given the same amount of agent. (cdc.gov)
The following is a more comprehensive list of signs and symptoms that may be encountered in a person exposed to a nerve agent or OP pesticide. (cdc.gov)
Plasma or RBC cholinesterase may be disproportionately inhibited depending on the particular nerve agent, amount of exposure and time interval since exposure. (cdc.gov)
Note: The actual clinical manifestations of an exposure to a nerve agent or an organophosphate pesticide may be more variable than the syndrome described in this document. (cdc.gov)

Phosphodiesterase type 5 inhibitors enhance the effects of nitric oxide in smooth muscle relaxation of the corpus cavernosum by inhibiting the degradation of cGMP. (medscape.com)
[7] When PDE5 becomes inhibited, the accumulation of cGMP leads to increased cGMP-dependent protein kinase activity, which phosphorylates multiple targets in the smooth muscle cell. (nih.gov)

Dr. Tracey developed an electrical device that stimulates the vagus nerve and prevents production of TNF by a type of immune cell called a macrophage, effectively inhibiting inflammation. (chienergytraining.com)

Most of the drugs that stimulate or inhibit smooth muscle contraction do so by regulating the concentration of intracellular calcium , which is involved in initiating the process of contraction. (britannica.com)

G-series agents, or G agents, include GA (tabun), GB (sarin), GD (soman), and GF (cyclosarin), which were developed by Nazi Germany before and during World War II. (msdmanuals.com)

The description of childhood autonomic behavior of a boy undergoing biological drug treatment alerts the scientific community to a low-cost measurement test and mild discomfort such as HRV, which is an effective follow-up method. (bvsalud.org)
The treatment of JIA has taken place in the last 10 years with the introduction of biological or immunobiological therapies aiming to inhibit Tumor Necrosis Factor alpha (TNF α ) and cytosine. (bvsalud.org)

Neurocardiogenic syncope is a self-limiting condition caused by an abnormal or exaggerated autonomic response to certain stimuli. (uspharmacist.com)

Nerve agents are chemical warfare agents that have the same mechanism of action as OP organophosphate pesticides insecticides. (cdc.gov)

Nerve agents are readily absorbed from the respiratory tract. (cdc.gov)

This article discusses the roles of serotonin, the use of serotonergic agents, the diagnosis of serotonin syndrome, and its diagnostic differentials. (lww.com)
Increased risk when co-administered with serotonergic agents (e.g. (nih.gov)

Infections with any pathogen (viral, bacterial, fungal, protozoan, or helminthic) in any location of the body, may be associated with the use of corticosteroids alone or in combination with other immunosuppressive agents. (recallguide.org)
Acute neurologic effects produced by immunosuppressive agents have been widely described. (ajnr.org)

Anticholinergic agents can precipitate acute narrow angle glaucoma and acute urinary retention. (nih.gov)

The clinical used antihypertensive agent rilmenidine may reduce blood pressure via an activation of imidazoline I 1 -receptors in brain to lower sympathetic tone [ 8 , 9 ]. (hindawi.com)

Most nerve agents, like organophosphate insecticides, take hours to age fully, but GD (soman) can age essentially completely within 10 minutes of binding. (msdmanuals.com)

They are also called Novichok agents, and representative compounds are A-230, A-232, and A-234, which are liquids that are even more persistent than V-series agents and are just as potent. (msdmanuals.com)

When pharmacotherapy is warranted, selection of treatment agent(s) should be made based on the patient's medical history, cancer type, and disease severity. (cancernetwork.com)

These oral agents act peripherally to induce smooth muscle relaxation of the corpora cavernosa. (medscape.com)

They can be used to treat signs and symptoms of benign prostatic hyperplasia, hypertension (but not as first line agent), pheochromocytoma, extravasation management and reversal of local anesthesia. (wikipedia.org)
Some comprise additional neuropathic pain to the quick syndromes or struggle with order roxithromycin no prescription autonomic dysfunction, such as vasovagal symptoms. (upb.ro)

Most of the nerve agents were originally synthesized in a search for insecticides, but because of their toxicity, they were evaluated for military use. (cdc.gov)

Thus, agmatine-like compound has the potential to develop as a new therapeutic agent for hypertension in the future. (hindawi.com)

The essential oil of Ylang contains linalool, a compound that inhibits cell melanogenesis and has immune-system cytotoxicity. (shivaexportsindia.com)
Similarly, pretreatment with the mast cell degranulating agent, compound 48/80, rendered the animal refractory to nerve growth factor. (portlandpress.com)

The adverse effects of non-selective alpha blockers are caused by the autonomic response to the systemic changes induced by the adrenergic blocking agents. (wikipedia.org)
Furthermore, pretreatment with hexamethonium did not inhibit the hypotensive response to nerve growth factor. (portlandpress.com)
The autonomic state can be a predictor for verifying the response to immunomodulation therapy. (bvsalud.org)

They are also much more potent than the G-series agents. (msdmanuals.com)

Lidocaine HCl stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. (nih.gov)

However, it is unclear whether it is better to prescribe intensive glucose-lowering treatment than conventional treatment for stroke management, and whether specific antidiabetic agents are safer and more efficacious than other drugs for stroke management. (j-stroke.org)

The clinical manifestations depend on the state of the agent, route of exposure, and dose. (msdmanuals.com)
The rate of aging is highly variable, from several minutes to days, depending on the route of exposure as well as the specific OP. Dimethyl OP compounds (eg, dimethoate) generally age more quickly than diethyl agents (eg, chlorpyrifos), and lipophilic OP compounds can be released into the systemic circulation from fat stores for many days to weeks following exposure, prolonging both the duration of clinical toxicity and the aging window. (mhmedical.com)

These agents are useful in cases of difficult bladder emptying. (medscape.com)
Flavoxate is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome. (nih.gov)

G-type nerve agents (GA, GB, and GD) are clear, colorless liquids that are volatile at ambient temperatures. (cdc.gov)
G-type agents are clear,colorless, and tasteless liquids that are miscible in water and most organic solvents. (cdc.gov)

An A-series agent was used in a 2018 assassination attempt in the United Kingdom, and another A-series agent was used in the 2020 assassination attempt on Russian activist Alexei Navalny. (msdmanuals.com)

Thiazolidinedione (TZD) was introduced in the late 1990s, and new antidiabetic agents have been introduced since 2000. (j-stroke.org)

Nerve agents are readily absorbed by inhalation, ingestion, and dermal contact. (cdc.gov)

We also discuss evidence from recent large clinical trials of thiazolidinedione (TZD) and new antidiabetic medications such as dipeptidyl peptidase-4 (DPP4) inhibitors, sodium-glucose cotransporter-2 (SGLT2) inhibitors, and glucagonlike peptide-1 (GLP1) analogues, which suggest the potential of these agents in primary and secondary stroke prevention. (j-stroke.org)

Overview of Chemical-Warfare Agents Chemical-warfare (CW) agents are chemical mass-casualty weapons (MCWs) developed by governments for wartime use and include Toxic agents (intended to cause serious injury or death) Incapacitating. (msdmanuals.com)
Nerve agents are the most toxic of the known chemical warfare agents. (cdc.gov)
Although related organophosphate chemicals are used in medicine, pharmacology, and agriculture, these are not as toxic as the nerve agents. (cdc.gov)

Many agents used in clinics are mentioned to produce side effects. (hindawi.com)
1. The observation that the area postrema expresses a high level of nerve-growth-factor-receptor immunoreactivity prompted an investigation of the effects of nerve growth factor on autonomic function in the rat. (portlandpress.com)

A-series agents are nerve agents developed by the Soviet Union beginning in the 1970s. (msdmanuals.com)

The autonomic system is related to the inflammatory disease's expression, consisting of a therapeutic or cofactor target that influences the treatment. (bvsalud.org)

None of these agents has a pronounced odor or causes local skin irritation. (msdmanuals.com)

and are potentially able to circumvent the Chemical Weapons Convention list of banned agents and precursors. (medscape.com)
Other chemical agents were used in combat before World War II and are sometimes called first-generation chemical agents. (msdmanuals.com)
see Warfare Agents-chemical and Table II-64 ). (mhmedical.com)

Currently, results are available from two studies with TZD focusing on cardiovascular diseases, including stroke, and from 12 cardiovascular outcome trials focusing on major adverse cardiovascular events associated with new antidiabetic agents (four with dipeptidyl peptidase-4 inhibitors, three with sodium-glucose cotransporter-2 inhibitors, and five with glucagon-like peptide-1 analogues). (j-stroke.org)

Thus, it is of special interest to characterize the I-2R using guanidinium derivatives in blood vessels for development of antihypertensive agent(s). (hindawi.com)

Thus, development of the better agent to handle hypertension is urgent [ 1 ]. (hindawi.com)
Thus, development of new agent for management of hypertension is essential. (hindawi.com)
Then, this may help the development of new agent(s) for hypertension in the future. (hindawi.com)

Diseases1

Chemicals and Drugs6

Information Science1

Nervous system9

Ganglia2

Acetylcholine6

Fibers6

Muscarinic2

Reuptake2

Peripheral1

Instability1

CONTRAINDICATIONS2

Organophosphorus1

Local anesthetic agent2

Cardiac2

Nerve agent14

CGMP2

Inflammation1

Contraction1

Tabun1

Biological2

Abnormal1

Organophosphate pesticides1

Respiratory1

Serotonergic agents2

Immunosuppressive agents2

Acute1

Receptors1

Soman1

Novichok1

Pharmacotherapy1

Smooth muscle1

Symptoms2

Insecticides1

Therapeutic agent1

Compound2

Response3

Potent1

Action1

Drugs1

Route of exposure2

Bladder2

Liquids2

20181

1990s1

Dermal1

Clinical1

Toxic3

Effects2

1970s1

Treatment1

Odor1

Chemical3

Inhibitors1

Derivatives1

Hypertension3