• Serotonin receptors were split into two classes by Gaddum and Picarelli when it was discovered that some of the serotonin-induced changes in the gut could be blocked by morphine , whilst the remainder of the response was inhibited by dibenzyline leading to the naming of M and D receptors respectively. (wikipedia.org)
  • In the pre-molecular-cloning era when radioligand binding and displacement was the only major tool, spiperone and LSD were shown to label two different serotonin receptors, and neither of them displaced morphine, leading to naming of the 5-HT 1 , 5-HT 2 and 5-HT 3 receptors, corresponding to high affinity sites from LSD , spiperone and morphine respectively. (wikipedia.org)
  • Its most prominent actions are on the beta receptors of the heart, vascular and other smooth muscle. (nih.gov)
  • Neuroblastoma or endothelial cell death (after 24 hours incubation) with 50-100 nM autoantibodies was completely or nearly completely (91%) prevented by co-incubation with 200 nM M100907, a highly selective 5-HT2-AR antagonist. (symbiosisonlinepublishing.com)
  • In situ analysis of alpha-adrenoceptors on arteriolar and venular smooth muscle in rat skeletal muscle microcirculation. (ahajournals.org)
  • These data suggest that adrenergic regulation of large arterioles and venules in skeletal muscle uses both alpha 1- and alpha 2-adrenoceptors. (ahajournals.org)
  • The agonist-mediated Cai2+ increase was dependent on intracellular Ca2+ stores and was inhibited by the phospholipase C inhibitor U73122. (arvojournals.org)
  • These data suggest that neural- and endothelial- inhibitory effects in autoantibodies from older adult diabetes with nephropathy and obesity/inflammation-associated complications are mediated by agonist autoantibodies directed against the 5-hydroxytryptamine 2 receptor positively coupled to the phospholipase C/inositol triphosphate/ cytosolic Ca2+ release pathway. (symbiosisonlinepublishing.com)
  • At substimulatory glucose, anaplerotic flux rate in the clonal INS-1 832/13 cells was approximately 40% of Kreb's cycle flux, with similar contributions from each pathway. (jove.com)
  • 11 . The crystalline form of claim 3 or 4 , wherein the single crystalline form is characterized by an x-ray powder diffraction pattern substantially in accordance with FIG. 1 or FIG. 2 , or a combination thereof. (google.co.uk)
  • Alpha-1 adrenergic, angiotensin II, metabotropic glutamate 5, or endothelin A (100 nM-10μM) receptor antagonists did not substantially inhibit autoantibody-induced cell death. (symbiosisonlinepublishing.com)
  • Co-incubation with specific antagonists of the 5-hydroxytryptamine- 2A receptor significantly prevented acute N2A neurite retraction induced by 50-100 nM concentrations of diabetic pathologies' autoantibodies. (symbiosisonlinepublishing.com)
  • Beta-2 adrenergic receptor activation also appears to be important in the MSA and MPOA, resulting in dose-dependent increases in time spent awake ( 4 ). (frontiersin.org)
  • This receptor was first noted for its importance as a target of serotonergic psychedelic drugs such as LSD . (wikipedia.org)
  • McN-5652 inhibited tetrabenazine-induced ptosis in rats and mice but was much less effective in blocking the sedation caused by tetrabenazine. (aspetjournals.org)
  • Clinical usefulness of serum prostate specific antigen for the detection of prostate cancer is preserved in men receiving the dual 5-alpha-reductase inhibitor dutasteride. (thefreedictionary.com)
  • Table 1 also lists adverse reactions that were reported by greater than 2% of subjects treated with Fexofenadine hydrochloride tablets at doses of 180 mg once daily. (drugs.com)