DermalPesticideToxicityCOMBIVENT Inhalation AerosolAerosolInhalerPowder formulationsAcute inhalationExposureParticlePesticidesSuspensionsDoseIpratropium bromideTablet formulationPowdersAerosolsTopicalIntravenousOrally inhaledLactoseLipidTabletsInhalationalSystemicOccurPharmaceuticalRESPICLICKPediatricPatients2017DosesCharacterizationEfficacyNasalResiduesManufactureStabilityInjectionDrugNicotineAnalyticalScientificallyDeliveryApproachesAdministrationDemonstrateDevelopmentMedicinalIngredientLungDrugs2018Chronic
Dermal4
- Reported exposures were predominantly ingestions (93.2%), although 2.8% involved inhalation, and 4.0% involved other routes of exposure, including dermal. (cdc.gov)
- End use formulations were also tested for oral, dermal, and inhalation toxicity and eye and skin irritation. (cdc.gov)
- Occupational exposure may occur through both inhalation and dermal adsorption during the manufacture of atrazine, its formulation, and its application. (who.int)
- Immunological and neurological ef- duces the greatest hazard for individual ex- fects on the respiratory system linked to posure to these toxic substances [ 1 ], by the local and systemic toxic actions of pes- inhalation, dermal or oral exposure [ 2,3 ]. (who.int)
Pesticide5
- With pesticide formulations, toxicity may also occur from inhalation of the solvents used to dissolve chlordane. (cdc.gov)
- The testing of the inert ingredients in a pesticide formulation was conducted separately for each ingredient. (cdc.gov)
- The Specification of the technical material and the related formulations of the pesticide in accordance with chapters 4 to 9 of the 1st edition of the "FAO/WHO Manual on Pesticide Specifications. (who.int)
- Inhalation pare the effect of acute exposure to pesti- of pesticide dust, vapours, mists and gases cides of these workers with a group of may therefore represent a significant occu- workers not occupationally exposed to pational hazard [ 6 ] with workers vulnerable pesticides. (who.int)
- This surveillance case definition refers to any acute adverse health effect resulting from exposure to a pesticide product (defined under the Federal Insecticide Fungicide and Rodenticide Act [FIFRA]3) including health effects due to an unpleasant odor, injury from explosion of a product, inhalation of smoke from a burning product, and allergic reaction. (cdc.gov)
Toxicity3
- Inhalation - Inhalation exposure from Health effects are determined or powder glyphosate released into the atmosphere by the dose (how much), the The main targets of glyphosate toxicity in may occur on or near agricultural land. (cdc.gov)
- C8-alkyl naphthalene sulfonate) for acute inhalation toxicity is not appropriate. (europa.eu)
- Testing for acute toxicity by inhalation route is therefore generally not needed according to REACH regulation (EC) 1907/2006 (Annex VIII, point 8.5, column 2). (europa.eu)
COMBIVENT Inhalation Aerosol5
- The dose of Combivent Inhalation Aerosol is two inhalations four times a day. (rxlist.com)
- COMBIVENT Inhalation Aerosol is a combination of ipratropium bromide (as the monohydrate) and albuterol sulfate. (rxlist.com)
- COMBIVENT Inhalation Aerosol is indicated for use in patients with chronic obstructive pulmonary disease (COPD) on a regular aerosol bronchodilator who continue to have evidence of bronchospasm and who require a second bronchodilator. (rxlist.com)
- Safety and efficacy of additional doses of COMBIVENT Inhalation Aerosol beyond 12 puffs/24 hours have not been studied. (rxlist.com)
- Combivent Inhalation Aerosol is a combination of the anticholinergic bronchodilator, ipratropium bromide, and the beta 2 -adrenergic bronchodilator, albuterol sulfate. (theodora.com)
Aerosol3
- Combivent® (ipratropium bromide and albuterol sulfate) Inhalation Aerosol contains a microcrystalline suspension of ipratropium bromide and albuterol sulfate in a pressurized metered-dose aerosol unit for oral inhalation administration. (rxlist.com)
- Also, safety and efficacy of extra doses of ipratropium or albuterol in addition to the recommended doses of Combivent® (ipratropium bromide and albuterol sulfate) Inhalation Aerosol have not been studied. (rxlist.com)
- Smoking" also includes the use in any manner or degree of an electronic smoking device which creates an aerosol or vapor, in any manner or in any form, or the used of any combustion or vapor device designed to facilitate inhalation of tobacco or nicotine products. (shepherd.edu)
Inhaler6
- It can be concluded that there is a link between inhaler design and the effect of carrier particle size, where larger carriers provide better dispersion in cyclone-type devices while smaller carriers seem to be more beneficial for inhalers which has a straight flow path for the powder formulation. (lu.se)
- Because most conventional dry powder inhaler (DPI) products contain an extremely small dose of active pharmaceutical ingredient (API) in the form of a very fine, highly cohesive powder, the majority of DPIs rely on excipients, especially lactose, to overcome formulation performance problems. (inhalationmag.com)
- Inhalation powder: dry powder inhaler that delivers 108 mcg of albuterol sulfate (equivalent to 90 mcg of albuterol base) from the mouthpiece per actuation. (nih.gov)
- The inhaler is supplied for 200 inhalation doses. (nih.gov)
- Afrezza consists of a dry powder formulation of human insulin delivered from a small and portable inhaler. (globenewswire.com)
- The PUR3100 formulation uses Pulmatrix's novel, proprietary dry powder delivery technology, iSPERSE™ to deliver DHE via oral inhalation using a dry powder inhaler. (abc4.com)
Powder formulations1
- Although a few DPIs, such as AstraZeneca's Turbohaler Pulmicort budesonide product, include no excipients at all, the majority of dry powder formulations contain inhalation grade lactose. (inhalationmag.com)
Acute inhalation1
- Toxic effects can occur after acute inhalation of a spray or mist containing chlordane and after chronic inhalation, usually by occupants of contaminated houses. (cdc.gov)
Exposure2
- however, solid residues can result in contaminated air and inhalation exposure. (cdc.gov)
- rodent nasal cavity following inhalation exposure. (cdc.gov)
Particle8
- Finally, three 'prototype' formulations with carriers of different particle size were produced and tested in the Novolizer and Easyhaler devices. (lu.se)
- When the Novopulmon and the DuoResp formulations were assayed in the Easyhaler device, poor fine particle fractions were obtained. (lu.se)
- Along the same lines, all three 'prototype' formulations produced high fine particle fractions in the Novolizer device, with the formulation with the largest carrier giving the best performance. (lu.se)
- Tested in the Easyhaler device, the prototype formulations produced low fine particle fractions, but interestingly, the formulation with the smallest carrier particle size yielded the highest FPF. (lu.se)
- Areas of interest include the stability of colloidal suspensions, ageing of particle networks, rheology and enhancement of biodelivery of actives through formulation design. (soci.org)
- Micronization, as well as other particle size engineering techniques, enables effective and cost-efficient particle reduction of crystalline formulations which can aid solubility of compounds and improve the uniform distribution of API within formulations. (outsourcing-pharma.com)
- The company also offers integrated API, particle design and formulation development and manufacturing. (hovione.com)
- HGCP can also be used to design drug particles with suitable aerodynamic properties and specific particle size distribution for pulmonary inhalation. (outsourcing-pharma.com)
Pesticides1
- WHO establishes and publishes specifications* for technical material and related formulations of public health pesticides with the objective that these specifications may be used to provide an international point of reference against which products can be judged either for regulatory purposes or in commercial dealings. (who.int)
Suspensions1
- is widely adopted in many formulations including oral solid, topical creams, suspensions and inhalation delivery. (outsourcing-pharma.com)
Dose3
- We therefore decided to study in detail the fu II potential of nebulised AMB in different formulations, with the aim of answering the following questions: What is the pharmacokinetic behaviour of nebulised AMB, which dose would be sufficient and which frequency of dosing? (eur.nl)
- Each actuation of TUDORZA PRESSAIR provides a metered dose of 13 mg of the formulation which contains lactose monohydrate (which may contain milk proteins) as the carrier and 400 mcg of aclidinium bromide. (rxlist.com)
- Catalent's capabilities now range from its API optimization platform to formulation and final dose form design services, bioavailability solutions and hot melt extrusion technologies. (outsourcing-pharma.com)
Ipratropium bromide1
- The bronchodilation following inhalation of ipratropium bromide is primarily a local, site-specific effect, not a systemic one. (theodora.com)
Tablet formulation1
- Catalent offered a tablet formulation through its OptiForm ® Total Supply solution, incorporating formulation development, clinical trial material manufacturing, and supply and distribution to patients. (drug-dev.com)
Powders1
- Formulation pre-screening of inhalation powders using computational atom-atom systematic search method. (ebsco.com)
Aerosols2
- Use aerosols in an open space to avoid inhalation. (cdc.gov)
- There are no hydrocarbon emissions and there is no inhalation risks, Airopack therefore represents a clean, safe, attractive alternative to conventional aerosols. (prnewswire.com)
Topical1
- and (2) any product or formulation of matter containing biologically active amounts of nicotine that is delivered via topical oral, inhalation, chewing, etc. (shepherd.edu)
Intravenous2
- Administering drugs by oral, intravenous and inhalation routes. (bath.ac.uk)
- The half-life of elimination is about 2 hours after inhalation or intravenous administration. (theodora.com)
Orally inhaled2
- ARMONAIR RESPICLICK should be administered as 1 inhalation twice daily (approximately 12 hours apart) by the orally inhaled route. (drugs.com)
- PUR3100 is an orally inhaled formulation of dihydroergotamine (DHE) engineered with iSPERSE™ for the treatment of acute migraine. (abc4.com)
Lactose1
- Understanding how lactose and other excipients can affect formulation performance. (inhalationmag.com)
Lipid2
- What is the value of nebulised lipid formulations of AMB as compared to nebulised AMB-DOC? (eur.nl)
- To that end, Catalent has invested in technology and capabilities such as hot melt extrusion, spray-dry dispersions, and lipid formulation to provide options for small-molecule development, often to address the all-too-common hurdle of poor solubility and bioavailability. (drug-dev.com)
Tablets2
- Extrusion 3D Printing of Paracetamol Tablets from a Single Formulation with Tunable Release Profiles Through Control of Tablet Geometry. (nottingham.ac.uk)
- None of the approved opioid formulations with tamper-resistance or abuse-deterrent features, including those that received the FDA's abuse-deterrent labelling, can deter abuse through oral ingestion of a large number of tablets - the most common form of abuse. (cadth.ca)
Inhalational1
- The primary aim of the work presented in this thesis was to evaluate the merits of inhalational AMB formulations in the prophylaxis and treatment of i.1vasive pulmonary aspergillosis. (eur.nl)
Systemic1
- Tobramycin and amikacin for inhalation are classified together with the systemic formulations in J01GB01 and J01GB06 respectively. (whocc.no)
Occur2
- Consider discontinuation of Levalbuterol Inhalation Solution, USP if these effects occur. (nih.gov)
- The vapour pressure of the test substance was determined to be 1.7 × 10-4 Pa at 25 °C. Due to the very low vapour pressure inhalation of vapours leading to irritation of airways will not occur. (europa.eu)
Pharmaceutical4
- With an increased number of drug candidates in pipeline and a tight time schedule for pharmaceutical companies to reach clinical testing, an early plan for what administration route and formulation is needed for the specific active pharmaceutical ingredient (API) is required. (ri.se)
- The global pharmaceutical manufacturing market is segmented on the basis of formulation, route of administration, prescription, drug development, distribution channels, and geography. (medgadget.com)
- The demand for outsourcing pharmaceutical formulation development and manufacturing is on the rise for drug developers at all levels. (drug-dev.com)
- In this annual Drug Development & Delivery magazine report, some of the key players in the CDMO market present case studies about how they are helping pharmaceutical and biopharma companies overcome a variety of formulation and manufacturing challenges. (drug-dev.com)
RESPICLICK1
- Treatment of asthma in patients 12 years and older: 1 inhalation of ARMONAIR RESPICLICK 55 mcg, 113 mcg, or 232 mcg twice daily. (drugs.com)
Pediatric1
- Smoke inhalation in pediatric victims. (medscape.com)
Patients3
- Patients with smoke inhalation should be monitored for 4-6 hours in the ED. Those who are at low risk for injury and whose vital signs and physical examination findings remain normal can usually be discharged with close follow-up and instructions to return if symptoms develop. (medscape.com)
- In some patients, 1 inhalation every 4 hours may be sufficient. (nih.gov)
- Afrezza (insulin human) Inhalation Powder is a rapid-acting inhaled insulin indicated to improve glycemic control in adult patients with diabetes mellitus. (globenewswire.com)
20171
- As of January 17, 2017, the FDA has approved abuse-deterrent labelling for nine opioid formulations based on pre-market data. (cadth.ca)
Doses1
- Need for more doses of Levalbuterol Inhalation Solution, USP than usual may be a sign of deterioration of asthma and requires reevaluation of treatment. (nih.gov)
Characterization2
Efficacy1
- Using HGCP NMT will provide a new formulation of the hyperlipidemia treatment which will increase efficacy, lower drug dosage and improve patient compliance. (outsourcing-pharma.com)
Nasal1
- Note the many hallmarks of smoke inhalation complexed with burn injury (ie, facial burns, carbonaceous particles in the nasal cavity, periorbital edema, hair singeing). (medscape.com)
Residues1
- The gastrointestinal tract has been amount of glyphosate and other glyphosate residues and/or through duration inhalation MRLs were derived identified as the most sensitive target of ingredients included in these ingestion of contaminated water. (cdc.gov)
Manufacture1
- It is all science that relates to the design, performance, stability, testing and manufacture of formulations, from biology to mathematics, physics to biochemistry, chemistry to engineering to name but a few. (soci.org)
Stability4
- This six-day (two part) module provides basic formulation principles, including preformulation studies, bioavailability considerations and the effect of excipients on physical and chemical stability. (rssl.com)
- Formulation development requires a deep understanding of how the physicochemical properties of an API will affect the stability, solubility and bioavailability of the molecule. (ri.se)
- We also have the ability for specific analysis development for the API to ensure that the right formulation strategy is being developed that maximizes the stability, solubility and bioavailability of the drug. (ri.se)
- Excipient screening/formulation strategy for increased stability and solubility. (ri.se)
Injection2
- Inhaled antiinfectives are classified here based on the fact that preparations for inhalation can not be separated from preparations for injection. (whocc.no)
- Committee members also said that the company had convincingly proven that this formulation would prevent abuse by inhalation or injection. (medscape.com)
Drug7
- Drug formulation. (bath.ac.uk)
- A well-designed formulation can have a crucial role for the drug candidate's success clinically. (ri.se)
- Our formulation scientists have good knowledge of the drug development process and can help from early preformulation to production of GMP classed trial material. (ri.se)
- We at RISE can help solve an existing formulation problem or have a larger active role during the formulation development of a new drug candidate and involve an expert team to work as an extension of the own company. (ri.se)
- The development of a new drugs may require that the formulation is being adjusted and optimized during the preclinical phase and initial animal studies, and further developed before clinical testing and finalized drug product. (ri.se)
- In the present study, chitosan-loaded cisplatin microspheres were prepared and evaluated for dry powder inhalation delivery of cisplatin for local action of the drug in lungs, and thereby achieve improved therapy in lung cancer. (ijpsonline.com)
- Inhalation deposits the drug directly in the airways, so that it acts quickly, but the drug may not reach airways that are severely narrowed. (msdmanuals.com)
Nicotine1
- This formulation suggests that the rules apply to both ENDS as well as on electronic non-nicotine delivery systems. (who.int)
Analytical2
- My research is focused on the application of novel analytical and formulation strategies to develop new medicines and biomedical devices, primarily via 3D printing, and in particular with colleagues in Additive Manufacturing in the Faculty of Engineering and a number of industrial collaborators. (nottingham.ac.uk)
- There can be several reasons to outsource the formulation development externally, such as time limitations internally or the need to quickly recruit the right expertise and analytical capacity when needed during the development process. (ri.se)
Scientifically1
- Discovering new innovations, understanding how they work scientifically and then applying them into new formulation designs to enhance their performance and properties. (soci.org)
Delivery1
- Work continues to correlate inhalation profiles with delivery of medication to the desired areas in the lungs. (pharmtech.com)
Approaches1
- Work is ongoing to validate nonanimal approaches for formulations. (acs.org)
Administration1
- More frequent administration or a larger number of inhalations is not recommended. (nih.gov)
Demonstrate1
- 8. Demonstrate the ability to use the study inhalation device properly. (astrazenecaclinicaltrials.com)
Development2
Medicinal1
- The Qualified Person should have a thorough knowledge of formulation and processing of the medicinal products they are asked to certify. (rssl.com)
Ingredient3
- ingredient in herbicide formulations. (cdc.gov)
- If you can design a formulation that allows a functional component or active ingredient to perform at a new level of performance that is a remarkable achievement. (soci.org)
- Achieving something new and better - it is relatively easy to reproduce an existing formulation, for example with a new active ingredient, but to achieve something innovative and new is highly challenging since formulations are complex systems and improving one element can adversely affect other elements. (soci.org)
Lung1
- Administered at the beginning of a meal, Afrezza dissolves rapidly upon inhalation to the lung and passes quickly into the bloodstream (in less than one minute). (globenewswire.com)
Drugs1
- In her new project RatInhalRNA (Rational and Simulation-Supported Design of Inhalable RNA Nanocarriers) , Merkel is seeking to develop efficient siRNA-based drugs that can be administered to the lungs through inhalation. (uni-muenchen.de)
20181
- As you may already know, the SCI Formulation Forum will officially be launched in January 2018 - so what better way to find out about formulation and the Formulation Forum than straight from its founding committee? (soci.org)
Chronic1
- Tudorza Pressair (aclidinium bromide) inhalation powder is an anticholinergic indicated for the long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease ( COPD ), including chronic bronchitis and emphysema . (rxlist.com)