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  • toxicity
  • 2010). We present an integrative approach to derive inhalation specific threshold values, which are based on a dataset of 296 chemicals with repeated-dose toxicity studies (www.fraunhofer-repdose.de). (fraunhofer.de)
  • According to the report, CHIE studies allow measurements to be made of "biomarker or physiologic responses to those exposures that can indicate pathways of toxicity and mechanisms of air-pollution responses. (aiha.org)
  • The PETA International Science Consortium (PISC) awarded four VITROCELL in vitro exposure systems to researchers from institutions in the UK, US, and Belgium who are leading the development of non-animal methods to test the toxicity of airborne substances. (iivs.org)
  • An animal inhalation exposure unit for toxicity screening / by L.J. Leach, C.J. Spiegl. (hathitrust.org)
  • Daily exposure of a grill operator, while grilling meat, to PM 2.5 -bound PAHs, adjusted to benzo[a]pyrene toxicity equivalent (BaP eq ), was 326.9, 401.6, and 0.04 ng/d for lump charcoal, charcoal briquettes, and gas powered grill, respectively. (springer.com)
  • For this reason, the current study investigated the inhalation toxicity potential of multiwall CNTs (MWCNTs). (oup.com)
  • Acute
  • Gerrity TR, Bennett WD, Keefe M, DeWitt P, Chapman W (1991) The response of tracheobronchial clearance of inhaled particles to acute ozone exposure in healthy humans. (springer.com)
  • mice were exposed
  • Nonallergic (healthy) and ovalbumin-sensitized (asthmatic) mice were exposed via inhalation to two different sizes of titanium dioxide particles, nanosized (nTiO 2 ) and fine (fTiO 2 ), for 2 hours a day, three days a week, for four weeks at a concentration of 10 mg/m 3 . (biomedcentral.com)
  • One week after i.p. injections, mice were exposed by inhalation to MWCNT (5 mg/m 3 , 5 hours/day, 5 days/week) or filtered air (controls) for a total of 15 days. (biomedcentral.com)
  • ozone exposure
  • The overall goals of this study were (1) to develop a system capable of automatically controlling the ozone exposure levels so the steady-state error remained less than 1% and (2) to optimize the system's response time. (cdc.gov)
  • Drechsler-Parks DM, Bedi JF, Horvath SM (1987) Pulmonary function response of older men and women to ozone exposure. (springer.com)
  • studies
  • The application of the Cramer decision tree to datasets of repeated-dose studies with inhalation exposure resulted in very low thresholds compared to oral TTC values. (fraunhofer.de)
  • A new report published by the National Academies Press (NAP) focuses on EPA's controlled human inhalation exposure (CHIE) studies, which are also referred to as human clinical studies or human challenge studies. (aiha.org)
  • A free PDF download of Controlled Human Inhalation-Exposure Studies at EPA is available on NAP's website . (aiha.org)
  • lung
  • Badyda A, Grellier J, Dąbrowiecki P (2016) Ambient PM 2.5 exposure and mortality due to lung cancer and cardiopulmonary diseases in Polish Cities. (springer.com)
  • Devlin RB, McDonnell WF, Mann R, Becker S, House DE, Schreinemachers D, Koren HS (1991a) Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung. (springer.com)
  • These data demonstrate that some MWCNT exposures promote the growth and neoplastic progression of initiated lung cells in B6C3F1 mice. (biomedcentral.com)
  • tumors
  • The relationship of these tumors to exposure to MIBK was uncertain. (sigmaaldrich.com)
  • By contrast, 90.5% of the mice which received MCA followed by MWCNT had bronchiolo-alveolar adenomas and adenocarcinomas with an average of 2.9 tumors per mouse 17months after exposure. (biomedcentral.com)
  • subsequent
  • The aim of the present study was to assess whether asthma onset prior to entering the workforce influences whether a person holds a subsequent job with asthma-related inhalation exposures. (cdc.gov)
  • concentration
  • The system allows you to vary the concentration of airborne pathogens, the rate of air flow, and the length of exposure, so experiments can be reproduced accurately and adjusted easily. (glascol.com)
  • This lack of response at the high concentration after 6 weeks exposure, appeared to correlate with a significant induction of glutathione S-transferase in the liver. (utmb.edu)
  • gases
  • The present study seeks to define the possible cancer risk arising from the inhalation exposure to particle (PM)-bound polycyclic aromatic hydrocarbons (PAHs) present in barbecue emission gases and to compare the risk depending on the type of fuel used for grill powering. (springer.com)
  • effects
  • In many respects, the effects of T-2 toxin on pigs dosed by inhalation are similar those following intravascular injection. (illinois.edu)
  • In the present study we explored the effects of repeated inhalation exposure in asthmatic and healthy mice to two different sizes of TiO 2 . (biomedcentral.com)
  • The present study indicates that the CTP is sufficiently sensitive to identify toxicological effects after exposure to ambient levels of a gas mixture. (utmb.edu)
  • ambient levels
  • A study was conducted using a combined testing protocol (CTP), to determine whether short-term biological end-points, singly or in combination, are sufficiently sensitive to identify damage induced by exposure to ambient levels of industrial chemicals. (utmb.edu)
  • causes
  • PM inhalation causes several adverse changes in cardiac function that are reflected in the electrocardiogram (ECG), including altered cardiac rhythm, myocardial ischemia, and reduced heart rate variability (HRV). (ecu.edu)
  • human
  • The TTC concept derives thresholds to structural groups of compounds below which a risk for human health is not assumed for a life-time exposure. (fraunhofer.de)
  • Research
  • RIFM Innovative Model Calculates Inhalation Exposure To Fragrance Materials [03-May-- RIFM 2-Box Indoor Air Dispersion Model Is An Alternative Method To Calculate Inhalation Exposure To Fragrance WOODCLIFF LAKE, New Jersey, May 3, 2012 /PRNewswire/ --The Research Institute for Fragrance Materials, Inc. (RIFM) is beta testing its innovative 2-Box Indoor Air Dispersion Model software, an alternative method for assessing inhalation exposure to fragrance materials. (comunicati.net)
  • study
  • In this work, a computer tower in an office setting provides a case study to examine the emissions of, and exposure to, PBDEs. (utexas.edu)
  • effect
  • Bascom R, Naclerio RM, Fitzgerald TK, Kagey-Sobotka A, Proud D (1990) Effect of ozone inhalation on the response to nasal challenge with antigen of allergic subjects. (springer.com)