• The main source of polyphenols is dietary, since they are found in a wide array of phytochemical-bearing foods. (wikipedia.org)
  • There is no substantial evidence, however, that dietary polyphenols have an antioxidant effect in vivo. (wikipedia.org)
  • PhO-OPh Consuming dietary polyphenols have been evaluated for biological activity in vitro, but there is no evidence from high-quality clinical research as of 2015[update] that they have effects in vivo. (wikipedia.org)
  • Data indicate that the polyphenols, phenolic acids and tannins from strawberry and apple are potent inhibitors of GLUT2 and SGLT1 at concentrations predicted after dietary ingestion. (nutraingredients.com)
  • We hypothesized that acute dietary nitrate (beet juice) ingestion improves insulin sensitivity in obese but not in nonobese adults. (hindawi.com)
  • In this regard, ingestion of dietary nitrate may hold promise. (hindawi.com)
  • Recent but scarce data indicate that chronic ingestion of high-flavanol cocoa might be a promising approach to dietary photoprotection against UV light. (biomedcentral.com)
  • Vinegars are also a dietary source of polyphenols, compounds synthesized by plants to defend against oxidative stress. (lizkane.ie)
  • Phenolic acids formed by microbial degradation of the dietary polyphenols in the gut could be detected. (biomedcentral.com)
  • Better knowledge of dietary polyphenols could offer a very economical public health intervention in maintaining oral health. (bvsalud.org)
  • Findings included in this systematic review indicated that a certain percentage of dietary macronutrients, the consumption of specific amounts of polyunsaturated or monounsaturated fatty acids, as well as the ingestion of nutraceuticals or dietary supplements could be considered as potential strategies for the development of a wide range of nutrigenetic interventions since they have a direct impact on the blood levels of lipids. (cdc.gov)
  • Polyphenols and phenolic acids from strawberry and apple may decrease glucose uptake by blocking transport through human intestinal cells, according to a new study. (nutraingredients.com)
  • The research, published in Molecular Nutrition & Food Research ​, suggests that some polyphenols, phenolic acids and tannins extracted from ​apples and strawberries may block the transport of glucose across intestinal tissues, potentially blunting post-meal glucose spikes. (nutraingredients.com)
  • "There is recent evidence that some bioactive compounds, in particular polyphenols, phenolic acids and tannins (PPTs), can affect the shape of the blood glucose curve … Some studies have shown that these compounds may result in an altered pattern of intestinal glucose uptake, possibly due to interactions between compounds and sugar transporters," ​ said the authors. (nutraingredients.com)
  • They said that PPTs have the potential to "readily affect glucose absorption in the small intestine," ​noting that many polyphenols, phenolic acids and tannins can interact with certain sugar transporters - for example, inhibition of sodium-dependent glucose transporter 1 (SGLT1 - an active transport mechanism in which glucose is co-transported with sodium ion) or by inhibition of GLUT2. (nutraingredients.com)
  • "The results obtained demonstrate that polyphenols, phenolic acids and tannin-rich extracts from strawberry and apple were able to influence glucose uptake into the cells and transport … by inhibiting activities of the glucose transporters," ​said the authors. (nutraingredients.com)
  • In particular, we explored the modulation of the human microbiota, in response to MD adherence, focusing the attention on polyphenols, polyunsaturated fatty acids (PUFA) ω-3 and fiber. (karger.com)
  • In the first part, the optimal production conditions for short-chain inulin conjugated with gallic acids (GA) and tea polyphenol (TP) were determined. (ncl.edu.tw)
  • Mate is a traditional drink obtained from the leaves of yerba mate and rich in a diversity of plant bioactive compounds including polyphenols, particularly chlorogenic acids. (cambridge.org)
  • Although tomatoes are not often touted for their nutritional value, the high availability of tomatoes all year round makes them an important source of cancer-fighting bioactive compounds, such as carotenoids and polyphenols. (naturalnews.com)
  • These health benefits, in part, relate to the bioactive catechin polyphenol content of GT, of which (−)-epigallocatechin-3-gallate (EGCG) can account for between 50-80% of the total catechin content [ 18 ]. (biomedcentral.com)
  • High-polyphenol chocolate reduces endothelial dysfunction and oxidative stress during acute transient hyperglycaemia in Type 2 diabetes: A pilot randomized controlled trial. (coventry.ac.uk)
  • To investigate the effects of high-polyphenol chocolate upon endothelial function and oxidative stress in Type 2 diabetes mellitus during acute transient hyperglycaemia induced following a 75-g oral glucose challenge. (coventry.ac.uk)
  • High-polyphenol chocolate protected against acute hyperglycaemia-induced endothelial dysfunction and oxidative stress in individuals with Type 2 diabetes mellitus. (coventry.ac.uk)
  • These metabolites can carry potent biological activity and may explain the apparent paradoxical relationship of low bioavailability and high bioactivity of plant polyphenols. (gaiaherbs.com)
  • Transcription factors, such as MEF2A, MYB or HNF1A, could have their activity modulated by mate consumption either by direct interaction with polyphenol metabolites or by interactions of metabolites with cell signalling proteins, like p38 or ERK1/2, that could modulate transcription factor activity and regulate expression of genes observed. (cambridge.org)
  • Polyphenols (PPs) are reactive metabolites abundant in plant derived foods, especially fruits, seeds and leaves. (bvsalud.org)
  • Polyphenols are also referred to as aromatic compounds. (sundtsupplements.com)
  • At present, many thousands of compounds are referred to as polyphenols. (sundtsupplements.com)
  • 5 Achiwa Y,Hibasami H,Katsuzaki H.Inhi-bitory effects of persimmon(Diospyros kaki)extract and related polyphenol compounds on growth of human lymphoid leukemia cells J .Biosci biotechnol Biochem,1997,61(7):1099 1101. (100md.com)
  • In order to absorb the full content of polyphenols, it is important that you also eat the skin or peel of fruits and vegetables, as this is where most of the polyphenols in these foods are found. (sundtsupplements.com)
  • In addition, polyphenols also contribute to the taste, smell and color of fruits and vegetables. (sundtsupplements.com)
  • In recent years, a growing body of evidences has shown that herbs, fruits, nuts, and a wide diversity of substances commonly used in daily diet, because of their high content of polyphenols, have definitive effects upon the metabolic pathway of inflammation, with consequent inhibition of prostaglandins synthesis. (edu.pl)
  • In the preparation of short-chain inulin-polyphenol complexes, the amount of H2O2/AA, H2O2 concentration, and H2O2/AA reaction time all affected the total phenolic content of the inulin-polyphenol complexes. (ncl.edu.tw)
  • With an increase in the amount of H2O2/AA and higher H2O2 concentration, the total phenolic content of the inulin-polyphenol complexes also increased. (ncl.edu.tw)
  • The addition of the polyphenol solution to the reaction system and subsequent reaction completion within 30 minutes had no effect on the total phenolic content. (ncl.edu.tw)
  • While some indicate potential health effects of certain specific polyphenols, most studies demonstrate low bioavailability and rapid excretion of polyphenols, indicating their potential roles only in small concentrations in vivo. (wikipedia.org)
  • However, no studies have compared the timing of green tea ingestion on glucose metabolism and changes in catechin concentrations. (elsevierpure.com)
  • Our study demonstrated that acute ingestion of catechin-rich green tea in the evening reduced postprandial plasma glucose concentrations. (elsevierpure.com)
  • A 4 week dGTE intervention favourably enhanced substrate utilisation and subsequent performance indices, but did not alter TFA concentrations in comparison to PL. The results support the use of catechin polyphenols from dGTE in combination with exercise training in recreationally active volunteers. (biomedcentral.com)
  • More recent studies have focused on the biological activity of various extracts of cocoa or of waste materials from the chocolate industry, such as cocoa bean husk, which is known to contain high concentrations of polyphenols. (bvsalud.org)
  • A growing body of scientific evidence shows that berry polyphenols' antioxidant capacity powerfully targets numerous degenerative diseases, from cancer and atherosclerosis to impaired glucose control and blood lipid abnormalities. (lifeextension.com)
  • Green tea polyphenols, particularly catechins, decrease fasting and postprandial glucose. (elsevierpure.com)
  • A 75-g oral glucose load was used to induce hyperglycaemia, which was administered to participants 60 min after they had ingested either low (control) or high-polyphenol chocolate. (coventry.ac.uk)
  • Measurements were made at baseline and 2 h post-ingestion of the glucose load. (coventry.ac.uk)
  • Prior consumption of high-polyphenol chocolate before a glucose load improved endothelial function (1.7 ± 0.1 vs. 2.3 ± 0.1%, P = 0.01), whereas prior consumption of control chocolate resulted in a significant increase in intercellular adhesion molecule 1 (321.1 ± 7.6 vs. 373.6 ± 10.5 ng/ml, P = 0.04) and 15-F2t-isoprostane (116.8 ± 5.7 vs. 207.1 ± 5.7 mg/mol, P = 0.02). (coventry.ac.uk)
  • This anti-inflammatory action of polyphenols, when ingested during the third trimester of pregnancy, may interfere with the dynamics of fetal ductus arteriosus flow and cause ductal constriction. (edu.pl)
  • In addition to their protective, antioxidant effect, polyphenols and carotenoids have shown some remarkable abilities when it comes to fighting tumors and improving survival rates. (naturalnews.com)
  • Curcumin, a polyphenol and the bright yellow pigment found in turmeric, has been shown to be a highly potent therapeutic substance. (moonandmercury.com)
  • Studies indicate that Curcumin, a potent polyphenol, can help with gastrointestinal problems. (moonandmercury.com)
  • 1. Relieves indigestion Curcumin ingestion causes the gallbladder to produce more bile which improves the digestion process. (moonandmercury.com)
  • According to the authors, developing new functional tomato varieties with increased levels of carotenoids and polyphenols could hold the key to cancer prevention . (naturalnews.com)
  • Other possible effects may result from consumption of foods rich in polyphenols, but are not yet proved scientifically in humans, so are not allowed as health statements by the FDA. (wikipedia.org)
  • For example, apple consumption has been the subject of quite a few studies on colorectal cancer risk reduction.2-4 This article will focus on a specific component of apples, their polyphenols and the health-promoting benefits they provide. (naturalpractitionermag.com)
  • Multigenomic modifications in human circulating immune cells in response to consumption of polyphenol-rich extract of yerba mate ( Ilex paraguariensis A. St.-Hil. (cambridge.org)
  • Chocolate is very rich in PPs, and a minor consumption of chocolate may significantly contribute to total polyphenol intake 68 . (bvsalud.org)
  • Boosts metabolism - Yerba mate ingestion has been shown to increase energy expenditure and fat burning in several studies. (mystroud.com)
  • Oak, M.H., ElBedoui, J. and Schini-Kerth, V.B. (2005) Antiangiogenic Properties of Natural Polyphenols from Red Wine and Green Tea. (scirp.org)
  • Cocoa polyphenols tend to reduce inflammation by regulating proinflammatory mediators and controlling processes that oxidize low density lipids (LDL) in the development of atherosclerosis 73 . (bvsalud.org)
  • Research shows that polyphenol extracts from olive fruit help protect normal LDL cholesterol from oxidation. (mindsharecommerce.com)
  • Cereals, chocolate and dry legumes also contribute to the total polyphenol intake 67 . (bvsalud.org)
  • Evidence suggests that some of these powerful polyphenols may reduce the risk of breast, lung, liver, stomach and colorectal cancer. (naturalnews.com)
  • It has been found in several studies that polyphenols make a positive contribution to the healing of cancer. (sundtsupplements.com)
  • It has been found that polyphenols in pomegranates help inhibit the growth of cancer cells in different parts of the body. (sundtsupplements.com)
  • Ingestion of polyphenols in humans enhances in vivo antioxidant protection and reduces cancer risk. (lizkane.ie)
  • 2 Stoner GD,Mukhtar H.Polyphenols as cancer chemopreventive agents J .J Cell Biochem Suppl,1995,22:169 180. (100md.com)
  • 4 Okabe S,Suganuma M,Hayashi M,et al.Mechanisms of growth inhibition of human lung cancer cell line,PC 9,by tea polyphenols J .Jpn J Cancer Res,1997,88(7):639 643. (100md.com)
  • According to a hypothesis, polyphenol (PP) activity against several forms of cancer, proliferative diseases, inflammation and neurodegeneration is mainly exerted through the inhibiting and modulating activities against a wide range of receptors, enzymes and transcription molecules 88 . (bvsalud.org)
  • The ORAC value of a given food is proportional to its polyphenol content. (lifeextension.com)
  • In the modified Mediterranean diet, added extra virgin olive oil or nuts were supplemented in order to increase the polyphenol content of the meal plan. (healthyfellow.com)
  • Consequently, supplementation studies may differ from their natural ingestion in food," they wrote. (naturalnews.com)
  • Polyphenols exert preventive activity against infectious and degenerative diseases including oral diseases. (bvsalud.org)
  • Polyphenols (PPs) exert preventive activity against infectious and degenerative diseases and may also help prevent oral diseases via various mechanisms 58 . (bvsalud.org)
  • This webinar will review the metabolism of plant polyphenols and in so doing challenge current conceptions of dosing and toxicity. (gaiaherbs.com)
  • Polyphenols are naturally occurring substances that can only be found in plants. (sundtsupplements.com)
  • Each serving (2 softgels) provides a similar olive polyphenol level as over 4 tablespoons of extra-virgin olive oil. (mindsharecommerce.com)
  • This assumes 318 mg/kg of olive polyphenol in extra-virgin olive oil as reported for Bertolli Extra Virgin Olive Oil. (mindsharecommerce.com)
  • Ingestion of olive oil may provide additional benefits beyond olive polyphenols. (mindsharecommerce.com)
  • Polyphenols protect the plant from "predators" or also attract insects for pollination. (sundtsupplements.com)
  • The Mediterranean Diet Gets a Green Boost Modifying the Mediterranean diet with additional green plant-based proteins/polyphenols results in intriguing benefits. (medscape.com)
  • In a human study,10 the unripe apples were pressed to obtain apple pomace, which was then processed, dried and milled to prepare apple powder (providing polyphenols). (naturalpractitionermag.com)
  • Since much of the research on apple polyphenols (AP) have been conducted on ApplePhenon (BGG), a patented, proprietary polyphenol extract produced from wild unripe apple fruit from the central Asia region, this article will primarily focus on that extract. (naturalpractitionermag.com)
  • however, these sources were not powerful enough to fight the free radicals and are also excreted by the body within a short time of ingestion. (bodybuildingforyou.com)