Infusion tumor specific peptide. Medical search. Frequent questions

Dr. Chapuis and colleagues established a platform for developing gene-modified adoptive T cell therapies targeting an array of tumor antigens in solid and liquid tumors. (fredhutch.org)
In 1959, Lewis Thomas suggested that the human immune system can recognise tumour-specific antigens on the surface of newly developing tumour cells as 'foreign' and eliminate them (3). (cambridgemedicine.org)
Following this, in 1971, Sir Frank Mac Farlane Burnet hypothesised that tumour cell antigens induced immunological reaction against cancer and postulated the "immune surveillance theory" (4). (cambridgemedicine.org)
Recognition of antigens by T-cells is mediated by T-cell receptor (TCR), which binds to peptides presented by Major Histocompatibility Complex (MHC) found on the surface of antigen-presenting cells (6). (cambridgemedicine.org)
CAR T-cells are T-cells that have been engineered to express receptors that specifically target tumour-associated antigens (8). (cambridgemedicine.org)
The anti-tumour activity of blinatumomab immunotherapy is not dependent on T-cells bearing a specific TCR or on peptide antigens presented by cancer cells, but is polyclonal in nature and independent of human leukocyte antigen (HLA) molecules on target cells. (evidentic.com)
The implication of these results would be that myeloma-specific T cell subfamilies might be positively selected from the donor inoculum and infused to myeloma patients post ASCT, to afford separation of allo- from tumor-reactive T cells without the prior need to define specific target antigens. (biomedcentral.com)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)

BACKGROUND: Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) is a promising immunotherapeutic approach for patients with advanced solid tumors. (bvsalud.org)
A clinical trial evaluating IMA402 in patients with solid tumors is expected to start in 2023. (advfn.com)
HLA-A*02:01-positive patients with different solid tumors expressing PRAME will initially receive weekly infusions of IMA402. (advfn.com)

The drug candidate is administered as an intravenous infusion. (pharmaceutical-technology.com)
In contrast to conventional external radiotherapy, TRT is defined by the intravenous infusion of a radiopharmaceutical. (memoinoncology.com)
Tebentafusp-tebn was administered weekly by intravenous infusion at 20 μg on day 1, 30 μg on day 8, 68 μg on day 15, and every subsequent week until disease progression or unacceptable toxicity. (medscape.com)
Administer only as an intravenous infusion ( 2.1 ). (drugs.com)
The follow up dose for adult patients with GPA and MPA who have achieved disease control with induction treatment, in combination with glucocorticoids is two 500 mg intravenous infusions separated by two weeks, followed by a 500 mg intravenous infusion every 6 months thereafter based on clinical evaluation ( 2.6 ). (drugs.com)
During the continuous intravenous infusion over 4 weeks, the pharmacodynamic response was characterised by T-cell activation and initial redistribution, rapid peripheral B-cell depletion, and transient cytokine elevation. (evidentic.com)

University of Chicago Medicine experts work together to provide compassionate, leading-edge care for patients with neuroendocrine tumors. (uchicagomedicine.org)
UChicago Medicine was one of the first hospitals to offer peptide receptor radionuclide therapy (PRRT) to treat neuroendocrine tumors. (uchicagomedicine.org)
Neuroendocrine tumors, or NETs, are tumors that form in neuroendocrine cells. (uchicagomedicine.org)
They work together to accurately diagnose neuroendocrine tumors, and to determine the most effective treatment for each patient. (uchicagomedicine.org)
In this document, we review the literature on the use of 177 Lu-DOTATATE in neuroendocrine tumors (NETs) of different primary origin, discuss issues of controversy, and review potential contraindications to treatment. (snmjournals.org)
the treatment of adult patients with unresectable, well- or moderately-differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) to improve progression-free survival. (guidelinecentral.com)

However, the study of tumor immune heterogeneity holds great potential for clinical immunotherapy. (spandidos-publications.com)
Programmed cell death protein-1 (PD-1) checkpoint immunotherapy efficacy remains unpredictable in glioblastoma (GBM) patients due to the genetic heterogeneity and immunosuppressive tumor microenvironments. (elifesciences.org)
Here, we report a microfluidics-based, patient-specific 'GBM-on-a-Chip' microphysiological system to dissect the heterogeneity of immunosuppressive tumor microenvironments and optimize anti-PD-1 immunotherapy for different GBM subtypes. (elifesciences.org)
Researchers found that patients who used a text-messaging triage system were able to save more than 1 hour on days they were scheduled to receive an immunotherapy infusion. (cancer.net)
On days when patients are scheduled to receive an immunotherapy infusion, their days often involve lab tests, having their vital signs taken, a clinic visit, and then the actual infusion. (cancer.net)
The time spent going from visit to visit for an immunotherapy infusion can add up to many hours spent at the clinic. (cancer.net)
This study is looking at the effectiveness of combining a PARP inhibitor called niraparib and an immunotherapy called dostarlimab for treating people with an inherited BRCA mutation (found with genetic testing) or a tumor mutation (found through tumor testing) who have breast, pancreatic, ovarian, fallopian tube or primary peritoneal cancer that is metastatic or advanced and cannot be removed by surgery (unresectable). (facingourrisk.org)
These data demonstrate that a transplantation protocol involving only selective tumor-reactive donor T cell families is an effective immunotherapy and results in long-term survival in a mouse model of human MM. The results highlight the need to develop similar ATCT strategies for MM patients that result in enhanced survival without symptoms of GvHD. (biomedcentral.com)
We then outline preclinical approaches that employ CAR-NK cells for GB immunotherapy, and give an overview on the ongoing clinical development of ErbB2 (HER2)-specific CAR-NK cells currently applied in a phase I clinical trial in glioblastoma patients. (frontiersin.org)

The Chapuis team is developing strategies to modulate infused T cell products and the resident tumor microenvironment to enhance clinical efficacy. (fredhutch.org)
Liquid biopsy is a useful tool for accurately monitoring dynamic changes in tumor immune heterogeneity and the tumor microenvironment. (spandidos-publications.com)
Tumor cells are influenced by both genetic factors and environmental elements in the microenvironment, resulting in a complex regulation process ( 1 ). (spandidos-publications.com)
Various subclonal tumor cells have the ability to modify the tumor microenvironment in order to obtain adaptations. (spandidos-publications.com)
Furthermore, tumor heterogeneity has a significant impact on both the immune microenvironment and the infiltration of various immune cells within tumors, such as cytotoxic T lymphocytes (CTLs) ( 5 ), myeloid antigen-presenting cells ( 6 ) and cancer-associated fibroblasts (CAFs) ( 7 ). (spandidos-publications.com)
It has been discovered that the genetic structure of tumor cells and the components of the immune microenvironment interact with each other. (spandidos-publications.com)
This interaction results in a more complex alteration of both the heterogeneity of tumor cells and the heterogeneity of the tumor microenvironment. (spandidos-publications.com)
However, the tumour may evade immune responses through regulatory T-cell-mediated immune suppression in the tumour microenvironment, defective antigen presentation, and production of immunosuppressive cytokines (5). (cambridgemedicine.org)
While GB tumors are frequently infiltrated by natural killer (NK) cells, these are actively suppressed by the GB cells and the GB tumor microenvironment. (frontiersin.org)
Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)

With the growing use of 177 Lu-DOTATATE peptide receptor radionuclide therapy (PRRT), there are many unanswered questions regarding patient selection. (snmjournals.org)

Reports of spontaneous regression and tumour infiltration with T-lymphocytes makes melanoma candidate for immunotherapies. (mdpi.com)
Adoptive cellular therapy (ACT) using tumor-infiltrating lymphocytes (TILs) has potential to treat bladder cancer, as previously demonstrated by successful expansion of tumor reactive T cells from human bladder tumors. (bmj.com)
We used an MHC-matched/miHA-disparate B10.D2 → Balb/c bone marrow transplantation (BMT) murine model and MOPC315.BM MM cells to develop an ATCT protocol consisting of total body irradiation, autologous-BMT and infusion of selective, myeloma-reactive lymphocytes of T cell receptor (TCR) Vβ 2, 3 and 8.3 families (MM-auto BMT ATCT). (biomedcentral.com)
In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)

ANP is secreted in response to: Stretching of the atrial wall, via Atrial volume receptors Increased Sympathetic stimulation of β-adrenoceptors Increased sodium concentration (hypernatremia), though sodium concentration is not the direct stimulus for increased ANP secretion Endothelin, a potent vasoconstrictor Three types of atrial natriuretic peptide receptors have been identified on which natriuretic peptides act. (wikipedia.org)
They are all cell surface receptors and designated: guanylyl cyclase-A (GC-A) also known as natriuretic peptide receptor-A (NPRA/ANPA) or NPR1 guanylyl cyclase-B (GC-B) also known as natriuretic peptide receptor-B (NPRB/ANPB) or NPR2 natriuretic peptide clearance receptor (NPRC/ANPC) or NPR3 NPR-A and NPR-B have a single membrane-spanning segment with an extracellular domain that binds the ligand. (wikipedia.org)
Targeted radiopharmaceuticals are created by linking a medical radioisotope to a targeting molecule (e.g., peptide, antibody, small molecule) that can precisely recognize tumor cells and bind to tumor-specific characteristics, like receptors on the tumor cell surface. (memoinoncology.com)
Chimeric antigen receptor (CAR) T-cell therapy is a novel therapeutic T-cell engineering option, where T-cells obtained from a patient's blood are engineered ex vivo to express specific tumour antigen receptors. (cambridgemedicine.org)
Autologous as well as allogeneic CD8 + T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. (oncotarget.com)
At their best, they usually rely on some mysterious things called ionic pumps, that perform active transport, powered by little motors, under instructions from molecules that act on their specific receptors. (raypeat.com)
Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)

Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. (nwbio.com)
The real-time analysis in GBM-on-a-Chip showed that mesenchymal GBM niche attracted low number of allogeneic CD154+CD8+ T-cells but abundant CD163+ tumor-associated macrophages (TAMs), and expressed elevated PD-1/PD-L1 immune checkpoints and TGF-β1, IL-10, and CSF-1 cytokines compared to proneural GBM. (elifesciences.org)

Two courses of four weekly infusions of rituximab with or without interferon-2a: final results from a randomized phase III study in symptomatic indolent B-cell lymphomas. (cancercentrum.se)

Diagnosis involves measurement of pituitary hormone levels and CT or MRI to detect structural pituitary anomalies or brain tumors. (msdmanuals.com)

METHODS: We analyzed infused TIL products from metastatic melanoma patients previously treated with ACT for the presence of neoantigen-specific T cells. (bvsalud.org)
Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)
In uveal melanoma, the tumors arise from the pigment cells (melanocytes) that reside within the iris, ciliary body, or choroid (collectively known as the uvea) and give color to the eye. (medscape.com)

Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)

Data from recent clinical trials have highlighted the potential for this therapeutic modality to effect potent anti-tumor activity. (biomedcentral.com)
In vivo studies in mice demonstrated dose-dependent anti-tumor activity of IMA402. (advfn.com)

The reasons for this are multiple and include the variable and often long times to progression, the fact that direct measurements on target tumors are often not possible, and also include patient- intrinsic effects related to both patient and tumor heterogeneity. (biomedcentral.com)
The heterogeneity of glioblastoma can suppress immune cell function and lead to immune evasion, which presents a challenge in developing effective molecular therapies for tumor cells. (spandidos-publications.com)
Glioblastoma (GBM) is characterized by significant genetic heterogeneity among tumor cells. (spandidos-publications.com)
This heterogeneity is referred to as 'polymorphism', as tumor cells rapidly undergo mitosis, resulting in the formation of numerous subclones and uncertainty regarding the state of the genome. (spandidos-publications.com)
This heterogeneity can vary greatly between different types of immune cells, leading to further complexity in understanding the immune response to tumors. (spandidos-publications.com)
Consequently, the heterogeneity of tumor cells is constantly evolving. (spandidos-publications.com)
Thus, tumor heterogeneity has an important role in tumor development. (spandidos-publications.com)
These studies reveal a wide range of genetic tumor heterogeneity in both spatial and temporal dimensions, encompassing diverse single-nucleotide mutations, insertions, deletions and copy number variations ( 9 , 10 ). (spandidos-publications.com)

A large retrospective analysis from a single institution revealed an improved cancer-specific survival advantage, even with resection of more than one metastatic lesion. (medscape.com)
To view a multidisciplinary tumor board case discussion, see Memorial Sloan Kettering e-Tumor Boards: Metastatic Clear Cell Renal Cell Carcinoma . (medscape.com)
Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)

CONCLUSIONS: Despite methods which often focus on CD8+T cells, our study supports the importance of prospective identification of neoantigen-specific CD4+ T cells within TIL products as they are a potent source of tumor-specific effectors. (bvsalud.org)
VEGF is crucial in the process of tumor-induced angiogenesis, and recent experiments strongly suggest that the molecule is most potent when bound to the extracellular matrix (ECM). (proteasomesignaling.com)
The aim of this study is to investigate preliminary efficacy of Modi-1 vaccine(s), in an open labelled clinical trial, in participants with TNBC, SCCHN, RCC and HGSOC, powered to demonstrate that Modi-1 vaccines have potent anti-tumour activity. (clinicaltrials.gov)

A member of the natriuretic peptide gene family, NPPA encodes an important cardiac signaling molecule known as atrial natriuretic peptide/factor (ANP). (wikipedia.org)

For patients with intermediate- to high-grade tumors, there is potential for local recurrence, distant metastasis, and death, and therefore surveillance following treatment is encouraged. (bvsalud.org)
Schwab noted that UC San Diego Health is the only local health system to offer an infusion center dedicated to patients with breast cancer. (newswise.com)
The 12-chair infusion center is a few steps away from our new clinics so that patients are always close to their doctors and nurses. (newswise.com)
Patients who are part of a clinical trial or who are receiving standard treatment can receive their infusions here at the Koman Family Outpatient Pavilion. (newswise.com)
Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
Bleumer I, Tiemessen DM, Oosterwijk-Wakka JC, Völler MC, De Weijer K, Mulders PF, Oosterwijk E. Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells. (nwbio.com)
Because the T-cell receptor binding domain only recognizes a specific gp100-derived peptide presented on HLA-A*02:01, tebentafusp can only be used to treat patients with this HLA type. (medscape.com)
Monitor patients and discontinue RUXIENCE infusion for severe reactions ( 5.1 , 6.1 ). (drugs.com)
Our ex vivo patient-specific GBM-on-a-Chip provides an avenue for a personalized screening of immunotherapies for GBM patients. (elifesciences.org)
lt;p>In this study, the researchers used a text-message system to communicate with patients in the 4 days before their infusion visit. (cancer.net)
These data highlight the possibility that tumor-specific ATCT may lead to long-term disease-free survival without GvHD in patients with MM. (biomedcentral.com)

TILs were isolated from MB49 orthotopic tumors and expanded ex vivo in IL-2. (bmj.com)
The second-generation CAR T-cells consist of one additional co-stimulatory component (mainly CD28, CD137 or CD134) in the intracellular domain, which amplifies anti-tumour responses in vivo (8). (cambridgemedicine.org)

molecules cleaved from the ECM may be distributed in patterns that are not conducive to chemotactic migration buy Thiazovivin toward a tumor, depending on the spatial distribution of MMP molecules. (proteasomesignaling.com)
Since GvT responses involve T-cell recognition of tumor-specific peptides presented by MHC molecules [ 14 ], it may be possible to identify and select donor T cells that provide beneficial GvT responses but minimal GvHD risk. (biomedcentral.com)
In addition to humoral factors, tumour-derived molecules have also been proposed as mediators of cancer cachexia. (biomedcentral.com)

We are personalizing therapies to the specific type of breast cancer and to the patient's preferences for care. (newswise.com)
The Phase 2a dose expansion part of the trial will be designed to comprise several cohorts to further evaluate IMA402 in specific indications and combination therapies. (advfn.com)

BACKGROUND AND OBJECTIVES: Primary cutaneous leiomyosarcoma (cLMS), a rare, typically intradermal tumor, has previously been reported to exhibit an indolent course of disease with zero-to-low risk of local recurrence or distant metastasis. (bvsalud.org)
The possibility of disease-free survival increases after resection of primary tumor and excision of isolated metastasis. (medscape.com)
Integrins also function in pathological processes such as inflammation, wound healing, angiogenesis, and tumor metastasis. (thno.org)

The therapeutic approach to renal cell carcinoma (RCC) is guided by the probability of cure, which is related directly to the stage or degree of tumor dissemination. (medscape.com)

Results Systemic ACT-treated mice had a decrease in tumor growth, increase in T cell infiltration and long-term immune protection compared with control-treated mice. (bmj.com)
Blocking CXCR3 on OT-I T cells prior to intravesical delivery decreased T cell infiltration into the tumor and prevented the control of tumor growth. (bmj.com)

TILs were enriched on reactivity to neoantigen peptides derived and prioritized from patient sample-directed mutanome analysis. (bvsalud.org)

OT-I T cells delivered intravesically were able to control tumor growth without lymphodepleting chemotherapy or IL-2 in MB49OVA orthotopic tumors. (bmj.com)
Intravesical delivery of TIL expanded from MB49 tumors was also able to decrease tumor growth in mice with MB49 orthotopic tumors. (bmj.com)

RESULTS: We discovered that neoantigen-specific TIL clones were predominantly CD4+ T cells and were present in both therapeutic responders and non-responders. (bvsalud.org)
As transferred T cell persistence is critical to clinical success, new strategies aim to increase the tumor-binding strength (affinity/avidity) of tumor-specific TCRs and to use T cell subset(s) with long-lived therapeutic potential. (fredhutch.org)
State-of-the-art tests (HTTCS and pMHC multimer binding assays) are being used to characterize the diversity of T cells (identify individual clonotypes) within therapeutic T cell products, track them post-infusion, and then deduce the frequencies and characteristics of the specific T cells ultimately responsible for effecting tumor regression. (fredhutch.org)
The peptide took over four years of trial and error to develop and builds on nearly a decade of research investigating vulnerabilities in senescent cells as a therapeutic option to combat some aspects of aging. (fightaging.org)

While numerous advances have been made, the contribution of neoantigen-specific CD4+T cells within TIL infusion products remains underexplored and therefore offers a significant opportunity for progress. (bvsalud.org)
Discussing the drug at a meeting last year, Jessica Hassel, MD, of University Hospital Heidelberg in Germany, explained that tebentafusp is a bispecific fusion protein designed to target gp100 through a high-affinity T-cell receptor binding domain and an anti-CD3 T-cell engaging domain, which redirects T cells to kill gp100-expressing tumor cells. (medscape.com)
Methods A model system using OT-I T cells and an ovalbumin expressing MB49 tumor cell line (MB49OVA) was developed to study ACT in bladder cancer. (bmj.com)
Collaborating with Fred Hutch colleagues in Dr. Phil Greenberg's group, Dr. Chapuis participated in the identification and generation of a native, high-affinity WT1-specific TCR (TCR C4 ) and optimized the Good Manufacturing Process (GMP) methods for transfer (by lentiviral transduction) into T cells for clinical use. (fredhutch.org)
Dr. Chapuis wrote and successfully obtained necessary regulatory approvals, and the team is now evaluating the safety and efficacy of transplant donor-derived CD8+ T cells carrying the HLA-A*0201-restricted WT1-specific TCR C4 . (fredhutch.org)
Evidence of anti-leukemic activity with adoptive transfer of WT1-specific T cells From: Chapuis AG et al. (fredhutch.org)
In addition, intrinsic differences in subclonal tumor cells that arise from random mutations can create distinct niches within limited lesions. (spandidos-publications.com)
However, rather than actively modifying the environment, multiple mechanisms guide the evolution of tumor cells through the selection of subclones with the most adaptive phenotype by environmental factors ( 1 ). (spandidos-publications.com)
Multiregional whole-exome or genome sequencing has revealed that there is significant variation in the genetic makeup of tumor cells across different anatomical locations and within the same tumor over time ( 4 ). (spandidos-publications.com)
High-throughput sequencing methods are utilized to analyze the mutational spectrum and evolutionary trajectories of tumor cells. (spandidos-publications.com)
The increasing presence of senescent cells is one of the root causes of degenerative aging and directly contributes to many specific age-related diseases. (fightaging.org)
While senescence has short-term roles to play in tumor suppression, by shutting down the ability to replicate in potentially cancerous cells, and in wound healing , these cells have no clear and evident long-term use in the body. (fightaging.org)
Regular infusions of a peptide that can selectively seek out and destroy broken-down cells that hamper proper tissue renewal, called senescent cells, showed evidence of improving healthspan in naturally-aged mice and mice genetically engineered to rapidly age. (fightaging.org)
By interfering with the FOXO4-p53 crosstalk, the peptide causes senescent cells to go through apoptosis, or cell suicide. (fightaging.org)
Only in senescent cells does this peptide cause cell death. (fightaging.org)
The immune system interacts closely with tumour cells via complex mechanisms and can result in either eradication of the tumour or immune evasion by the tumour (5). (cambridgemedicine.org)
Consequently, immune cells fail to recognise and kill tumour cells. (cambridgemedicine.org)
We identified HLA-A*02:01/peptide-restricted T cells directed against ADRB3 295 . (oncotarget.com)
After TCR identification, we generated HLA-A*02:01/peptide restricted TCR transgenic T cells by retroviral transduction and tested T cell expansion rates as well as A*02:01/peptide recognition and ES killing in ELISpot and xCELLigence assays. (oncotarget.com)
24h after TCR transduction, CD107a expression correlated with low expansion rates due to apoptosis of ADRB3 specific T cells in contrast to CHM1 specific transgenic T cells. (oncotarget.com)
Comparison of peptide motive binding affinities revealed extended fratricide among ADRB3 295 specific TCR transgenic T cells in contrast to CHM1 319 . (oncotarget.com)
Therefore, the specific detection of negatively stranded viral RNA in tissues or cells is a reliable marker of active enteroviral replication. (proteasomesignaling.com)
Blinatumomab mediates the formation of a cytolytic synapse between the T-cell and the tumour cell, releasing proteolytic enzymes to kill both proliferating and resting target cells. (evidentic.com)
Transplanting only tumor reactive donor T cells that mediate a graft-versus-myeloma (GvM) but not GvHD may overcome this problem. (biomedcentral.com)
Much of the curative potential of allografts is attributed to the graft-versus-tumor (GvT) response that aims to destroy residual tumor cells that persist after induction therapy and ASCT [ 5 ]. (biomedcentral.com)
In this work, we used cytotoxicity and enzymatic assays and morphological analysis to examine the effects of a proteolysis-inducing factor (PIF)-like molecule purified from ascitic fluid of Walker tumour-bearing rats (WF), which has been suggested to be responsible for muscle atrophy, on cultured C 2 C 12 muscle cells. (biomedcentral.com)
The study proposes a trial of novel Modi-1/Modi-1v vaccines, consist of a combination of specific peptides conjugated to a toll-like receptor ligand 1/2 adjuvant, designed to enhance immune responses against peptides commonly expressed or upregulated by cancer cells. (clinicaltrials.gov)

Tumor lysis syndrome: Administer aggressive intravenous hydration, anti-hyperuricemic agents, monitor renal function ( 5.5 ). (drugs.com)

In primary tumors, mutations in driver genes frequently provide a survival advantage and give rise to a dominant clonal population. (spandidos-publications.com)
By contrast, mutations in noncoding regions do not provide significant growth advantages during tumor evolution ( 11 ). (spandidos-publications.com)

CD4+ TIL demonstrated an effector T cell response with cytotoxicity toward autologous tumor in a major histocompatibility complex class II-dependent manner. (bvsalud.org)

Repeated infusion of naïve myeloma-reactive T cell TCRVβ 2, 3 and 8.3 subfamilies was also effective. (biomedcentral.com)

Glioblastoma (GB) is the most frequent malignant primary brain tumor in adults, without any curative treatment options available at present. (frontiersin.org)

As a result, the radioisotope accumulates at the tumor site and decays, releasing a small amount of ionizing radiation, thereby destroying tumor tissue. (memoinoncology.com)
They are testing whether naïve and central memory CD8+ T cell subsets do persist longer, localize better to tumor tissue, retain function and are more effective at eliminating detectable tumor, as previous findings suggest. (fredhutch.org)
For instance, they can provide localized, site-specific drug delivery, which is especially important in applications such as cardiology and oncology, where targeted delivery can improve the effectiveness of treatment and minimize side effects or damage to healthy tissue. (drug-dev.com)
endocrinopathies result when the tumor produces hormones or destroys hormone-producing tissue. (msdmanuals.com)

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. (pharmaceutical-technology.com)
One of the biggest advantages of the spacious new infusion center is that it offers healing panoramic views of the La Jolla canyons," said Schwab, who is also clinical director of the infusion center. (newswise.com)
The dose for RA in combination with methotrexate is two-1,000 mg intravenous infusions separated by 2 weeks (one course) every 24 weeks or based on clinical evaluation, but not sooner than every 16 weeks. (drugs.com)
Various clinical features occur depending on the specific. (msdmanuals.com)

This has been demonstrated in studies of senescent cell removal showing life extension in mice , as well as those that have demonstrated specific improvements and reversals in the pathology of various age-related diseases and aged tissues. (fightaging.org)
We treated mice for over 10 months, giving them infusions of the peptide three times a week, and we didn't see any obvious side effects. (fightaging.org)
Their isolation and infusion into MM-bearing mice resulted in a vigorous GvM response without induction GvHD and long-term survival. (biomedcentral.com)

Its oncology management platform arises from the ability of soricidin and the C-series peptides to modulate the activity of a calcium ion channel. (pharmaceutical-technology.com)

CONCLUSIONS: Primary tumor resection of cLMS provides excellent local control for low-grade tumors as no low-grade cases experienced recurrence. (bvsalud.org)
MES GBM accounts for 30-50% of primary tumors and is associated with particularly poor response to therapy, while PN GBM is associated with a somewhat better prognosis. (elifesciences.org)
Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and currently incurable. (frontiersin.org)
Hypopituitarism can be primary (a pituitary disorder) or secondary to interference with hypothalamic secretion of specific releasing hormones that control anterior pituitary hormone (GH, FSH, LH, ACTH, TSH) production. (msdmanuals.com)

Absolute and relative CD4 + T-cell counts did not change following PGT121 infusion in HIV-infected participants. (nature.com)
These results were validated by paired TCR and single cell RNA sequencing, which elucidated transcriptomic profiles distinct to neoantigen-specific CD4+ TIL. (bvsalud.org)
The drug is tebentafusp-tebn (Kimmtrak, from Immunocore Limited), which acts as a bispecific gp100 peptide-HLA-directed CD3 T-cell engager. (medscape.com)
In particular, the MAGE-A1antigen is frequently expressed in triple-negative breast cancer and in other poor prognosis tumor types, including squamous non-small cell lung carcinoma and advanced-stage melanomas, so the MAGE-targeting therapy they are developing may be broadly useful. (fredhutch.org)
After the binding of the MHC/peptide complex to the TCR, the TCR heterodimer interacts with the antigen and facilitates clustering of the CD3 complex, which mediates further signalling that initiates T-cell activation (6). (cambridgemedicine.org)
The immunological responses measured throughout the study will include the level of SARS-CoV-2 neutralizing antibodies against SARS-CoV-2 variants of concern (VOC), including the newly identified Omicron VOC, as well as specific T-cell responses. (geovax.com)
In this regard, immune-transcriptome analyses of T cell receptor (TCR) Vβ CDR3-size and sequence is being used to characterize alloreactive versus tumor-specific T-cell responses. (biomedcentral.com)

Two individuals with low baseline viral loads experienced ART-free viral suppression for ≥168 days following antibody infusion, and rebound viruses in these individuals demonstrated full or partial PGT121 sensitivity. (nature.com)
Several bNAbs have been tested to date in HIV-1-infected individuals, including the CD4-binding, site-specific antibodies VRC01, 3BNC117, VRC07-523LS and N6-LS, the V3-glycan-specific antibody 10-1074 and the V2-apex-specific antibodies PGDM1400 and CAP256-VRC26.25 (refs. (nature.com)

We hope the trial results accelerate the process of identifying drugs that are effective for specific breast cancer subtypes. (newswise.com)
Dr, Lewis currently serves as Founder and CEO of A28 Therapeutics where he is developing targeted lytic peptides for treatment of cancer. (johnshufeldtmd.com)
With passion, he unveils the distinctive approach of his current company, A28 Therapeutics, which pioneers a targeted lytic peptide for combating cancer, with a particular emphasis on liver metastases. (johnshufeldtmd.com)
He currently serves as founder and CEO of A28 Therapeutics, where he's developing a targeted lytic peptides for the treatment of cancer. (johnshufeldtmd.com)
GM-CSF is also involved in bone cancer pain development by regulating tumor-nerve interactions, remodeling of peripheral nerves and sensitization of damage-sensing (nociceptive) nerves. (iasp-pain.org)
Here, we showed that GM-CSF promotes bone cancer-associated pain by enhancing excitability of DRG neurons via the Jak2-Stat3-mediated upregulation of expression of nociceptor-specific voltage-gated sodium channels. (iasp-pain.org)

RCC is an immunogenic tumor, and spontaneous regressions have been documented. (medscape.com)

At UChicago Medicine, treatment for NETs often includes surgery, even for tumors that have spread to other organs. (uchicagomedicine.org)

The preprohormone is activated via post-translational modification that involves cleavage of the 25 amino acid signal sequence to produce proANP, a 126 amino acid peptide that is the major form of ANP stored in intracellular granules of the atria. (wikipedia.org)
The test involves an IV-infusion, with subsequent measurement of glucose and insulin level. (myhealth.gov.my)
Treatment usually involves specific hormone replacement and removal of any causative tumor. (msdmanuals.com)

Molecular GBM subgroups are associated with distinct histological patterns, suggesting that tumor microenvironmental features reflect the specific underlying molecular genetic abnormalities. (elifesciences.org)

Implantable infusion pumps for continuous administration of test agents to unrestrained laboratory animals. (alzet.com)

ITM Isotope Technologies Munich SE, a leading radiopharmaceutical biotech company, is dedicated to providing a new generation of radiomolecular precision diagnostics and therapeutics for hard-to-treat tumors. (memoinoncology.com)

Human immunodeficiency virus (HIV)-1-specific broadly neutralizing monoclonal antibodies are currently under development to treat and prevent HIV-1 infection. (nature.com)

For anticoagulation potency, the formation of the SP/protease protein complex and the associated non-specific polar interaction between the negatively and positively charged groups in the polysaccharide and protein is responsible for anticoagulant activity. (springer.com)

Anatomy12

Organisms17

Diseases49

Chemicals and Drugs75

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Phenomena and Processes53

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Health Care5

Antigens9

Solid tumors3

Intravenous infusion6

Neuroendocrine tumors6

Immunotherapy9

Microenvironment10

Receptor radionuclide therapy1

Lymphocytes4

Receptors7

Allogeneic2

Weekly infusions1

Brain tumors1

Melanoma3

Cytokines1

Anti-tumor activity2

Heterogeneity8

Metastatic3

Potent3

Signaling molecule1

Patients11

Vivo2

Molecules3

Therapies2

Metastasis3

Renal Cell Carc1

Infiltration2

TILs1

Orthotopic2

Therapeutic4

Cells27

Lysis1

Mutations2

Autologous1

Reactive1

Malignant1

Tissue4

Clinical4

Mice3

Modulate1

Primary4

Cell7

Antibody2

Cancer6

Spontaneous1

NETs1

Involves3

Genetic1

Continuous1

Therapeutics1

Antibodies1

Activity1