• We set out to assess the effectiveness of all kinds of epidural analgesia (including combined-spinal-epidural) on the mother and the baby, when compared with non-epidural or no pain relief during labour. (cochrane.org)
  • Epidural solutions are given by bolus injection (a large, rapid injection), continuous infusion or using a patient-controlled pump. (cochrane.org)
  • Combined-spinal-epidural involves a single injection of local anaesthetic or opiate into the cerebral spinal fluid for fast onset of pain relief, as well as insertion of the epidural catheter for continuing pain relief. (cochrane.org)
  • There are highly variable findings such as a longer labour, experiencing very low blood pressure, and being unable to move for a period of time after the birth (motor blockade), probably due to higher concentrations of local anaesthetic being used in the epidural or the use of epidural infusions rather than epidural doses of pain relief administered at intervals. (cochrane.org)
  • The cephalad part of the spinal epidural space begins at the level of foramen magnum, where the periosteal and spinal layers of dura fuse together. (medscape.com)
  • To determine the cross tolerance to the antinociceptive effects of μ and δ opioids in the spinal cord, rats received a 7-day infusion of one of three concentrations each of morphine (2, 6, or 20 nmol/h) or D-ala 2 -D-leu 5 - enkephalin (DADLE) (2, 6, or 20 nmol/h). (okstate.edu)
  • I had discovered that persistent pain up-regulates the opioid peptide dynorphin in the dorsal spinal cord, the first synaptic processing station for pain'first observing this with a radioimmunoassay for dynorphin peptide and later measuring the corresponding mRNA increases, performing studies to localize the spinal neurons involved, and eventually examining seven base pairs of enhancer sequence in the promoter. (nih.gov)
  • Epidural anesthetics delivered to the distal portion of the spinal cord block central sensitization and provide pain relief, and epidural steroids reduce inflammatory responses at the injured dorsal root ganglion, spinal cord, and surrounding peripheral tissue. (medsci.org)
  • Special attention should be given to patients at apparent risk (e.g., spinal cord injuries at T-6 or above, communication difficulties, history of withdrawal symptoms from oral or intrathecal baclofen). (nih.gov)
  • I had always been a basic bench scientist, and my lab had been studying synaptic-induced gene regulation in the spinal cord in models of persistent peripheral inflammation. (nih.gov)
  • That first summer, we asked whether plasmids could transfect neurons or glia in the spinal cord in vivo or in primary cultures. (nih.gov)
  • We tried direct injections of plasmid into tissue and even prolonged infusions (for a week, using an osmotic mini-pump) of about 10 billion plasmid molecules into the cerebrospinal fluid (CSF) space surrounding the spinal cord. (nih.gov)
  • Patients in Group B (EPOCH-R) receive rituximab as described above for Group A. Doxorubicin, etoposide and vincristine are then given by continuous infusion over the next 4 days for a total of 96 hours. (nih.gov)
  • In this study, we randomly assigned 42 patients with severe ZAP beyond the acute phase, as determined by a numeric rating scale (NRS) score ≥7, to receive continuous epidural infusion of local anesthetics with either a one-time 5-mg dose or intermittent repeated doses (15 mg total) of dexamethasone. (medsci.org)
  • GABLOFEN is a gamma-aminobutyric acid (GABA) ergic agonist indicated for use in the management of severe spasticity of cerebral or spinal origin in adult and pediatric patients age 4 years and above. (nih.gov)
  • Patients should first respond to a screening dose of intrathecal baclofen prior to consideration for long term infusion via an implantable pump. (nih.gov)
  • Patients who do not respond to a 100 mcg intrathecal bolus should not be considered for an implanted pump for chronic infusion. (nih.gov)
  • Patients in group B may receive the drugs through a portable infusion pump. (nih.gov)
  • Patients in Group A (R-CHOP) are given rituximab by IV infusion on the first day of treatment over several hours. (nih.gov)
  • Patients at risk of their disease spreading to the central nervous system may be given methotrexate injected into the spinal fluid. (nih.gov)
  • 18 years undergoing spinal surgery in prone position. (bvsalud.org)