We therefore examined whether polymorphisms in DNA base-excision repair (BER) genes, XRCC1 G399A and OGG1 C326G, were associated with CCA risk and whether they modified the effect of smoking and alcohol drinking in the Thai population. (bmj.com)
Results Our results suggest that, in the Thai population, polymorphisms in XRCC1 and OGG1 genes, particularly in combination, are associated with increased susceptibility to CCA, and that their role as modifiers of the effect of smoking and alcohol consumption influences the risk of CCA. (bmj.com)
Single nucleotide p1
Blood-based single nucleotide polymorphism (SNP) analysis was performed. (cancerindex.org)
Susceptibility2
Estimation of the level of genetic susceptibility showed that the individual calculated risk value (iCRV) ranged from 1 to 16, with a higher iCRV indicating a greater genetic susceptibility to lung cancer. (scielo.br)
The polymorphic variants of the IGF genes may serve as a susceptibility factor for pancreatic cancer. (aacrjournals.org)
Variants3
We investigated a panel of 34 known high/moderate-risk cancer genes, including 16 related to breast or ovarian cancer (BC/OC) genes, and 63 candidate genes to BC/OC in 192 clinically suspicious of hereditary breast/ovarian cancer (HBOC) Spanish families without pathogenic variants in BRCA1 or BRCA2 (BRCA1/2). (cancerindex.org)
We identified 38 unique pathogenic variants (PVs) in 13 different cancer-predisposing genes among 57 patients (25.4%), of which 6 variants were novel. (bvsalud.org)
The genes encoding enzymes involved in the process of metabolic activation, detoxification and DNA repair are polymorphic and there are some structural variants of genes in the population associated with different activity of the enzyme they encode. (biomedcentral.com)
Mutations1
In cases with mutations in the HOXB13 gene, the family history of cancer was negative. (biomedcentral.com)
Variability2
The genetic variability of this population was distributed in six clusters that were defined based on their genetic characteristics. (scielo.br)
Gene-nutrient interactions may help explain this variability in response to food that is associated with IBD. (mdpi.com)
XRCC21
Two SNPs in X-Ray Repair Cross Complementing 2 gene (XRCC2) rs2040639 and interferon gamma (IFNG) rs2069705 genes were found to be associated with ARSR. (cancerindex.org)
Candidate genes1
Among the 12 candidate genes located in these regions, the gene CAB39L may be a candidate that affects running speed and endurance of the Tazy dog. (bvsalud.org)
Apoptosis2
In each category, studies related to growth control genes, cell proliferation, apoptosis, DNA repairgenes, antioxidant and drug detoxification genes, genes of drug metabolizing enzymes, tissue remodeling genes and genes of antibody-dependent cellular cytotoxicity were discussed separately. (researchsquare.com)
HOX and homeobox genes play an important role in the regulation of many processes including cell proliferation, differentiation, angiogenesis, receptor signaling, apoptosis and regulate transcription of target androgen receptor genes [ 16 ]. (biomedcentral.com)
RAD511
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. (cancerindex.org)
SNPs3
Thirty SNPs of well-defined functional genes were investigated. (cancerindex.org)
Variations in toxicity and response to therapy are observed among patients despite similar clinicopathologic characteristics which are attributed to single nucleotide polymorphisms (SNPs). (researchsquare.com)
So, the aim of this review was to investigate the effect of single nucleotide polymorphisms (SNPs) on response rate and toxicity in HNSCCs. (researchsquare.com)
Tumor3
Thus the genetic basis leading to a better or worse prognosis for survival in cancer patients may be dependent on functional polymorphisms in genes such as genes responsible for tumor transformation, xenobiotic metabolism, oxidative stress, detoxification and DNA repair. (biomedcentral.com)
A mutation in the TP53 gene overexpresses the p53 protein and increases the risk of tumor progression [ 7 ]. (biomedcentral.com)
Altered expression of HOX genes may be important for oncogenesis and tumor suppression by influencing various pathways that promote tumorigenesis and metastasis. (biomedcentral.com)
Methylation1
A number of mechanisms play a large role in the initiation of neoplastic transformation of bladder or kidney cancer, including: mutation of suppressor genes, activation of proto-oncogenes, abnormal and over-expression of oncogenes through amplification and deletion of some regions of chromosomes, and methylation. (biomedcentral.com)
Patients4
Understanding gene polymorphisms will help us move toward personalized medicine and determine which patients will actually benefit from therapies for HNSCCs. (researchsquare.com)
Individual genetic variations lead to different responses of patients to a single treatment regimen. (researchsquare.com)
Therefore, knowing the genetic variations (polymorphisms) will be effective in predicting the response to treatment, and accordingly, we can determine which patients will benefit from chemo- or radiotherapy (Ansell et al. (researchsquare.com)
Single nucleotide polymorphisms were investigated using the TaqMan method in 892 patients with pancreatic ductal adenocarcinoma and 783 healthy controls who were recruited from The University of Texas M. D. Anderson Cancer Center from 2000 to 2007. (aacrjournals.org)
Variations1
To determine whether genetic variations of IGF modify pancreatic cancer risk, we compared the frequency of six single nucleotide polymorphisms of IGF1 and IGF2 in a large-scale case control study. (aacrjournals.org)
Ovarian1
In fact, over 75 genes associated with POI have been implicated in ovarian development and meiosis [ 15 ]. (nature.com)
Factors5
We aimed to identify population-specific genetic markers associated with the risk of developing early-onset BC and test their association with clinical and prognostic factors. (bvsalud.org)
The combined influence of all risk factors revealed contributions of 24.7% for health status and 14.2% for genetic status, while other impacts go to all unaccounted factors. (bvsalud.org)
The HOX gene family belongs to the homeobox superfamily of transcription factors. (biomedcentral.com)
Many risk factors for breast cancer have been identified, including genetic, environmental, and lifestyle factors. (medscape.com)
Once the level of risk has been established, physician and patient can discuss the best screening and management, which may involve measures such as addressing modifiable risk factors or genetic counseling. (medscape.com)
Etiology3
In the past decade, there has been an increase in the number of lung cancer cases in young people, which suggests an important role for genetic background in the etiology of this disease. (scielo.br)
Although its genetic etiology has been extensively investigated, most POI cases remain unexplained. (nature.com)
The genetic etiology of isolated POI is highly heterogeneous. (nature.com)
Chromosome2
The resulting recombinase-coated ssDNA filaments can invade the homologous chromosome dsDNA, searching for a complementary sequence (chromosome pairing), which will foster genetic material exchange. (nature.com)
It is noteworthy that the HOXB13 gene is located on chromosome 17q, the loss of heterozygosity of which has been noted in cancer of the kidney, breast, ovary, colon and some haematological malignancies. (biomedcentral.com)
Cancer4
Individual Genetic Variation Might Predict Acute Skin Reactions in Women Undergoing Adjuvant Breast Cancer Radiotherapy. (cancerindex.org)
Entire coding regions (>1700 exons) and the flanking noncoding regions of 94 cancer-associated genes were sequenced from blood DNA using MiSeq platform. (bvsalud.org)
Genes whose expression leads to the development of bladder and kidney cancer are being searched for. (biomedcentral.com)
To date, no genes with high penetration into bladder cancer or kidney cancer have been identified. (biomedcentral.com)
Repair1
This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. (cancerindex.org)
Eight genes could belong to an evolutionarily conserved complex as they were clustered in a large protein network with strong linkages. (bvsalud.org)
Role1
It identifies gene-nutrient interactions associated with the nutritional deficiencies that people with IBD commonly experience, and the role of the Western diet in influencing these. (mdpi.com)
High3
Polymorphisms in BER genes were analysed using a PCR with high-resolution melting analysis. (bmj.com)
A high level of chromosomal aberrations was evidenced for individual genetic risk manifestations. (bvsalud.org)
These are the so-called high penetration genes or so-called low penetration genes whose expression disturbs metabolism and may initiate the process of neoplastic transformation of various organs. (biomedcentral.com)
Response1
A web-based search of all original articles about the impact of gene polymorphisms on toxicity and response to therapy in HNSCCs was done until September 2021 using international English language databases including Google Scholar, Scopus, PubMed and Web of science. (researchsquare.com)