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  • potentiation
  • Moreover, CAPS2-KO mice exhibited several GABA system-associated deficits, including reduced late-phase long-term potentiation at CA3-CA1 synapses, decreased hippocampal theta oscillation frequency, and increased anxiety-like behavior. (pnas.org)
  • barbiturates
  • Nevertheless, barbiturates remain an important class of drugs from a scientific point of view, because they have played a central role in the characterization of the GABA A receptor complex. (acnp.org)
  • These findings led naturally to a focus on interactions of barbiturates with the GABA A receptor. (acnp.org)
  • Drugs
  • Investigation on its structure-activity relationship has discovered 200 morphine derivatives (e.g., codeine and related drugs) and synthesis of morphine-derived antagonist drugs (e.g., naloxone, naltrexone and nalorphine) (3). (ac.ir)
  • gamma
  • The present invention concerns novel steroid compounds that act on the gamma-aminobutyric acid receptor-chloride ionophore (GABA A -R) complex, and which can be used in the treatment of GABA and GABA-steroid related and/or steroid induced disorders of the central nervous system (CNS). (freepatentsonline.com)
  • past decade
  • In the past decade, the influence of the gastrointestinal (GI) tract on the occurrence, development, and treatment of brain diseases had been noted in humans, and a bidirectional communication route between the GI tract and the central nervous system (CNS) was termed the "gut-brain axis" ( Maqsood and Stone, 2016 ). (aspetjournals.org)
  • specific
  • In current clamp, blocking L-type Ca channels with the specific blocker nifedipine greatly reduced prolonged poststimulus firing and occluded the effect of adding group I mGluR antagonists. (jneurosci.org)
  • Further, Dr. Criswell demonstrated that neurosteroids alone and when synthesized locally by ethanol act postsynaptically to enhance the effect of GABA released by ethanol in a region specific manner. (pubmedcentralcanada.ca)
  • Also, the administration of a specific Y1 receptor antagonist had no effect on the ability of NPY to influence the resetting of light during the early and late night. (gla.ac.uk)
  • drug
  • Although it would be a legitimate medicine that a doctor saw fit, those prescribed it should keep in mind driving, or yielding heavy machinery (such as chainsaws) is, by no means, a good idea while influenced by this drug. (listverse.com)