Inflammatory stat1 transcription factor. Medical search. Frequent questions

LCC-09 was shown to inhibit pro-inflammatory cytokine tumor necrosis factor-α (TNFα)-induced expression of adhesion molecules and inflammatory cytokines, leading to reduced leukocyte adhesion to ECs. (elsevierpure.com)
Pro-inflammatory cytokines such as interleukin (IL)-1β, tumour necrosis factor (TNF)-α, and vascular endothelial growth factor (VEGF) mediate key points in inflammation [ 5 ]. (biomedcentral.com)
Effector CD4 + T cell subsets have been defined based on their secretion of cytokines, as well as based on transcription factors and cytokines required for their development and maintenance. (jci.org)
Treatment of HCEpiC with 1 ng/ml IL-1β for 18 h significantly increased release of the cytokines/chemokines granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1), while hyperosmolarity-induced release of IL-6 and MCP-1. (molvis.org)
IFN-γ is one of the principle cytokines secreted by lamina propria cells in inflamed mucosa and elevated levels of the transcription factor required for IFN-γ signaling, STAT1 (signal transducer and activator of transcription 1), are present in the colonic mucosa of patients with ulcerative colitis and Crohn's disease. (elsevierpure.com)
Proinflammatory cytokines, including IFN-γ, play an important role in the pathogenesis of inflammatory bowel disease, and abnormal activity of STAT1 is associated with human malignancies and intestinal inflammatory diseases. (elsevierpure.com)
In contrast, the peritumoral stroma is highly infiltrated with various immune cells that actively secrete high concentrations of inflammatory cytokines for enhancing cell growth, angiogenesis, and tissue remodelling [ 3 ]. (hindawi.com)
Conclusions These findings are of prominence as CD3/CD28/CpG treatment can induce the anti-inflammatory cytokines IL-10 and IL-30 and the activation or inhibition of the CD40/CD154 functions as molecular rheostat of the expression of IL-10 or IL-30. (bioerc-iend.org)
p38 MAPKs (α, β, γ, and δ) are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. (targetmol.jp)
This can be recapitulated in vitro by treating MSCs with inflammatory cytokines TNF α and IFN γ , which induce indoleamine 2,3-dioxygenase (IDO) and TNF-stimulated gene-6 (TSG-6). (biomedcentral.com)
The glycolysis-dependent anti-inflammatory property of MSCs conferred by inflammatory cytokines is mediated by PI3K-AKT signaling pathway. (biomedcentral.com)
MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. (icr.ac.uk)
In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. (icr.ac.uk)
In the murine model inflammatory lesion severity is also closely linked to macrophage activation by IFN�� leading to increased production of nitric oxide (NO) proteases cytokines Nutlin 3b and chemokines among other inflammatory mediators of tissue injury (7-10). (bio-biz-navi.com)
The IFN-1 are cytokines that are synthesized and released during viral infections and can promote inflammatory responses through the activation of the signaling JAK/STAT pathway. (fapesp.br)
Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)
STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. (thermofisher.com)

A new research led by Tokyo Medical and Dental University (TMDU) in chemically induced mouse model of inflammatory bowel disease (IBD) reveals the role of protein signaling pathway in the generation of macrophages that may induce inflammation in the colon. (medindia.net)
The signaling pathway enhances access to the promoters of genes encoding inflammatory mediators, thus increasing their expression. (medindia.net)
This shows the importance of the IFNγ-Stat1 signaling pathway in colonic inflammation. (medindia.net)
For example, it is well known that the activation of the signal transducer and activator of transcription (STAT) signaling pathway plays a central role in interferon-gamma (IFN-gamma)-induced microglial CD40 expression. (alstuttu.org)
Activation of nuclear factor-κB (NF-κB) signaling pathway has been shown to be associated with inflammatory response induced by SCI. (biomedcentral.com)
E1/E2 heterodimer binding on CD81 activates the epithelial growth factor receptor (EGFR) signaling pathway (PubMed:22855500). (proteopedia.org)
Human granulocytic anaplasmosis (HGA) is caused by the obligate intracellular bacterium induces an immunopathologic response by activating IFN�� production through the signal transducer and activation of transcription 1 (Stat1) signaling pathway. (bio-biz-navi.com)
Specifically, we found that at the initial stage of MG infection in cells, gga-miR-365-3p was rapidly increased and activated the JAK/STAT signaling pathway by inhibiting SOCS5, which induced the secretion of inflammatory factors and triggered immune response against MG infection. (biomedcentral.com)

Mechanistically, LCC-09 inhibits the phosphorylation of signal transducer and activator of transcription 1 (STAT1), TNFα-induced degradation of NF-κ-B Inhibitor-α (IκBα) and phosphoryla-tion of NFκB p65, resulting in reduced NFκB transactivation activity and binding to E-selectin promoter. (elsevierpure.com)
In addition, apigenin and luteolin markedly inhibited IFN-γ-induced phosphorylation of STAT1 with little impact on cell survival. (alstuttu.org)
In addition, apigenin and luteolin markedly inhibited IFN-gamma-induced phosphorylation of STAT1 with little impact on cell survival. (alstuttu.org)
Notably, withaferin A inhibited STAT3 phosphorylation and abolished the STAT3, STAT1, and NF-κB interactions. (bvsalud.org)
We demonstrated that this short chain fatty acid inhibits IFN-γ-induced tyrosine and serine phosphorylation of STAT1. (elsevierpure.com)
Upon phosphorylation, STAT3 proteins dimerize and translocate to the nucleus where they bind to promoter elements of target genes and modulate their transcription (4). (abwizbio.com)
The binding of a growth factor brings the multiple monomeric receptor chains into close proximity resulting into the trans-phosphorylation of their cytoplamic domains, which consequently activates downstream signaling cascades. (openrheumatologyjournal.com)
Formation of the cytokine receptor / JAK signaling complex and activation of JAK kinases leads to the phosphorylation of receptor chains, which creates docking sites for STAT ( S ignal T ransducers and A ctivators of T ranscription) transcription factors. (openrheumatologyjournal.com)
The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. (icr.ac.uk)
Not shown here is the activation under certain conditions of Jaks that are bound to some G-protein-coupled receptors (GPCRs) and the phosphorylation of STATs directly by certain ligand-activated growth factor receptors (RTKs) as well as non-receptor tyrosine kinases. (shu.edu)
The loss of STAT1 function in humans or mice results in a dramatically increased susceptibility to viral bacterial and protozoan infections (13 14 16 infection-induced IFN�� signaling leads to phosphorylation of Stat1 in mice (17) and dexamethasone suppression of STAT1 expression reduces inflammatory signaling and disease severity in infection has not been otherwise studied. (bio-biz-navi.com)
Recent findings in the literature and results from our research group revealed that Nef acts inhibiting the STAT1 phosphorylation and blocking the JAK/STAT pathway, through a yet unknown mechanism. (fapesp.br)
After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. (thermofisher.com)
In addition, zVAD inhibited ERK and Akt phosphorylation induced by LPS and poly I:C. Of note, zVAD-induced enhancement of the IRF3/IFN/STAT1 axis was abolished by necrostatin-1, while zVAD-induced inhibition of ERK and Akt was not. (molcells.org)

Cytokine & Growth Factor Reviews. (wikipedia.org)
Social behavior and neuronal connectivity in rodents have been shown to be shaped by the prototypical T lymphocyte-derived pro-inflammatory cytokine Interferon-gamma (IFNγ). (biorxiv.org)
Several studies have clearly demonstrated that distinct cytokine activated signalling and transcription factors regulate the commitment of a naïve T cell along the Th1 or T helper cell type 2 (Th2) phenotype, as well as maintenance of the polarised phenotype. (bmj.com)
STAT3, STAT1, and NF-κB physically interacted upon the cytokine stimulation. (bvsalud.org)
Additionally these two sets of signals CD3/CD28 plus CpG (CD3/CD28/CpG) synergistically induces high levels of the anti-inflammatory cytokine IL-30 [16] therefore suggesting that this same phenomenon may occur in IL-10 regulation. (bioerc-iend.org)
2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human en. (targetmol.jp)
Upon cytokine and growth factor stimulation STAT3, a transcription factor, is activated. (abwizbio.com)
Growth factor cytokine receptors typically have intrinsic kinase activity. (openrheumatologyjournal.com)
Upon cytokine activation receptor chain- bound STATs are then phosphorylated on the tyrosine residues, which results in dimerisation of STAT proteins that translocate to the nucleus and activate gene transcription. (openrheumatologyjournal.com)
Canonical NF-κB pathway activation underlines much of the immune response after SCI including cytokine, chemokine, and apoptosis-related factor production as well as immune cell activation and infiltration. (biomedcentral.com)
The JAK family of enzymes is a central component in signal transduction pathways, which are critical to normal blood cell growth and development as well as inflammatory cytokine expression and immune responses. (shu.edu)

Treg cells are inhibited by IL-27 through STAT1 and STAT3. (wikipedia.org)
Also involved are the STAT1 and STAT3 transcription factors that bind specifically to the receptor subunits, IL-27ɑ and glycoprotein. (wikipedia.org)
Interestingly, ID-associated genes exhibit promoter-localized MER41 LTRs that harbor TF binding sites (TFBSs) for not only STAT1 but also other immune TFs such as, in particular, NFKB1 (Nuclear Factor Kappa B Subunit 1) and STAT3 (Signal Transducer And Activator Of Transcription 3). (biorxiv.org)
Combined treatment of IL-6 and TNF-α phosphorylated transcription factors STAT3 in a synergistic manner. (bvsalud.org)
however in Th2 cells GATA3 Jun BMS-582664 and MAF are specific transcription factors for IL-10 expression while STAT3 or STAT1 are the important factors for IL10 in Th17 expression [11-14]. (bioerc-iend.org)
Signal transducer and activator of transcription 3 (STAT3) was initially showed to control acute-phase genes in response to interleukin-6 (IL-6) and epidermal growth factor (EGF) during inflammatory processes (1). (abwizbio.com)
STAT3 belongs to the STAT family of cytoplasmic transcription factors that induces cell membrane-mediated nuclear signal transduction in various cellular activities (2). (abwizbio.com)
It had been shown that STAT3 can also autoregulate its own transcription. (abwizbio.com)
RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. (icr.ac.uk)

However, an inappropriate immune response can lead to chronic inflammation and the development of inflammatory bowel disease (IBD) . (medindia.net)
New genetic test helps in early diagnosis of inflammatory bowel disease in children and also predict its severity. (medindia.net)
Data highlights the need for research into prevention of inflammatory bowel disease and innovations in health-care systems. (medindia.net)
Thus it may be a potential therapeutic target for the prevention of Inflammatory bowel disease (IBD). (medindia.net)
Biopsies are commonly performed in patients with or without suspected IgA vasculitis (HSP) to rule out infection, inflammatory bowel disease, and less commonly, vasculitis. (stanfordchildrens.org)
While the clinical and histologic findings may mimic early inflammatory bowel disease, the presence of predominant small bowel involvement, especially erosive duodenitis, should raise suspicion for IgA vasculitis (HSP). (stanfordchildrens.org)
A Mobile Infliximab Dosing Calculator for Therapy Optimization in Inflammatory Bowel Disease. (stanfordchildrens.org)
Tyk2 inhibitors are in development and are considered to be promising tools for the treatment of human diseases, including psoriasis, rheumatoid arthritis and inflammatory bowel disease. (jak-stat.at)
Inflammatory bowel disease (IBD) mouse model was established by subjecting mice to dextran sulfate sodium (DSS) in drinking water for 7 days. (biomedcentral.com)
More importantly, these acute activation processes of PI3K-AKT signaling were critical for the production of anti-inflammation factors such as IDO1 and TSG-6 and anti-inflammatory therapeutic effect in the inflammatory bowel disease (IBD) model. (biomedcentral.com)

Molecular docking models suggest the binding of LCC-09 to NFκB essential modulator (NEMO) and Janus tyrosine kinase (JAK) may lead to dual inhibition of NFκB and STAT1. (elsevierpure.com)
Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. (alstuttu.org)
Thus, our data suggest that butyrate negatively regulates mucosal inflammation through the inhibition of IFN-γ/STAT1 signaling. (elsevierpure.com)
Genetic knockdown or chemical inhibition of IDO abolishes the anti-inflammatory function of human MSCs. (biomedcentral.com)
This eventually leads to an inhibition of replication, transcription and translation of the viral genome, followed by its degradation and recruitment of immune cells. (asbmb.org)
We conclude that enhanced TRIF-RIP1-dependent autocrine action of IFNβ, rather than inhibition of ERK or Akt, is involved in TLRs/zVAD-induced autophagic and necroptotic cell death via the JAK/STAT1/ROS pathway. (molcells.org)

There are two types of responses, pro-inflammatory and anti-inflammatory, which involve different types of cells, such as macrophages, dendritic cells, T cells, and B cells. (wikipedia.org)
Inflammatory monocytes and macrophages in the colons of IBD mice showed increased expression of proteins that promote inflammatory responses compared with other cell populations. (medindia.net)
Mice lacking Stat1 expression differentiated fewer inflammatory macrophages from their monocyte lineage, and additionally developed less severe inflammation of their colons than control mice," study first author Yusuke Nakanishi says. (medindia.net)
As well as contributing to the differentiation of inflammatory monocytes into macrophages capable of inducing colonic inflammation, the team also found that IFNγ signaling was required to maintain this macrophage population in the inflamed colon. (medindia.net)
Specific immune cells known as macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin-10 (IL-10). (medindia.net)
Using 5′ RACE, we identified three transcription start sites and several splice variants of ChemR23 in both monocytes and macrophages. (aai.org)
Although the promoters P1 and P3 are used equally in unpolarized macrophages, stimulation with LPS or IFN-γ leads to increased transcription from P3 in inflammatory M1 macrophages. (aai.org)
Repolarization of ChemR23-expressing M1 macrophages with 10 nM RvE1 increases IL-10 transcription and phagocytosis of microbial particles, leading to a resolution-type macrophage distinct from the M2 phenotype. (aai.org)
Mononuclear myeloid cells include terminally differentiated macrophages and dendritic cells (DC), as well as monocytes, which under inflammatory conditions differentiate in tissues to macrophages and DCs. (aacrjournals.org)
Accordingly, both cell death and ROS production induced by TLR ligands plus zVAD were abrogated in STAT1 knockout macrophages. (molcells.org)

IL-10 acts in an anti-inflammatory manner by suppressing inflammatory responses. (wikipedia.org)
Experimental autoimmune encephalomyelitis (EAE), which serves as an animal model of MS, is also induced by the activation of myelin reactive CD4 + T cells and their subsequent migration in the CNS, where they mediate inflammatory responses, resulting in demyelination and neurodegeneration. (jci.org)
infections IL-10 from effector Th1 cells is necessary for suppression of inflammatory responses during acute BMS-582664 contamination whereas IL-10- generating antigen-specific Foxp3+ CD4+ T cells (T regs) suppress the clearance of the parasite by the effector CD4+ T cells [9 10 Additionally the molecular mechanism for the upregulation of IL-10 differs among cell types. (bioerc-iend.org)
Interferons limit inflammatory responses by induction of tristetraprolin. (jak-stat.at)
Furthermore, network analysis revealed significant DEGs such as ITGAM and STAT1 , which may be necessary for T2DM-TB immune responses. (springeropen.com)
Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NF-kappa-B activation, and activates AP-1 (By similarity). (proteopedia.org)
STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. (thermofisher.com)

In this review we summarize the evidence for a type-I IFN signature in AD and other tauopathies and examine the role of aggregated proteins as inflammatory stimuli. (frontiersin.org)
Results The essential transcription factor(s) or pathway(s) that activates IL-10 expression is dependent on the type of both the cell and stimuli [11 15 While many studies have attempted to understand the regulation of IL-10 in a specific cell type through a specific stimulus the role of cell-to-cell communication or conversation in the induction of IL-10 is largely unknown. (bioerc-iend.org)
These results show that ChemR23 is tightly regulated in response to inflammatory and anti-inflammatory stimuli. (aai.org)
RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. (icr.ac.uk)
In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. (icr.ac.uk)
In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. (icr.ac.uk)
Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. (thermofisher.com)

Furthermore, the anti-inflammatory effect of LCC-09 was validated in the lipopolysaccharides (LPS)-induced inflammation model in zebrafish. (elsevierpure.com)
T H 17, and its effector molecules interleukin-17 (IL-17) and IL-22, are potent inducers of tissue inflammation and have been associated with a number of inflammatory and autoimmune diseases [ 5 , 6 ]. (hindawi.com)
2012). antigens that induce airway inflammation with the release of Although many studies investigated the association between inflammatory mediators. (cdc.gov)

Th1 cells, which express IFNγ, are generated by IL-27 through STAT1 dimerization and nuclear localization which subsequently leads to the expression of T-bet and signature Th1 genes. (wikipedia.org)
Once activated, p38 phosphorylates a number of targets, including the nuclear transcription factors ATF2 and Max. (rndsystems.com)
Once activated, p38 alpha phosphorylates a number of targets, including the cytoplasmic kinases MNK 4 and PRAK5 and the nuclear transcription factors ATF2 1 and STAT1. (rndsystems.com)
Luteolin exerted an inhibitory effect on transcription factor activity including nuclear factor κB (NF-κB), signal transducer and activator of transcription 1 (STAT1) and interferon regulatory factor 1 (IRF-1) in LPS/IFN-γ-activated BV-2 microglial cells. (alstuttu.org)
Effects of EGCG on nuclear factor kappa B (NFκB) and activator protein-1 (AP-1) transcriptional activity were assessed by reporter gene assay. (molvis.org)
Accordingly, STAT1 nuclear translocation and its DNA binding were completely inhibited in butyrate-treated cells. (elsevierpure.com)
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone. (targetmol.jp)

It has also been demonstrated that STAT1 (Signal Transducer And Activator Of Transcription 1), a transcription factor (TF) crucially involved in the IFNγ pathway, binds consensus sequences that, in humans, are located with a high frequency in the LTRs (Long Terminal Repeats) of the MER41 family of primate-specific HERVs (Human Endogenous Retrovirus). (biorxiv.org)
Signal transducer and activator of transcription 1 (STAT1) is a transcription factor that predominantly mediates signaling downstream of IFN-α, IFN-β, IFN-γ, and IFN-λ. (jci.org)

Many important questions remain however regarding factors which induce and maintain Th1 cell polarisation in CD. (bmj.com)
STAT1-deficient effector T cells became the target of NK cell-mediated killing, limiting their capacity to induce EAE. (jci.org)

This led us to investigate the role of IFNγ in a similar context, and we found that IFNγ loosened the chromatin structure around the promoters of two genes encoding inflammatory mediators, leading to an increase in their expression. (medindia.net)
Downregulated transcripts were found for the ATM interactome component Usp2, many non-coding RNAs, ataxia genes Itpr1, Grid2, immediate early genes and immunity factors. (bvsalud.org)
Thereafter, the STATs dimerize, each using its SH2 domain to bind to the phosphotyrosine of its partner, and then translocate to the nucleus, where they operate as transcription factors to activate expression of key genes, for example, the gene encoding an interferon. (shu.edu)
These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)

Several promising compounds that inhibit p38 alpha are being investigated as potential therapies for arthritic and inflammatory diseases. (rndsystems.com)
Inflammatory bowel diseases Piester, T. n. (stanfordchildrens.org)
These findings establish tau as a causative factor in pathological progression, at least in these rare diseases and potentially more broadly in the tauopathies. (frontiersin.org)
Tyk2 deficiency results in increased sensitivity to microbial infections and increased tumor development but improves clinical symptoms in several autoimmune and inflammatory diseases. (jak-stat.at)
This defect crucially contributes to both the increased sensitivity to infections and the resistance against inflammatory diseases. (jak-stat.at)
MSCs expanded in vitro have been widely used for the therapy of autoimmune and inflammatory diseases. (biomedcentral.com)

Conclusions This study provides further evidence of non-infection related inflammatory pathways contributing to term labour, in particular identifying inflammatory changes in the decidua similar to those in myometrium and cervix. (bmj.com)
Our analyses highlight the role of ITGAM and STAT1 in T2DM-TB-associated pathways and advances our knowledge of the genetic processes driving this comorbidity. (springeropen.com)
Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by blocking the formation of phosphorylated STAT1 and promoting ubiquitin-mediated proteasome-dependent degradation of STAT1 (PubMed:23799612) (By similarity). (proteopedia.org)
While the inflammatory implications of SARS-CoV-2 have been well studied, researchers do not yet understand the effect of the virus on signaling pathways. (asbmb.org)

Receptor tyrosine kinase-mediated resistance to mitogen-activated protein kinase targeted therapies and activation of the inflammatory signaling associated with immune therapy involves transitions along this differentiation trajectory, which lead to increased sensitivity to ferroptosis. (bvsalud.org)

The resulting phosphotyrosines attract STAT proteins, such as the STAT1 and STAT2 shown here (dark blue, dark green), which bind via their SH2 domains and become phosphorylated on specific phosphotyrosines, indicated here as Y's (inset), by the Jaks. (shu.edu)
In particular, the authors monitored two specific molecules, RIG-1 and STAT1, involved in interferon signaling and found that the levels of these proteins correlate with viral loads. (asbmb.org)

Recent studies have shown that certain flavonoids possess anti-inflammatory and neuroprotective properties distinct from their well-known anti-oxidant effects. (alstuttu.org)
To determine the anti-inflammatory and anti-oxidant effects of epigallocatechin gallate (EGCG), the major polyphenol component of green tea, in human corneal epithelial cells (HCEpiC). (molvis.org)

It has potent anti-inflammatory activity. (targetmol.jp)

This study revealed that extracts of Feretia apodanthera possess anti-inflammatory effects against right hind paw oedema of albino rats and can act as an effective antioxidant. (biomedcentral.com)

Using mice with selective deletion of STAT1 in T cells (STAT1 CD4-Cre ), we identified a potentially novel mechanism by which STAT1 regulates neuroinflammation independently of Foxp3 + Tregs. (jci.org)
Elimination of NK cells restored EAE susceptibility in STAT1 CD4-Cre mice. (jci.org)
Materials and Methods Mice and contamination Six week old 129Sv WT mice and Stat1 knockout (KO) mice (129S6/SvEv-Webster strain was used. (bio-biz-navi.com)

Accordingly, a major hurdle in recovery from SCI is the upregulation of certain inflammatory molecules after an injury that results in gliosis. (biomedcentral.com)

The goal of this study is to identify novel synthetic compounds that inhibit EC inflammatory response with minimal organ toxicity. (elsevierpure.com)
GCMS analysis revealed compounds that are potential anti-inflammatory agents. (biomedcentral.com)
In addition, as an important drug discovery tool, IPA predicted several compounds that might be useful to ameliorate the inflammatory phenotype. (cdc.gov)

T-bet and STAT-4, two Th1 promoting transcription factors, and STAT-6 and GATA-3, transcription factors which govern T helper cell type 2 (Th2) cell polarisation, were examined in duodenal biopsies by western blotting. (bmj.com)
In late stages of infection, MG escaped host immunity by reducing intracellular gga-miR-365-3p and inhibiting the JAK/STAT pathway to suppress the secretion of inflammatory factors and promote MG adhesion or invasion. (biomedcentral.com)
STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. (thermofisher.com)

The new Mechanistic Network Analysis in IPA was used to computationally construct a plausible hypothesis that TRIM24 inactivation may lead to activation of IRF7 and STAT1 and other upstream regulators to drive the gene expression profile after the first exposure. (cdc.gov)

Th17 cells, which express IL-17, IL-22, and granulocyte macrophage colony-stimulating factor (GM-CSF), are inhibited by IL-27 through STAT1 and expression of transcription factor RORγt. (wikipedia.org)
Luteolin, baicalein and quercetin inhibited the release of histamine, leukotrienes (LTs), prostaglandin D2 (PGD2), and granulocyte macrophage-colony stimulating factor (GM-CSF) from HCMC in a concentration-dependent manner. (alstuttu.org)

They also expressed more Stat1, which is a transcription factor that upregulates gene expression in response to stimulation by IFNγ, a signaling molecule released in the presence of pathogens. (medindia.net)
During Th1 differentiation, the transcription factor T-bet, which is weakly induced by TCR stimulation, is further upregulated by IFN-γ/STAT1-mediated signaling ( 13 ) and promotes the expression of IL-12Rβ2. (jci.org)

More recent studies have uncovered links between FOXP3 dysfunction and an inflammatory helper T-cell subtype (Th17), as well as loss of peripheral B-cell tolerance. (medscape.com)

MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. (icr.ac.uk)

RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling. (medscape.com)

However, the putative role of an IFNγ/STAT1/MER41 pathway in human cognition and/or behavior is still poorly documented. (biorxiv.org)
The transcription factor STAT1 plays a critical role in modulating the differentiation of CD4 + T cells producing IL-17 and GM-CSF, which promote the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). The protective role of STAT1 in MS and EAE has been largely attributed to its ability to limit pathogenic Th cells and promote Tregs. (jci.org)
We tested the role of glycolysis for the anti-inflammatory effect of MSCs and found that the glycolytic level increased within several minutes after MSCs were treated by TNF α and IFN γ . (biomedcentral.com)
These Nutlin 3b results show that Stat1 plays an important role in controlling bacterial loads but also by unexpectedly providing an undefined mechanism for dampening of the immunopathologic response observed with infection. (bio-biz-navi.com)
Therefore the aim of this study was to determine what if any role STAT1 and related signaling play in inflammatory lesions and disease with contamination. (bio-biz-navi.com)

Our laboratory is interested in the pathogenesis of viral gastroenteritis, specifically in intestinal factors which are critical to the outcome of rotavirus infection which range from asymptomatic viral shedding to severe clinical disease. (stanford.edu)
https://doi.org/10.1084/jem.20230106 ) discovered that interleukin-22 (IL-22) represses MHC class II expression by epithelial cells with an opposite impact on chronic inflammatory disease and viral infection. (rupress.org)
Immune response to a viral antigen is wide-ranging, from an interferon-mediated antiviral response to downstream events that activate transcription factors. (asbmb.org)

The analysis results establish the importance of interferons and the IRF-family of transcription factors, predicting that they are activated at 4 hours and maintained through 28 days in both blood and lung. (cdc.gov)

We believe that local gastrointestinal factors determine the outcome of rotavirus infection. (stanford.edu)
Human infection ranges from a moderate to severe febrile disease with inflammatory complications such as septic and toxic shock-like syndromes IkBKA and acute respiratory distress syndrome (2-4). (bio-biz-navi.com)

One way that IL-27 can have an anti-inflammatory response is through the expression of IL-10. (wikipedia.org)
Conclusion: Our results support that LCC-09 inhibits EC inflammatory response but does not elicit significant toxicity. (elsevierpure.com)
Hence, inflammatory response has been suggested to be rerouted in a tumor-promoting direction. (hindawi.com)
In this paper, the potential linkage between these three factors and the possible therapeutic implications of probiotics to modulate T H 17-mediated response for tumor growth will be discussed. (hindawi.com)
Following the primary injury, secondary injury begins, which includes a strong inflammatory response that governs the final outcome of SCI. (biomedcentral.com)
Such inflammatory response is important for the clearance of cellular debris, which can prevent the regeneration of surviving axons. (biomedcentral.com)
Journal of Immunotoxicology Downloaded from informahealthcare.com by CDC Information Center on 03/30/15 inflammatory response (Maestrelli et al. (cdc.gov)

Although zVAD did not affect LPS- or poly I:C-induced activation of IKK, JNK, and p38, it enhanced IRF3 and STAT1 activation as well as type I interferon (IFN) expression. (molcells.org)

To analyse expression of transcription factors which control the Th1 cell commitment in CD. (bmj.com)
Interferon γ (IFN-γ) and interleukin (IL)-4 RNA expression was examined in T lamina propria lymphocytes by quantitative reverse transcription-polymerase chain reaction. (bmj.com)
Luteolin concentration-dependently abolished LPS/IFN-γ-induced NO, tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) production as well as inducible nitric oxide synthase (iNOS) protein and mRNA expression. (alstuttu.org)
A time- and dose-dependent STAT1 expression system. (jak-stat.at)

CONCLUSION: Our findings provide further support for apigenin and luteolin's anti-inflammatory effects and suggest that these flavonoids may have neuroprotective/disease-modifying properties in various neurodegenerative disorders, including Alzheimer's disease (AD). (alstuttu.org)
While clinical signs with contamination in murine models are not observed the inflammatory disease process can be tracked by histopathologic studies (6). (bio-biz-navi.com)
Correction to: National and subnational burden of female and male breast cancer and risk factors in Iran from 1990 to 2019: results from the Global Burden of Disease study 2019. (medscape.com)

their antioxidant activity was determined using in-vitro DPPH radical scavenging activity assay and their anti-inflammatory activity was determined using carrageenan induced paw oedema model. (biomedcentral.com)
Anti-inflammatory effects and mechanisms were confirmed by ELISA for interleukin-6 (IL-6) and TNF-alpha, lactate dehydrogenase (LDH) assay, and STAT1 Western blotting. (alstuttu.org)

Transient transfection experiments using a reporter gene construct containing eight GAS sites (γ-activated sites) revealed that butyrate inhibits IFN-γ induced, STAT1-dependent, transcriptional activation. (elsevierpure.com)
p38 MAPK is involved in regulation of HSP27, MAPKAPK-2 (MK2), MAPKAPK-3 (MK3), and several transcription factors including ATF-2, Stat1, the Max/Myc complex, MEF-2, Elk-1, and indirectly CREB via activation of MSK1. (targetmol.jp)
Activation of this pathway triggers the transcription of ISGs that encode antiviral factors, some of which with documented activity against HIV (such as APOBEC3G, Tetherin, and IFITMs). (fapesp.br)

EGCG acts as an anti-inflammatory and anti-oxidant agent in HCEpiC and therefore may have therapeutic potential for ocular inflammatory conditions such as dry eye. (molvis.org)

Host, reproductive, and lifestyle factors in relation to quantitative histologic metrics of the normal breast. (medscape.com)
Although not fully understood, the presence of diabetes appears to be related to inflammatory destruction of the islet cells, supported by the histologic presence of lymphocytic infiltrates of the pancreas. (medscape.com)

Anatomy16

Organisms8

Chemicals and Drugs138

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes67

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Cytokines17

Signaling pathway8

Phosphorylation14

Cytokine11

STAT39

Bowel disease10

Inhibition6

Macrophages10

Responses7

Stimuli7

Inflammation3

Nuclear7

Signal transducer and activator2

Induce2

Genes4

Diseases6

Pathways4

Tyrosine1

Proteins2

Anti-oxidant effects2

Potent anti-inflammatory1

Possess anti-inflammatory1

Mice3

Molecules1

Compounds3

STAT3

Upstream regulators1

Macrophage2

Stimulation2

Foxp31

Regulate1

Regulates1

Role5

Viral3

Interferons1

Infection2

Response7

IRF31

Expression4

Disease3

Assay2

Activation3

Therapeutic1

Histologic2