Inflammatory neointimal. Medical search. Frequent questions

This is also known as Neointimal Hyperplasia (NIHA). (wikipedia.org)
This perspective suggests that thalidomide will show utility in the prevention or treatment of a wide range of disorders, including solid tumors, proliferative retinopathies, many inflammatory diseases, neointimal hyperplasia, and osteoporosis. (nih.gov)
2. Use of the anti-inflammatory agent bindarit to control neointimal hyperplasia Chemokines are a family of proteins that regulate the migration of circulating leukocytes to sites of arterial injury as well as the activation of SMCs. (unina.it)
Neointimal hyperplasia, induced by an inflammatory reaction after deendothelialisation of the vessel wall during catheter intervention, is the key mechanism of restenosis after percutaneous, transluminal revascularisation. (tum.de)
In the present study overexpression of IL-1ra for the inhibition of the neointimal hyperplasia was developed. (tum.de)
Neointimal hyperplasia occurs when smooth muscle cells migrate to the innermost layer of the blood vessel (the intima) and multiply, which causes thicker vessel walls, decreased lumen space, and will eventually completely obstruct the vessel. (vasocuretherapeutics.com)
The phenotypic transformation of proliferation and migration in vascular smooth muscle cells (VSMCs) from media to intima is the basic pathology of neointimal hyperplasia after angioplasty in hypertensive patients. (hindawi.com)
It is unknown whether fisetin would inhibit neointimal hyperplasia. (hindawi.com)
The rat thoracic aortic smooth muscle cells (A10 cells) stimulated by AngII were used as the in vitro neointimal hyperplasia model, where AngII significantly induced the proliferation and migration in A10 cells. (hindawi.com)
The in vivo neointimal hyperplasia model was established 2 weeks after the carotid artery balloon injury in SHR rats. (hindawi.com)
Administration of fisetin (ip 3 mg/kg daily for 2 weeks) right after the injury significantly increased PON2 expression in the artery, inhibiting ROS production, and efficiently reduced carotid neointimal hyperplasia. (hindawi.com)
These results indicate that fisetin increases the expression of antioxidant PON2 via activation of PPAR γ , reducing oxidative stress, inhibiting VSMC proliferation and migration, and alleviates neointimal hyperplasia after intimal injury. (hindawi.com)
Neointimal hyperplasia after vascular injury plays a critical role in the process of vascular restenosis, but the mechanism has not been fully elucidated yet [ 3 ]. (hindawi.com)
For years, conventional wisdom stated that neointimal hyperplasia was a phenomenon governed by tissue reaction from the inner vessel layers (the intima and media). (mercatormed.com)
In vascular inflammation, RvD1 reduces the activation of smooth muscle cells by inflammatory stimuli and inhibits the hyperplasia of the intima. (fatsoflife.com)
Therefore, sirolimus with biodegradable polymers can be a useful and selective drug for coating the coronary stent to inhibit neointimal hyperplasia. (e-ceth.org)
Several pathogenic mechanisms have been associated with restenosis development, among which we can find elastic recoil of the vessels, arterial remodeling, and neointimal hyperplasia. (hindawi.com)
This procedure had major drawbacks such as acute vessel closure due to arterial recoil, coronary artery dissection, acute arterial thrombosis, and restenosis due to neointimal hyperplasia. (statpearls.com)
Stenotic lesions caused by neointimal hyperplasia commonly occur resulting in patients requiring a fistuloplasty. (kcl.ac.uk)
Localized drug delivery systems, such as drug-coated balloons and stent coatings with anti-inflammatory or antiproliferative agents, are being explored to minimize neointimal hyperplasia and neo-atherosclerosis formation. (medicosnotes.com)
Although BMS work in this sense, they have been closely associated with risks such as neointimal hyperplasia which subsequently causes in-stent restenosis [ 1 ][ 2 ]. (ukessays.com)
IL-35-treated New Zealand White rabbits with implanted SESs showed lower percentages of cross-sections with an uncovered strut, elevated mean neointimal hyperplasia (NIH) thickness, and inhibited inflammatory responses.Conclusions: We investigated the effect of IL-35 expression on early stent endothelialization in vivo and in vitro and identified a crucial role for IL-35 in inducing the activation of an anti-inflammatory M2-like macrophage phenotype. (consensus.app)
The neighborhood software of RAPA has proved very effective in inhibiting neointimal hyperplasia and vein graft restenosis in experimental vein grafts [19, 20]. (thetechnoant.info)

The most problematic complication of PCI, with or without stent implantation, is the restenosis defined as the re-narrowing of the enlarged artery and characterized by an immune/inflammatory response going with a hyperplastic reaction, involving smooth muscle cell (SMC) migration/proliferation, and remodelling of the arterial wall. (unina.it)
Laser light is believed to influence the inflammatory process, a major factor during early events in the restenosis cascade ( 10 - 12 ). (iiarjournals.org)
Therefore, despite the existing anti-RAAS medicines, finding a novel downstream molecule exclusively targeting to inhibit neointimal formation and vascular remodeling may be a promising strategy for the treatment of vascular restenosis after angioplasty in hypertension. (hindawi.com)
Background: Neointimal formation plays an important role in the pathogenesis of coronary restenosis after percutaneous coronary intervention (PCI), especially in patients with diabetes mellitus. (omeka.net)
Angiographically, restenosis is defined dichotomously as a luminal narrowing of more than 50% in the follow-up angiography, which occurs as a consequence of arterial damage with subsequent neointimal tissue proliferation [ 1 ]. (hindawi.com)
This study demonstrates that there is a systemic inflammatory response to the fistuloplasty procedure and that monocyte subsets and IL-6 may be important in the pathophysiology of restenosis. (kcl.ac.uk)
Restenosis after bare-metal stenting (BMS) is mostly due to neointimal proliferation. (ecrjournal.com)

The cell dynamics and molecular signals driving neointimal lesion formation have been difficult to elucidate as classic mouse models of PH do not develop neointima. (stanfordchildrens.org)
Furthermore, adenoviral-mediated gene transfer of miRNA-145/143, which downregulate the expression of this miRNAs after injury, inhibits neointimal lesion formation in injured rat carotid arteries [ 11 ]. (hindawi.com)
Immune mechanisms are thought to play a pivotal role in atherosclerosis, 1, 2 and inflammatory mediators are thought to be instrumental in early atherosclerotic lesion formation, plaque progression, and plaque rupture. (bmj.com)

Analysis of the cellular composition in neointimal lesions of apoE-/- mice treated with bindarit showed that the relative content of macrophages and the number of SMCs were reduced by 66% and 30%, respectively, compared with the control group. (unina.it)
This vascular remodeling, which includes thickening of the smooth muscle layer (an early finding) and formation of occlusive neointimal lesions (a late finding) in the pulmonary arteries, is a major driver of morbidity and mortality in PH. (stanfordchildrens.org)
Advanced intracoronary imaging techniques, such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS), can provide more detailed information on neointimal characteristics and help identify neo-atherosclerotic lesions. (medicosnotes.com)

In the vasculature, activation of STAT1 and STAT3 promotes inflammatory response ( 5 ), increases neointimal formation ( 6 ), and accelerates the development of atherosclerosis ( 7 ), a chronic disease characterized by inflammation in the artery wall ( 8 ). (diabetesjournals.org)
PAD can result from atherosclerosis, embolism, thrombus formation or inflammatory processes leading to arterial stenosis or blockage. (mercatormed.com)
The development of atherosclerosis is a good example of a chronically activated inflammatory response that over the course of many years leads to profound remodeling of sub-endothelial vascular tissue, leading to vascular changes and the formation of hardened plaques that can rupture and form dangerous emboli. (fatsoflife.com)
Atherosclerosis development represents a chronic maladaptive pro-inflammatory state over the course of years, in response to some forms of continuous stress on the vasculature. (fatsoflife.com)
Neo-atherosclerosis is characterized by the accumulation of lipids and foam cells within the neointimal tissue, leading to the development of atheromatous plaques. (medicosnotes.com)
PVAT transplantation in the setting of high fat diet dramatically enhanced wire injury- induced neointimal formation and atherosclerosis, and increased adventitial inflammation and angiogenesis, providing direct evidence that PVAT plays a pathogenic role in CVD. (elsevierpure.com)

It is commonly believed that abnormal proliferation and migration of medial vascular smooth muscle cells (VSMCs) are the pathological causes of neointimal formation after intima injury [ 4 ]. (hindawi.com)
It is now known that the adventitial inflammatory process recruits cells and leads to proliferation and migration of fibroblasts from the adventitia, through the media and into the intima, where these cells contribute to neointimal volume and vessel narrowing. (mercatormed.com)
Following stent implantation, endothelial injury and inflammation stimulate smooth muscle cell (SMC) proliferation and migration, leading to the formation of neointimal tissue. (medicosnotes.com)

TLR3 signalling induces pro- and anti-inflammatory cytokine production and regulates inflammation-associated apoptosis and tyrosine kinase signalling. (ox.ac.uk)
The present study aimed to identify the relationship between the anti-inflammatory cytokine interleukin (IL) 35 (IL-35) and early strut coverage in vivo and in vitro Methods: We utilized a retrospective study design to measure IL-35 levels in 68 stents from 68 patients with coronary artery disease and recorded serial optical coherence tomography (OCT) images (0 and 3 months) to assess stent endothelialization. (consensus.app)

Our results demonstrate that the NBD peptide reduces neointimal formation and SMC proliferation/migration, both effects associated with the inhibition of NF-κB activation. (unina.it)
Bindarit is an original compound with peculiar anti-inflammatory activity due to a selective inhibition of the chemokines MCP-1, MCP-3, and MCP-2. (unina.it)
Similar results were observed in apoE-/- mice in which bindarit administration resulted in a 42% reduction of the number of proliferating cells at day 7 after carotid injury and in a 47% inhibition of neointimal formation at day 28. (unina.it)

Disruption of endothelial cells leads to the loss or dysfunction of endothelial caveolin-1, resulting in reciprocal activation of proliferative and inflammatory pathways, leading to cell proliferation, medial hypertrophy, and PH, which initiates PH and facilitates its progression. (touro.edu)

Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. (lookformedical.com)

In this study, we investigated the effect of NBD peptide on neointimal formation using two animal models of arterial injury: rat carotid artery balloon angioplasty and wire-induced carotid injury in apolipoproteinE-deficient (apoE-/-) mice. (unina.it)
Our laboratory has developed a robust model of PVAT transplantation to the mouse carotid artery to determine its role in eliciting vascular pathology and the mechanisms whereby PVAT interacts with metabolic factors, chemokines, inflammatory cells and the blood vessel wall. (elsevierpure.com)

In a model of systemic arterial injury, TLR3 signalling was shown to modulate neointimal remodelling in a protective manner. (ox.ac.uk)

In conclusion, our data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponectin are associated with higher levels of hs-CRP and IL-6, two inflammatory mediators and markers of increased cardiovascular risk. (diabetesjournals.org)
and ii) pro-resolving mediators that limit the extent of the activity of the pro-inflammatory mediators and actively shut down inflammatory responses when metabolic and physical disruption has abated, and there is no more infectious material present anymore, and thus allow and actively promote tissue repair. (fatsoflife.com)
Counteracting the activity of LTB 4 and other pro-inflammatory mediators is important, to limit overactive inflammatory responses that would be destructive to the body's own tissues. (fatsoflife.com)
Counter-regulation and active termination of inflammatory responses is executed by pro-resolving mediators that are formed locally during self-limiting inflammation. (fatsoflife.com)

Effect of NBD peptide on injury-induced neointimal formation The activation of nuclear factor-κB (NF-κB) is a crucial step in the arterial wall's response to injury. (unina.it)
In addition, the NBD peptide (0.01 to 1 μM) reduced rat SMC proliferation, migration, and invasion in vitro, processes contributing to the injury-induced neointimal formation in vivo. (unina.it)
In the present study we evaluated the effect of bindarit on neointimal formation using both animal models described above. (unina.it)
Treatment of rats with bindarit (200 mg/kg/day) significantly reduced balloon injury-induced neointimal formation by 39% at day 14 without affecting re-endothelialisation and reduced the number of medial and neointimal proliferating cells at day 7 by 54% and 30%, respectively. (unina.it)
We have shown that Pedifin significantly reverses neointimal disease and atherosclerotic plaque formation in animal models, returning vessel function without any surgical intervention. (vasocuretherapeutics.com)
Therefore, we investigated the role of fisetin in neointimal formation in vitro and in vivo. (hindawi.com)
Adenovirus-mediated transfer of a dominant-negative H-ras suppresses neointimal formation in balloon-injured arteries in vivo. (semanticscholar.org)
Flow remains in and out of the aneurysm until it is "completely occluded by thrombus and aneurysmal neck neointimal formation along the stent," Dr. Malek and colleagues write, adding that the "rate of thrombus egress or escape" during the transition from implantation to healing remains unclear. (neurovascularexchange.com)
Moreover, preliminary data suggest that transplanting PVAT from mice lacking the chemokine MCP-1 attenuates neointimal formation, consistent with pleiotropic effects of MCP-1 to promote vascular remodeling. (elsevierpure.com)

Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. (lookformedical.com)

Clinical and experimental evidence added to the existing literature all of which pointed to the negative effects of permanent and biodegradable polymer coating such as extensive inflammatory response and neointimal thickening within pig coronary arteries [ 3 ]. (ukessays.com)
IL-35 promotes early stent endothelialization by inducing an anti-inflammatory M2-like macrophage phenotype, offering a potential new therapeutic strategy for coronary artery disease. (consensus.app)

In a range of inflammatory disorders, the physiological stimuli that trigger the inflammatory response or actively turn inflammation off, i.e. resolution, are not in a proper balance. (fatsoflife.com)
BHT has been found to reduce inflammation in animal studies, and some researchers believe it may have potential as a treatment for inflammatory diseases in humans. (earthclinic.com)

However, over time, the body's inflammatory immune response (described below in the "Causes" section) reacts to the stent-graft via smooth muscle proliferation, etc., which literally pushes the stent-graft back, narrowing the vessel and losing at least a percentage of what was previously gained, or late loss. (wikipedia.org)
This stasis causes thrombosis and an inflammatory response with eventual sealing of the aneurysm neck by endothelialization and neointimal growth with the stent as a scaffold. (neurovascularexchange.com)
The true measure of the efficacy of DES, representing the best angiographic surrogate of neointimal proliferation with the unique ability to separate it from other procedural and intrinsic vessel variables, is in-stent late luminal loss (LL). (ecrjournal.com)

Since integrins are crucial for cell-matrix interactions, and the beta 2 integrins of leukocytes mediate adhesion to endothelium, it is reasonable to postulate that thalidomide inhibits cell migration in susceptible species, and that this accounts for its anti-inflammatory, anti-angiogenic, and teratogenic activity. (nih.gov)
In myeloid cells, VEGFR-1 mediates monocyte migration and has a regulatory role in the development of inflammatory diseases such as rheumatoid arthritis and arteriosclerosis. (cusabio.com)

In vascular smooth muscle cells (SMCs), VEGFR-1 is inducibly expressed by vascular injury and participates in neointimal development. (cusabio.com)

In the cardiovascular system, miRNAs regulate basic functions in almost all cell types including cardiac muscle, endothelial cells, smooth muscle, inflammatory cells, and fibroblasts and, therefore, play a pivotal role in the pathogenesis of several cardiovascular diseases (CVDs). (hindawi.com)

CD54 known also as intercellular adhesion molecule-1 (ICAM-1) is an adhesion molecule crucial in inflammatory process by controlling monocyte endothelium interactions. (iiarjournals.org)

The inflammatory response may be unrestrained and too intense, with neutrophils damaging the inflamed tissue, or even triggering a systemic overactivation, with multiple organs being compromised in their function. (fatsoflife.com)

This reactive process leads to neointimal disease that narrows the vessel lumen. (vasocuretherapeutics.com)

This is accompanied by an inflammatory immune response. (wikipedia.org)
Background: Regarding recent findings on the proven influence of laser light on healing and endothelial regeneration processes, this study was conducted in order to examine the influence of low-power laser illumination on the endothelial inflammatory response. (iiarjournals.org)
Laser influence on HUVEC inflammatory response was measured by stimulating them with Interleukin-1β (IL-1β) followed by laser light illumination. (iiarjournals.org)
Finally, we found that infusion of AngII caused a more severe inflammatory response in AMPKα2 knockout mouse aortas, all of which were suppressed by chronic administration of fludarabine. (diabetesjournals.org)
The metabolic abnormalities of type 2 diabetes, including hyperglycemia, dyslipidemia, and insulin resistance, activate the Janus kinases/signal transducer and activator of transcription (JAK/STAT) signaling pathway, a major intracellular inflammatory cascade that transmits the intracellular signaling to the nucleus ( 2 ), promoting inflammatory response, inducing insulin resistance ( 3 ), and accelerating the development of cardiovascular complications ( 4 ). (diabetesjournals.org)
Here, we found that cyclic adenosine monophosphate (cAMP) signaling exacerbated the inflammatory response and attenuated the expression level of the transcription factor forkhead box O1 (FOXO1) in ILC3s. (bvsalud.org)
The high blood flow stresses and stretches the vascular access and results in an inflammatory response. (vasocuretherapeutics.com)

However, it has been postulated that the constituents of the metal alloys used in intracranial stents may also induce an inflammatory reaction that results in ISS. (bmj.com)

3 Moreover, inflammatory markers, such as C reactive protein (CRP), are strong independent predictors of future cardiovascular risk. (bmj.com)

Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance. (diabetesjournals.org)

The neointimal cells have low caveolin-1 and normal eNOS expression that may be responsible for promoting nitrosative and oxidative stress, furthering cell proliferation and metabolic alterations. (touro.edu)

Plasma fibrinogen is an acute phase reactant with known inflammatory mechanism, but it also affects platelet aggregation and blood viscosity (3, 4). (hvt-journal.com)

[ 2 ] Initial results with his techniques were disappointing because of the high rate of degeneration and vascular failure due to poor preservation methods, immunologic rejection, and inflammatory reactions that produced fibrosis, calcification, and aneurysms. (medscape.com)
It really is generally recognized that stress itself and surgical stress shall activate inflammatory reactions. (thetechnoant.info)

One key pro-inflammatory mediator is leukotriene B 4 (LTB 4), which is produced by macrophages from arachidonic acid (AA) through the activity of the 5-lipoxygenase enzyme, very early in the inflammatory process. (fatsoflife.com)

A growing number of human inflammatory disorders are reported to respond to treatment with thalidomide, and recently this drug has been shown to inhibit angiogenesis in the rabbit, in doses which can elicit teratogenicity in this species. (nih.gov)

Exposure of macrophages to RvD1 switches their activity towards a less inflammatory state that is characteristic of a cell type that regulates a variety of processes necessary for orderly resolution. (fatsoflife.com)

Most commonly, this phenomenon seems to take place as a result of neointimal proliferation. (bmj.com)

Conclusion: Low-power laser illumination diminishes the pro-inflammatory and pro-coagulant activity of IL-1β-stimulated HUVECs. (iiarjournals.org)

IL-35 induced the activation of an anti-inflammatory M2-like macrophage phenotype by targeting the signal transducer and activators of transcription (STAT)1/4 signalling pathway, and IL-35-treated macrophages induced endothelial proliferation and alleviated endothelial dysfunction. (consensus.app)

Anatomy36

Organisms18

Diseases30

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment61

Phenomena and Processes32

Disciplines and Occupations1

Technology, Industry, Agriculture12

Health Care7

Hyperplasia23

Restenosis7

Lesion formation3

Lesions3

Atherosclerosis6

Proliferation and migration3

Anti-inflammatory cytokine2

Inhibition3

Proliferative1

Cytokines1

Carotid2

Arterial injury1

Mediators4

Formation9

Chemokines1

Coronary2

Inflammation2

Stent3

Migration2

Vascular injury1

Endothelial cells1

Adhesion molecule1

Tissue1

Vessel1

Response7

Reaction1

Reactive1

Insulin resistance1

Metabolic1

Mechanism1

Reactions2

Process1

Disorders1

Processes1

Phenomenon1

Activity1

Transcription1