Inflammatory ischemia reperfusion. Medical search. Frequent questions

The aim of this study was to study the possible anti-inflammatory effect of hydrogen-rich saline (H(2) saline) on rat hearts with regional myocardial ischemia and reperfusion (I/R). Sixty-six rats were equally randomized to three groups: sham-operated group, I/R group (control group) and I/R plus H(2) saline treatment group. (molecularhydrogenstudies.com)
H(2) saline has an anti-inflammatory effect on rat hearts with regional myocardial I/R. (molecularhydrogenstudies.com)
Zhang Y, Sun Q, He B, Xiao J, Wang Z, Sun X. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. (molecularhydrogenstudies.com)
This study was conducted to determine whether treatment with relaxin, an anti-inflammatory and vasoactive hormone, prevents IR. (nih.gov)
The present study aimed to identify the anti‑inflammatory and antioxidant effects of GRh2 on I/R in the myocardium and its underlying mechanism. (spandidos-publications.com)
The expression of the following genes was salient: (a) Cd163, an anti-inflammatory stroke-associated gene, was the most differentially expressed gene by NPD1+RvD1, displaying more than a 123-fold upregulation in the ipsilesional penumbra (Lisi et al. (springer.com)
2021 ). They exert multiple biological functions, including limiting excessive inflammatory responses, regulating metabolism and immune cell functions, decreasing the production of pro-inflammatory factors, increasing anti-inflammatory mediators, and promoting tissue repair and homeostasis (Miao et al. (springer.com)
Spite and Serhan 2010 ), including Neuroprotectin D1 (NPD1) and D-series resolvins (RvD1), which display potent anti-inflammatory and immunoregulatory properties (Asatryan and Bazan 2017 ). (springer.com)
Lee, D. Targeted echogenic and anti-inflammatory polymeric prodrug nanoparticles for the management of renal ischemia/reperfusion injury. (beilstein-journals.org)
Moringa species are well-known for their antioxidant, anti-inflammatory, anticancer, and antihyperglycemic activities. (frontiersin.org)
Etoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. (koreamed.org)
Bucillamine, an oral drug with anti-inflammatory and antiviral properties, is currently being evaluated in a Phase 3 clinical trial (the "Study") ( NCT04504734 ) in patients with mild to moderate COVID-19. (biospace.com)
The potential of Bucillamine for COVID-19 is evident with its anti-inflammatory and antiviral properties and its potential use in patients who have taken SARS-CoV-2 mRNA vaccines," said Michael Frank, CEO of Revive. (biospace.com)
Statins are known to improve pulmonary arterial hypertension (PAH) by their anti-inflammatory and anti-proliferative effects in animal models. (escardio.org)
IL-37, a newly found anti-inflammatory cytokine of the IL-1 family, has both extracellular and intracellular functions. (nature.com)
IL-37: a new anti-inflammatory cytokine of the IL-1 family. (nature.com)
Xia S, Sun Q, Zou Z, Liu Y, Fang X, Sun B, Wei S, Wang D, Zhang A, Liu Q. Ginkgo biloba extract attenuates the disruption of pro-and anti-inflammatory T-cell balance in peripheral blood of arsenicosis patients. (ijbs.com)
The present investigation describes a previously unknown mechanism showing that an imbalance of pro- and anti-inflammatory T cells is involved in the pathogenesis of arsenicosis and that a GBE exerts effects on arsenicosis through regulation of the pro- and anti-inflammatory T cell balance. (ijbs.com)
Among them, tanshinone IIA has been extensively studied for its anti-inflammatory effects, which have shown significant pharmacological properties and can be applied clinically. (bvsalud.org)
Background Dexmedetomidine has been shown to confer direct renoprotection by stabilizing the sympathetic system, exerting anti-inflammatory effects and attenuating ischemia/reperfusion (I/R) injury in preclinical studies. (medscape.com)

Meng X, Zhang L, Han B and Zhang Z: PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis. (spandidos-publications.com)
Abouzaki NA, Christopher S, Trankle C, Van Tassell BW, Carbone S, Mauro AG, Buckley L, Toldo S and Abbate A: Inhibiting the inflammatory injury after myocardial ischemia reperfusion with plasma-derived Alpha-1 Antitrypsin: A post hoc analysis of the VCU-α1RT study. (spandidos-publications.com)
In this review, based on bibliometric studies, we first discussed the relationship between oxidative stress-induced endothelial dysfunction and CVDs, then summarized the role of melatonin in the treatment of atherosclerosis, hypertension, myocardial ischemia-reperfusion injury, and other CVDs. (bvsalud.org)

In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
Experimental stroke (transient focal cerebral ischemia) was induced by a 2-hour middle cerebral artery occlusion (MCAO) with the use of a suture inserting into the lumen of the internal carotid artery (ICA) in male Wistar rats. (banglajol.info)
MCAO induced inflammatory injury, involving the ipsilateral cortex and basal ganglia with massive infiltration of neutrophils, macrophages and microvascular proliferation, was exhibited in all normothermic rats. (banglajol.info)
However, hypothermic MCAO rats showed minimal inflammatory response. (banglajol.info)
These results suggested that HSP90β is involved in the process of cerebral ischemia‑reperfusion injury in rats and that inhibition of HSP90β expression increases EAAT2 levels, conferring a neuroprotective effect in MCAO model rats. (spandidos-publications.com)
To investigate the effect of sevoflurane on renal ischemia-reperfusion injury (IRI) in rats and its regulatory effect on reperfusion injury salvage kinase (RISK) signaling pathway. (ajol.info)
Sevoflurane represses the release of inflammatory factors, lowers ROS level and apoptosis of renal cells and improves renal function through activation of RISK signaling pathway in kidney tissues of rats with renal IRI. (ajol.info)
Indeed, berberine reduced lipopolysaccharide-induced injury in intestine, ischemia-reperfusion-induced tight junction injury, and polymicrobial sepsis-induced damage to intestinal mucosal barrier in rats. (usda.gov)
We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)

Pulmonary injury leading to early allograft dysfunction is caused by ischemia-reperfusion injury (IR) and originates from multiple pathogenic events, including endothelial damage, neutrophil extravasation into tissue, and peroxidation of cell membrane lipids, followed by pulmonary cell alterations and edema. (nih.gov)
The Hellman Group studies TLR-dependent pathways expressed by macrophages as well as non-conventional inflammatory cells, including endothelial cells, in Inflammatory Critical Illness, focusing on their roles in coagulopathy, vascular permeability, neutrophil trafficking to organs, and organ injury and failure. (ucsf.edu)

Background: The impact of liver allograft ischemia/reperfusion injury (IRI) on native renal function remains to be characterized. (atcmeetingabstracts.com)
Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). (mdpi.com)

The effect of moderate whole body hypothermia (300 C) on transient focal cerebral ischemia induced inflammatory injury was investigated. (banglajol.info)
Our results indicate that moderate hypothermia has a significant protective effect on the inflammatory injury induced by transient focal cerebral ischemia. (banglajol.info)
The present study aimed to investigate the effects of changes in heat shock protein (HSP)90β expression and verify whether HSP90β regulates EAAT2 expression in a cerebral ischemia‑reperfusion injury model. (spandidos-publications.com)
A model of cerebral ischemia‑reperfusion was established using the MCAO method. (spandidos-publications.com)
When ischemic stroke occurs, cerebral ischemia and hypoxia cause the release of excessive excitatory amino acids, mainly glutamic acid and aspartic acid, which exert excitotoxic effects on the central nervous system. (spandidos-publications.com)
These excitotoxic effects play important roles in neuronal and blood-brain barrier damage after cerebral ischemia ( 5 , 6 ). (spandidos-publications.com)
Endothelial pyroptosis promotes cerebral ischemia/reperfusion injury (CIRI). (bvsalud.org)
Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)

The findings suggest that targeting IL-1b could suppress inflammation associated with multiple inflammatory diseases, including multiple sclerosis , ischemia-reperfusion injury, atherosclerosis, liver disease, pancreatitis, psoriasis, inflammatory bowel disease , and infectious diseases . (edu.au)

In conclusion, the present study confirmed that GRh2 could reduce oxidative stress and inflammation in cardiomyocytes after reperfusion, and its mechanism of action may be related to its regulation of the Nrf2/HO‑1/NLRP3 signalling pathway. (spandidos-publications.com)

1. The role of cell-specific extracellular signal-regulated kinases (ERK1/2 and ERK5) in sepsis and inflammatory critical illness. (ucsf.edu)
Within two minutes of ischemia, extracellular pH can drop from about 7.3 to about 6.7. (benbest.com)

In stroke, the ischemic crisis activates a series of events, including the inflammatory reactions that are potentiated by reperfusion, eventually leading to neuronal damage. (banglajol.info)
Not only can both produce symptoms that mimic ischemic stroke, but they can also aggravate ongoing neuronal ischemia. (medscape.com)

Regrettably, uncontrolled complement activation also contributes significantly to pathology of many diseases (some examples: rheumatoid arthritis, ischemia/reperfusion injury, glomerulonephritis, multiple sclerosis, Alzheimer´s, hyperacute rejection of grafts) due to the fact that complement sometimes misdirects its activities towards own tissues. (lu.se)

Finally, the ischemia reperfusion (I/R) injury model was used in C57BL/6J mice to induce retinal inflammation and investigate the effects of caffeine treatment. (frontiersin.org)
The state of ischemia also produces and recruits a variety of factors and cells that promote inflammation to help protect from infection and haul off debris from dying cells. (scitechdaily.com)
Institute scientists have revealed a potent inflammatory molecule released by dying cells triggers inflammation during necroptosis, a recently described form of cell death linked to inflammatory disease. (edu.au)
However, necroptosis can become inappropriately or excessively activated, triggering damaging inflammation that leads to inflammatory disease. (edu.au)
Now that we have discovered IL-1b is the 'root' of the inflammation associated with necroptosis, we speculate that targeting this molecule could be an effective way of treating inflammatory diseases. (edu.au)
We are also exploring how IL-1b is signalled to be secreted during necroptosis, so that we can create new drugs to stop its release and reduce inflammation to treat inflammatory diseases. (edu.au)
Acute respiratory distress syndrome (ARDS), which is an acute pulmonary inflammatory syndrome, is characterized by the diffuse inflammation in the lung parenchyma and osmotic pulmonary oedema [ 1 ]. (karger.com)

We are now further exploring these observations, testing the basic hypotheses that ERK1/2 and ERK5 regulate TLR-dependent and TLR-independent activation of endothelial inflammatory pathways and contribute to endothelial dysfunction in septic shock and organ failure. (ucsf.edu)

Cardiopulmonary bypass (CPB) causes systemic inflammatory response and ischemia-reperfusion (IR) injury. (hindawi.com)
However, CPB inevitably causes systemic inflammatory response and ischemia-reperfusion (IR) injury, which can negatively affect postoperative cardiac function and a patient's long-term prognosis [ 1 ]. (hindawi.com)
Finally, pharmacological GLP-2 treatment decreased gut permeability, systemic and hepatic inflammatory phenotype associated with obesity to a similar extent as that observed following prebiotic-induced changes in gut microbiota. (bmj.com)

Prebiotic-treated mice exhibited a lower plasma lipopolysaccharide (LPS) and cytokines, and a decreased hepatic expression of inflammatory and oxidative stress markers. (bmj.com)
Cannabidiol (CBD) protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response of oxidative and nitrative stress, and thereby cell death and tissue injury, but independent from classical CB1 and CB2 receptors. (standardofcare.com)

4. The effects of TLR2 activation on the vascular endothelium, including on endothelial inflammatory responses, leucocyte trafficking, coagulation pathways and permeability: Endothelial cell (EC) activation, coagulopathy, and vascular leak contribute to sepsis-induced organ failure. (ucsf.edu)
This decreased inflammatory tone was associated with a lower intestinal permeability and improved tight-junction integrity compared to controls. (bmj.com)
Increased intestinal permeability increases translocation of toxins such as lipopolysaccharides that are produced by gut microorganism into the body, causing inflammatory injuries in the gut wall. (usda.gov)
Inflammatory injury is a characteristic of most gut infections, implying that the increased susceptibility to gut infections of pigs after weaning is mainly due to increased intestinal permeability to toxins and hence inflammatory injury. (usda.gov)

Heusch G: Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. (spandidos-publications.com)

An ischemic stroke consists of two related pathological injury processes: Primary ischemia-induced brain injury and secondary ischemia reperfusion injury ( 3 ). (spandidos-publications.com)
A study has shown that neurons in the ischemic penumbra may undergo apoptosis hours or days after ischemia and alleviating ischemia reperfusion injury is an achievable therapeutic goal in the early intervention of ischemic stroke aimed at limiting the amount of infarction ( 4 ). (spandidos-publications.com)

Dr. Saubermann's clinical interest is centered on taking care of adolescents and adults with Inflammatory Bowel Diseases, such as Crohn's Disease, Ulcerative Colitis, Celiac Sprue(gluten sensitive enteropathy), and microscopic /lymphocytic colitis, though he also sees patients with a variety of gast. (rochester.edu)
Cerebrovascular diseases (CVDs) have become a global public health problem and ischemia‑reperfusion injury, the major cause of neurological impairment exacerbation, is closely related to excitotoxicity. (spandidos-publications.com)
Revive's cannabinoid pharmaceutical portfolio focuses on rare inflammatory diseases and the company was granted FDA orphan drug status designation for the use of Cannabidiol (CBD) to treat autoimmune hepatitis (liver disease) and to treat ischemia and reperfusion injury from organ transplantation. (biospace.com)
The discovery could lead to new and existing medicines that target the molecule being investigated as a way of treating inflammatory diseases, such as psoriasis and inflammatory bowel disease. (edu.au)
7 10 - 14 Several pieces of clinical and experimental data have confirmed that LPS significantly contributes to the development of obesity-related inflammatory liver diseases such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. (bmj.com)

H(2) saline treatment attenuated I/R-induced cardiac cell apoptosis, presenting as significant improvement of heart function parameters 24h after reperfusion, including left ventricular systolic pressure (LVSP), left ventricular diastolic pressure (LVEDP), +(dP/dt)max and -(dP/dt)max. (molecularhydrogenstudies.com)
Receptor interacting protein 1 kinase (RIPK1) is a key mediator of not only a process of regulated necrosis, termed necroptosis, but also promotion of caspase-8-dependent apoptosis and pro-inflammatory gene expression 13 . (nature.com)
Astragaloside IV might suppress autophagy initiation directly or indirectly through suppressing the oxidative stress and inflammatory response, which further enhances the cell viability and tight junction and reduces apoptosis in LPS-stimulated pulmonary endothelial ARDS cell model, thus exerting its therapeutic function in ARDS. (karger.com)

Myocardial I/R was established by occlusion of the left anterior descending (LAD) coronary artery for 30 min and reperfusion for 24 h. (molecularhydrogenstudies.com)
For these studies, they caused an occlusion in the left coronary artery of mice for about 45 minutes, then enabled reperfusion to reflect what happens when a human has a heart attack, then gets treatment. (scitechdaily.com)
Inadequate blood and oxygen to the heart, or ischemia, resulting from a clot or other occlusion of a big blood vessel in the heart, is the primary problem. (scitechdaily.com)

Lack of myocardial reperfusion in the presence of a patent coronary artery is referred to as a no-reflow phenomenon and is attributed to microvascular dysfunction. (standardofcare.com)

Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)
Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)

We hypothesize that the endothelial endocannabinoid system may represent a novel regulatory system to therapeutically manipulate in order to ameliorate the manifestations of a variety of inflammatory disorders, including sepsis. (ucsf.edu)

The present review elucidated the inflammatory signaling pathways of pharmaceuticals that have been investigated for their therapeutic efficacy in AD and elucidates their underlying mechanisms. (bvsalud.org)

yet at the same time it can induce ischemia-reperfusion injury, which leads to brain damage both in the ischemic core and penumbra area. (spandidos-publications.com)

This highly inflammatory state produces a lot of free radicals, and unstable atoms that can cause even more damage to heart cells. (scitechdaily.com)
Hypothermia minimizes a patient's production of deadly free radicals during reperfusion. (standardofcare.com)

The patient had severe cardiac dysfunction and atrial fibrillation and presented with acute ischemia in the right lower limb 24 h after receiving an inferior vena cava filter. (medscape.com)
This happens due to oxidative stress-induced mitochondrial dysfunction, inflammatory responses, and reduced levels of nitric oxide. (bvsalud.org)

Maneuvers to prevent IRI and/or AKI may involve manipulation of inflammatory processes that may ultimately improve the outcomes. (atcmeetingabstracts.com)
These processes result from a complex inflammatory response that is initiated through the innate immune system by interactions between host cells and microbes or endogenous host factors that are released during injury or cell death. (ucsf.edu)

We still need to see how and if it can protect the heart long term, but we find in the short term when we give enough of this microRNA, it protects the heart from reperfusion injury," Tang says. (scitechdaily.com)

TBARS value according to the method of (pro-inflammatory cytokine) as markers of Mitsura and Midori. (who.int)

We hypothesized that elevated levels of circulating inflammatory mediators are associated with IRI and/or acute kidney injury (AKI) after liver transplantation (LT). (atcmeetingabstracts.com)
Mihaylov P, Li P, Skill J, Timsina L, Fridell J, Ekser B, Mangus R, Kubal C. Ischemia Reperfusion Injury in Liver Transplantation is Associated with Acute Kidney Injury: Role of Inflammatory Mediators [abstract]. (atcmeetingabstracts.com)

In myocardial infarction aims to provide early, full and sustained restoration of antegrade flow at the epicardial level and to achieve adequate reperfusion at the myocardial level. (standardofcare.com)

Intra- and postoperative monitoring of flap microcirculation may provide useful information for better understanding and following-up the ischemia-reperfusion-related alterations in tissue perfusion 6 6. (scielo.br)
Studies in animal models indicate that ischemia triggers alterations in endothelial function that contribute significantly to the overall degree and severity of a kidney injury. (eurekaselect.com)

Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
During the period of ischemia - when the heart attack happens - they saw seriously reduced miR322 levels, which recovered after blood and oxygen were restored but dropped dramatically again one day later, the lowest point was seven days later. (scitechdaily.com)

However, whether GRh2 has a protective effect on ischaemia/reperfusion (I/R) in the myocardium has yet to be elucidated. (spandidos-publications.com)

Ischemia and reperfusion can cause serious brain damage in stroke or cardiac arrest. (benbest.com)
In this article I attempt to evaluate the nature & extent of ischemic & reperfusion injury -- primarily focused on the impact for cryonics (although certainly relevant to stroke and cardiac arrest). (benbest.com)

The chief aim in this study was to investigate whether changing temperature during and after ischemia could minimize this damage by reducing the inflammatory injury. (banglajol.info)

reduces the impact of high-fat diet-induced metabolic endotoxaemia and inflammatory disorders. (bmj.com)

Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
They antagonize pro-inflammatory signaling on macrophage/neutrophil infiltration, enhance macrophage phagocytosis towards apoptotic cells, and accelerate tissue repair (Cheng and Rong 2019 ). (springer.com)
2. Siemionow M, Arslan E. Ischemia/reperfusion injury: a review in relation to free tissue transfers. (scielo.br)

Microscopically, inflammatory cell infiltration in response to bacterial invasion is much more prominent than RBC extravasation in the nonreperfused attenuated wall. (ajronline.org)

Klarik Z, Tamas R, Toth E, Kiss F, Kovacs EL, Jäckel M, Furka I, Nemeth N. Intra and postoperative evaluations of microcirculation and micro-rheological parameters in a rat model of musculocutaneous flap ischemia-reperfusion. (scielo.br)
In their mouse model of this ischemia/reperfusion injury of the heart, they've found they can reduce heart muscle death by 40 percent by giving a manmade version of the microRNA miR322, they report in the Journal of Molecular and Cellular Cardiology . (scitechdaily.com)

The family of Toll-like receptors (TLRs) recognize different microbial components and endogenous host factors, and are critical in initiating inflammatory responses to infection. (ucsf.edu)

Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide (NO) synthesis inhibitor and pro-inflammatory factor. (mdpi.com)

IR injury and inflammatory response can substantially activate cell autophagy [ 6 ], and autophagy has been demonstrated to play an important role in the pathologic process of cardiac muscle injury [ 7 ]. (hindawi.com)
This latter was able to reduce the inflammatory response in ARPE-19 cells exposed to LPS, attenuating the release of IL-1β, IL-6, and TNF-α and the nuclear translocation of p-NFκB. (frontiersin.org)
Sun W, Wang Z, Sun M, Huang W and Wang Y and Wang Y: Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway. (spandidos-publications.com)

Clemons collaborated with Luis H. Toledo-Pereyra at Western Michigan University Homer Stryker M.D. School of Medicine, to publish a manuscript on the effects of hydroxyl radicals after ischemia perfusion. (wikipedia.org)

We have found TLR2-dependent activation of endothelial inflammatory pathways, as well as pathways involved in coagulopathy and vascular leak in vitro and in vivo. (ucsf.edu)
Research has shown that pharmaceuticals have the potential to ameliorate AD by reducing neuroinflammation mainly through regulating inflammatory signaling pathways such as NF-κB, MAPK, NLRP3, PPARs, STAT3, CREB, PI3K/Akt, Nrf2 and their respective signaling pathways. (bvsalud.org)

Our research has pinpointed that, during necroptosis, dying cells release IL-1b, a potent inflammatory signal," Dr Lindqvist said. (edu.au)

Effect of short-term ischemia on microcirculation and wound healing of adipocutaneous flaps in the rat 1 1 Research performed at Department of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Hungary. (scielo.br)
We aimed to follow-up the effect of ischemia on adipocutaneous flaps' wound healing and microcirculation. (scielo.br)

Anatomy32

Organisms15

Diseases31

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes37

Disciplines and Occupations1

Health Care3

Anti-inflammatory20

Myocardial ischemia reperfusion3

Rats9

Including endothelial2

Renal2

Cerebral8

Atherosclerosis1

Oxidative Stress and Inflammation1

Extracellular2

Neuronal2

Multiple sclerosis1

Inflammation7

Endothelial dysfunction1

Systemic3

Hepatic2

Permeability4

Cardioprotection1

Ischemic stroke2

Diseases5

Apoptosis3

Occlusion3

Coronary artery1

Hypoxia2

Sepsis1

Therapeutic1

Induce1

Free radicals2

Dysfunction2

Processes2

Protects1

Cytokine1

Mediators2

Infarction1

Alterations2

Oxygen2

Protective effect1

Cardiac arrest2

Investigate1

Disorders1

Tissue3

Infiltration1

Model2

Responses1

Endogenous1

Response3

Effects1

Pathways2

Potent1

Effect2