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  • cell depletin
  • Current standard of care for the initial treatment of AAV is glucocorticoids in combination with either cyclophosphamide (CYC) or the B cell depleting antibody, rituximab. (springer.com)
  • pANCA
  • Libraries of colonic bacteria were generated using aerobic and anaerobic microbiologic culture conditions, and bacterial pools and clonal isolates were evaluated for cross-reactive antigens by immunoblot analysis using the pANCA monoclonal antibody Fab 5-3. (asm.org)
  • Two major species of proteins immunoreactive to pANCA monoclonal antibodies were detected in bacteria from the anaerobic libraries. (asm.org)
  • These findings demonstrate that a pANCA monoclonal antibody detects a recurrent protein epitope expressed by colonic bacteria and implicates colonic bacterial proteins as a target of the disease-associated immune response. (asm.org)
  • Using human monoclonal pANCA antibodies, we have recently characterized the neutrophil autoantigen and epitope specificity (a PKKAK motif of histone H1) ( 15 , 19a ). (asm.org)
  • pANCA and IBD-associated antibacterial serum antibodies were recently reported to cross-compete for bacterial and pANCA antigen binding ( 42 ). (asm.org)
  • antigen
  • This combination of effector cells requires a crosslinking antigen to evoke an antibody driven PMN inflammatory response via their Fc receptors. (bmj.com)
  • Changes in mucosal bacteria, and a switch from internal to surface antigen/antibody reactivity of a predominantly IgG1 type, leads to greater opsonisation of the respiratory burst in PMN, providing a mechanism for maintaining the inflammatory state in UC. (bmj.com)
  • The clinical picture and a previous history of non-Hodgkin lymphoma prompted us to rule out an acquired form of paraneoplastic, C1-inhibitor (C1-INH) deficiency: C1q and both antigen and functional C1-INH tested normal, whilst we found low plasma levels of C3 and C4 possibly related to the parallel detection of antiphospholipid antibodies. (springer.com)
  • Berger S, Ballo H, Stutte HJ (1996) Immune complex-induced interleukin-6, interleukin-10 and prostaglandin secretion by human monocytes: a network of pro- and anti-inflammatory cytokines dependent on the antigen:antibody ratio. (springer.com)
  • mucosal
  • Antibody enhancement of the respiratory burst in PMN was also investigated, against a range of mucosal isolates. (bmj.com)
  • infective
  • Though not always straightforward, distinguishing an infective from an inflammatory process is pivotal in order to guide appropriate therapy. (hindawi.com)
  • positivity
  • The following analyses were performed: comparison of positivity based on the established values in IBD, median values, the number of subjects in each serology in the 4th quartile of a normal distribution, and the mean quartile sum of all the antibodies. (biomedcentral.com)
  • detection
  • Antibodies and detection reagents. (asm.org)
  • At last but not least, detection of anti-sperm antibodies (ASA) has become important due to their association with infertility occurring in the absence of mechanical obstruction of female reproductive system. (ke-i.org)
  • responses
  • Distinct differences were observed in some bacterial populations in UC biopsies, which were generally reflected in antibody responses towards these organisms. (bmj.com)
  • response
  • 32,It is hypothesized that this occurs due to the intense inflammatory response advertised by silica, which may promote neutrophil migration and simultaneous formation of antibodies against neutrophil components. (woofahs.com)
  • Antibodies from UC patients greatly enhanced the respiratory burst in PMN, in response to individual bacterial species. (bmj.com)
  • patient
  • Recurrent autonomic and sensory neuropathy in a patient with anti-ganglionic acetylcholine receptor antibodies. (nih.gov)
  • To better define the roles of these antibodies in AS, larger studies with more precisely defined patient characteristics are required. (biomedcentral.com)
  • factors
  • Variation in penetrance, as well as demographic and epidemiologic features, indicates an important role for environmental factors in the inflammatory process of UC ( 38 , 48 ). (asm.org)
  • bacteria
  • The aim of this investigation was to compare the principal culturable bacterial populations on the rectal mucosa of UC patients, and to determine whether specific antibodies towards these bacteria can activate infiltrating PMN through opsonisation. (bmj.com)