• Fulcrum Therapeutics, a Massachusetts-based biotechnology company, identified p38α/β MAPK inhibitors as potent suppressors of DUX4 expression, the de-suppression of which is accepted as the cause FSHD. (wikipedia.org)
  • Among p38α/β MAPK inhibitors, Fulcrum chose losmapimod as its preferred developmental candidate due to its "substantial and attractive preclinical and clinical data" from previous GlaxoSmithKline (GSK) clinical trials. (wikipedia.org)
  • As Fulcrum discovered the potential utility of p38 MAPK inhibition in treating FSHD, a Saint Louis University (SLU) research group independently arrived at the same conclusion. (wikipedia.org)
  • Recent evidence indicates that p38 MAPK inhibition could be therapeutic, possibly by attenuating the exaggerated inflammatory response following SARS-CoV-2 infection. (wikipedia.org)
  • The secretion of inflammatory factors as well as the marker proteins in the mitogen-activated protein kinase (MAPK) pathway were detected by Western blot. (frontiersin.org)
  • 2013 ). In myocardial injury models, inhibition of p38 MAPK decreased the infarction size (Ma et al. (frontiersin.org)
  • 2010 ). In addition, the p38 MAPK inhibitor effectively shortened the duration of seizures in epileptic rats (Yang et al. (frontiersin.org)
  • High salt enhanced the activity of the p38 mitogen-activated protein kinase (p38/MAPK) and increased the interleukin (IL)-8 release in a p38/MAPK-dependent manner. (frontiersin.org)
  • Whereas inhibition of p38/MAPK did not result in improved neutrophil defense, pharmacological blockade of the phagocyte oxidase (PHOX) or its genetic ablation mimicked the impaired antimicrobial activity detected under high salt conditions. (frontiersin.org)
  • Shapiro, professor of pharmaceutical sciences and associate dean of research and advanced graduate studies, University of Maryland School of Pharmacy (UMSOP), was working on developing novel drugs that target a class of enzymes called kinases - specifically ERK mitogen-activated protein kinases (MAPK) that are important in cancer - that instruct cells to perform certain functions and are implicated in many diseases. (umaryland.edu)
  • Hasday, the Dr. Herbert Berger Professor of Medicine and division head, pulmonary and critical care medicine, University of Maryland School of Medicine (UMSOM), was working on the role of a related enzyme called p38 MAPK in acute respiratory distress syndrome (ARDS), a lung disease with high mortality and few available treatments. (umaryland.edu)
  • Working to develop compounds to target inflammatory processes - with funding from UM Ventures, which is UMB's tech transfer arm, and the UMB Institute for Clinical and Translational Research (ICTR) - Hasday, Shapiro, and their research team discovered a novel class of drugs that selectively inhibits the function of p38 MAPK that promotes disease-causing inflammation but preserves its beneficial functions. (umaryland.edu)
  • Effects of EGCG on mitogen-activated protein kinase (MAPK) phosphorylation were determined by cell-based enzyme-linked immunosorbent assay (ELISA) and western blotting. (molvis.org)
  • The inhibitory effects of inotilone were also observed on the activation of phosphatidylinositol 3-kinase/Akt (PI3K/Akt), extracellular signal-regulated protein kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK) signaling pathways both in vitro and in vivo. (rutgers.edu)
  • We found that direct exposure of rat cardiac myocytes in vitro to UFTiO2 (1 mu g/ml) for 4 hrs did not alter myocyte contractility, calcium handling, or the phosphorylation level of cardiac proteins, such as p38 mitogen-activated protein kinase (p38 MAPK) and cardiac troponin I (cTnI). (cdc.gov)
  • In contrast, pulmonary inhalation of UFTiO2 (6 mg/m3) for 4 hrs significantly increased the phosphorylation status of p38 MAPK and cardiac cTnI in the heart. (cdc.gov)
  • Our results suggested that pulmonary exposure to UFTiO2-enhanced the phosphorylation level of p38 MAPK and cTnI in cardiac tissue. (cdc.gov)
  • We measured on Northern gels the migration of reporter mRNAs isolated from cells transfected only with reporter plasmid or co-transfected with an active mutant of MAPK kinase-6, and treated either with or without the p38 MAPK inhibitor SB 203580. (ox.ac.uk)
  • p38 MAPK activation inhibited the deadenylation of reporter mRNAs containing either the cyclooxygenase-2 or tumor necrosis factor AREs. (ox.ac.uk)
  • The regulation of deadenylation by p38 MAPK was found to be specific because deadenylation of the beta-globin reporter mRNA either lacking an ARE or containing the c-Myc 3'-untranslated region (which is not p38 MAPK-responsive) was unaffected by p38 MAPK. (ox.ac.uk)
  • It was concluded that the p38 MAPK pathway predominantly regulates deadenylation, rather than decay of the mRNA body, and this provides an explanation for why p38 MAPK regulates mRNA stability in some situations and translation in others. (ox.ac.uk)
  • Microglial density increases were seen in the dorsal spinal cord and in thalamic nuclei and were accompanied by elevation of phosphorylated p38 MAPK, a marker of microglial activation. (biomedcentral.com)
  • Cannabidiol was also associated with restriction in elevation of microglial density in the dorsal spinal cord and elevation in phosphorylated p38 MAPK. (biomedcentral.com)
  • Title: Antagonism of p38 MAPK Alpha (p38α) Reverses APP-Induced Endosomal Abnormalities and Improves Lysosomal Dysfunction in Down Syndrome Fibroblasts. (eippharma.com)
  • So far, JEL3108's high selectivity for mitogen-activated protein kinase (MAPK, p38-alpha) has demonstrated the capability to potentially inhibit the intracellular inflammation cascade. (carocellbio.com)
  • The p38 mitogen-activated protein kinase (MAPK) pathway is a key mediator of vascular inflammatory responses in lung disease and is an important drug target for the treatment of chronic obstructive pulmonary disease (COPD) and cancer. (uga.edu)
  • Despite the wealth of information available, it is still unclear exactly how p38 MAPK signaling pathways are regulated by many GPCRs, with current p38 targeted therapies having failed to meet clinical needs. (uga.edu)
  • The effect of modifying early neutrophil-mediated inflammation on the development of airway hyperresponsiveness (AHR) was investigated using an interleukin (IL)-1 receptor antagonist (IL-1Ra), an anti-IL-18 antibody (anti-IL-18) or a p38 mitogen-activated protein kinase (MAPK) inhibitor (M39). (elsevierpure.com)
  • These results demonstrate that early neutrophil influx following allergen challenge is mediated by IL-1, IL-18, and p38 MAPK. (elsevierpure.com)
  • The effects of inhibiting p38 MAPK in decreasing AHR indicate activities independent of its prevention of neutrophil accumulation. (elsevierpure.com)
  • Our previous study showed that mitogen-activated protein kinase (MAPK) p38/ MAPK-activated protein kinase 2 (MK2) regulates the expression of ICAM-1 and IL-8 at the post-transcriptional level in HPMECs after TNF-α stimulation [ 4 ]. (biomedcentral.com)
  • Mitogen-activated protein kinases (MAPK) p38 and c-Jun N-terminal kinases (JNKs) are activated during the cellular response to stress signals. (datadryad.org)
  • Furthermore, olmesartan treatment down-regulated the myocardial expressions of glucose regulated protein-78, growth arrest and DNA damage-inducible gene, caspase-12, phospho-p38 mitogen-activated protein kinase (MAPK) and phospho-JNK. (ijbs.com)
  • GEn1E Lifesciences purchased exclusive rights to the therapeutics, known as the p38α mitogen-activated protein kinase inhibitor program. (umaryland.edu)
  • We here evaluated the effects of SP600125 (anthra[1,9- cd ]pyrazole-6 (2 H )-one), an inhibitor of c-Jun NH 2 -terminal kinase (JNK), on the activation of PSCs. (aspetjournals.org)
  • U0126 is a potent and selective non-competitive inhibitor of MAP kinase kinase. (rndsystems.com)
  • Identification of a novel inhibitor of mitogen-activated protein kinase kinase. (rndsystems.com)
  • Losmapimod is an inhibitor of p38 mitogen activated protein (MAP) kinase, an enzyme understood to play a central role in the acute inflammation that occurs during a heart attack. (drugtargetreview.com)
  • Microarray analysis was performed to screen aberrantly expressed mRNAs and activated signaling pathways between epileptic rats and normal controls. (frontiersin.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. (geneticsmr.com)
  • We found that CYN potentiated the effect of bacterial and cyanobacterial LPS that was documented by activation of inflammatory signaling pathways including mitogen-activated protein kinase p38 as well as consequent expression of inducible nitric oxide synthase (iNOS) and increased production of pro-inflammatory mediators such as nitric oxide (NO), TNF-alpha, interleukin-6 (IL-6). (muni.cz)
  • Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has proven to be a modulator of multiple intercellular signalling pathways linked to inflammation, to proliferation, growth, invasion, drug sensitivity, angiogenesis and metastasis of cancer cells. (researchgate.net)
  • Transforming growth factor-β activated kinase-1 (TAK1) is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family that regulates several signaling pathways including NF-κB signal transduction and p38 activation. (rcsb.org)
  • 2012) . Sterile inflammation associat- The key mechanistic pathways and vation of inflammatory cel s (Balkwill, ed with inhalation of crystal ine silica mediators involved in inflamma- 2012 ). (who.int)
  • EGCG significantly inhibited phosphorylation of the MAPKs p38 and c-Jun N-terminal kinase (JNK), and NFκB and AP-1 transcriptional activities. (molvis.org)
  • Nanoparticle inhalation enhances cardiac protein phosphorylation and neurotransmitter synthesis in the nodose ganglia of rats. (cdc.gov)
  • In DoHH2 cells, (5Z)-7-Oxozeaenol potently inhibited the p38 phosphorylation driven by TAK1, and the inhibition lasted over 6 h after withdrawal of (5Z)-7-Oxozeaenol. (rcsb.org)
  • In addition, my experiments showed that the active form of p38 associates with caspase 8 and caspase 3, which is necessary for p38-induced phosphorylation of serine-362 and serine-150 on these caspases. (lu.se)
  • The results in this dissertation also demonstrate that the protein phosphatase type 2A (PP2A) can directly and independently decrease the phosphorylation levels of both p38 and caspase 3. (lu.se)
  • The present study was designed to investigate the effect of Rehmannia glutinosa on phosphorylation of extracellular signal-regulated kinase(ERK) and cAMP response element-binding protein(CREB) in the acute cocaine-treated rats. (koreascience.kr)
  • Increase in c-Fos, phosphorylated extracellular signal-regulated kinase, and hyperexcitability of PVA neurons were detected in hyperalgesic mice. (iasp-pain.org)
  • Conversely, inhibition of PVA neuronal activity using DREADDs (designer receptors exclusively activated by designer drugs) or inactivation of PVA extracellular signal-regulated kinase at the critical time window blunted mechanical hyperalgesia in chronic pain models. (iasp-pain.org)
  • In response to pancreatic injury and in cell culture, pancreatic stellate cells (PSCs) are transformed ("activated") into highly proliferative myofibroblast-like cells that express α-smooth muscle actin and produce extracellular matrix components. (aspetjournals.org)
  • SP600125 inhibited interleukin-1β-induced JNK activity and activator protein-1 activation, but it did not affect the activation of extracellular-regulated kinase, p38 mitogen-activated protein kinase, and nuclear factor-κB. (aspetjournals.org)
  • In addition, systemic inflammation and hyperactivity of the HPA-axis have been consistently observed among depressed patients. (biomedcentral.com)
  • Blood cell counts and differentials did not indicate significant systemic inflammation. (cdc.gov)
  • Such responses may contribute to cardiac dysfunction which is independent of the direct interaction of UFTiO2 with the heart or systemic inflammation, but may involve a lung-neuron-regulated pathway. (cdc.gov)
  • We sought to determine if hypertonic saline (HTS) impacted alveolar macrophage (AM) activation and intracellular inflammatory gene signaling in a model of systemic inflammation. (stanfordhealthcare.org)
  • They were simultaneously treated with an intraperitoneal injection of zymosan, which induces noninfectious systemic inflammation. (stanfordhealthcare.org)
  • In vivo HTS prevents excessive AM activation during systemic inflammation. (stanfordhealthcare.org)
  • It is always secondary to an underlying disorder and is associated with a number of clinical conditions, generally involving activation of systemic inflammation. (medscape.com)
  • Facio Therapies, a Dutch pharmaceutical company with their own drug candidate for FSHD, announced that they had eliminated p38 kinase inhibitors (including losmapimod) as a developmental candidate because p38 kinase inhibitors resulted in impaired myotube formation on their drug development platform. (wikipedia.org)
  • We used Paul's strategy for ERK inhibitors to develop a new class of p38 inhibitors, and it seems to work," Hasday said of the collaboration, which is exactly what IRG is set up to do at UMSOM - facilitate the exchange of ideas about mechanisms of inflammation across disciplines and research laboratories to lead to new ideas. (umaryland.edu)
  • 1999). p38 mitogen-activated protein kinase inhibitors-mechanisms and therapeutic potentials. (geneticsmr.com)
  • Collectively, our results suggest a role of JNK in the activation of PSCs, and a potential application of JNK inhibitors for the treatment of pancreatic fibrosis and inflammation. (aspetjournals.org)
  • Specificity and mechanism of action of some commonly used protein kinase inhibitors. (rndsystems.com)
  • Stress kinases are well-described elements of the response to otic injury and the otoprotective potential of JNK inhibitors is being tested in clinical trials. (datadryad.org)
  • Outside the blood vessels, neutrophils spontaneously undergo apoptosis, and are therefore removed by phagocytic cells at the site of inflammation. (lu.se)
  • Using two different methods it was possible to detect constitutive activity of p38 mitogen-activated protein kinase (p38) in newly isolated neutrophils. (lu.se)
  • During the transient loss of p38 activity there was a temporary Fas-induced increase in phosphatidylinositol 3-kinase (PI3K) activity, which also had a pro-apoptotic impact on the neutrophils. (lu.se)
  • Activated inflammatory cel s, in- persistent inflammation cluding neutrophils and macrophag- es, produce reactive oxygen species and reactive nitrogen species. (who.int)
  • In the healthy brain, p38a regulates inflammation through effects on immune cells. (eippharma.com)
  • Protein kinase C regulates human pluripotent stem cell self-renewal. (rndsystems.com)
  • Here, we show that human antigen R (HuR), an RNA binding protein which binds preferentially to AU-rich elements (AREs) and stabilizes mRNAs, regulates TNF-α-induced ICAM-1 expression in the MK2/HuR signaling pathway. (biomedcentral.com)
  • His work carried out in the field of Molecular biology brings together such families of science as Plasma protein binding, Enzyme, Luciferase, Transduction and Cytotoxicity. (research.com)
  • Neflamapimod is a brain-penetrant oral small molecule that inhibits the intra-cellular enzyme p38 mitogen activated protein kinase alpha (p38α). (eippharma.com)
  • Inhaled corticosteroids suppress airway inflammation and components of airway remodelling in bronchial asthma. (ersjournals.com)
  • Airway inflammation is a central feature of bronchial asthma. (ersjournals.com)
  • Corticosteroids are the most effective drugs to suppress airway inflammation, mainly by downregulation of pro-inflammatory proteins 22 , 23 . (ersjournals.com)
  • Inhaled corticosteroids suppress airway inflammation, which is responsible for asthma-associated changes of the airway vasculature. (ersjournals.com)
  • However, neutralization of IL-1 and IL-18 did not affect the later development of AHR and eosinophilic airway inflammation. (elsevierpure.com)
  • During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
  • Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)
  • 4] After allergen exposure, that produced exceptionally large quantities of airway inflammation is orchestrated mainly by cytokine IL-9. (cdc.gov)
  • The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation. (nih.gov)
  • GM-CSF activated the Jak2 and Stat3 signaling pathway which promoted the transcription of Nav1.7-1.9 in DRG neurons. (iasp-pain.org)
  • Here, we show that, in addition to its kinase activity, TAK1 has intrinsic ATPase activity, that (5Z)-7-Oxozeaenol irreversibly inhibits TAK1, and that sensitivity to (5Z)-7-Oxozeaenol inhibition in hematological cancer cell lines is NRAS mutation status and TAK1 pathway dependent. (rcsb.org)
  • The SLU research group found that p38α and p38β isoforms independently contribute to DUX4 expression, which indicates potential gain in exploring isoform specific (p38α or p38β) inhibition to balance therapeutic effects with side effects. (wikipedia.org)
  • A theoretical limitation of losmapimod is that p38 kinase inhibition could impair myogenesis, the opposite effect of what is desired. (wikipedia.org)
  • However, Fulcrum found that p38 kinase inhibition did not impair myotube fusion at levels sufficient for DUX4 reduction. (wikipedia.org)
  • Detailed biochemical characterization revealed that (5Z)-7-Oxozeaenol inhibited both the kinase and the ATPase activity of TAK1 following a bi-phase kinetics, consistent with the irreversible inhibition mechanism. (rcsb.org)
  • Increasing evidence indicates that pro-inflammatory mediators, protein degradation-associated factors, and some other circulating mediators drive this process ( 18 ). (spandidos-publications.com)
  • This may limit their effectiveness as the concomitant production of many inflammatory mediators continues to activate nociceptive neurons, contributing to pain hypersensitivity. (biomedcentral.com)
  • By activating caspase-1, NLRP3 inflammasome can induce the maturation and secretion of pro-inflammatory factors: Interleukin-1beta (IL-1β) and Interleukin-18 (IL-18). (ijbs.com)
  • The anti-inflammatory actions of corticosteroids occur with a considerable delay (within hours or days) because of the multiple steps of cellular actions required to change protein expression. (ersjournals.com)
  • Both ICAM-1 and IL-8 are the most important inflammatory mediators that are responsible for the migration, recruitment, and infiltration of neutrophil that are produced to combat acute lung inflammation in humans [ 7 , 8 ]. (biomedcentral.com)
  • AGE treatment increased the gene expression of pro-inflammatory cytokines such as tumor necrosis factor- ${\alpha}$ (TNF- ${\alpha}$ ), interleukin- $1{\beta}$ (IL- $1{\beta}$ ), monocyte chemotactic protein-1 (MCP-1) and cyclooxygenase-2 (COX-2). (koreascience.kr)
  • Reverse transcriptase-polymerase chain reaction and Western blot analysis revealed that S. baicalensis had inhibitory effects on the expression of pro-inflammatory genes and protein levels in AGE-treated THP-1 cells. (koreascience.kr)
  • MK2 were subjected to a knockdown by interfering RNA, the mRNA and protein levels of HuR in human pulmonary microvascular endothelial cells (HPMECs) were not affected. (biomedcentral.com)
  • Myostatin binding to type IIB activin receptor (ActRIIB) on muscle surface induces the recruitment and activation of activin receptor-like kinase 5 (ALK5), and eventually leads to forkhead box O3 (FoxO3a)-dependent transcription to promote muscle protein breakdown via the ubiquitin-proteasome system ( 23 ). (spandidos-publications.com)
  • Our studies have revealed a novel mechanism for GPCR dependent activation of non-canonical p38 signaling. (uga.edu)
  • Grimsey NJ, Aguilar, B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V and Trejo J. (2015) Ubiquitin Plays an Atypical Role in GPCR-Induced p38 MAP Kinase Activation on Endosomes. (uga.edu)
  • [ 1 ] Consumption and subsequent exhaustion of coagulation proteins and platelets (from ongoing activation of coagulation) may induce severe bleeding, though microclot formation may occur in the absence of severe clotting factor depletion and bleeding. (medscape.com)
  • Genomic actions involve the regulation of target genes, and suppress most of the vascular elements of inflammation and angiogenesis in the airway. (ersjournals.com)
  • The Grimsey lab focuses on the impact of G protein-coupled receptor (GPCR) mediated non-canonical p38 Mitogen Activated Protein (MAP) kinase signaling in vascular inflammation, angiogenesis and chronic lung disease. (uga.edu)
  • Description Inflammation, a complex process, involving numerous mediators of cellular and plasma origins, is considered to be a critical factor in many human diseases and conditions, including obesity, cardiovascular diseases, diabetes, aging, and cancers. (rutgers.edu)
  • Treatment of HCEpiC with 1 ng/ml IL-1β for 18 h significantly increased release of the cytokines/chemokines granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1), while hyperosmolarity-induced release of IL-6 and MCP-1. (molvis.org)
  • Treatment with olmesartan attenuated the myocardial mRNA expressions of proinflammatory cytokines, [Interleukin (IL)-1β, monocyte chemoattractant protein-1, tumor necrosis factor-α and interferon-γ)] and the protein expression of tumor necrosis factor-α compared with that of vehicle-treated rats. (ijbs.com)
  • Further studies have shown that the protective effects can be ascribed to H 2 S-mediated anti-oxidation, anti-inflammation, anti-apoptosis, and pro-survival activity, which are also summarized in the review. (springer.com)
  • Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is composed of NLRP3, apoptosis associated speck like protein (ASC) and pro-caspase-1. (ijbs.com)
  • NLRP3 inflammasome is the most thoroughly studied one, which is composed of NLRP3, apoptosis associated speck like protein (ASC) and caspase-1 precursor (pro-caspase-1) (Figure 1 ) [ 5 - 10 ]. (ijbs.com)
  • The p38 survival signal was transiently lost during both spontaneous and Fas-induced apoptosis, favoured induction of the apoptotic process. (lu.se)
  • Myocardial protein expressions of AT 1 R, NADPH oxidase subunits (p47phox, p67phox, gp91phox) and the expression of markers of oxidative stress (3-nitrotyrosine and 4-hydroxy-2-nonenal), and the cardiac apoptosis were also significantly decreased by the treatment with olmesartan compared with those of vehicle-treated rats. (ijbs.com)
  • The company hopes the therapeutics will help its efforts to combat ARDS, which kills 40 percent of the people that contract it due to excess lung inflammation and has few therapeutic options. (umaryland.edu)
  • GREATER MANCHESTER, UK - Today, Carocell Bio , the anti-inflammation therapeutics company, announced that it has received £250,023.32 from Deepbridge Capital , an investment firm focused on life sciences, disruptive technologies and renewable energy. (carocellbio.com)
  • We examined the effects on cellular viability and inflammation signaling of CYN on murine macrophage-like RAW 264.7 cells. (muni.cz)
  • However, neither mRNA expression nor protein synthesis of TNF-alpha, IL-1 and IL- 6 was detected in the heart or peripheral blood respectively. (cdc.gov)
  • Consequently, knockdown of HuR by RNA interference in HPMECs, there was reduction in the stability of ICAM-1 mRNA and ICAM-1 protein level. (biomedcentral.com)
  • Nevertheless, HuR silencing had no effect on the mRNA and protein levels of IL-8. (biomedcentral.com)
  • Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
  • The protein encoded by this gene is a receptor for C-C type chemokines. (cancerindex.org)
  • Although several types of inflammasomes have been identified so far, nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is the most characteristic one [ 1 ]. (ijbs.com)
  • Grimsey NJ , Coronel LJ, Cordova IC, and Trejo J. (2016) Recycling and Endosomal Sorting of Protease-Activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins. (uga.edu)
  • Dores MR, Lin H, Grimsey NJ , Mendez F and Trejo J. (2015) The -Arrestin ARRDC3 Mediates ALIX Ubiquitination and G Protein-Coupled Receptor Lysosomal Sorting. (uga.edu)
  • Nuclear FoxO3a activates the atrogin1 promoter ( 27 ). (spandidos-publications.com)
  • Effects of EGCG on nuclear factor kappa B (NFκB) and activator protein-1 (AP-1) transcriptional activity were assessed by reporter gene assay. (molvis.org)
  • This divergence may origin from the differential effect of inotilone on transcription factors, nuclear factor κB (NF κB) and CCAAT enhancer-binding protein (C/EBP). (rutgers.edu)
  • Here, we report that GABAergic (GABA) and dopaminergic (DA) neurons in the ventral tegmental area (VTA) are activated with different temporal patterns during acute and chronic itch. (iasp-pain.org)
  • Medial tibial stress syndrome, or shin splints, is the inflammation of the tendons, muscles, and bone tissue around the tibia. (southlakepeds.com)
  • Interleukin-1β activated both 46- and 54-kDa JNK, whereas platelet-derived growth factor-BB activated only 46-kDa JNK. (aspetjournals.org)
  • His Capsid study combines topics from a wide range of disciplines, such as Plasma protein binding, Immune system, Antigen, Peptide sequence and Peptide. (research.com)
  • Inflammasome is a complex composed of several proteins and an important part of the natural immune system. (ijbs.com)
  • From inflammation to sickness and depression: when the immune system subjugates the brain. (bioseek.eu)
  • GSK investigated losmapimod as a therapeutic for COPD, but multiple phase II clinical trials failed to show that losmapimod improves exercise tolerance, lung function, arterial inflammation, endothelial function, or rate of COPD exacerbations in subjects with COPD. (wikipedia.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Furthermore, the ability of inotilone to prevent inflammation-associated tumorigenesis was also evaluated using a classical two-stage mouse skin carcinogenesis model. (rutgers.edu)
  • Kupffer Cell p38 Mitogen-Activated Protein Kinase Signaling Drives Postburn Hepatic Damage and Pulmonary Inflammation When Alcohol Intoxication Precedes Burn Injury. (ucdenver.edu)
  • NLRP3 inflammasome can be activated by different stimuli including pathogen associated molecular patterns (PAMPs) and damage associated molecular pattern (DAMPs). (ijbs.com)
  • Tibialis anterior tendonitis is a condition whereby there is damage to the tibialis anterior tendon with subsequent inflammation and degeneration. (southlakepeds.com)
  • The unfolded protein response regulator ATF6 promotes mesodermal differentiation. (uga.edu)
  • SP600125 inhibited platelet-derived growth factor-induced proliferation, inducible monocyte chemoattractant protein-1 production, and serum-induced type I collagen production. (aspetjournals.org)
  • MCP-1, monocyte chemoattractant protein-1. (aspetjournals.org)
  • where it plays a major role in inflammation and/or amyloid beta induced synaptic toxicity, including the impairment of synaptic plasticity that is a major driver of the development of deficits in learning and memory formation which are defining characteristics of Alzheimer's disease. (eippharma.com)
  • p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation. (ox.ac.uk)
  • Future research should therefore focus on determining the effects of protein timing on muscular adaptations in those with at least 1 year or more of regular, consistent resistance training experience. (screeninglibraries.com)
  • Our drug discovery program demonstrates that it may be more beneficial to tweak the function of the kinase rather than turn it off so we can selectively eliminate the disease-causing activity and preserve the beneficial functions. (umaryland.edu)
  • High salt diets ( 1 , 2 ), renal impairment ( 3 - 6 ), inflammation, and infection ( 7 - 11 ) can induce Na + accumulation in skin tissues that can be simulated by addition of approximately 40 mM NaCl to standard cell culture media (= high salt condition, HS) ( 2 , 8 , 12 , 13 ). (frontiersin.org)
  • It belongs to family 1 of the G protein-coupled receptors. (cancerindex.org)
  • His work in Capsid covers topics such as Antibody which are related to areas like Viral protein. (research.com)