Intima-media thiArteriesStenosisPlaquesSystemicUltrasoundAtherosclerosis in patientsCommon CarotiMarkers of inflammationBiomarkersVascularArterialJoint inflammationPathologyStrokeArtery wallAtherosclerotic plaqueEndarterectomyIschemiaAortaArteriosclerosisInfectionEndothelial dysfunctionDiagnosisCardiovascular riskAssessmentBifurcationDiseaseRheumatoid arthritisInsulin resistancePeripheralSymptomsChronicPatientsVulnerabilityThrombosisAcutePlaque formationLipidAccumulationPredictorCorrelationReducesInflammatoryMacrophagesProteinCharacteristicBloodPotent
Intima-media thi7
- Methods: The common carotid artery (CCA) intima-media thickness (IMT), CCA resistive index (RI), and carotid plaques were measured by ultrasonography in 192 patients with RA. (elsevierpure.com)
- 2010). 'The role of Carotid Intima-Media Thickness (CIMT) Measurement and Echo-tracking in the Assessment of Preclinical Carotid Artery Atherosclerosis in HIV-infected Patients', Infektološki glasnik , 30(1), pp. 35-41. (srce.hr)
- Višković K, Krolo I, Brnić Z, Podoreški D, Stermberger L, Begovac J. The role of Carotid Intima-Media Thickness (CIMT) Measurement and Echo-tracking in the Assessment of Preclinical Carotid Artery Atherosclerosis in HIV-infected Patients. (srce.hr)
- Carotid intima-media thickness (CIMT) measurement by B-mod ultrasound is an important tool for evaluation of early stages of atherosclerosis. (srce.hr)
- In particular, deficient levels of the vitamin have been associated with increased carotid intima-media thickness (IMT), an important indicator of hardening of the arteries, a major risk factor for cardiovascular disease. (aidsmap.com)
- We used existing data on carotid intima-media thickness in UK Biobank as a marker of subclinical atherosclerosis (N = 22,179). (cam.ac.uk)
- A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima-media thickness). (cdc.gov)
Arteries26
- If subsequent natural history studies link increased FDG-PET activity in carotid arteries with clinical events, this noninvasive measure could be used to identify a subset of patients with carotid atherosclerosis in need of intensified medical therapy or carotid artery intervention to prevent stroke. (nih.gov)
- The carotid arteries provide the main blood supply to your brain. (medlineplus.gov)
- Carotid artery disease occurs when plaque builds up inside the carotid arteries. (medicalnewstoday.com)
- There are two large common carotid arteries, one on each side of the neck. (medicalnewstoday.com)
- Each of these arteries separates into an external and internal carotid artery leading up to the brain. (medicalnewstoday.com)
- A bruit is a sound present in the arteries of some people with carotid artery disease. (medicalnewstoday.com)
- During a physical examination, the doctor will place a stethoscope on the neck near the carotid arteries and listen for a slight "whooshing" sound. (medicalnewstoday.com)
- Doctors generally use one or more imaging tests to see inside the carotid arteries and check for narrowing. (medicalnewstoday.com)
- A carotid ultrasound uses sound waves to create images of the inside of the arteries. (medicalnewstoday.com)
- It is the most common form of imaging test for carotid artery disease, and in most cases, it can help reveal any narrowing of the arteries. (medicalnewstoday.com)
- Atherosclerosis in the carotid arteries is an established predictor of these events. (tudelft.nl)
- Subclinical atherosclerosis of carotid arteries can also be detected by measuring the number and area of present plaques and arterial stiffness assessment. (srce.hr)
- This is a randomized placebo-controlled study in treated and suppressed HIV-infected individuals aged ≥40 years with either known CVD or 1 CVD risk factor to study the effect of Bempedoic acid (BA) on safety, arterial inflammation as assessed by FDG-PET/CT, lipids, inflammation, immune activation, cardiometabolic indices, and non-calcified plaque (NCP) in the coronary arteries (assessed by coronary CT angiography, CCTA). (uclahealth.org)
- Stenosis, or stiffening, of the carotid arteries occurs when fatty deposits, or plaques, adhere to the walls of the arteries that supply blood to the brain. (southnassau.org)
- Carotid duplex ultrasound: An ultrasound that measures the velocity of blood flow in the carotid arteries. (southnassau.org)
- Giant cell arteritis is inflammation of the walls of the arteries, most commonly in the arteries in the head. (southnassau.org)
- Carotid artery wall thickness, a measure of arteries that supply the brain and an indicator of heart disease, also improved with Actos. (natap.org)
- For the induction of cerebral ischemia, the common carotid arteries were exposed, and then aneurysm clips were used to occlude the common carotid arteries bilaterally for 7 minutes. (iasp-pain.org)
- Instead of the carotid plaque burden, Mease would have liked to have seen the authors evaluate calcium scores in coronary arteries as measured by CT. (medscape.com)
- A recent study suggests that people with persistent asthma are more susceptible to developing plaque buildup in their carotid arteries, which may increase the risk of heart attack or stroke. (dmc.org)
- According to the study, individuals with persistent asthma had double the odds of having excess plaque in their carotid arteries. (dmc.org)
- The carotid arteries are two large blood vessels on each side of the neck that supply blood to the brain, neck and face. (dmc.org)
- When atherosclerosis forms in your carotid arteries, it can block blood flow to your brain, leading to a stroke. (dmc.org)
- Carotid ultrasound: This test is a very simple, non-invasive early screening that allows doctors insight into early plaque build-up and inflammation in arteries of the neck. (firerescue1.com)
- Immunostaining of en face mesenteric arteries of LPS-treated mice showed that syndecan-1 was fully restored after LNPG administration. (bvsalud.org)
- Blockage can occur with inflammation of the arteries (called arteritic, typically as part of. (msdmanuals.com)
Stenosis2
- Here, we aimed to determine whether matrix metalloproteinases (MMP-1, MMP-2, MMP-7, MMP-9 and MMP-10), tissue inhibitor of MMPs (TIMP-1) and in vivo inflammation studied by F-18-FDG-PET/CT predict recurrent cardiovascular events in patients with carotid stenosis who underwent endarterectomy. (unav.edu)
- 70%) carotid stenosis who were scheduled for carotid endarterectomy between July 2013 and March 2016. (unav.edu)
Plaques5
- We established that FDG-PET imaging can be used to assess the severity of inflammation in carotid plaques in patients. (nih.gov)
- Moreover, a range of PET tracers has been independently employed to investigate the association of atherosclerosis disease with specific molecular processes in plaques, such as inflammation with 18F-Fluorodeoxyglucose (18F-FDG) or micro-calcification with 18F-sodium fluoride (18F-NaF). (snmjournals.org)
- Thus, we aim at the co-registered in-vivo imaging of inflammation and micro-calcification processes in carotid plaques to enable parallel evaluations of any potential correlations between their activity progress and response to therapy at different stages of atherosclerosis. (snmjournals.org)
- The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imaging for the detection of these biomarkers. (tudelft.nl)
- v) APP and Aβ are present in human carotid plaques ( 15 ). (spandidos-publications.com)
Systemic8
- An UCCAO caused a slight cerebral ischemia (cerebral blood flow [CBF] 70%) without hypotension (MABP 85 mmHg), systemic inflammation, multiple organs injuries, or neurological injury. (medsci.org)
- An HS caused a moderate cerebral ischemia (52% of the original CBF levels), a moderate hypotension (MABP downed to 22 mmHg), systemic inflammation, and peripheral organs injuries. (medsci.org)
- However, combined an UCCAO and an HS caused a severe cerebral ischemia (18% of the original CBF levels), a moderate hypotension (MABP downed to 17 mmHg), systemic inflammation, peripheral organs damage, and neurological injury, which can be attenuated by whole body cooling. (medsci.org)
- Also, chronic systemic inflammation itself is an independent CV risk factor. (bmj.com)
- RA is the archetype of a systemic immune-mediated disease and it is defined as a chronic symmetric inflammation primarily involving the synovial joints ( table 1 ). (bmj.com)
- 2 Alongside joint involvement, the systemic inflammation distinctive for RA can affect other organs including the bowels, skin, lungs, kidneys, nervous system and also the heart and blood vessels. (bmj.com)
- Psoriasis and psoriatic arthritis are both associated with greater risk of cardiovascular morbidity and mortality, partly because of systemic inflammation that leads to atherogenesis. (medscape.com)
- HERMES: Effects of ziltivekimab versus placebo on morbidity and mortality in patients with heart failure with mildly reduced or preserved ejection fraction and systemic inflammation. (who.int)
Ultrasound1
- Blad M, Gustafsson N, Engström G, Kennbäck C, Klinge B, Nilsson PM, Jönsson D, Levring Jäghagen E. Defined shapes of carotid artery calcifications on panoramic radiographs correlate with specific signs of cardiovascular disease on ultrasound examination. (lu.se)
Atherosclerosis in patients1
- Association between genetic polymorphisms and carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma. (cdc.gov)
Common Caroti1
- This study aimed to investigate whether resuscitation after a hemorrhagic shock (HS) and/or mild cerebral ischemia caused by a unilateral common carotid artery occlusion (UCCAO) can cause brain injury and concomitant neurological dysfunction, and explore the potential mechanisms. (medsci.org)
Markers of inflammation3
- Published in the online edition of Antiviral Therapy , investigators found that vitamin D was associated with CD4 cell count after starting antiretroviral therapy, markers of inflammation, and an important indicator of increased cardiovascular risk. (aidsmap.com)
- But Actos also improved several heart disease risk factors, including cholesterol and markers of inflammation, such as C-reactive protein. (natap.org)
- There are few reports assessing the prognostic value of markers of inflammation in relation to the risk of cardiovascular disease after carotid endarterectomy. (unav.edu)
Biomarkers4
- Background: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. (tudelft.nl)
- Search for Reliable Circulating Biomarkers to Predict Carotid Plaque Vulnerability. (nih.gov)
- But researchers who conducted the study note that neither of the two biomarkers identified in the study ― cardiac troponin I (cTnI) and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) ― led to an improvement in predictive performance when combined with the FRS, despite their association with carotid plaque burden. (medscape.com)
- We conducted linear regressions analyses (adjusted for sex, waist circumference, physical activity, hormone use, and season) to assess the relationship between 25-hydroxyvitamin D and biomarkers of dysglycemia, dyslipidemia, and inflammation in the study population. (cdc.gov)
Vascular7
- Cardiovascular (CV) risk factors such as hypercholesterolemia, hyperglycaemia, obesity, hypertension, smoking, and aging promote vascular inflammation and endothelial activation [ 7 - 9 ]. (hindawi.com)
- vi) APP transgenic mice with apolipoprotein E (ApoE) deficiency had increased atherosclerosis and vascular inflammation ( 16 ). (spandidos-publications.com)
- This study was designed to characterize the molecular mechanisms by which AMPK suppresses vascular inflammation. (diabetesjournals.org)
- We conclude that AMPK activation suppresses STAT1 signaling and inhibits vascular inflammation through the upregulation of MKP-1. (diabetesjournals.org)
- Assessing the Usefulness of an Innovative Biomarker for the Resolution of Inflammation in Vascular Disease. (fatsoflife.com)
- In vascular inflammation, RvD1 reduces the activation of smooth muscle cells by inflammatory stimuli and inhibits the hyperplasia of the intima. (fatsoflife.com)
- Thermography is a specialized camera that can see the inflammation, physiological and thermal vascular changes in your body. (thermographyforlife.org)
Arterial4
- Cardiovascular disease is a major health problem & our research focuses on myocardial infarction, myopathies & inflammation, coronary heart disease, arterial thrombosis, peripheral artery disease, stroke & angina, plus underlying causes such as arthrosclerosis. (ed.ac.uk)
- This baseline arterial TBR cutoff excludes the rare individual that lacks appreciable arterial inflammation. (uclahealth.org)
- Atherosclerosis is a progressive disease, with a characteristic increase in lipid accumulation, inflammation, and plaque formation within the arterial walls [ 1 ]. (springer.com)
- Carotid arterial stiffness and risk of incident cerebral microbleeds in older people: the Age, Gene/Environment Susceptibility (AGES)-Reykjavik study. (cdc.gov)
Joint inflammation3
- Literally means joint inflammation. (lupus.org)
- Although joint inflammation is a symptom or sign rather than a specific diagnosis, the term arthritis is often used to refer to any disorder that affects the joints. (lupus.org)
- Shared clinical features of spondyloarthropathies are axial joint inflammation, enthesitis, dactylitis and oligoarthritis. (bmj.com)
Pathology1
- However, many non-communicable diseases have a component of unregulated inflammation in their pathology. (fatsoflife.com)
Stroke5
- Diagnosing carotid artery disease as early as possible is important to prevent potentially life threatening complications, such as stroke. (medicalnewstoday.com)
- And less inflammation may mean less heart disease and stroke. (natap.org)
- Over time, asthmatic airway inflammation can contribute to artery plaque buildup (atherosclerosis), a condition associated with a higher risk of plaque rupturing, which can lead to heart attack or stroke. (dmc.org)
- A stroke is also another sign of carotid artery disease. (dmc.org)
- Evidence HDAC9 genetic variant associated with ischemic stroke increases risk via promoting carotid atherosclerosis. (cdc.gov)
Artery wall1
- In the vasculature, activation of STAT1 and STAT3 promotes inflammatory response ( 5 ), increases neointimal formation ( 6 ), and accelerates the development of atherosclerosis ( 7 ), a chronic disease characterized by inflammation in the artery wall ( 8 ). (diabetesjournals.org)
Atherosclerotic plaque1
- Given the importance of inflammation in atherosclerosis, we sought to determine if atherosclerotic plaque inflammation could be measured noninvasively in humans using positron emission tomography (PET). (nih.gov)
Endarterectomy2
- Here we tested the ability of FDG-PET to measure carotid plaque inflammation in patients who subsequently underwent carotid endarterectomy (CEA). (nih.gov)
- Background Major adverse cardiovascular events are the main cause of morbidity and mortality over the long term in patients undergoing carotid endarterectomy. (unav.edu)
Ischemia2
- As with cerebral parenchymal lesions, injury can occur because of direct effects of inflammation, tissue ischemia due to thrombosis of inflamed blood vessels, or compression due granulomatous tissue formation and edema. (medscape.com)
- Adenosine A2A receptor agonist polydeoxyribonucleotide ameliorates short-term memory impairment by suppressing cerebral ischemia-induced inflammation via MAPK pathway. (iasp-pain.org)
Aorta1
- 1.6 of the MDS of the carotid/aorta at baseline. (uclahealth.org)
Arteriosclerosis2
- Background: Accumulating evidence highlights the existence of distinct morphological subtypes of intracranial carotid arteriosclerosis. (tudelft.nl)
- Carotid Arteriosclerosis has been observed to be reduced by Tocotrienol in several studies. (eannatto.ca)
Infection3
- Inflammation and infection. (radiologyassistant.nl)
- To see if vitamin D was related to makers of inflammation in HIV infection. (aidsmap.com)
- Inflammation is the organ and system response that puts tissues in a state of alert, in order to defend their integrity against infection and physical disruption. (fatsoflife.com)
Endothelial dysfunction2
- He was among the earliest investigators that focused on the relevance of endothelial dysfunction and inflammation for the high risk of cardiovascular disease in these populations. (wikipedia.org)
- Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
Diagnosis1
- Inflammation and immunity are key factors for the development and complications of atherosclerosis, and therefore, the whole atherosclerotic process is a target for diagnosis and treatment. (hindawi.com)
Cardiovascular risk1
- In conclusion, the presented study gives evidence of an anti-inflammatory and potential antiatherogenic effect of pioglitazone that is indicated by improvements in several traditional and nontraditional cardiovascular risk markers and carotid IMT, independent of an improvement in long-term glycemic control. (natap.org)
Assessment1
- I would have loved to have seen the researchers using that in addition to the carotid plaque assessment, to see what that would show us about these patients," he said. (medscape.com)
Bifurcation1
- and a firm, mobile mass that is palpable at the left carotid bifurcation. (medscape.com)
Disease13
- In this article, learn more about the symptoms of carotid artery disease, as well as the risk factors and treatment options. (medicalnewstoday.com)
- Many people with carotid artery disease do not have any symptoms at first. (medicalnewstoday.com)
- Carotid artery disease generally starts causing noticeable symptoms as the condition gets worse. (medicalnewstoday.com)
- Some people may not experience symptoms of carotid artery disease until they have a transient ischemic attack (TIA). (medicalnewstoday.com)
- Plaque buildup is the direct cause of carotid artery disease. (medicalnewstoday.com)
- If the doctor feels that a person may be at risk for carotid artery disease, they may run a physical exam or order other tests to check the person's blood health. (medicalnewstoday.com)
- But chronic (or persisting) inflammation, even at low grade, is problematic, as it is associated in the long term to many conditions such as heart disease or cancer. (aidsmap.com)
- There is growing evidence that a specific class of diabetes drugs may help fight heart disease by also fighting inflammation. (natap.org)
- In recent years research has pointed to inflammation as a possible cause of heart disease. (natap.org)
- And early studies have hinted that the type 2 diabetes drugs Actos and Avandia may help fight heart disease not only by improving blood sugar but also by battling inflammation. (natap.org)
- Gender differences in the prevalence of a normal IMT with increasing severity of carotid disease. (escardio.org)
- When there is illness or disease in the body, it generally starts as inflammation. (thermographyforlife.org)
- The most important indicator of a potential illness or disease is inflammation. (thermographyforlife.org)
Rheumatoid arthritis1
- used in cases of rheumatoid arthritis because TNF instigates inflammation of the joints. (lupus.org)
Insulin resistance3
- Inflammation is thought to be an important factor in accelerated atherosclerosis in RA, whereas insulin resistance is a known risk factor for atherosclerosis in RA. (elsevierpure.com)
- We hypothesised that adipokines could be a link between inflammation, insulin resistance, and atherosclerosis in RA. (elsevierpure.com)
- The drugs' insulin-resistance properties may help reduce inflammation within the lining of the vessels. (natap.org)
Peripheral1
- Presentations may involve chronic, acute, or stepwise deterioration referable to parenchymal or meningeal inflammation and scarring, and this variable tempo of onset also may be seen in the associated peripheral nerve syndromes and cranial neuropathies. (medscape.com)
Symptoms2
- A history of headaches and other symptoms related to inflammation of meningeal or parenchymal structures should be sought initially and on follow-up visits. (medscape.com)
- Thermography can detect inflammation, often long before you feel any symptoms. (thermographyforlife.org)
Chronic3
- Inflammatory joint disorders (IJD) are characterised by chronic inflammation of the joints and related tissues. (bmj.com)
- Chronic low-grade inflammation is an important pathogenic factor in the development of type 2 diabetes and cardiovascular diseases ( 1 ). (diabetesjournals.org)
- Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF-кB pathway through microbiota-gut-brain axis - Phytother Res 2023 Apr 10 - 'Diabetic cognitive impairment (DCI) is a serious neurodegenerative disorder caused by diabetes, with chronic inflammation being a crucial factor in its pathogenesis. (qualitycounts.com)
Patients3
- Seventeen patients with severe carotid stenoses underwent FDG-PET imaging 3 h after FDG administration (13 to 25 mCi), after which carotid plaque FDG uptake was determined as the ratio of plaque to blood activity (target to background ratio, TBR). (nih.gov)
- A few patients presenting with signs of meningeal inflammation have been reported in whom diffuse dural enhancement was seen on magnetic resonance imaging. (medscape.com)
- Les IFN et les IL-10 étaient signi cativement élevés chez ceux qui présentaient une néphropathie diabétique (ND) et une maladie rénale en phase terminale (MRPT) par rapport aux témoins et aux patients diabétiques sans ND. (who.int)
Vulnerability1
- Vulnerability of carotid atherosclerosis: relationship with plaque location, plaque eccentricity and vessel remodeling patterns. (escardio.org)
Thrombosis1
- The contact activation pathway plays an essential role in hemostasis, and also in the progression of thrombosis and inflammation ( 31 ). (spandidos-publications.com)
Acute1
- 4 We present a case of sCAD with early progression and marked gadolinium enhancement suggestive of acute inflammation. (neurology.org)
Plaque formation1
- Positive association of MMP 14 gene polymorphism with vulnerable carotid plaque formation in a Han Chinese population. (cdc.gov)
Lipid2
- The ratio integrates resolution and inflammation processes using lipid mediator levels that can be determined by an ELISA method in readily collected saliva. (fatsoflife.com)
- A superfamily of pro-resolving molecules formed during self-limiting inflammation is derived from long-chain polyunsaturated fatty acids (LCPUFA), in particular lipoxin A 4 from AA, and resolvins, protectin, maresins and other specialized pro-resolving lipid mediators (SPMs) from the omega-3 LCPUFA, eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA). (fatsoflife.com)
Accumulation1
- Electronegative LDL Promotes Inflammation and Triglyceride Accumulation in Macrophages. (nih.gov)
Predictor1
- The presence of carotid artery plaque is a strong predictor of future cardiovascular events. (dmc.org)
Correlation1
- ii) There are reports of a correlation between carotid atherosclerosis and AD ( 7 ) as well as atherosclerosis of the circle of Willis and AD ( 8 , 9 ). (spandidos-publications.com)
Reduces1
- can also refer to a drug that reduces inflammation. (lupus.org)
Inflammatory4
- High-grade inflammation as well as anti-inflammatory treatment alter traditional CV risk factors, such as lipids. (bmj.com)
- In a range of inflammatory disorders, the physiological stimuli that trigger the inflammatory response or actively turn inflammation off, i.e. resolution, are not in a proper balance. (fatsoflife.com)
- Counter-regulation and active termination of inflammatory responses is executed by pro-resolving mediators that are formed locally during self-limiting inflammation. (fatsoflife.com)
- Further investigations showed that pterostilbene reduced the level of lipopolysaccharide, modulated colon and brain TLR4/NF-κB signaling pathways, and decreased the release of inflammatory factors, which in turn inhibited intestinal inflammation and neuroinflammation. (qualitycounts.com)
Macrophages1
- Less than 1 month after imaging, subjects underwent CEA, after which carotid specimens were processed to identify macrophages (staining with anti-CD68 antibodies). (nih.gov)
Protein1
- And L:A ratio was related to the CCA RI after adjustment for conventional and nonconventional CV risk factors, including HOMA-IR, erythrocyte sedimentation rate and C-reactive protein.Conclusion: L:A ratio was associated with HOMA-IR and carotid RI. (elsevierpure.com)
Characteristic1
- Anti-inflammation are characteristic properties of Tocotrienols. (eannatto.ca)
Blood2
- Hormones released from the kidney control many important functions in the body, including managing blood sugar levels, regulating inflammation, regulating the balance of salt and water, controlling the "fight or flight" response to stress, maintaining pregnancy, and initiating and controlling sexual maturation during childhood and puberty. (lupus.org)
- Previous studies have showed multiple beneficial effects as a result of such contact, including better sleep, normalization of cortisol, reduced inflammation, pain and stress, and better blood flow. (scirp.org)
Potent1
- Carrying potent inflammation-resolving activity, resolvin D1 (RvD1) is one of the best-characterized SPMs to date. (fatsoflife.com)