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  • induces
  • When the organ is ready for the transplantation, the reperfusion of the organ induces an increase of the oxidative stress, endoplasmic reticulum stress, and inflammation which causes tissue damage, resulting in a decrease of the transplantation success. (mdpi.com)
  • triggers
  • Gene expression studies have revealed that the increase in oxygen radicals post-ischemia triggers the expression of a number of pro-inflammatory genes. (eurekaselect.com)
  • cell proliferation
  • Peroxisome proliferator-activated receptor-γ (PPARγ) is a member of the nuclear subfamily of transcription factors with pleiotropic effects on lipid and glucose homeostasis, cell proliferation, and control of inflammation ( 6 ). (jimmunol.org)