Inflammation in bronchoalveolar lavage fluid. Medical search. Frequent questions

Researchers from the Department of Respiratory Medicine, Osaka City University Graduate School of Medicine have found that in a ImmuBalance-treated group of asthma model mice, white blood cells associated with asthma called eosinophils were significantly reduced in the bronchoalveolar lavage fluid (BALF). (sciencedaily.com)
In the ImmuBalance-treated group, the number of eosinophils in BALF was significantly reduced, and inflammation around the bronchi and mucus production in the bronchial epithelium was suppressed. (sciencedaily.com)
Also, the expression of Th2 cytokines and the immunoglobulin serum IgE that induce eosinophilic inflammation in BALF were measured and found to be significantly suppressed when compared to mice fed a normal diet. (sciencedaily.com)
Inflammation was measured by neutrophilia in BALF. (biomedcentral.com)
In addition, bronchoalveolar lavage fluid (BALF) was analysed for inflammatory cells and proteins, as well as histological analysis was performed and scored for inflammation and fibrosis. (lu.se)
Lactate dehydrogenase (LDH) activity, inflammatory cells, and total protein concentration were analyzed in bronchoalveolar lavage fluid (BALF). (lu.se)

Currently, the influence of local and systemic inflammation on disease progression following WC-Co exposure remains unclear. (cdc.gov)
COPD is characterized as a chronic inflammatory condition due to the persistent accumulation of innate and adaptive immune cells in the airways along with increased systemic inflammation ( 3 ). (frontiersin.org)
Cancer patients frequently suffer from weight loss and systemic inflammation in the context of advanced disease, which is related to adverse outcome. (karger.com)
Background Accelerated thrombus formation induced by exposure to combustion-derived air pollution has been linked to alterations in endogenous fibrinolysis and platelet activation in response to pulmonary and systemic inflammation. (anma.it)
Intravenous DEP produced an earlier (2 h) acceleration of thrombosis (as did CB) without pulmonary or systemic inflammation. (anma.it)
This effect is dissociated from pulmonary and systemic inflammation and from impaired fibrinolytic function. (anma.it)

Background: Bronchoalveolar lavage is a useful bronchoscopy technique. (sun.ac.za)

Bronchoalveolar lavage fluid was analyzed for cytology and inflammatory mediators. (nih.gov)
Resolution of inflammation is an active process timely controlled by endogenous specialized pro-resolving lipid mediators (SPMs) produced locally in inflammatory loci to restrain this innate response, prevent further damages to the host, and permit return to homeostasis. (frontiersin.org)
Additionally, in the OVA-induced asthma model, the number of immune cells in the bronchoalveolar lavage fluid, the concentration of OVA-specific IgE, the infiltration of inflammatory cells, the bronchial thickness and the levels of the inflammatory mediators interleukin-4 (IL-4), IL-13 and COX-2 were significantly lower in the OVA + SEAC‑treated group compared with the OVA + vehicle‑treated group. (spandidos-publications.com)
Physicochemical properties are likely to impact the mechanism by which pulmonary lipid mediators and pro-inflammatory cytokine-mediated inflammation occurs following exposure to PM. (biomedcentral.com)
Lavage fluid from the lumen of the asthmatic airway contains numerous mediators including histamine, prostaglandins (predominantly PGD2 and PGF2), leukotrienes, kinins, kallikrein, and eosinophil derived major basic protein. (edu.pk)

The first event in acute inflammation is edema formation, followed by infiltration of PMN, and then monocyte and macrophages that clear PMN leading to resolution, which is essential for ensuring host protection and sparing from tissue damage. (frontiersin.org)
The pathogeneses of bacterial and viral exacerbations are significant as clinical symptoms are more severe and there is a marked increase in neutrophilic inflammation and tissue damage. (frontiersin.org)
Inflammation is maintained through the continual recruitment and activation of leukocytes, which perpetuate a state of oxidative stress and local tissue damage. (frontiersin.org)
COPD is characterised by tissue destruction and inflammation. (bmj.com)
Fetal lung fluid (FLF), bronchoalveolar lavage fluid (BAL), right mainstem bronchi and peripheral lung tissue were evaluated for inflammation. (edu.au)
Fetal lung fluid (FLF), bronchoalveolar lavage fluid (BAL), right mainstem bronchi and peripheral lung tissue were evaluated for inflammation.ResultsRecruitment volume increased from 0.4 +/- 0.04 mL/kg at 4 cmH(2)O to 2.4 +/- 0.3 mL/kg at 16 cmH(2)O. The lambs were surfactant deficient, and all pressures were below the opening inflection pressure on pressure-volume curve. (edu.au)
The amount of SP-A in BAL fluid and the composition of phospholipid as well as phosphatidylcholine molecular species in BAL fluid and lung tissue was unchanged in cftrm1HGU/m1HGU mice compared with controls. (bmj.com)
We observed increased MRI signal correlating to inflammation and fibrosis as confirmed by BAL and tissue markers. (lu.se)

In other species, BAL fluid cytology has better correlation with pulmonary histopathology than tracheal fluid. (cornell.edu)
A consistent lack of acute local pulmonary inflammation was observed in terms of the broncho-alveolar lavage fluid parameters examined (i.e. (cdc.gov)
however, significant acute pulmonary inflammation was observed in the CeO2 NP group. (cdc.gov)
The various mechanisms believed to be responsible are pulmonary arterial vasoconstriction and elevated pulmonary artery pressure, resulting in circulatory shear forces and a consequent permeability leak and antidiuresis possibly mediated by increased antidiuretic hormones, which contribute to fluid retention. (medscape.com)
Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and death world-wide, where chronic inflammation accelerates lung function decline. (frontiersin.org)
The suppressive effect of intracellular released soluble iron on particle-induced inflammation has implications on how ambient PM-associated but soluble metals influence pulmonary toxicity of ambient PM. (biomedcentral.com)
Results Instillation of DEP reduced the time to thrombotic occlusion in vivo, coinciding with the peak of DEP-induced pulmonary inflammation (6 h). (anma.it)
However, the fundamental question of whether surfactant alterations in the CF lung are secondary to the pulmonary damage or are present before initiation of chronic infection and inflammation has yet to be resolved in patients with cystic fibrosis but can now be addressed in CF mice that exhibit the basic defect in the airways. (bmj.com)

These triggers functionally mature MSCs towards either a pro-inflammatory or anti-inflammatory phenotype to regulate inflammation. (bmj.com)
These findings indicate that SEAC is a suppressor of airway inflammation and remodeling, and may therefore be useful as an anti-inflammatory drug for the treatment of asthma. (spandidos-publications.com)
Lee DY, Choo BK, Yoon T, Cheon MS, Lee HW, Lee AY and Kim HK: Anti-inflammatory effects of Asparagus cochinchinensis extract in acute and chronic cutaneous inflammation. (spandidos-publications.com)

The concentration of eosinophils in bronchoalveolar lavage fluid was highest in the moderate asthmatics not on glucocorticoids, with very little difference between normal controls and severe asthmatics (significant difference among the groups, p = 0.007). (nih.gov)
Results showed a decreased presence of eosinophils in bronchoalveolar lavage fluid, a decrease in mucus production in the bronchial epithelium, and a suppression of proteins that induce eosinophilic inflammation. (sciencedaily.com)
Eosinophils are known to be an indirect marker of airway inflammation in asthma. (edu.pk)
Airway inflammation is present during an acute exacerbation of asthma, and is characterized by infiltration and activation of both eosinophils and neutrophils 2 . (edu.pk)

Acute inflammation is a protective process arising in vascularized tissues upon damages, altered homeostasis, and infections. (frontiersin.org)
The lack of acute inflammation following WC-Co NP exposure contrasts with earlier in vivo reports regarding WC-Co toxicity in rats, illuminating the critical role of NP dose and exposure time and bringing into question the potential role of impurities in particle samples. (cdc.gov)
in addition, there may be superimposed foci of acute inflammation, organizing pneumonia, and mucostasis. (medscape.com)

These results were compared with lavage and endo- and transbronchial biopsy studies in normal controls and patients with moderate asthma. (nih.gov)

After 55 days, infected diabetic mice exhibited fewer leukocytes in both peritoneal lavage fluid (PeLF) and bronchoalveolar lavage fluid and reduced secretion of interleukin- (IL-) 6 in lungs. (hindawi.com)
The data suggest that diabetic mice present impaired immunological response to Pb18 infection and insulin modulates inflammation by reducing IL-6 levels in lung and CINC-1 levels in spleen and liver homogenates, restoring leukocyte concentrations in PeLF and also restoring populations of dendritic cells and B lymphocytes in lungs of diabetic mice, permitting the host to better control the infection. (hindawi.com)
Neutrophilic inflammation is particularly prominent in COPD where neutrophils degranulate with increasing severity of COPD, resulting in uncontrolled release of proteolytic enzymes (neutrophil elastase and matrix metalloproteinase 9-MMP9) that further damage the lungs ( 4 ). (frontiersin.org)
The reaction can cause inflammation in the air sacs in one or both lungs. (medicalnewstoday.com)
Any fluid filling the lungs can be a deadly complication of pneumonitis if it is not caught early and treated. (medicalnewstoday.com)
METHODS: The amount and composition of phospholipid classes and phosphatidylcholine molecular species were determined in bronchoalveolar lavage (BAL) fluid and lavaged lungs by high performance liquid chromatography (HPLC). (bmj.com)
Histological examinations of the lungs and determination of cell number in the bronchoalveolar lavage fluids (BALFs) were studied. (openrespiratorymedicinejournal.com)

Spherical agglomerated particles of smaller nominal tube dimension were linked to granulomatous inflammation while a mixture of smaller and larger dimensional CNT/F resulted in more severe alveolar injury. (cdc.gov)

After killing of the animals pressure-volume curves were recorded, and bronchoalveolar lavage (BAL) was performed for assessment of protein content and the small/large surfactant aggregate ratio. (nih.gov)
For each 60 ml syringe, you may obtain 30‐50 cc frothy (surfactant), slightly turbid fluid. (cornell.edu)
Surfactant protein A (SP-A) levels in BAL fluid were determined by ELISA and surfactant for functional measurements was isolated from BAL fluid by differential ultracentrifugation. (bmj.com)

Collection of exhaled breath condensate (EBC) has been suggested as a simple, noninvasive, and easily repeatable procedure, and samples from the lower respiratory tract for monitoring airway inflammation and oxidative stress can be obtained with this technique. (rcjournal.com)
11 The measurement of MDA in biological fluids is a widely used test for determination of oxidative stress. (rcjournal.com)
Recent experimental studies reported the occurrence of lung inflammation and oxidative stress following acute and subacute exposure to WPS. (who.int)
Here, we wanted to verify the extent of inflammation and oxidative stress in mice chronically-exposed to WPS and to evaluate, for the first time, its effect on alveolar injury and DNA damage and their association with impairment of lung function. (who.int)
CONCLUSION: We show the persistence of lung inflammation and oxidative stress in mice chronically-exposed to WPS and demonstrate, for the first time, the occurrence of DNA damage and enlargement of alveolar spaces and ducts associated with impairment of lung function. (who.int)

This study was designed to evaluate both the presence and type of airway inflammation in patients with severe asthma. (nih.gov)
Feb. 6, 2020 Eosinophilic chronic rhinosinusitis (ECRS) is a type of airway disease that involves nasal inflammation. (sciencedaily.com)

Bronchial asthma causes symptoms such as wheezing and cough due to chronic airway inflammation, but there is no fundamental treatment for it, leaving a desire for new prevention and treatment methods. (sciencedaily.com)
Pathological inflammation is worsened by chronic bacterial lung infections and susceptibility to recurrent acute exacerbations of COPD (AECOPD), typically caused by viral and/or bacterial respiratory pathogens. (frontiersin.org)
Here, we review emerging mechanisms into why COPD patients are susceptible to chronic bacterial infections and highlight dysregulated inflammation and production of reactive oxygen species (ROS) as central causes. (frontiersin.org)

DP1 gene knockout and/or DP1 inhibition by receptor antagonists markedly reduces airway inflammation, obstruction, hypersensitivity, and pro-allergic cytokine and chemokine production in a mouse model of ovalbumin-induced asthma as well as allergic symptoms in a guinea pig model of allergic conjunctivitis, rhinitis, and asthma. (wikipedia.org)
Asthma, characterized by reversible airflow obstruction, airway inflammation, remodeling, and hyper-responsiveness, is a complex disease with variable phenotype and aberrant T-helper (Th) 2 cytokine profile ( 1 , 2 ). (iiarjournals.org)

Properdin Contributes to Allergic Airway Inflammation through Local C3a Generation. (nih.gov)
Although less is known about an additional receptor, cysLT2, emerging evidence indicates that it likely also contributes to cysLT actions promoting inflammation, vascular permeability, and perhaps fibrosis. (springer.com)
Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. (biovendor.com)

Also, in addition to a decrease in inflammation and mucus around the bronchi, the team found a suppression of proteins that induce eosinophilic inflammation. (sciencedaily.com)

Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease. (frontiersin.org)
The main feature of NSIP is temporally homogenous inflammation and fibrosis, as opposed to the heterogeneity in usual interstitial pneumonia. (msdmanuals.com)

Allergen challenge stimulated P release into the airways of asthmatic patients, and P levels positively correlated with proinflammatory cytokines in human bronchoalveolar lavage (BAL). (nih.gov)
RESULTS: In bronchoalveolar lavage fluid, WPS increased neutrophil and lymphocyte numbers, lactate dehydrogenase, myeloperoxidase and matrix metallopeptidase 9 activities, as well as several proinflammatory cytokines. (who.int)

Conversely, intranasal reconstitution of P to P(-/-) mice at the challenge phase restored airway inflammation to wild-type levels. (nih.gov)
Notably, C3a levels in the BAL of OVA-challenged P(-/-) mice were significantly lower than in wild-type mice, and intranasal coadministration of an anti-C3a mAb with P to P(-/-) mice prevented restoration of airway inflammation. (nih.gov)
RESULTS: BAL fluid of cftrm1HGU/m1HGU mice contained 1.02 (95% confidence interval (CI) 0.89 to 1.16) mumol phospholipid and 259 (239 to 279) ng SP-A. BAL fluid of MF1, BALB/c, C57BL/6, and C3H/He mice contained 0.69 (0.63 to 0.75), 0.50 (0.42 to 0.57), 0.52 (0.40 to 0.64), and 0.45 (0.27 to 0.63) mumol phospholipid, respectively. (bmj.com)
After correction for the different body weights of mouse strains, phospholipid levels in BAL fluid of cftrm1HGU/m1HGU mice were increased by 64 (52 to 76)%, 60 (39 to 89)%, 72 (45 to 113)%, and 92 (49 to 163)%, respectively, compared with controls. (bmj.com)
The increase in phospholipids in BAL fluid of cftrm1HGU/m1HGU mice resulted from an increased fraction of large aggregates which exhibited normal surface tension function. (bmj.com)
In mice, the intranasal administration of S1P might aggravate the antigen-induced airway inflammation. (openrespiratorymedicinejournal.com)

Exposure of guinea pigs to cigarette smoke resulted in progressive protein damage, inflammation, apoptosis and lung injury up to 21 days of the experimental period. (biomedcentral.com)

Following 24-hr exposure, broncho-alveolar lavage fluid and whole blood were collected and analyzed. (cdc.gov)
We hypothesised that mechanisms independent of inflammation contribute to accelerated thrombus formation following exposure to diesel exhaust particles (DEP). (anma.it)

Several studies have demonstrated that IL-17F plays a pivotal role in allergic airway inflammation and induces several asthma-related molecules such as CCL20. (hindawi.com)
IL-17F-induced CCL20 may attract Th17 cells into the airway resulting in the recruitment of additional Th17 cells to enhance allergic airway inflammation. (hindawi.com)
IL-17F is expressed in activated CD4 + T cells, basophils, and mast cells, three important cell types involved in allergic airway inflammation [ 3 ]. (hindawi.com)
Endo Y, Hirahara K, Yagi R, Tumes DJ and Nakayama T: Pathogenic memory type Th2 cells in allergic inflammation. (spandidos-publications.com)
Our aim was to investigate the effects of intranasal application of S1P on antigen-induced airway inflammation in a mouse model of allergic bronchial asthma. (openrespiratorymedicinejournal.com)

Bronchoalveolar lavage fluid has an increased percentage of lymphocytes in more than half of patients, but this finding is nonspecific. (msdmanuals.com)

These results show that P plays a key role in allergen-induced airway inflammation and represents a potential therapeutic target for human asthma. (nih.gov)
Due to the low solubilities of diisocyanates in the aqueous matrix of the lung fluid, the presence of MDI substances results in heterogeneous mixture (two distinct phases - diisocyanate and water). (europa.eu)
METHODS & RESULTS: In both fog machines and shisha pipes heating of glycerol-based fluids before evaporation renders chemical transversion to malodorous acrolein. (who.int)

Find a laboratory with experience reading BAL fluid cytology to determine your differential count. (cornell.edu)

In addition, we exposed male WKY rats to monodispersed Fe 2 O 3 particles by intratracheal instillation (1.3 or 4.0 mg/kg body weight) to examine in vivo inflammation. (biomedcentral.com)

Lung inflammation was identified by computed tomography. (cdc.gov)

The evidence showing inflammation and remodelling in distal airways, and their possible involvement in asthma control and natural history, was reviewed. (ersjournals.com)
Inflammation in distal airways appeared more intense in severe and uncontrolled asthma. (ersjournals.com)

Lower airway inflammation of cattle may reflect irritation, allergy, and/or diffuse infection typical of poor air quality in an environment with inadequate ventilation, sub optimal cleanliness, over crowding and/or commingled age groups of cattle. (cornell.edu)

Research advances over the past several years suggest that cysLT1 also mediates the ability of cysLTs to modulate inflammation, immune responses, and airway remodeling. (springer.com)

CONCLUSION: From our data we conclude that hapten fragrances such as cinnamon aldehyde may during heating in glycerol fluids associate to complete antigens and via inspiration lead to specific immediate type hypersensitivity. (who.int)

Increase in permeability of microvessels determines plasma fluid leakage and accumulation in tissues, leading to edema ( Figure 1 ). (frontiersin.org)
Measures of inflammation were determined in plasma and bronchoalveolar lavage fluid. (anma.it)

Clean the exterior and lumen of the catheter with dilute Chlorhexidine solution, rinse with water, expel any fluid from the lumen and let dry either coiled or hung over a hook in a clean, dust‐free area of the clinic. (cornell.edu)

Bronchoalveolar lavage was performed, and fluid was collected for bacterial culture and molecular analysis. (cdc.gov)
But the latter fluid is the preferred sample to determine the bacterial cause for bronchopneumonia in a herd of cattle. (cornell.edu)

The present study examined the therapeutic effects and action mechanism of a saponin-enriched extract of Asparagus cochinchinensis (SEAC) on airway inflammation and remodeling in an ovalbumin (OVA)-induced asthma model. (spandidos-publications.com)

Patients who recover from HAPE have rapid clearing of edema fluid and do not develop long-term complications. (medscape.com)

Role of neprilysin in airway inflammation induced by diesel exhaust emissions. (arizona.edu)
Dive into the research topics of 'Role of neprilysin in airway inflammation induced by diesel exhaust emissions. (arizona.edu)

The role of inflammation in the pathogenesis of severe asthma chronically treated with high doses of glucocorticoids is poorly understood. (nih.gov)
These findings suggest that inflammation remains in severe symptomatic asthmatics despite treatment with high dose glucocorticoids which may be due to the severity of disease, glucocorticoid treatment, or other as yet undefined factors. (nih.gov)

abstract = "BackgroundMechanical ventilation at birth causes airway injury and lung inflammation in preterm sheep. (edu.au)

6, 2022 Researchers evaluated whether dietary fiber intake was associated with a decrease in inflammation in older adults and if fiber was inversely related to cardiovascular disease. (sciencedaily.com)

Liver from a 62-year-old woman (lung transplant patient) showing acute necrosis of hepatocytes and minimal inflammation. (medscape.com)

Accruing data indicate that SPMs carry protective functions against unrelenting inflammation and infections in preclinical models and human CF systems. (frontiersin.org)
Here, we reviewed their roles and actions in controlling resolution of inflammation, evidence for their impairment in CF, and proofs of principle for their exploitation as innovative, non-immunosuppressive drugs to address inflammation and infections in CF. (frontiersin.org)

Anatomy27

Organisms14

Diseases67

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment42

Psychiatry and Psychology1

Phenomena and Processes29

Disciplines and Occupations3

Health Care7

BALF6

Systemic inflammation6

Bronchoscopy1

Mediators5

Tissue8

Pulmonary8

Inflammatory3

Eosinophils4

Acute inflammation3

Biopsy1

Lungs7

Granulomatous inflammation1

Surfactant3

Oxidative5

Type of airway2

Chronic3

Obstruction2

Contributes3

Proteins1

Fibrosis2

Cytokines2

Mice6

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Exposure2

Allergic5

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Results3

Cytology1

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Airways2

Infection1

Immune1

Hypersensitivity1

Plasma2

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Asthma model1

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