InflammasomesCaspase 1Interleukin-1betaCarrier ProteinsInterleukin-18Receptors, Purinergic P2X7MacrophagesPurinergic P2X Receptor AntagonistsCytoskeletal ProteinsInflammationFrancisellaMice, KnockoutMice, Inbred C57BLNeuronal Apoptosis-Inhibitory ProteinApoptosis Regulatory ProteinsOptic Disk DrusenImmunity, InnateMycobacterium marinumCathepsin BCARD Signaling Adaptor ProteinsAsepsisSignal TransductionInterleukin-1alphaReactive Oxygen SpeciesCalcium-Binding ProteinsReceptors, Pattern RecognitionUric AcidReceptors, Interleukin-1Host-Pathogen InteractionsImmune EvasionCells, CulturedReal-Time Polymerase Chain ReactionFlagellinPrimary Cell CulturePhagosomesMyeloid Differentiation Factor 88Macrophage ActivationToll-Like Receptor 2Adenosine TriphosphateSilicon DioxideToll-Like Receptor 4Caspase InhibitorsLysosomesPotassiumInflammation MediatorsCell DeathCell LineRetinal Pigment EpitheliumHEK293 CellsRNA InterferenceLipopolysaccharidesMonocytesEnzyme ActivationMacrophages, AlveolarAdaptor Proteins, Signal TransducingMacrophages, PeritonealCytokinesInterferon-betaNuclear ProteinsPeritonitisBacterial InfectionsCryopyrin-Associated Periodic SyndromesBlotting, WesternEnzyme-Linked Immunosorbent AssayRNA, Small InterferingDendritic CellsDisease Models, AnimalNod Signaling Adaptor ProteinsBacterial ProteinsVirulenceMitochondriaReverse Transcriptase Polymerase Chain ReactionGene Expression RegulationDown-RegulationApoptosisReceptors, Purinergic P2X4LungUp-Regulation