• In vitro, CCK8 assays and lipid peroxidation assays were performed to analyze cell viability and lipid peroxidation in human renal tubular epithelial cells (HK2 cells) induced by erastin. (bvsalud.org)
  • Immunostaining of the renal specimen of IgAN patients revealed that TFF3 is located in the renal tubular epithelial cells. (omicsdi.org)
  • The necrosis degree and range of renal tubular epithelial cells and inflammatory cell infiltration degree were reduced in the IRI+ MDSC group. (cma-cmc.com.cn)
  • Renal biopsy revealed tubulointerstitial nephritis, with tubular epithelial cell degeneration, tubular atrophy, interstitial inflammation and focal fibrosis. (biomedcentral.com)
  • Characteristic pathological changes are focal lymphocytic infiltration around the epithelial ducts and production of autoantibody by hyperactive B cells [ 2 ]. (biomedcentral.com)
  • Fanconi syndrome, the result of proximal tubule epithelial cell (PTEC) injury leading to proximal RTA (type II RTA), hypophosphatemia, hypouricemia, aminoaciduria, glycosuria and urine loss of low molecular weight proteins, is a rare manifestation of pSS. (biomedcentral.com)
  • Thus, the present study elucidated a novel mechanism by which both BNIP3-mediated and PINK1-PARK2-mediated mitophagy protects against cisplatin-induced renal tubular epithelial cell ferroptosis through the ROS/HO1/GPX4 axis. (ijbs.com)
  • The mechanism of cisplatin-induced acute kidney injury includes oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum stress, which result in apoptosis, necrosis and ferroptosis of renal tubular epithelial cells, causing rapid loss of kidney function [ 8 - 11 ]. (ijbs.com)
  • Histopathological findings revealed a considerable reduction in cellular infiltration, edema, epithelial denudation, and bleeding. (boswellia.org)
  • In rodents, the unilateral ureteral obstruction (UUO) model is widely used to study progressive renal fibrosis because pathological features of CKD, such as tubular dilation, interstitial expansion, loss of tubular mass, leukocyte infiltration, tubular epithelial cell death, and the accumulation of myofibroblasts, are present in this model [ 4 ]. (krcp-ksn.org)
  • Pathogenically, hemodynamic changes are caused by mechanical stretching, apoptosis of epithelial tubular cells, oxidative stress, and inflammation, all of which contribute to progressive renal tubulointerstitial fibrosis [ 5 ]. (krcp-ksn.org)
  • Western blotting, Sirius red staining and transmission electron microscopy were used to analyze renal tubular injury, interstitial fibrosis, and inflammation in the kidneys of UUO and UIR mice. (bvsalud.org)
  • RESULTS: In vivo, vitexin treatment significantly ameliorated renal tubular injury, interstitial fibrosis, and inflammation in the kidneys of UUO and UIR mice. (bvsalud.org)
  • Renal fibrosis is the hallmark of chronic kidney disease progression and is characterized by an exaggerated wound-healing process with the production of renal scar tissue. (omicsdi.org)
  • They appear to be the key factors in driving renal fibrosis, independent of the underlying kidney disease. (omicsdi.org)
  • Tubulointerstitial fibrosis is a common end point of chronic kidney diseases, and preventing its progression is key to avoiding renal failure. (omicsdi.org)
  • The present study demonstrated that LOXL2 is expressed in compartments of renal tissue, where it appears to contribute to the progression of tubulointerstitial fibrosis. (omicsdi.org)
  • Renal expression of trefoil factor 3 mRNA in association with tubulointerstitial fibrosis in IgA nephropathy. (omicsdi.org)
  • The aim of this study is to detect the TFF3 mRNA in kidney and elucidate the relationship between renal TFF3 mRNA and tubulointerstitial fibrosis in IgA nephropathy (IgAN). (omicsdi.org)
  • The renal TFF3 mRNA expression was significantly associated with the urinary TFF3 secretion and the tubulointerstitial fibrosis score in the IgAN group alone. (omicsdi.org)
  • There is no imaging modality available to measure the development of graft fibrosis and current practice involves a biopsy when renal function deteriorates [ 8 ]. (hindawi.com)
  • Monocytes and macrophages are known to play a role in chronic renal allograft damage [ 10 ] and are key promoters of fibrosis in other organs, such as the liver [ 11 , 12 ]. (hindawi.com)
  • It is therefore possible that inhibiting complement activation would reduce inflammation, lead to reduced fibrosis and preservation of renal function. (wjgnet.com)
  • Li X , Peng C , Zhu Z , Cai H , Zhuang Q , . The networks of m 6 A-SARS-CoV-2 related genes and immune infiltration patterns in idiopathic pulmonary fibrosis. (aging-us.com)
  • Therefore, we investigated the effects of DIZE on the progression of renal fibrosis after unilateral ureteral obstruction (UUO), a well-established model of chronic kidney disease. (krcp-ksn.org)
  • On the 7th day after UUO, kidneys were collected for analysis of renal fibrosis (α-smooth muscle actin, phosphorylated SMAD3, transforming growth factor (TGF)-β, Masson's trichrome, and Sirius red staining), inflammation (macrophage infiltration, proinflammatory cytokines/chemokines), apoptosis/necrotic cell death (TUNEL and periodic acid-Schiff staining), and ACE2 activity and messenger RNA (mRNA) expression. (krcp-ksn.org)
  • Treatment with DIZE exacerbated renal fibrosis by upregulating the profibrotic TGF-β/SMAD3 pathway, proinflammatory cytokine/chemokines (interleukin [IL]-1β, monocyte chemoattractant protein-1, IL-6, and macrophage inflammatory protein-2) levels, M2 macrophage accumulation (CD206, IL-4, IL-10, and CX3CL1), and apoptotic/necrotic cell death in the obstructed kidneys of female mice but not male mice. (krcp-ksn.org)
  • DIZE exacerbates UUO-induced renal fibrosis by aggravating tubular damage, apoptosis, and inflammation through independent of angiotensin (1-7), angiotensin II levels, and ACE2 expression/activity, rather than protecting against renal fibrosis after UUO. (krcp-ksn.org)
  • Furthermore, there are no ideal drugs for the treatment or prevention of renal fibrosis, which is a major cause of the development and progression of CKD. (krcp-ksn.org)
  • In addition, renal fibrosis, regardless of its cause, is the final common stage in almost all CKDs [ 2 ]. (krcp-ksn.org)
  • Renal fibrosis is characterized by increased numbers of myofibroblasts, infiltration and accumulation of inflammatory cells, and excessive accumulation of extracellular matrix (ECM) components such as collagen and fibronectin [ 3 ]. (krcp-ksn.org)
  • RESULTS: A decrease in renal function was shown after 2 hours of cold ischemia with tubular necrosis and mild cell infiltration, while after 24 hours of cold ischemia there was severe renal failure with tubular and glomerular necrosis, and leukocyte infiltration. (unica.it)
  • In addition to inflammatory cell infiltration in the bronchial wall 1 , histological analysis of endobronchial biopsy specimens and new methods of blood flow measurements have revealed prominent alterations of the tracheobronchial (airway) vasculature in patients with asthma. (ersjournals.com)
  • In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
  • The results showed that the TFs significantly attenuated cell injury and markedly decreased serum creatinine (Cr) and blood urea nitrogen (BUN) levels in rats. (mdpi.com)
  • The NP rat model was constructed by chronic constriction injury (CCI) surgery in rats. (bvsalud.org)
  • The objective of this study was to determine whether homing of endothelial progenitor cells (EPCs) induced by ischemic preconditioning (IPC) contributed to the protection of renal acute ischemia-reperfusion injury (IRI) in male rats. (annalsoftransplantation.com)
  • Renal gene expression profiles in rats Because the supplement with ginger extract at twenty mg kg showed negligible effects on all phenotypic parameters, compari sons in gene expression have been restricted to water handle, fructose control and fructose ginger 50 mg kg groups. (micrornainhibitors.com)
  • This study aims to explore the role of standardized Boswellia serrata (containing 35 % boswellic acid) in attenuating kidney and liver damage in a model of rats with renal insult. (boswellia.org)
  • Sprague-Dawley rats, exposed to renal injury via ischemia-reperfusion model, were administered a daily regimen of 1000 or 2000 mg/kg Boswellia for seven days then rats were sacrificed on day eight. (boswellia.org)
  • Results Cisplatin challenged rats demonstrated kidney injury as shown by reduced creatinine clearance, increased of plasma BUN, plasma creatinine, and kidney MDA, decreased of kidney GSH levels, and kidney histopathology alterations. (thieme-connect.com)
  • Calcium oxalate (CaOx), the major constituent of most kidney stones, induces inflammatory infiltration and injures renal tubular cells. (biomedcentral.com)
  • citation needed] Tissue swelling and fasciotomy Following ischemia, reperfusion induces local tissue swelling. (wikipedia.org)
  • Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). (mdpi.com)
  • Excess myoglobin may thus cause renal tubular obstruction, direct nephrotoxicity (ischemia and tubular injury), intrarenal vasoconstriction, and acute kidney injury (AKI). (medscape.com)
  • Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
  • This review of literature discusses kidney injury associated with the use of AAS and ADE, highlighting the mechanisms of acute and chronic renal lesion, such as direct renal toxicity, glomerular hyperfiltration and hypercalcemia. (revistanefrologia.com)
  • Future perspectives regarding evaluation and early diagnosis of kidney injury in these patients are also discussed. (revistanefrologia.com)
  • However, the role of γδT cells in CaOx-mediated kidney injury remains unclear. (biomedcentral.com)
  • In inflammatory-mediated kidney injury, a variety of T cells (γδT cells, NKT cells, regulatory T cells) infiltrate the kidney, and the number and subset composition of infiltrating T cells varies among the different forms of kidney injury [ 13 ]. (biomedcentral.com)
  • A significant improvement in renal function and decrease in kidney lactoferrin content was evident in group 1 compared to group 2 at 72 hours, while no significant difference was noted in groups 3 and 4. (unica.it)
  • Clinical evidence suggests that tissue injury in both acute kidney injury and heart failure has immune-mediated inflammatory consequences that can initiate remote organ dysfunction. (biomedcentral.com)
  • Clinical evidence suggests that tissue injury such as acute kidney injury (AKI) is not an isolated event and it has become apparent that much of the increased risk of death is derived from distant complications [ 5 , 6 ]. (biomedcentral.com)
  • IR injury contributes to disease and mortality in a variety of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease and sleep apnea. (wikipedia.org)
  • citation needed] Serum creatinine and BUN may be elevated in the setting of acute kidney injury. (wikipedia.org)
  • citation needed] While some investigations suggest a possible beneficial effect of mesenchymal stem cells on heart and kidney reperfusion injury, to date, none have explored the role of stem cells in muscle tissue exposed to ischemia-reperfusion injury. (wikipedia.org)
  • Organs involved in filtration (e.g., the kidneys and the liver), may be overwhelmed by the high load of cellular break down products, and face injury themselves (e.g., acute kidney injury). (wikipedia.org)
  • The present study evaluated LOXL2 expression in human and mouse kidney tissues, as well as in cultured renal cells. (omicsdi.org)
  • Two cohorts of mice underwent renal transplantation with either a syngeneic isograft or allograft kidney. (hindawi.com)
  • Magnetic resonance imaging (MRI) offers detailed characterization of the kidney structure without using ionizing radiation and is suitable for monitoring renal allograft damage with repeated scanning. (hindawi.com)
  • Outcome of acute kidney injury: how to make a difference? (springeropen.com)
  • Acute kidney injury (AKI) is one of the most frequent organ failure encountered among intensive care unit patients. (springeropen.com)
  • A poor short- and mid-term outcome was also observed in patients with sub-clinical AKI (defined by positive biomarkers of kidney injury but not meeting the current definition of AKI) [ 16 ]. (springeropen.com)
  • Interestingly, even patients who apparently recovered from AKI at ICU discharge (based on serum creatinine) but with positive biomarkers of kidney injury had a higher risk of death during the year following ICU discharge. (springeropen.com)
  • For the first time to our knowledge, we demonstrate that CRELD2 can serve as a sensitive urinary biomarker for detecting ER stress in podocytes or renal tubular cells in murine models of podocyte ER stress-induced nephrotic syndrome and tunicamycin- or ischemia-reperfusion-induced acute kidney injury (AKI), respectively. (jci.org)
  • Nephrotoxicity due to cisplatin is one of the most common clinical causes of acute kidney injury (AKI), which has a poor prognosis and high mortality. (oncotarget.com)
  • Acute kidney injury (AKI) is a primary cause of renal failure and a serious global health concern [ 1 ]. (oncotarget.com)
  • a) Nuclear protein had been extracted from kidney cells 1 day after renal IRI and incubated with an NF-B probe for 25 min (three mice had been sacrificed for every group). (sipurpashut.net)
  • Li demonstrated which the inhibition of TLR4/MyD88 signaling covered mice against ischemia induced severe kidney damage26. (sipurpashut.net)
  • In I/R, DCs take part in the early stage of IRI and play a central function in mediating renal I/R harm21,29 by binding kidney endothelium infiltrating the kidneys30, and priming the adaptive immune system response. (sipurpashut.net)
  • Cisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. (ijbs.com)
  • Here, we investigated the mechanism underlying both BNIP3-mediated and PINK1-PARK2-mediated mitophagy-induced attenuation of ferroptosis in cisplatin-induced acute kidney injury. (ijbs.com)
  • The results showed that cisplatin induced mitochondrial injury, ROS release, intracellular iron accumulation, lipid peroxidation and ferroptosis in the kidney, which were aggravated in Bnip3 knockout , Pink1 knockout or Park2 knockout cisplatin-treated mice. (ijbs.com)
  • Drug-induced acute kidney injury is the second most common cause of acute kidney injury in hospitalized patients, especially in the intensive care unit[ 1 , 2 ]. (ijbs.com)
  • Among all types of acute kidney injury, drug-induced acute kidney injury accounts for 14-37.5% in several studies [ 3 , 2 ]. (ijbs.com)
  • Nephrotoxic drugs, such as antibiotics (gentamicin), diuretics (furosemide), chemotherapeutic drugs (cisplatin) and calcineurin inhibitors (tacrolimus), induce acute kidney injury [ 1 ]. (ijbs.com)
  • During cisplatin treatment, approximately 20%-30% of patients develop acute kidney injury [ 7 ]. (ijbs.com)
  • Elucidating the precise molecular mechanisms underlying cisplatin-induced acute kidney injury will provide evidence for future treatment. (ijbs.com)
  • Acute kidney injury (AKI) is a sudden incident that is linked with a high lethality rate commonly due to distant organ injury. (boswellia.org)
  • A marked increase in TLR9, NF-κB, IL-6, IL-1β, TNF-α, and MDA besides decreased GSH levels were observed in the kidney and liver after renal IRI. (boswellia.org)
  • We conclude that the anti-inflammatory and antioxidant effects of Boswellia could be beneficial in ameliorating kidney and liver damage after AKI and that TLR9 might be the connection that signals liver injury in response to renal damage. (boswellia.org)
  • Over the last few decades, it has been studied that the mechanisms of cisplatin-induced kidney damage are complex and involved numerous cellular and molecular processes including inflammation, apoptosis, accumulation of cisplatin in renal tubular cells via renal drug transporters, Ctr1 and OCT2, and involvement of mitogen-activated protein kinases (MAPK) pathways [ 3 ] [ 4 ]. (thieme-connect.com)
  • In particular, extracellular-regulated kinase (ERK) 1/2, one of the MAPK pathway is considered as an important mediator of signal transduction processes, namely cell survival, cell division, gene expression, and cell metabolism that plays role in injury, death, and inflammation of kidney tubular cells due to cisplatin administration [ 5 ]. (thieme-connect.com)
  • Striated nephrogram which is an appearance of gas in the renal area in emphysematous described for acute pyelonephritis shows discrete pyelonephritis or abscess and the typical mass like rays of alternating hypo attenuation and hyper calcification in end stage renal tuberculosis (Putty attenuation radiating from the papilla to the cortex kidney). (egyptianjournal.xyz)
  • METHODS: In vivo, the effect of vitexin on CKD was evaluated by using mouse models of unilateral ureteral obstruction (UUO) and unilateral ischemia-reperfusion (UIR). (bvsalud.org)
  • The recommended phases of CT scan for Imaging is not routinely indicated in urinary tract evaluating renal infections are a non-contrast scan, infections, however with severe symptoms, high nephrographic phase at 50-90 s and excretory phase risk immunocompromised state, diabetic patients at 2 min if there is obstruction ( 4) . (egyptianjournal.xyz)
  • The vast majority of data regarding vascular reconstructive surgery in pediatric patients come from experience with right ventricular outflow obstruction, midaortic syndrome, renal-artery occlusive disease and hypertension, iatrogenic vascular trauma, and access for hemodialysis. (medscape.com)
  • have compared 3,769 to 13,598 matched patients treated or not treated with renal replacement therapy (RRT) in ICU and observed a higher incidence of end-stage renal disease with RRT (2.63 vs. 0.91/100 patient-years, hazard ratio = 3.23 [2.70-3.86]) [ 20 ]. (springeropen.com)
  • Arrow indicates interstitial inflammatory monocyte infiltration. (jci.org)
  • In patients with progressive CKD there is histological evidence of inflammation in the interstitium and strategies that reduce inflammation reduce renal injury in pre-clinical models of CKD. (wjgnet.com)
  • In this review we discuss current evidence that complement activation contributes to progression of CKD, how complement could cause renal inflammation and whether complement inhibition would slow progression of renal disease. (wjgnet.com)
  • One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
  • Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice. (kanazawa-u.ac.jp)
  • Native kidneys and skeletal muscle were imaged as reference tissues and renal explants analysed by histology and electron microscopy. (hindawi.com)
  • The injury of tissues for CHF is identified more than three disease in the selective 15 nerves. (siriuspixels.com)
  • Each of these hydrocarbons, accordingly, consume immunologically guided to characterize organized to industrialized reperfusion, an artificially contractile correction of the 2+ Source that is carried by albumin iron-molybdenum pacemakers( PRRs), high as the listed modifiers( TLRs) randomized by tissues and features, that are persistently same echocardiographic data on fats. (siriuspixels.com)
  • Poor enhancement severity of acute pyelonephritis and its of renal parenchyma, absent excretion of contrast complications. (egyptianjournal.xyz)
  • C.T has the ability to diagnose and assess renal infection site and extension of infection to pararenal fascia, renal infection unilateral or bilateral and infection focal or diffused. (egyptianjournal.xyz)
  • After muscle injury, massive plasma myoglobin levels exceed protein binding (of haptoglobin) and can precipitate in glomerular filtrate. (medscape.com)
  • Esta revisión de literatura analiza la lesión renal asociada con el uso de AAS y vitaminas ADE, destacando los mecanismos de la lesión renal aguda y crónica, como la toxicidad renal directa, la hiperfiltración glomerular y la hipercalcemia. (revistanefrologia.com)
  • We investigated the renal mRNA expression of TFF3 by real-time PCR analysis in biopsy specimens from patients with IgAN, other glomerulonephritis (OGN) and minor glomerular abnormalities (MGA). (omicsdi.org)
  • Patients presented with different degrees of proximal renal tubule lesion and decreased estimated glomerular filtration rate (eGFR). (biomedcentral.com)
  • Renal involvement is observed in pSS, with both tubular and glomerular abnormalities reported. (biomedcentral.com)
  • Several animal models of allograft rejection exhibit monocyte and macrophage infiltration in allograft tissue [ 13 - 17 ], and these cells have a central role in human chronic allograft damage [ 18 , 19 ]. (hindawi.com)
  • A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
  • Bilateral subcostal incision or median laparotomy should be used for left renal and left adrenal primary tumors. (thoracickey.com)
  • B ) Representative IF images of human renal biopsies obtained from patients with p.H177-R185 del or p.W202S UMOD mutation and from normal kidneys, stained for CRELD2 (green) and uromodulin (red) with a nuclear counterstain (Hoechst 33342, blue). (jci.org)
  • Acute renal failure (ARF) is an important clinical problem with a high mortality and morbidity. (biomedcentral.com)
  • Progressive AKI leads to acute renal failure (ARF)[ 1 ]. (biomedcentral.com)
  • We investigated whether ultrasmall paramagnetic particles of iron oxide- (USPIO-) enhanced magnetic resonance imaging (MRI) can detect experimental chronic allograft damage in a murine renal allograft model. (hindawi.com)
  • The role of monocytes and macrophages in chronic renal allograft damage has been well established [ 9 ]. (hindawi.com)
  • Renal inflammatory diseases range from mild to severe, acute to chronic and may be associated with predisposing risk factors like diabetes mellitus, human immunodeficiency virus (HIV), leukemia, vesico- ureteric reflux and staghorn calculi. (egyptianjournal.xyz)
  • As demonstrated in Fig. 3j,k, TJ-M2010-2 treatment or dual program inhibition decreased renal MPO activity significantly. (sipurpashut.net)
  • Renal ischemia-reperfusion injury (IRI) impaired renal and liver function significantly, but Boswellia attenuated this impairment in a dose-dependent fashion. (boswellia.org)
  • IL-22 is reported to play a key role in several inflammatory diseases, such as drug-induced acute hepatitis, inflammatory bowel diseases, pneumonia, asthma, and renal ischemia-reperfusion injury [ 12 ]. (biomedcentral.com)
  • Sham group (n = 6), mice underwent same anesthetic and surgical procedures except for ischemia induction. (biomedcentral.com)
  • MATERIALS AND METHODS: We randomly divided 34 Macaca cynomolgus monkeys into groups 1 and 2, which received a renal autograft after 2 hours of cold ischemia, and groups 3 and 4, which received the autograft after 24 hours of cold ischemia. (unica.it)
  • We also determined the renal localization of TFF3 and the levels of urinary TFF3 by immunostaining and ELISA, respectively. (omicsdi.org)
  • Above all, PGRN also provides protection in the initial phase following myocardial ischemia-reperfusion injury. (biomedcentral.com)
  • In this study, we found that cross-presentation of tumor antigen by tumor endothelial cells(tECs) promotes infiltration of tumor specific CTLs in tumors. (nii.ac.jp)
  • In addition, histological examination was utilized to assess changes in renal structure. (annalsoftransplantation.com)
  • Graft process biopsies were performed 4 h after reperfusion to assess early immunohistochemical and histological adjustments. (gasyblog.com)
  • This study reports the clinical and pathological features of 12 cases of primary Sjogren syndrome (pSS) with renal involvement presenting with proximal tubular dysfunction in a single center, and investigates the possible correlation of ectopic germinal center formation and megalin/cubilin down-expression. (biomedcentral.com)
  • The objective of present study was to assess the effects of MK-886 and DITPA on renal I/R injury. (biomedcentral.com)
  • Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have made intermediate-term survival after lung transplantation an achievable goal. (ersjournals.com)
  • Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have contributed to increase the 1‐yr patient survival after lung transplantation (LTx) to 70-80% 1 . (ersjournals.com)
  • Nitric oxide production (by iNOS) may play several roles in renal pathophysiology, including induction of tubular damage. (biomedcentral.com)
  • The term cardiorenal syndrome (CRS) is often used to describe this condition and represents an important model for exploring the pathophysiology of cardiac and renal dysfunction. (biomedcentral.com)
  • Renal biopsy remains the gold-standard for detecting allograft rejection but is associated with significant morbidity and mortality. (hindawi.com)
  • Identifying the origins of renal myofibroblasts may elucidate the diverse characteristics and behaviors of myofibroblasts, which in turn could aid in the development of therapeutic strategies for the treatment and prevention of CKD [ 6 ]. (krcp-ksn.org)
  • In addition, ectopic germinal centers characterized by CD21 + follicular dendritic cells were present in the renal interstitium. (biomedcentral.com)
  • We describe the presence of EGCs in the renal interstitium, the prevalence of Th17/IL-17 expression, and alterations in megalin and cubilin expression, to investigate their possible correlation. (biomedcentral.com)
  • Ischemia-reperfusion (IR) tissue injury is the resultant pathology from a combination of factors, including tissue hypoxia, followed by tissue damage associated with re-oxygenation. (wikipedia.org)
  • The activation of renal fibroblasts (NRK-49 F cells) was also analyzed. (bvsalud.org)
  • Stem cells have been implicated in the regeneration of skeletal muscle after traumatic and blast injuries, and have been shown to hone to muscle damaged after exercise. (wikipedia.org)
  • The PDGF family consists of four isoforms (PDGF-A, -B, -C, and -D) and two receptor chains (PDGFR-α and -β), which are constitutively or inducibly expressed in most renal cells. (omicsdi.org)
  • To investigate the effect and mechanism of myeloid-derived suppressor cells (MDSCs) on renal ischemia-reperfusion injury (IRI) in mice. (cma-cmc.com.cn)
  • Therefore, we analyzed ROS amounts in renal cells. (sipurpashut.net)
  • IL-17 secreted by Th17 subtype effector T cells was diffusely detected in the renal proximal tubule, with a negative correlation of IL-17 and megalin expression. (biomedcentral.com)
  • The origins of renal myofibroblasts have been investigated over the last decade as the key reactive cells in renal fibrogenesis. (krcp-ksn.org)
  • Compared with vehicle mice, mice treated with bpV(pic) (specific inhibitor of PTEN) had exacerbated renal damage due to cisplatin-induced AKI. (oncotarget.com)
  • present that TLR2 performed a crucial function in the induction of inflammatory damage in renal I/R25. (sipurpashut.net)
  • Long term studies are had a need to additional delineate the part of dental donor preconditioning against ischemia-reperfusion damage. (gasyblog.com)
  • PURPOSE: We established a primate model to investigate the effects of the antileukocyte function associated antigen 1 (CD 11a) mAb odulimomab (Imtix-Sangstad, Lyon, France) for preventing renal ischemia-reperfusion injury. (unica.it)
  • CONCLUSIONS: This study provides evidence for the validity of this ischemia-reperfusion injury model in primates. (unica.it)
  • The current definition has been expanded into five subtypes whose etymology reflects the primary and secondary pathology, the time frame, as well as cardiac and renal co-dysfunction secondary to systemic disease [ 1 ] (Table 1 ). (biomedcentral.com)
  • Rhabdomyolysis is a syndrome caused by injury to skeletal muscle and involves leakage of large quantities of potentially toxic intracellular contents into plasma. (medscape.com)
  • Moreover, it was observed that, PGRN protects the heart against ischemia-reperfusion injury. (biomedcentral.com)
  • The ischemia-reperfusion injury associated with surgical tourniquets is typically not clinically apparent when used for less than two hours. (wikipedia.org)
  • Sirius Pixels HDe AVC Encoder While renal congestive book into the stimulates assigned confined to these documents, the single animals that are and help their novel determine thus also increased. (siriuspixels.com)
  • All patients diagnosed with primary Sjogren syndrome with renal Fanconi syndrome in Peking Union Medical College Hospital (PUMCH) from 1994 to 2014 were enrolled. (biomedcentral.com)