Infiltration by chronic inflammatory cells. Medical search. Frequent questions

They have proinflammatory functions: they produce effector molecules (reactive oxygen and nitrogen intermediates) and inflammatory cytokines (IL-1 β , TNF α , and IL-6) and participate as inducer and effector cells in polarized Th1 responses. (hindawi.com)
These results suggest that ICTA provides protection against local carrageenan-induced enhanced pain sensitivity, and that the neutralization of proinflammatory cytokines may result in inflammatory cell apoptosis. (iasp-pain.org)
Activities such as impaired angiogenic response and microvascular complications, macrophage and neutrophil function, keratinocyte and fibroblast migration and proliferation, sustained production of pro-inflammatory cytokines and reduced growth factor production has been reported in diabetic animal models 3 , 9 . (scialert.net)
In contrast, inflammatory cytokines are produced in response to inflammation in tissue (10). (researchsquare.com)
Obesity triggers a low-grade chronic inflammation leading to insulin resistance, characterized by increased pro-inflammatory cytokines produced by adipocytes and infiltrated immune cells, which contributes to metabolic syndrome. (bvsalud.org)
The present study also examined the expression of various inflammatory cytokines, MAPK and NF‑κB in TNF‑α/IFN‑γ‑stimulated HaCaT cells. (spandidos-publications.com)
SNL significantly reduced the levels of cytokines released from HaCaT cells stimulated with TNF‑α/IFN‑γ. (spandidos-publications.com)
The results of the current study suggest that SNL exerts a suppressive effect on pro‑inflammatory cytokines in vitro and in vivo through the regulation of the immune system. (spandidos-publications.com)

Macrophage activation has been described as a dynamic process: the same cell may initially induce proinflammatory and cytotoxic reactions and later may take part in the resolution of inflammation and wound healing [ 9 ]. (hindawi.com)
The clinical signs and inflammation caused by MC903 are drastically reduced in MyD88 -/- mice with diminished eosinophil, neutrophil infiltration and Th2 cytokine expression. (nih.gov)
IL-33 is expressed in keratinocytes, and MyD88 signaling in dendritic cells (DCs) is crucial for AD development as inflammation was drastically reduced in DC-specific MyD88 -/- mice (CD11c-cre × MyD88-floxed). (nih.gov)
In this study, we investigated the effects of inflammatory cytokine-targeting aptamers (ICTA), putative neutralizers of TNF-alpha and IL-1 beta activation, on local carrageenan-induced prostate inflammation, allodynia, and hyperalgesia in rats. (iasp-pain.org)
Dr. Enninga and her team are developing novel methods for diagnosing placental inflammation during gestation and looking for clues as to why these maternal cells become activated in the first place. (mayo.edu)
The NLRP3-inflammasome potentially plays a role in the process of activation and inflammation of glomerular mesangial cells as induced by high-glucose conditions. (biomedcentral.com)
The focal inflammation can be destructive not only for the infected cells, but also for the nonparasitized cells. (hindawi.com)
Presence of many small lymphocytes in the liver FNA may indicate chronic inflammation, but is not conclusive. (vin.com)
We aim to limit aneurysm growth by inhibition of inflammation and reducing endothelial cell (EC) activation with immunosuppressive drug azathioprine (Aza). (dna-pksignal.com)
Increased size of submucosal glands in large airways (Reid index: ratio of thickness of mucosal glands to thickness of wall between epithelium and cartilage) -Peribronchiolar chronic inflammation. (slideserve.com)
Bronchiectasis - Permanent abnormal dilation of bronchi and bronchioles, - Usually associated with chronic necrotizing inflammation - Patients have fever, cough, foul-smelling sputum. (slideserve.com)
INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and inflammatory cell (LEUKOCYTES) infiltration. (bvsalud.org)
The neutralization of IL-17 greatly reduces pulmonary neutrophilia, underscoring a key role for IL-17 in promoting chronic airway inflammation. (elsevierpure.com)
These findings emphasize the role of IL-17 in mediating neutrophil-driven pulmonary inflammation and highlight a new mouse model that may be used for the development of novel therapies targeting Th17 cells in asthma and other chronic pulmonary diseases. (elsevierpure.com)
This chronic inflammation can result in trouble swallowing, chest pain, vomiting and impaction of food in the esophagus - a medical emergency. (celldex.com)
Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation. (cdc.gov)
Asthma is a heterogeneous lung disorder characterized by airway obstruction, inflammation and eosinophil infiltration into the lung. (cdc.gov)

Different cell types (neutrophils, macrophages, lymphocytes, mast cells and fibroblasts) are responsible for the reconstruction of the extracellular matrix involving growth factors and inflammatory mediators 6 . (scialert.net)
Qualitatively, inflammatory infiltration in esophagus and colon, with or without mega, was similar, consisting predominantly of T lymphocytes (CD3+), scarce macrophages (CD68+), and rare B lymphocytes (CD20+). (hindawi.com)
We have found that STAT3 hyperactivity in T lymphocytes causes an expansion of Th17 cells, which home preferentially to the lungs. (elsevierpure.com)
On microscopy, renal malakoplakia is certainly seen as a huge collections of plump macrophages with relatively few plasma and lymphocytes cells. (buyresearchchemicalss.net)
The classic histopathologic presentation of erythema nodosum is that of a septal panniculitis with a mixed cellular infiltrate of lymphocytes , histiocytes , giant cells , and occasional eosinophils and a characteristic absence of vasculitis (figures 1-3). (dermnetnz.org)
In vivo blockade of PI3Kδ activity with seletalisib, a PI3Kδ-selective inhibitor, in a murine model of focal sialoadenitis decreased accumulation of lymphocytes and plasma cells within the glands of treated mice in the prophylactic and therapeutic regimes. (ox.ac.uk)
This review will which many cells play a role, in particular mast cells, eosino- phils, and T lymphocytes. (cdc.gov)
Histologically the lungs of WPS-exposed mice had foci of mixed inflammatory cells infiltration in the interalveolar interstitium which consisted of neutrophils, lymphocytes and macrophages. (who.int)

Histopathology of biopsy specimen showed some granuloma with central neutrophils infiltration and adjacent multinucleated giant cells and inflammatory cell infiltration. (jpgmonline.com)
Psoriasis is a chronic inflammatory skin disease, often accompanied by increased infiltration of immune cells, especially neutrophils. (scimea.cn)

Especially, distinction between low-grade lymphoma, simple lymphocytic infiltration in the portal triad and chronic cholangiohepatitis is not possible. (vin.com)
Primary Sjögren's syndrome (pSS) is a chronic immune-mediated inflammatory disease characterised by exocrine gland lymphocytic infiltration and B-cell hyperactivation which results in systemic manifestations, autoantibody production and loss of glandular function. (ox.ac.uk)

The disorder can be confused clinically with rectal cancer or other conditions such as inflammatory bowel disease, even when a biopsy is done. (wikipedia.org)
Biopsy usually shows skin and lymphatics involvement by cancer cells and treatement usually is chemotherapy followed by surgery then radiation. (healthtap.com)
This is further supported by the finding that mast cells are present in the biopsy tissue of some patients who continue to suffer from EoE even after eosinophils have been fully depleted. (celldex.com)

To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research for T. cruzi and to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) and 50 colons (25 with and 25 without megacolon). (hindawi.com)
Inflammatory infiltrate shows an important role in the pathogenesis of chronic chagasic myocarditis [ 6 ] and inflammatory lesions in the enteric nervous system, associated with a drastic reduction in the number of neurons, reinforcing clinical findings in chagasic megacolon/megaesophagus [ 7 - 10 ]. (hindawi.com)
A, Immunostain shows an infiltrate rich in IgG4+ plasma cells. (aad.org)
Innate and adaptive immune cells infiltrate the artery during development of the disease. (bio-thing.com)

IL-17 secretion then leads to neutrophil infiltration and lung epithelial changes, in turn leading to a chronic inflammatory state with increased mucus production and decreased lung function. (elsevierpure.com)

By using single cell RNA sequencing analysis of immune cells in the same model, we establish the functional heterogeneity of macrophages and define an early pro-fibrogenic phase of NICM that is driven by Ccl5- expressing Ly6c high monocytes. (nature.com)
Dr. Enninga investigates conditions in which regulation is not maintained at the maternal-fetal interface, leading to the infiltration of maternal immune cells into the placenta. (mayo.edu)
One biomarker she is particularly interested in is cell-free fetal DNA, which is released into the maternal circulation and may interact with the mother's immune cells to initiate inflammatory responses, especially those controlling the onset of labor. (mayo.edu)
At the early stage occurs persistent oxidative damage caused by reactive oxygen species (ROS), mainly produced by mitochondrial of immune cells 7 . (scialert.net)
Their critical role requires them to maintain physiological traffic and enable homing of cells that largely belong to a specific immune system. (researchsquare.com)
The pathogenesis of anaemia in cancer is multifactorial and includes classical features of the inflammatory anaemia of chronic disease, such as iron restriction within the reticuloendothelial system, an impaired biological activity of erythropoetin and a diminished proliferation of erythroid progenitor cells, all of which are the reflection of a cancer driven activated immune system ( 2 ). (iiarjournals.org)
Abstract] Atherosclerosis is a chronic inflammatory disease of the arterial wall characterized by lipid deposition, plaque formation, and immune cell infiltration. (bio-thing.com)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination, immune cell infiltration and neurodegeneration. (ucalgary.ca)
Our pipeline includes antibody-based therapeutics which have the ability to engage the human immune system and/or directly affect critical pathways to improve the lives of patients with inflammatory diseases and many forms of cancer. (celldex.com)

Histopathological changes including excess collagen deposition around myofibers, cell necrosis, inflammatory cell infiltration, and increased cytokine expression result from eccentric exercise, forced lengthening, exertion-induced injury, and repetitive strain-induced injury of muscles. (cdc.gov)

These conditions create chronic vascular trauma (ischemia/hypoperfusion) in the rectal mucosa, which predisposes it to ulceration, and pressure necrosis. (wikipedia.org)
Histopathologic examination showed extensive ulceration and granulation, with epidermal necrosis and subepidermal edema plus acute and chronic inflammatory cell infiltration. (cdc.gov)

Hyperplasia & metaplasia & chronic inflammatory cell infiltration into the stroma = carcinoma? (healthtap.com)

The inflammatory disease in the pancreas is pancreatitis, and that in the small intestine is inflammatory bowel disease (IBD). (vin.com)

Developmental lesions such as heterotopia of meningothelial cells in the scalp are believed to be the origin of meningiomas under the scalp and skin of the head. (medscape.com)
As the lesions evolve, there is neutrophilic infiltration followed by chronic infiltrates , granulomas and septal fibrosis. (dermnetnz.org)
Extract and methyl vanillate on atopic dermatitis-like skin lesions and TNF-α/IFN-γ-induced chemokines production in HaCaT cells. (spandidos-publications.com)
infected forest rodents had focal degenerative inflammatory lesions of myocardium (3). (cdc.gov)

The common inflammatory diseases in the liver include acute and chronic cholangiohepatitis. (vin.com)
Acute and chronic cholangiohepatitis can be crudely differentiated with fever, neutrophil left shift and toxic changes. (vin.com)

Secondary endpoints include the reduction of symptoms of dysphagia and esophageal intraepithelial infiltration of eosinophils and safety. (celldex.com)
The skin tissue was sectioned to measure the thicknesses of the epidermis and dermis, as well as the numbers of eosinophils, mast cells and CD8 infiltration by H&E, toluidine blue, Masson's trichrome and IHC staining. (spandidos-publications.com)

Therapeutic experiments in SCID mice implanted with Raj] cells showed significantly prolonged survival time with targeted liposomal vincristine compared to either free VCR or vincristine formulated in nontargeted liposomes. (dna-pksignal.com)

Perturbations of macrophage function and/or activation may result in impaired regeneration and fibrosis deposition as described in several chronic pathological diseases. (hindawi.com)
Indeed, several human diseases are characterized by attenuated repair responses and imbalances in the inflammatory response with increased number of infiltrating macrophages [ 3 - 5 ]. (hindawi.com)
Cats often have two or three inflammatory diseases concurrently, in the liver, pancreas and small intestine. (vin.com)
In veterinary medicine, however, especially in feline medicine, triaditis is a newly formed term, and it means inflammatory diseases involving three specific organs, namely the liver, pancreas and small intestine. (vin.com)
The reason why inflammatory diseases commonly occur in those three organs in cats is that they are in proximity connected in the duodenum. (vin.com)
Chemokines and chemokine receptors are critical players in the disease processes of two inflammatory joint diseases: rheumatoid arthritis (RA) and osteoarthritis (OA) (1). (researchsquare.com)
This study details how we found that CXCL1 promoted interleukin (IL)-6 expression in RA and OA synovial fibroblasts (SFs), worsening the inflammatory status in the joints of both diseases. (researchsquare.com)
Chronic hepatitis can be caused by viruses, medications, autoimmune diseases, and other unknown factors. (bvsalud.org)
In certain inflammatory diseases, such as chronic urticaria, mast cell activation plays a central role in the onset and progression of the disease. (celldex.com)
The CDC Surveillance Coordination Group has established a steering committee that is charged with the development of a broad range of case definitions for noninfectious conditions (e.g., environmental or occupational conditions, chronic diseases, adverse reproductive health events, and injuries). (cdc.gov)

Thus, adipose tissue regeneration and anti-inflammatory activity may represent possible mechanisms by which metformin exerts its positive effect on lipid metabolism. (bvsalud.org)
However, AlpaWash and Polysporin presented some additional benefits- anti-inflammatory activity, measured using myeloperoxidase and histological count, as well as fibroplasia and hydroxyproline production, suggesting that skin with a better quality could be formed following these two treatments. (blogspot.com)

Repetitive tasks have also been shown to result in tendon and neural injuries, with subsequent chronic inflammatory responses, followed by residual fibrosis. (cdc.gov)
Our present work suggests that the CXCL1/CXCR2 axis helps to orchestrate inflammatory responses in OA and RA SFs. (researchsquare.com)
KIT is expressed in a variety of cells, including mast cells, which mediate inflammatory responses such as hypersensitivity and allergic reactions. (celldex.com)

Multiple foci of chronic inflammatory cell infiltration were noted in the stroma. (jmedscindmc.com)

In HepG2 cells, exendin-4-reversed lipid deposition induced by palmitate was hampered when SIRT1 was silenced by SIRT1 RNA interference. (diabetesjournals.org)

[ 2 ] The arachnoid cells have several proposed functions, including acting as a structural barrier with cellular wrapping/ensheathing, acting as a conduit for cerebrospinal fluid (CSF) drainage/absorption into dural sinuses/veins (arachnoid villi), epithelial-like/secretory functions, monocytelike functions, trophic support and byproduct detoxification for glial and neuronal cells, and participation in reactive/reparative processes. (medscape.com)
Both non-neoplastic meningothelial cells and meningiomas possess mixed features of epithelial and mesenchymal cells. (medscape.com)
The epithelial lining was about 6-8 layers with a distinct granular cell layer subjacent to cornified layer and basal layer exhibited low cuboidal morphology with absence of palisading of nuclei ( Figure 3 ). (bvsalud.org)

Recent evidence implicates monocytes/macrophages in the etiopathology of cardiac fibrosis, but giving their heterogeneity and the antagonizing roles of macrophage subtypes in fibrosis, targeting these cells has been challenging. (nature.com)
IgG4-positive plasma cells, "storiform"-like fibrosis and obliterative phlebitis are noted histologically. (aad.org)
Human fibroblast monocultures were found to be insufficient to fully replicate in vivo fibrosis outcomes suggesting in vitro predictive potential depends upon more advanced cell culture in vitro models. (cdc.gov)

WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
To assess the therapeutic potential of naringin and the mechanisms involved, we cultured rat glomerular mesangial cells and grouped them according to different glucose concentrations, different action times, different concentrations of MCC950, and different concentrations of naringin.The cell proliferation was measured by MTT assay. (biomedcentral.com)
Naringin also inhibited the proliferation of cells. (biomedcentral.com)
Naringin inhibited the proliferation of cells that were induced by high glucose. (biomedcentral.com)
Furthermore, the conditioned medium of GC-MSCs pretreated with chemotherapeutic drugs was more effective in promoting the proliferation, migration, and stemness of GC cell lines than the conditioned medium of GC-MSCs without chemotherapeutic drugs treatment. (bvsalud.org)
Proliferation of peripheral blood mononuclear cells (PBMCs) co-cultured with metformin-treated UC-MSC-conditioned media was evaluated by dye dilution assay. (bvsalud.org)
BACKGROUND: The phosphatidylinositol 3-kinase delta isoform (PI3Kδ) belongs to an intracellular lipid kinase family that regulate lymphocyte metabolism, survival, proliferation, apoptosis and migration and has been successfully targeted in B-cell malignancies. (ox.ac.uk)

Alternatively activated M2 macrophages comprise cells exposed to low concentrations of M-CSF in the presence of IL-4, IL-13, or IL-10. (hindawi.com)
In vivo , the identification of macrophage phenotype is complicated since macrophages are obviously exposed to a microenvironment that is more complex respect to cell culture conditions, and they display characteristics that do not conform to the in vitro defined phenotypic categories. (hindawi.com)
A class of drugs, Bruton's tyrosine kinase (BTK) inhibitors are currently undergoing phase III clinical trials for the treatment of MS. BTK inhibitors primarily target the activity of B cells, but BTK activation is also downstream of pro-inflammatory signalling pathways in CNS myeloid cells, microglia, and macrophages. (ucalgary.ca)
Existing research into the role of BTK signalling in microglia and macrophages is cursory, and the connection between BTK expression and pro-inflammatory activities remains to be elucidated. (ucalgary.ca)
Lineage tracing of CNS macrophages revealed that both microglia and macrophages express BTK and pBTK without a preference by either cell type. (ucalgary.ca)
Cultured murine macrophages (RAW 264.7) were used to investigate the effects of fracking sand dust (FSD) for its pro-inflammatory activity, in order to gain insight into the potential toxicity to workers associated with inhalation of FSD during hydraulic fracturing. (cdc.gov)

Serum creatine kinase (CK) may show persistent elevation, and muscle biopsies can show inflammatory infiltrates. (wisdompanel.com)

Oligonucleotide aptamers are well known for their stability and flexibility in conjugating various inflammatory molecules. (iasp-pain.org)

The levels of mononuclear cell infiltration, pro-inflammatory cytokine interleukin-1 beta (b), caspase-1 (casp-1), and Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing proteins 1 and 3 (NALP1 and NALP3) in the prostate of rats were increased seven days after carrageenan injection. (iasp-pain.org)

EoE is the most common type of eosinophilic gastrointestinal disease, a chronic inflammatory disease of the esophagus. (celldex.com)

Reviewing the literature, we came across few studies of direct microscopic examination of Trypanosoma cruzi in chronically infected human tissues and we did not find studies evaluating both research on T. cruzi and inflammatory infiltration simultaneously in histological sections of esophagus and colon from chagasic patients with and without mega. (hindawi.com)

Please note: It is possible that disorder signs similar to the ones associated with this Inflammatory Myopathy variant could develop due to a different genetic or clinical cause. (wisdompanel.com)
Therapeutically, glucocorticoids alone or in combination with B-cell depletion with rituximab induces prompt clinical response to IgG4-RD (1). (aad.org)
Chronic Bronchitis - Clinical definition: persistent cough with sputum production for at least three months in at least two consecutive years. (slideserve.com)
Objective To present results of the Kyoto Global Consensus Meeting, which was convened to develop global consensus on (1) classification of chronic gastritis and duodenitis, (2) clinical distinction of dyspepsia caused by Helicobacter pylori from functional dyspepsia, (3) appropriate diagnostic assessment of gastritis and (4) when, whom and how to treat H. pylori gastritis. (gastroscan.ru)
Background: Adverse outcomes in breast cancer patients treated with recombinant human erythropoietin (rhEpo) have been linked to the expression of Epo-receptors (EpoR) in cancer cells, although limited data on the clinical significance of these observations are available. (iiarjournals.org)

A decline in renal function is related to the accumulation of inflammatory cells in the kidneys, which suggests a causative link. (biomedcentral.com)
The large, rapidly Gemcitabine HCl novel inhibtior growing nodules of malakoplakia may mimic renal cell carcinoma in imaging studies. (buyresearchchemicalss.net)
A unifocal renal lesion is usually uncommon and can resemble a necrotic renal cell carcinoma [1]. (buyresearchchemicalss.net)
In addition, co-existing factors such as vitamin deficiency, renal insufficiency, tumour infiltration into the bone marrow and local cytokine production by malignant cells within this compartment further contribute to cancer-related anaemia. (iiarjournals.org)

Apoptosis markers, B-cell lymphoma 2-associated X protein (Bax) and caspase-3, were elevated in ICTA-treated Chronic pelvic pain syndrome (CPPS) rats. (iasp-pain.org)

Although meningiomas commonly arise in locations where meningothelial cells are found, the embryonic origin of intraventricular and pulmonary meningiomas are intriguing. (medscape.com)

The excised mass was diagnosed as an inflammatory polyp based on histopathological examination. (jmedscindmc.com)

Chemokines are well-recognized for their ability to recruit different leukocytes (6) and for their involvement in the migration of circulating cells into or within tissue (7, 8). (researchsquare.com)
n\nApproach and Results Aza and its metabolite 6-mercaptopurine have anti-inflammatory effects on leukocytes. (dna-pksignal.com)

Among cardiac macrophage subtypes, WWP2 dysfunction primarily affects Ly6c high monocytes via modulating Ccl5, and consequentially macrophage infiltration and activation, which contributes to reduced myofibroblast trans -differentiation. (nature.com)
These effects were dependent on the activation of phosphorylated AKT (p-AKT) in GC cell lines. (bvsalud.org)
Given the central role of B cells in pSS pathogenesis, we investigated PI3Kδ pathway activation in pSS and the functional consequences of blocking PI3Kδ in a murine model of focal sialoadenitis that mimics some features of pSS. (ox.ac.uk)

Th17 cells are a proinflammatory subset of effector T cells that have been implicated in the pathogenesis of asthma. (elsevierpure.com)
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) of unknown pathogenesis. (bmj.com)

Mechanistically, we suggest that the VCAN-derived matrikine, versikine, promotes T-cell infiltration through legislation of Batf3-reliant dendritic cells (DC), a uncommon DC subset (21, 22) that's essential for effector T cell trafficking (23), T cell-mediated antitumor immunity (24, 25) and response to different immunotherapy modalities (26C28). (ampkpathway.com)

expression of interleukin-12, CCL5, CCL2, and vascular cell adhesion molecule-1 and inhibition of monocyte-EC adhesion. (dna-pksignal.com)

In medical terminology, there is "triaditis" but it means an inflammatory disease with characteristic three signs. (vin.com)
Dermatomyositis is an idiopathic inflammatory myopathy with characteristic cutaneous findings that occur in children and adults (see the image below). (medscape.com)

Solitary rectal ulcer syndrome or SRUS is a chronic, benign disorder of the rectal mucosa (the lining of the rectum). (wikipedia.org)
Atopic dermatitis (AD) is a chronic Th2 type inflammatory skin disorder. (nih.gov)
Inflammatory Myopathy is an inflammatory muscle disorder characterized by progressive weakness and muscle wasting. (wisdompanel.com)
Inflammatory Myopathy is a disorder associated with infiltration of inflammatory cells into the muscle, leading to chronic myositis. (wisdompanel.com)
IgG4-related disease (IgG4-RD) is a chronic fibro-inflammatory disorder that potentially affects virtually every organ system. (aad.org)
Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting joints with a hallmark of autoantibody production. (scimea.cn)
Asthma is a chronic inflammatory disorder of the airways in treatment of this heterogeneous lung disorder. (cdc.gov)

In response to environmental cues they display a proinflammatory (M1) or an alternative anti-inflammatory (M2) phenotype. (hindawi.com)

Erythropoetin (Epo) is a 30.4 kDa glycoprotein that regulates erythropoesis by stimulating growth, preventing apoptosis and inducing differentiation of red blood cell precursors. (iiarjournals.org)

To explore the impact of intraarticular injection of ropivacaine into knee joint on the postoperative analgesia and local inflammatory response after patellar fracture fixation is the main objective. (ijpsonline.com)

The aim of this study was to evaluate comparatively the inflammatory process in muscular and myenteric plexus of esophagus and colon from chronic chagasic patients with and without mega, with the purpose of ascertaining whether there are similarities between the process in esophagus and colon and between cases with and without evident parasitism in the organ. (hindawi.com)
We studied 50 segments of large intestine and 39 segments of esophagus from chronic chagasic patients obtained by surgery (16 colon and 4 esophagus) or autopsies performed at the Department of Surgical Pathology/Special Pathology from the Hospital of Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil. (hindawi.com)

Chronic diarrhea is characterized by persistent or relapsing diarrhea of 3-4 weeks duration or longer. (vin.com)

In addition, SNL significantly reduced the level of serum IgE and dermal thickness and the infiltration of mast cells and CD8 in the BALB/c mouse model of DNCB‑induced AD. (spandidos-publications.com)

Barzolvolimab is a humanized monoclonal antibody that specifically binds the receptor tyrosine kinase KIT with high specificity and potently inhibits its activity, which is required for the function and survival of the mast cell. (celldex.com)
We look forward to exploring the role of our mast cell depleting agent, barzolvolimab, in this setting and believe learnings from this study may inform expanded development into other GI disorders in the future. (celldex.com)
The primary endpoint of the study is reducing esophageal intraepithelial infiltration of mast cells as assessed by peak esophageal intraepithelial mast cell count. (celldex.com)
Given the lack of effective therapies for EoE and barzolvolimab's potential as a mast cell depleting agent, Celldex believes EoE is an important indication for study. (celldex.com)

Caesalpinia ferrea barks are used in the form of tea and portions to clean injuries and treat wounds and its stem barks infusion to treat enterocolitis, asthma, bruises, chronic cough and wounds. (scialert.net)
Kraneveld AD, Sagar S, Garssen J and Folkerts G: The two faces of mast cells in food allergy and allergic asthma: The possible concept of Yin Yang. (spandidos-publications.com)

In contrast to acute diarrhea that is often a self-limiting problem and does not typically require a comprehensive work-up of the animal, chronic diarrhea cases warrant a step-by-step approach to obtain a diagnosis and formulate an optimal therapeutic plan. (vin.com)
The therapeutic activity of a triterpenoid extract of Centella asiatica was observed in chronic hepatic disorders [ 3 ]. (ijpsonline.com)
We used various experimental assays, including dual 3D cultures of human adipose MSCs (hASCs), quantitative reverse transcription polymerase chain reaction (qRT-PCR), in vitro cell migration, Matrigel tube network formation, Matrigel plug assay, therapeutic assays using an ischemic hind limb mouse model, and immunohistochemical analysis. (bvsalud.org)

KIT signaling controls the differentiation, tissue recruitment, survival and activity of mast cells. (celldex.com)

drugs in targeted therapy of B-cell malignancies. (dna-pksignal.com)

The expression of Interleukin-1β(IL-1β) and Interleukin18 (IL-18) in the cell supernatant were detected by ELISA. (biomedcentral.com)
Further, it reduced the expression of inflammatory factors that are mediated by NLRP3 through the NLRP3-caspase-1-IL-1β/IL-18 signaling pathway, which makes naringin a potentially novel treatment for DKD disease. (biomedcentral.com)
Moreover, metformin inhibits UC-MSC inflammatory activity reducing the expression of IL-6, MCP-1, and COX-2. (bvsalud.org)
We find that maturation of the parvalbumin (PV)-cell network that controls plasticity onset is regulated by a selective re-expression of the embryonic Otx2 homeoprotein. (dna-pksignal.com)
To examine the anti-inflammatory effect of hydroxytyrosol in UV exposed HDFs, the expression of inflammatory interleukins IL-1β, IL-6, and IL-8 were analyzed. (researchgate.net)

Thus, citric acid cycle intermedi- ates are not used for adenosine triphosphate (ATP) production and are shuttled out of the mitochondria, providing precursors for nucleotide, amino acid, and lipid synthesis path- ways for the dividing cell [13]. (who.int)

A study conducted in rats found that the administration of Centella asiatica leaf powder prevented mortality rate due to gross protein deficiency, increased blood protein nitrogen and prevented fatty infiltration of liver [ 2 ]. (ijpsonline.com)

This study validates the popular use of C. ferrea barks in the inflammatory process and suggests PE-Cf as an alternative therapy to healing diabetic wounds. (scialert.net)

Chemokines can be either homeostatic or inflammatory, or display both qualities simultaneously. (researchsquare.com)

Survey experience is sufficient to conclude that laboratory aerosol infection does not occur in the course of routine work with cell cultures and animals not subject to chronic infection. (cdc.gov)

For diabetes induction, rats received alloxan (45 mg kg 1 ) by the intravenous route for pancreatic β cell destruction. (scialert.net)
The PE-Cf accelerates the healing process of diabetic rats, acting both in the inflammatory and proliferative phases. (scialert.net)
It was observed that in male Wistar rats, the administration of asiaticoside derivatives of Centella asiatica caused the restoration of 40% of the damaged liver cells to normal state [ 4 ]. (ijpsonline.com)
Fujii Y, Takeuchi H, Sakuma S, Sengoku T and Takakura S: Characterization of a 2,4-dinitrochlorobenzene-induced chronic dermatitis model in rats. (spandidos-publications.com)

UCP-1-expressing multilocular adipocytes, termed 'beige' or 'brite' (brown-in-white) adipocytes, can also be found interspersed among white adipocytes within SAT under conditions requiring increased heat production (e.g. chronic cold exposure). (springer.com)
Caesalpinia ferrea or Libidibia ferrea (Fabaceae), popularly known as "pau ferro", "jucá" or "jucaína", is widely used in folk medicine for inflammatory conditions. (scialert.net)
this finding, however, is not pathognomonic, as such cells may be seen in other inflammatory conditions. (aad.org)
In general, CXCL1 levels are extremely low under normal physiological conditions and greatly increased during inflammatory conditions. (researchsquare.com)

AD is a chronic inflammatory skin disease and is characterized by erythema, edema, increased pruritus and eczema. (spandidos-publications.com)

But some people also tend to include hepatic lipidosis although it is not an inflammatory disease in nature. (vin.com)
However, it is true that prolonged fasting in cats with chronic pancreatitis may increase the risk of hepatic lipidosis in some animals. (vin.com)

Chronic small bowel diarrhea may also be seen with IBD. (vin.com)
Although etiology is unclear, tropical sprue is thought to result from chronic infection of the small bowel by toxigenic strains of coliform bacteria. (msdmanuals.com)

Anatomy52

Organisms15

Diseases60

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes29

Disciplines and Occupations2

Health Care1

Cytokines8

Inflammation17

Lymphocytes8

Neutrophils2

Lymphocytic infiltration2

Biopsy3

Infiltrate4

Neutrophil infiltration1

Immune9

Cytokine expression1

Necrosis2

Hyperplasia1

Bowel disease1

Lesions4

Acute and chronic2

Eosinophils2

Mice1

Diseases10

Anti-inflammatory activity2

Responses3

Stroma1

Deposition1

Epithelial3

Fibrosis3

Proliferation7

Macrophages6

Infiltrates1

Various inflammatory1

Mononuclear1

Eosinophilic1

Histological1

Clinical5

Renal4

Lymphoma1

Pulmonary1

Histopathological1

Leukocytes2

Activation3

Pathogenesis2

Dendritic Cells1

Inhibition1

Characteristic2

Disorder7

Proinflammatory1

Apoptosis1

Postoperative1

Esophagus2

Persistent1

Dermal1

Mast cell4

Asthma2

Therapeutic3

Recruitment1

Malignancies1

Expression5

Lipid1

Nitrogen1

Suggests1

Simultaneously1

Occur1

Rats4

Conditions4

Edema1

Hepatic2

Small bowel2