DiseasesChemicals and Drugs
Churg-Strauss SyndromeVasculitisSyndromeWegener GranulomatosisMicroscopic PolyangiitisPolyarteritis NodosaAntibodies, Antineutrophil CytoplasmicEosinophilic Granuloma
EosinophiliaGranulomatosisTransient pulmonary infiltratesSystemicEGPAInflammatoryPediatric patientsInterstitialHypereosinophilic syndromePneumoniaMyocarditisLungWegener'sDiagnosisAsthmaNeutrophilsSmall vessel vasculitisAntineutrophilEosinophilsCharacteristicCutaneousAlveolarWidespreadArteriesSymptomsRenalSteroidComplicationInvolvementCoughLungsMigratoryGoodpastureChestManifestationsNeuropathyToxicManifestationCases
Eosinophilia10
  • Eosinophilic granulomatosis with polyangiitis (EGPA)-or, as it was traditionally termed, Churg-Strauss syndrome-is a rare systemic necrotizing vasculitis that affects small-to-medium-sized vessels and is associated with severe asthma and blood and tissue eosinophilia. (medscape.com)
  • In 1951, Churg and Strauss first described the syndrome in 13 patients who had asthma , eosinophilia , granulomatous inflammation, necrotizing systemic vasculitis, and necrotizing glomerulonephritis. (medscape.com)
  • Leukotriene receptor antagonist-associated Churg-Strauss syndrome may occur in asthma patients being treated with leukotriene receptor antagonists, occurring 2 days to 10 months after the antagonist has been started, with features of the syndrome including peripheral eosinophilia, pulmonary infiltrates, and less commonly neuropathy, sinusitis, and cardiomyopathy. (wikipedia.org)
  • Churg-Strauss syndrome is a vasculitis accompanied by asthma and eosinophilia. (qxmd.com)
  • Reports of Churg-Strauss syndrome (a systemic vasculitis accompanied by worsening asthma, pulmonary infil-trates, and eosinophilia) appear to have been coincidental, with the syndrome unmasked by the reduction in prednisone dosage made possible by the addition of zafirlukast or montelukast. (brainkart.com)
  • Idiopathic hypereosinophilic syndrome (HES) is a rare disorder characterized by peripheral eosinophilia exceeding 1500/mm 3 , a chronic course, absence of secondary causes, and signs and symptoms of eosinophil-mediated tissue injury. (wjgnet.com)
  • Given the patient's history of recurrent sinusitis, asthma, eosinophilia, and coronary aneurysms, we diagnosed eosinophilic granulomatosis with polyangiitis ( Churg-Strauss syndrome , CSS) and cardiac involvement, and recommended high-dose corticosteroid treatment. (medscape.com)
  • a syndrome of fleeting pulmonary findings and peripheral blood eosinophilia, is another eosinophilic pulmonary disease. (merckmanuals.com)
  • Pulmonary opacities on chest imaging associated with blood eosinophilia are sometimes called PIE (pulmonary infiltrates with eosinophilia) syndrome. (merckmanuals.com)
  • Daptomycin-induced pulmonary infiltrates with eosinophilia. (medscape.com)
Granulomatosis7
Transient pulmonary infiltrates2
Systemic2
  • After discontinuation of montelukast therapy and administration of systemic corticosteroids the patient's symptoms reversed rapidly and there was prompt resolution of the pulmonary infiltrates. (lookformedical.com)
  • We believe that cysteinyl leukotriene type 1 receptor antagonists are safe and effective drugs for most patients with asthma but caution is needed for those with more severe disease who require systemic corticosteroids, especially if they show characteristics of the atypical allergic diathesis seen in the prodromal phase of Churg-Strauss syndrome. (lookformedical.com)
EGPA1
  • An EGPA-like syndrome is a rare complication that develops in steroid-dependent patients with asthma who have their oral steroid dose reduced after they start treatment with a leukotriene receptor antagonist (eg, montelukast, zafirlukast). (medscape.com)
Inflammatory4
  • Brain biopsy showed transmural, predominantly eosinophilic, inflammatory infiltrates of medium-sized leptomeningeal arteries without granulomas. (bmj.com)
  • The infiltrate consists mostly of mononuclear inflammatory cells and neutrophils to a lesser extent, and in up to 22% of biopsies a small number of eosinophils are also found. (musculoskeletalkey.com)
  • Pathological examination of the lung tissue revealed severe widespread organizing pneumonia with accompanying eosinophil-rich inflammatory infiltrates (Figure 2 ). (biomedcentral.com)
  • These cells form inflammatory infiltrates in the epithelium and smooth muscles of the airway, causing remodeling, including smooth muscle hypertrophy. (nursingce.com)
Pediatric patients3
  • Churg-Strauss syndrome in pediatric patients is well described, but mostly as case reports. (medscape.com)
  • Here we report 2 pediatric patients with Churg-Strauss syndrome manifesting with prominent pulmonary involvement. (qxmd.com)
  • We report these cases to expand the scant knowledge about Churg-Strauss syndrome in pediatric patients and to heighten awareness that this serious disease may affect the pediatric population. (qxmd.com)
Interstitial4
  • Interstitial disease is present frequently, mostly characterized by a mild to severe interstitial infiltrate ( Figs. 3 and 4 ). (musculoskeletalkey.com)
  • The patient subsequently developed acute respiratory distress syndrome (ARDS) followed by rash and acute interstitial nephritis. (biomedcentral.com)
  • Described here is a case of vancomycin induced DRESS syndrome with an atypical presentation, which manifested initially with acute respiratory distress syndrome (ARDS), followed by rash, fever, and acute interstitial nephritis. (biomedcentral.com)
  • Computed tomography showed bilateral diffuse interstitial infiltrates that were refractory to antibiotic treatment. (biomedcentral.com)
Hypereosinophilic syndrome5
Pneumonia2
  • A pneumonia-like syndrome, with lung "infiltrates" can be seen on chest x-ray. (hopkinsvasculitis.org)
  • Ozdemir O. Loeffler's syndrome: a type of eosinophilic pneumonia mimicking community-acquired pneumonia and asthma that arises from Ascaris lumbricoides in a child. (medscape.com)
Myocarditis2
  • The principal causes of morbidity and mortality in Churg-Strauss syndrome are myocarditis and myocardial infarction secondary to coronary arteritis. (medscape.com)
  • There is a noticeable lymphocytic and inflamed cell infiltrate in chronic coxsackie myocarditis. (ontariohomeopath.ca)
Lung3
  • Lung biopsies revealed elements characteristic of Churg-Strauss syndrome, including eosinophilic microabscesses and vasculitis. (qxmd.com)
  • Minimal lung inflammation is normally seen in the inhalation fevers (e.g., organic dust toxic syndrome, metal fume fever and polymer fume fever ). (symptoma.com)
  • He was subsequently treated with high-dose prednisone, resulting in a complete resolution of his symptoms and lung infiltrates. (biomedcentral.com)
Wegener's1
Diagnosis1
  • The diagnosis of Goodpasture syndrome may be secured by demonstrating linear antibody staining of the basement membrane of renal or pulmonary biopsy specimens. (rheumaknowledgy.com)
Asthma2
  • A Churg-Strauss syndrome-like syndrome develops as a rare complication in people with asthma who are steroid-dependent and who are treated with leukotriene receptor antagonists (eg, montelukast, zafirlukast) upon reduction in their oral steroid dose. (medscape.com)
  • Churg-Strauss syndrome (Figure 114) is a small vessel vasculitis occurring in patients with asthma. (hrctpatternrecognition.com)
Neutrophils1
  • On the basis of a recent report that minocycline is effective in the treatment of acne inflammation by acting directly as an antioxidant on infiltrating neutrophils, we investigated whether doxycycline might also be capable of reducing the generation of reactive oxygen species, using human neutrophils and a cell-free, xanthine-xanthine oxidase system. (medicaljournals.se)
Small vessel vasculitis1
Antineutrophil1
  • Keogh KA, Specks U. Churg-Strauss syndrome: clinical presentation, antineutrophil cytoplasmic antibodies, and leukotriene receptor antagonists. (medscape.com)
Eosinophils1
  • Eosinophils were present in infiltrates, but in smaller numbers than lymphocytes. (lookformedical.com)
Characteristic1
  • Immunofluorescent staining of biopsy specimens from the lungs and kidneys of patients with Goodpasture syndrome reveals a characteristic linear pattern of anti-GBM antibody deposition. (rheumaknowledgy.com)
Cutaneous2
  • Blood samples remained sterile during the so-called 'septicemic syndrome' which represents the first phase of this syndrome and were positive for Candida albicans only when cutaneous nodules developed. (medicaljournals.se)
  • A 43-year-old homosexual man with the Acquired Immunodeficiency Syndrome (AIDS) developed cutaneous molluscum contagiosum-like lesions on face, ears, neck, hands and feet. (medicaljournals.se)
Alveolar4
  • Goodpasture syndrome is an autoimmune disorder characterized by pulmonary hemorrhage and rapidly progressive glomerulonephritis in association with antibodies to alveolar and glomerular basement membrane (GBM). (rheumaknowledgy.com)
  • Hemoptysis is the initial complaint in most patients, and alveolar infiltrates may be seen on chest radiographs. (rheumaknowledgy.com)
  • Chest radiographs usually reveal diffuse, extensive alveolar infiltrates. (rheumaknowledgy.com)
  • Alveolar hemorrhage syndromes. (rheumaknowledgy.com)
Widespread1
  • Tests for serum anti-GBM antibodies are most commonly used to diagnose Goodpasture syndrome because of their widespread availability and high sensitivity and specificity. (rheumaknowledgy.com)
Arteries1
  • Churg-Strauss syndrome (CSS), or allergic granulomatous angiitis, is a rare syndrome that affects small- to medium-sized arteries and veins. (medscape.com)
Symptoms1
  • Symptoms of Löffler syndrome are usually mild or absent and tend to spontaneously resolve after several days or, at most, after 2-3 weeks. (medscape.com)
Renal2
  • Various other pulmonary/renal syndromes , such as SLE , cryoglobulinemia , and several types of vasculitis, must be distinguished. (rheumaknowledgy.com)
  • In contrast to some other pulmonary renal syndromes, such as SLE, production of anti-GBM antibodies is usually self-limited. (rheumaknowledgy.com)
Steroid1
  • However, in rare cases, this syndrome has developed when a leukotriene receptor antagonist has been substituted for inhaled steroids ini patients without a history of oral steroid withdrawal. (medscape.com)
Complication1
  • [ 8 ] The Churg-Strauss syndrome-like complication is reported in people whose withdrawal of oral steroids is also facilitated by inhaled steroids. (medscape.com)
Involvement1
  • This provides an explanation for why end-organ involvement of Goodpasture syndrome is typically limited to the lungs and kidneys. (rheumaknowledgy.com)
Cough2
  • The other patient presented at age 6 with cough, weight loss, and radiographic infiltrates. (qxmd.com)
  • A Turkish case report describes a 5-year-old boy with Löffler syndrome caused by A lumbricoides , who initially presented with a 3-day history of cough, dyspnea, wheezing, and intermittent fever. (medscape.com)
Lungs1
Migratory1
  • Loeffler's syndrome (Figure 111) is characterized by migratory opacities with consolidation which may affect all lobes, both centrally and peripherally. (hrctpatternrecognition.com)
Goodpasture4
Chest1
Manifestations1
  • HLA-DRB4 positivity may be a genetic risk factor for the development of Churg-Strauss syndrome and may increase the likelihood of vasculitic manifestations of the disease. (medscape.com)
Neuropathy3
Toxic1
  • ODTS is also called Toxic Organic Dust Syndrome (TODS), grain fever , or pulmonary mycotoxicosis. (symptoma.com)
Manifestation1
  • This is the first case to report pulmonary manifestation as the initial symptom in vancomycin induced DRESS syndrome. (biomedcentral.com)
Cases4