Increases infectivityVitroInhibitVirulenceInfectionPathogenCharacterizationPeptidesAssaysViralProtein11.4MammalianTransmissibilityInhibitorReplicationVaccinationTissueTitrationReductionVirusProteinsVivoAntibodiesSolubleCorrelateDetectableCytotoxicityParasitesAttachmentScientistsTransmissionEvidenceContentCellsMETHODSEnhanceRatesDistributionPresentInternationalHigherCellSimilarFutureFoundCultureData
Increases infectivity1
- Researchers identify a protein in semen that enhances the transmission of HIV in culture, but whether it increases infectivity in humans is not yet known. (the-scientist.com)
Vitro1
- Neutralisation of virus infectivity was assessed in vitro by measurement of green fluorescent protein reporter gene expression. (ox.ac.uk)
Inhibit4
- Scientists at the Gladstone Institute of Virology and Immunology (GIVI) have discovered a new agent that might inhibit the infectivity of HIV. (medicalxpress.com)
- One of them was capable of neutralizing virus infectivity and inhibiting haemagglutination, while the other had no significant neutralizing or haemagglutination-inhibiting capability, but did inhibit virus-mediated haemolysis. (microbiologyresearch.org)
- We investigated whether cytolytic melittin peptides could inhibit HIV-1 infectivity when carried in a nanoparticle construct that might be used as a topical vaginal virucide. (msu.edu)
- Free melittin and melittin-loaded nanoparticles were prepared and compared for cytotoxicity and their ability to inhibit infectivity by CXCR4 and CCR5 tropic HIV-1 strains. (msu.edu)
Virulence2
- Infectivity has been shown to positively correlate with virulence, in plants. (wikipedia.org)
- Evidences pointed out to their participation in Trypanosoma cruzi virulence, infectivity, and purine acquisition. (fiocruz.br)
Infection3
- In epidemiology, infectivity is the ability of a pathogen to establish an infection. (wikipedia.org)
- Even though extensive research is being carried out across the globe to study different aspects of the virus and find out means to contain the infection, there is a gap in research regarding the accurate molecular understanding of the biogenesis of the virus and the factors responsible for the infectivity. (news-medical.net)
- Interpretation: These results suggest that BNT162b2 is moderately to highly effective in reducing infectivity, via preventing infection and through reducing viral shedding. (iucc.ac.il)
Pathogen1
- More specifically, infectivity is the extent to which the pathogen can enter, survive, and multiply in a host. (wikipedia.org)
Characterization1
- Characterization of retroviral infectivity and superinfection resistance during retrovirus-mediated transduction of mammalian cells. (uchicago.edu)
Peptides1
- In the present study, a minilibrary of linear, dimeric and dendrimeric peptides containing clusters of basic amino acids was screened with the aim of identifying peptides able to bind HSPGs and thus block RSV attachment and infectivity. (mattek.com)
Assays1
Viral3
- Title : Emerging Pattern of Rabies Deaths and Increased Viral Infectivity Personal Author(s) : Messenger, Sharon L.;Smith, Jean S.;Orciari, Lillian A.;Yager, Pamela A.;Rupprecht, Charles E. (cdc.gov)
- TZM-bl reporter cells expressing luciferase under the control of the HIV-1 promoter were incubated with HIV-1 NLHX (CXCR4) or HIV-1 NLYU2 (CCR5) viral strains and different doses of soluble CD4 (positive control) or free melittin to determine infectivity and viability. (msu.edu)
- These studies will provide new insights into the key mechanisms facilitating as well as inhibiting viral infectivity. (lu.se)
Protein3
- The primary function of the S protein is infectivity. (news-medical.net)
- This study was undertaken to determine when and where the pathological prion protein (PrP Sc ) and/or BSE infectivity can be found in the small intestine of cattle 4 to 6 months of age, orally challenged with BSE. (biomedcentral.com)
- Mutation in the Spike protein may explain higher infectivity of SARS-CoV-2 and accelerated disease. (immunopaedia.org.za)
11.42
- 11.4 g/L. We measured virus infectivity sequentially on polypropylene plastic, aluminum, and glass slides. (cdc.gov)
- Melittin nanoparticles safely and significantly decreased CXCR4 (IC(50) 2.4 μM and IC(90) 6.9 μM) and CCR5 (IC(50) 3.6 μM and IC(90) 11.4 μM) strain infectivity of TZM-bl reporter cells. (msu.edu)
Mammalian1
- The possible role of intracellular Ca 2+ level in the regulation of guanylyl cyclase activity as well as L. donovani infectivity was explored by measuring the intracellular survival of the parasites in mammalian macrophages after treatments, which decrease or elevate the intracellular Ca 2+ . (ias.ac.in)
Transmissibility2
- A pathogen's infectivity is different from its transmissibility, which refers to a pathogen's capacity to pass from one organism to another. (wikipedia.org)
- Sequential Transmission of Influenza Viruses in Ferrets Does Not Enhance Infectivity and Does Not Predict Transmissibility in Humans. (bvsalud.org)
Inhibitor1
- Of the hit compounds identified, the dendrimer SB105-A10 was the most potent inhibitor of RSV infectivity, with IC50 values equal to 0.35 μM and 0.25 μM measured in Hep-2 and A549 cells, respectively. (mattek.com)
Replication1
- There is an urgent need for information on virus replication, immunity and infectivity in specific sites of the body. (nature.com)
Vaccination2
- The authors state that these results are consistent with those of a study in adults with the Omicron variant, which found no association between vaccination status and infectivity duration. (medscape.com)
- Cite this: Vaccination Status Doesn't Impact Infectivity Timeline in Kids - Medscape - Oct 23, 2023. (medscape.com)
Tissue3
Titration1
- A comparison of polymerase chain reaction and an infectivity assay for human immunodeficiency virus type 1 titration during virus inactivation of blood components. (ox.ac.uk)
Reduction1
- The infectivity assay demonstrated a reduction index of at least 4.5 log10, while PCR showed an average 1.7 log10. (ox.ac.uk)
Virus6
- Regardless of the type of surface, fection of 0.001 onto Vero E6 cells incubated at 37°C in virus infectivity decreased 1 log within 2 h (Table). (cdc.gov)
- Both monoclonal antibodies could enhance virus infectivity of Fc receptor-bearing macrophage-like cells when present at suitable dilutions. (microbiologyresearch.org)
- These data suggest that HIV-1 PCR levels do not parallel HIV-1 infectivity levels during virus-inactivation procedures involved in coagulation factor concentrate production. (ox.ac.uk)
- The infectivity of the air-borne virus decreased so rapidly at a humidity of 50 per cent that it was impossible to secure a 100 per cent mortality rate in the exposed mice even by greatly increasing the dose of virus atomized. (condairgroup.com)
- Didier Trono s'est beaucoup intéressé aux interactions entre les virus et leurs hôtes, ce qui l'a conduit à étudier la biologie de pathogènes comme le VIH et le virus de l''hépatite B, et à créer des outils de transfert génétique dérivés du VIH aujourd'hui utilisés avec succès en thérapie génique. (epfl.ch)
- Usado con microorganismos, virus y parásitos para estudios sobre su capacidad para causar enfermedades en el hombre, animales o plantas. (bvsalud.org)
Proteins2
- The presence of proteins noticeably prolonged infectivity. (cdc.gov)
- 4 h on 10 about the role of interfering substances such as proteins aluminum (Figure 1 panel C). The probable adsorption on SARS-CoV-2 infectivity in the environment. (cdc.gov)
Vivo1
- The objectives of this study were to create a reproducible in vivo animal model of papillomavirus infectivity and to compare the infectivity of byproducts of surgically treated mouse papillomavirus (MmuPV1) warts. (johnshopkins.edu)
Antibodies1
- The Delta variant of SARS-CoV-2, which has become the dominant variant in countries including India and the UK, has most likely spread through its ability to evade neutralising antibodies and its increased infectivity, say an international team of researchers. (eurekalert.org)
Soluble2
- Moreover, treatment with selective inhibitors of soluble guanylyl cyclase also reduced infectivity, even in cases of calcium ionophore-treated parasites. (ias.ac.in)
- As expected, the soluble CD4 positive control inhibited CXCR4 (50% inhibitory concentration [IC(50)] 3.7 μg/ml) and CCR5 (IC(50) 0.03 μg/ml) tropic HIV-1 infectivity. (msu.edu)
Correlate1
- therefore, lack of visible lesions does not correlate with lack of potential infectivity. (medscape.com)
Detectable1
- In doing so nearly all of the cattle, from 4 up to 44 mpi, had detectable amounts of PrP Sc and/or infectivity in the distal ileum. (biomedcentral.com)
Cytotoxicity1
- SB105-A10 strongly reduced RSV infectivity in this model and presented no signs of cytotoxicity or pro-inflammatory effects. (mattek.com)
Parasites3
- Parasites loaded with intracellular Ca 2+ chelators displayed significantly decreased infectivity and cyclic GMP level. (ias.ac.in)
- In contrast, pretreatment with Ca 2+ ionophores, which elevated Ca 2+ levels in L. donovani, significantly enhanced the cyclic GMP level as well as the infectivity of the parasites. (ias.ac.in)
- Taken together, the partial silencing and overexpression of the TcNTPDase-1 gene generated viable parasites with low and high infectivity rates, respectively, corroborating that the enzyme encoded for this gene plays an important role to the T. cruzi infectivity. (fiocruz.br)
Attachment1
- Under certain conditions, SEVI can increase HIV infectivity 100,000 times by facilitating the attachment of viruses to target cells. (medicalxpress.com)
Scientists2
- Why would scientists NOT want to demonstrate infectivity of an agent that they propose is indeed infectious? (the-scientist.com)
- Is it that they are really obsolete, or do scientists really need an explanation for their inability to demonstrate infectivity of their hypothetical pathogenic microbes? (the-scientist.com)
Transmission1
- Nous en concluons que le cycle de transmission est sérieusement affaibli après la deuxième distribution massive de médicaments. (who.int)
Evidence1
- However, evidence for BSE infectivity or PrP Sc accumulations in other parts of the bovine small intestine, other than the distal ileum, has not been convincingly demonstrated for either experimentally or naturally occurring cases. (biomedcentral.com)
Content1
- Together these results suggest a possible link between guanylyl cyclase, intracellular Ca 2+ content and parasite infectivity. (ias.ac.in)
Cells3
- Based on VK2 viability, melittin nanoparticles were tested for prevention of CXCR4 and CCR5 tropic HIV-1 infectivity and viability of TZM-bl reporter cells. (msu.edu)
- 2 μM were not cytotoxic and were highly effective in reducing HIV-1 infectivity for both CXCR4 and CCR5 strains in TZM-bl reporter cells, while VK2 vaginal cell viability was adversely affected at all free melittin doses tested. (msu.edu)
- HIV-1 infectivity was measured by a syncytial infectivity assay in C8166 cells and then compared with levels determined by nested HIV polymerase chain reaction (PCR). (ox.ac.uk)
METHODS1
- It reviews recent insights into the molecular nature of the agent, methods for agent and disease detection and the developments in removal and inactivation of TSE infectivity. (bvsalud.org)
Enhance1
- Because SEVI can so greatly enhance HIV infectivity, supplementing current HIV microbicide candidates with SEVI inhibitors, such as surfen, might increase their potency and overall effectiveness," Greene explained. (medicalxpress.com)
Rates1
- Microfilaria uptake, infectivity rates and number of Wuchereria bancrofti L3 per mosquito were assessed. (who.int)
Distribution2
- The scientific basis for the current SRM regulations concerning the gut is based on the wide distribution of infectivity in the intestine of TSE infected sheep and on BSE studies that have had a limited scope. (biomedcentral.com)
- Des moustiques élevés en labora- toire ont été nourris sur 30 volontaires après 2 campagnes de distribution massive de médicaments. (who.int)
Present1
- Moreover, a non-octarepeat fifth-copper binding site is present where copper coordination seems to control infectivity. (sissa.it)
International1
- Das, Pijush K. (2006) Regulation of guanylyl cyclase by intracellular Ca 2+ in relation to the infectivity of the protozoan parasite, Leishmania donovani International Journal of Biochemistry & Cell Biology, 38 (8). (ias.ac.in)
Higher1
- Lower infectivity was correlated with higher IgG concentrations (R=0.36, p=0.01). (iucc.ac.il)
Cell2
- Researchers performed nasal swabs every other day for 10 days, sending the swab to a lab to be tested for cytopathic effect (CPE), or cell death, an indicator of infectivity. (medscape.com)
- Alterations to the composition or architecture of the mycobacterial cell envelope can affect the macrophage infectivity of the bacillus. (microbiologyresearch.org)
Similar1
- Among vaccinated children, the duration of infectivity was similar for children who received a booster and for those who had not. (medscape.com)
Future1
- Because SEVI can markedly influence HIV infectivity, it forms a rather attractive target for future therapies" said Greene. (medicalxpress.com)
Found1
- BSE infectivity was found not only in the ileum and ileocaecal junction but also in the jejunum. (biomedcentral.com)
Culture1
- But the requirements to culture microorganisms and demonstrate infectivity may have become obsolete. (the-scientist.com)