Infections by vaccine. Medical search. Frequent questions

Epidemiologists are adjusting their expectations for the future course of the pandemic after data from a recent outbreak in Massachusetts in the US suggest that while vaccination remains highly protective against the worst consequences of infection, it may not be sufficient on its own to stop the spread of the delta variant. (bmj.com)
New study results suggest that vaccination against the human papillomavirus (HPV) may sharply reduce oral HPV infections that are a major risk factor for oropharyngeal cancer , a type of head and neck cancer . (cancer.gov)
To investigate the relationship between HPV vaccination and oral HPV infection, the researchers analyzed data for 2,627 young adults who participated in NHANES , a national survey that assesses the health of a representative slice of the US population. (cancer.gov)
The prevalence of oral infections with these four HPV types was 1.61% in unvaccinated young adults versus 0.11% in vaccinated young adults-an 88% reduction in HPV prevalence with vaccination. (cancer.gov)
Vaccination rates were low overall, with only 29.2% of women and 6.9% of men in the study population reporting having received at least one dose of an HPV vaccine before age 26. (cancer.gov)
Consequently, apical membrane antigen 1 has been a target of vaccine development but vaccination with apical membrane antigen 1 alone in controlled human malaria infections failed to protect and showed limited efficacy in field trials. (nature.com)
Here we show that vaccination with AMA1-RON2L complex in Freund's adjuvant protects Aotus monkeys against a virulent Plasmodium falciparum infection. (nature.com)
Vaccination with AMA1 alone gave only partial protection, delaying infection in one of eight animals. (nature.com)
Our approach to improving the quality of antibodies elicited by AMA1 vaccination is to develop a vaccine that more closely mimics the AMA1 structure on the invading merozoite. (nature.com)
The conjugate vaccine (MCV4, protecting against serogroups A, C, W, and Y) is preferred for people 9 months to 55 years old and is used for routine childhood vaccination (see CDC: Meningococcal ACWY vaccine information statement ). (msdmanuals.com)
The MCV4 vaccine is a part of the routine vaccination schedule recommended for children (see CDC: Child and Adolescent Immunization Schedule by Age ). (msdmanuals.com)
And in a case-control study published in the journal , Asaf Shemer, MD, of Shamir Medical Center in Be'er Ya'akov, Israel, and colleagues found no association between recent vaccination with the Pfizer-BioNTech COVID-19 vaccine and risk of facial nerve palsy. (medpagetoday.com)
Israel is a leading country in vaccination rates per capita, exclusively using the Pfizer-BioNTech vaccine. (medpagetoday.com)
We surveyed 1,736 school girls to assess HPV vaccine coverage and established the Adverse Event Following Immunisation (AEFIs) Surveillance for HPV vaccine to monitor any AEFIs related to HPV vaccination. (bmj.com)
The vaccine is well tolerated and there is no evidence that the vaccination program had negative impact on the current cervical screening scheme. (bmj.com)
This is the first study to explore the possible impact of HPV vaccination on oral HPV infections. (mdanderson.org)
Background: Israel recently initiated a rapid nationwide COVID-19 vaccination campaign to immunize persons ≥16 years of age and used exclusively Pfizer-BioNTech BNT162b2 mRNA COVID-19 vaccine according to schedule (two doses, 21 days apart). (ssrn.com)
Methods: We used national surveillance data from the first 112 days (Dec 20, 2020 ‒ Apr 10, 2021) of Israel's vaccination campaign to estimate averted burden of four outcomes: SARS-CoV-2 infections and COVID-19-related hospitalizations, severe or critical hospitalizations, and deaths. (ssrn.com)
The study demonstrated that a combination of intramuscular PD1-based receptor-binding domain (RBD) DNA vaccine (PD1-RBD-DNA) prime and intranasal live attenuated influenza-based vaccine (LAIV-HK68-RBD) boost vaccination regimen induced the strongest mucosal broadly neutralising antibodies and lung resident memory CD8 T cells, which prevented live SARS-CoV-2 nasal challenges in two animal models. (hku.hk)
Although the current vaccination reduced rates of hospitalisation, severity and death significantly, these vaccines are much less effective in preventing SARS-CoV-2 respiratory transmission, which has posted great challenges for the pandemic control. (hku.hk)
When two vaccinated mouse models were challenged at the memory phase, 35 days after the second vaccination, prevention of robust SARS-CoV-2 infection in nasal turbinate was achieved primarily by the heterologous combination regimen besides consistent protection in lungs. (hku.hk)
The vaccine has been controversial, with some parents worried about possible health risks, and others worrying that vaccination could encourage earlier sexual activity . (keranews.org)
Many insurers cover HPV vaccination, and the federally sponsored Vaccines for Children program provides it free of charge for qualified patients. (keranews.org)
Again, there's no consistent pattern of deaths that have occurred after vaccination that would give us any cause to be concerned" that the vaccine was responsible. (keranews.org)
Stanford Medicine researchers have shown that prior SARS-CoV-2 infection reduces killer T cells' response to vaccination. (stanford.edu)
The good news is that vaccination after having had COVID-19 does somewhat boost the numbers and battle-readiness of this SARS-CoV-2-infection-impaired killer T cell population - just not nearly as much as if vaccination had preceded infection. (stanford.edu)
Of a total of 36,523 patients who did not have any evidence of existing or previous SARS-CoV-2 infection at the time of vaccination, 170 COVID-19 cases were reported with onset at least 7 days after the second dose was received. (onclive.com)
The primary end points of the trial comprised COVID-19 infection prevention in those who had not been infected with SARS-CoV-2 before vaccination and prevention of COVID-19, irrespective of whether patients had previous SARS-CoV-2 infection. (onclive.com)
Additionally, a 52.4% vaccine efficacy (95% CI, 29.5-68.4) was reported between dose levels 1 and 2, which indicates early onset of a partially protective effect of vaccination. (onclive.com)
COVID-19 vaccines are highly effective, but they do not block the virus 100% of the time, meaning that some breakthrough infections occur after vaccination. (850wftl.com)
The recommended vaccination schedule was inactivated vaccine against diphtheria, tetanus, pertussis, polio, and Haemophilus influenzae type b (DTaP-IPV-Hib) administered at ages 3, 5, and 12 months and MMR at age 15 months. (flutrackers.com)
Models were adjusted for comorbidities, long-term care facility residence, prior infection (for PF vac), country of birth, socio-economic conditions, and time since last vaccination (for PF inf). (lu.se)
PF vac was above 90% during the first month after vaccination, regardless of the number of vaccine doses. (lu.se)

Despite the high level of vaccine efficacy, a small percentage of fully vaccinated persons (i.e. received all recommended doses of an FDA-authorized COVID-19 vaccine) will develop symptomatic or asymptomatic infections with SARS-CoV-2, the virus that causes COVID-19 ( 2 - 8 ). (cdc.gov)
For this surveillance, a vaccine breakthrough infection is defined as the detection of SARS-CoV-2 RNA or antigen in a respiratory specimen collected from a person ≥14 days after receipt of all recommended doses of an FDA-authorized COVID-19 vaccine. (cdc.gov)
The MenB vaccine is given in two doses injected into a muscle. (msdmanuals.com)
As of May 15, 2021, the Vaccine Adverse Events Reporting System (VAERS) showed 1,743 events of Bell's palsy or facial paralysis after about approximately 270 million COVID-19 vaccine doses among 156 million individuals. (medpagetoday.com)
One of Papua New Guinea's leading doctors says Australia's promise to share COVID-19 vaccine doses is of vital importance. (abc.net.au)
Professor Mola welcomed Wednesday's announcement by Prime Minister Scott Morrison that Australia would share 8,000 vaccine doses and provide a range of other health supplies. (abc.net.au)
Methods Two doses of bivalent HPV vaccine were given to 5th grade girls in Phra Nakhon Si Ayutthaya province at 0 and 6 months. (bmj.com)
Serology studies showed that neutralizing activity against the Omicron variant decreased substantially in recipients of two COVID-19 vaccine doses 9 , 10 . (nature.com)
CDC officials say that HPV vaccines have a very good track record for safety following distribution of 56 million doses in this country. (keranews.org)
Maximum protection with the vaccine was reported at 2 doses. (onclive.com)
I'm beyond grateful to have received two doses of vaccine and, more recently, a booster - I'm certain that without them I would be doing much worse," he said. (northernpublicradio.org)

6 ), in most of these case reports, such as for our case, of 4 COVID-19 Vaccines, the source of contamination was unknown. (cdc.gov)
Frequency and Korea introduced 4 COVID-19 vaccines: ChAdOx1 clinical implications of the isolation of rare nontuberculous nCov-19 (AstraZeneca, https://www.astrazeneca. (cdc.gov)
COVID-19 vaccines are a critical tool for controlling the ongoing global pandemic. (cdc.gov)
The Food and Drug Administration (FDA) has issued Emergency Use Authorizations for three COVID-19 vaccines for use in the United States. (cdc.gov)
A comparison of patients with 63,551 matched individuals who were vaccinated from Jan. 1 to March 31, 2021, showed that the incidence of Bell's palsy was lower among people who received COVID-19 vaccines. (medpagetoday.com)
The mRNA COVID-19 vaccines also showed no higher safety signal for facial paralysis than other vaccines in VigiBase, the World Health Organization pharmacovigilance database, earlier this year. (medpagetoday.com)
One of the former U.S. officials who led the COVID-19 response during the Trump administration said July 22 that COVID-19 vaccines were not expected to protect against infection. (theepochtimes.com)
The Moderna and Pfizer COVID-19 vaccines were granted emergency use authorization in late 2020 to prevent symptomatic COVID-19, and were promoted by many health officials, including Birx. (theepochtimes.com)
Timely evaluation of the protective effects of Coronavirus Disease 2019 (COVID-19) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern is urgently needed to inform pandemic control planning. (nature.com)
The available coronavirus disease 2019 (COVID-19) vaccines have shown their effectiveness in clinical trials. (mdpi.com)
It's natural to wonder if highly effective COVID-19 vaccines are leading to the emergence of variants that evade the vaccine - like dark peppered moths evaded birds that hunted them. (org.in)
Secord says unlike the Pfizer and Moderna COVID-19 vaccines, the Novavax vaccine does not use messenger RNA. (wdet.org)

MSD Brazil and Instituto Butantan, initiated in 2012, for human papillomavirus (HPV) and Hepatitis-A vaccine products. (merck.com)
A vaccine against human papillomavirus - the most common sexually transmitted infection and the cause of almost all cervical cancer - is dramatically reducing the prevalence of HPV in teenage girls. (keranews.org)
In the first four years of immunizations, infections from the four strains of human papillomavirus targeted by the vaccines plummeted by more than half among 14-to-19-year-olds in the United States. (keranews.org)

Herd immunity is not relevant as we are seeing plenty of evidence of repeat and breakthrough infections. (bmj.com)
Andrew Noymer, an epidemiologist at the University of California at Irvine, said, "Although most cases did not result in hospital admission, showing the vaccine works in an important way, this study is portentous for the achievement of herd immunity. (bmj.com)
Even though FDA-authorized vaccines are highly effective, breakthrough cases are expected, especially before population immunity reaches sufficient levels to further decrease transmission. (cdc.gov)
A recent study in Mali found no difference in time-to-infection in both children and adults, indicating no pre-erythrocytic immunity, but adults were significantly protected from clinical disease. (nature.com)
These observations indicate the possibility of developing a vaccine that would accelerate the acquisition of protective immunity to disease in children. (nature.com)
Even if we get the vaccine this week, it will only start producing immunity in two or three weeks' time,' he told 7.30. (abc.net.au)
6 Victorian Infectious Diseases Reference Laboratory Epidemiology Unit at The Peter Doherty Institute for Infection & Immunity, The University of Melbourne and Royal Melbourne Hospital, Parkville, Victoria, Australia. (nih.gov)
The findings provided the proof-of-concept that vaccine-induced robust mucosal immunity is necessary for preventing SARS-CoV-2 nasal infection, which has significant implication for ending the ongoing COVID-19 pandemic. (hku.hk)
Soon after the Pfizer-BioNTech-designed COVID-19 vaccine became available, Davis, who directs Stanford's Institute for Immunity, Transplantation and Infection , and his colleagues set out to determine how it worked. (stanford.edu)
Even though antibody levels alone "are not necessarily indicative of waning immunity," this same study goes on to explain, "in this case given the higher risk of infection after aP (acellular pertussis) vaccine with time, it is strongly suggestive of it. (naturalnews.com)
It's a little science-heavy for the average person to understand, but suffice it to say that aP vaccines for pertussis, including DTaP, might appear to work initially, but ultimately fail to provide long-term protection from, also known as real immunity to, disease. (naturalnews.com)
The temporary "immunity" - if you can even call it immunity - provided by the DTaP vaccine is illusory at best. (naturalnews.com)
This suggests that protective immunity by the mRNA vaccines tested here are likely retained against the B.1.617.1 variant. (biorxiv.org)
Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants. (bvsalud.org)
Following either Delta or Omicron breakthrough infection , limited variant-specific cross-neutralizing immunity was observed. (bvsalud.org)
OBJECTIVES: Evidence on waning patterns in protection from vaccine-induced, infection-induced, and hybrid immunity against death is scarce. (lu.se)
A plague vaccine is used for an induction of active specific immunity in a susceptible organism to plague by means of administration an antigenic material (a vaccine) via a variety of routes to people at risk of contracting any clinical form of plague. (wikipedia.org)

In large, randomized-controlled trials, each vaccine was found to be safe and efficacious in preventing symptomatic, laboratory-confirmed COVID-19 ( 1 - 3 ). (cdc.gov)

When Pfizer-BioNTech and Moderna revealed adverse events in their trials, concerns about Bell's palsy and the vaccines grew, observed C. W. David Chang, MD, of the University of Missouri in Columbia, writing in an invited commentary accompanying the two papers. (medpagetoday.com)
Pfizer in November released initial trial results on the vaccine, which is currently under review by health regulators in both the United States and Europe. (cbc.ca)
Pfizer said severe illness occurred within three months in six infants whose mothers received the vaccine, compared with 33 infants from the placebo group who contracted serious RSV infections. (cbc.ca)
On Tuesday, Feb. 28, 2023, a panel of U.S. Food and Drug Administration advisers narrowly backed an experimental vaccine from Pfizer that could become the first shot to protect older adults against the RSV respiratory virus. (wboy.com)
When VRBPAC reviewed Abrysvo in May, Pfizer presented data that found neutralizing antibodies against RSV was higher in infants whose mothers received the vaccine through six months of age. (wboy.com)
We are incredibly grateful to the clinical trial participants and study investigator teams around the world, as well as our Pfizer colleagues, for their commitment to making this vaccine available," Pfizer Senior Vice President Annaliesa Anderson said in a statement. (wboy.com)
The Pfizer/BioNTech mRNA vaccine directed at COVID-19 is much better than natural infection at revving up key immune cells called killer T cells to fight future infection by SARS-CoV-2, the virus that causes COVID-19, Stanford Medicine investigators have found. (stanford.edu)
A panel of experts who advise the US Centers for Disease Control and Prevention on immunisation met on Tuesday to discuss the vaccine for kids made by Pfizer and BioNTech. (dailymaverick.co.za)
The meeting takes place on the day Pfizer raised its forecast for the year on the strength of its vaccine sales and projected 2022 revenue for the shot above analysts' expectations. (dailymaverick.co.za)
The authorization, which was granted to Pfizer and BioNTech, follows the first Vaccines and Related Biological Products Advisory Committee meeting from the FDA for the consideration of an Emergency Use Application for a COVID-19 vaccine candidate. (onclive.com)
Listen: How the Novavax vaccine is different than Pfizer and Moderna's vaccines. (wdet.org)

In the UK the expert advisory board SAGE predicted that new variants will eventually overcome existing vaccines. (bmj.com)
CDC is working with state and territorial health departments to investigate SARS-CoV-2 infections among persons who are fully vaccinated and to monitor trends in case characteristics and SARS-CoV-2 variants identified from persons with these infections. (cdc.gov)
The proportion of reported vaccine breakthrough infections attributed to variants of concern has also been similar to the proportion of these variants circulating throughout the United States. (cdc.gov)
Infection of vaccinated people with Beta, Delta, and future coronavirus variants is expected. (independent.co.uk)
On the contrary, taking data together from the laboratory, animal studies, and trials of other similar vaccines we can be confident that the Oxford vaccine will be highly effective at preventing severe disease and death with Beta, just as it does with Alpha and Delta variants. (independent.co.uk)
The confused messaging about Beta variants and vaccine effectiveness undermines our best tool for preventing death from Covid-19: the vaccines. (independent.co.uk)
We applied the VE-GD model to predict protection mediated by existing vaccines against new genetic variants and validated the results by published real-world and clinical trial data, finding high concordance of predicted VE with observed VE. (nature.com)
The VE-GD framework enables predictions of vaccine protection in real time and offers a rapid evaluation method against novel variants that may inform vaccine deployment and public health responses. (nature.com)
However, the protective effect of the various vaccine products is challenged by new genetic variants. (nature.com)
Among all the influencing factors, emerging genetic variants relative to the vaccine strain play a critical role in determining vaccine effectiveness. (nature.com)
With continuous emergence of SARS-CoV-2 variants of concerns including the rapidly spreading of immune escape Omicron strain, it is urgent to discover a more effective vaccine strategy to block or reduce nasal transmission of SARS-CoV-2. (hku.hk)
But with just under 40 per cent of people in the world having received a dose of a vaccine - only 2 per cent in low-income countries - and nearly a million new infections occurring globally every day , the emergence of new, more contagious variants, like delta, is being driven by uncontrolled transmission, not vaccines. (org.in)
The fact that it is only a small number of the viruses that start the next infection is the critical, random factor that limits the probability that new variants will arise. (org.in)
The biotech firm says its vaccine also works against variants. (wdet.org)
Novavax , a biotech firm in Delaware, says i ts vaccine is highly effective at preventing moderate to severe infections caused by the SARS-CoV-2 virus and some of its variants . (wdet.org)
The recent emergence of SARS-CoV-2 variants that are less sensitive to neutralization by convalescent sera or vaccine-induced neutralizing antibody responses has raised concerns. (biorxiv.org)
A second wave of SARS-CoV-2 infections in India is leading to the expansion of SARS-CoV-2 variants. (biorxiv.org)
These results suggest that Omicron breakthrough infections are less immunogenic than Delta , thus providing reduced protection against reinfection or infection from future variants. (bvsalud.org)

port vaccine effectiveness (VE) against mpox was based on All mpox, gonorrhea, and syphilis diagnoses in New York human immunologic and animal challenge studies ( 1 - 3 ). (cdc.gov)
It should stress vaccination's high impact on death and hospital admission rates but make clear that vaccine effectiveness against infection is lower, the document said, urging the CDC to "acknowledge that the war has changed. (bmj.com)
Future policy decisions should be driven by the effectiveness of vaccines against hospitalisation and death. (independent.co.uk)
Based on 78 vaccine efficacy or effectiveness (VE) data from 49 studies and 1,984,241 SARS-CoV-2 sequences collected from 31 regions, we analyzed the relationship between genetic distance (GD) of circulating viruses against the vaccine strain and VE against symptomatic infection. (nature.com)
Most investigations of vaccine efficacy have focused on these products' ability to generate antibodies, whose infection-blocking effectiveness can be measured in laboratory glassware with relative ease. (stanford.edu)

First, the number of reported COVID-19 vaccine breakthrough cases is likely a substantial undercount of all SARS-CoV-2 infections among fully vaccinated persons. (cdc.gov)

December 11, 2020 - The FDA has authorized the first vaccine for the prevention of coronavirus disease 2019. (onclive.com)
The FDA has granted Emergency Use Authorization to BNT162b2 as the first vaccine to prevent coronavirus disease 2019 in individuals aged 16 years and older. (onclive.com)

By contrast, the prevalence of oral infection with 33 HPV types not covered by the vaccine was 4.0% in vaccinated groups and 4.7% in non-vaccinated groups, the researchers found, a difference that was not considered to be statistically meaningful. (cancer.gov)
In studying the Middle East Respiratory Syndrome (MERS) coronavirus spike protein, researchers accelerated the process for designing COVID-19 mRNA vaccines. (asm.org)
For this current study, researchers analyzed data from 2011 to 2014 in which participants self-reported whether they had received one or more HPV vaccines. (mdanderson.org)
Researchers analyzed responses from 2,627 young adults ages 18-33, and compared the prevalence of an oral HPV infection in those who received one more dose of the vaccine to those who did not. (mdanderson.org)
A team of researchers led by Rudolf Valenta from MedUni Vienna's Center for Pathophysiology, Infectiology and Immunology has now demonstrated that a protein contained in the BM32 vaccine against grass pollen allergy induces antibodies that prevent the hepatitis B virus from docking onto liver cells. (news-medical.net)
While HIV and hepatitis C vaccines are still in experimental stages, researchers may have paved the way for a combined vaccine in which they're administered at the same time. (medicaldaily.com)
In a new study , researchers note that a combined HIV and hepatitis C vaccine may soon be on the horizon. (medicaldaily.com)
It's perhaps due to all of these reasons that the researchers were motivated to investigate a double whammy vaccine. (medicaldaily.com)
Researchers from the University of Vermont (UVM)'s Vaccine Testing Center are preparing to test new therapeutic agents against Cryptosporidium . (uvm.edu)
Researchers at the Department of Microbiology and State Key Laboratory of Emerging Infectious Diseases, LKS Faculty of Medicine of The University of Hong Kong (HKUMed) have conducted a comprehensive study for identifying an effective vaccine regimen in preventing SARS-CoV-2 nasal infection. (hku.hk)
The goal of the UB researchers is to identify M. catarrhalis antigens that are very similar among all strains, so that a vaccine based on a single antigen will protect against as many strains of the bacterium as possible. (hearingreview.com)
The researchers found that vaccine efficacy against reverse-transcriptase polymerase chain reaction-confirmed RSV-related lower respiratory tract disease was 82.6 percent, with seven and 40 cases in the vaccine and placebo groups, respectively (1.0 versus 5.8 per 1,000 participant-years). (healthday.com)

This finding suggests that both groups carried equal viral loads and were equally likely to pass on their infections, the US Centers for Disease Control and Prevention (CDC) warned. (bmj.com)
Our pipeline includes a vaccine for the treatment and prevention of recurrent urinary tract infections and compounds targeting infection and cancer. (prnewswire.com)
The Vaccine Safety Datalink , which is maintained by the Centers for Disease Control and Prevention, monitors prespecified potential safety signals at nine participating health care organizations using data from all health care encounters," Chang wrote. (medpagetoday.com)
HealthDay News is reporting that the Centers for Disease Control and Prevention (CDC) is stepping up its surveillance of Haemophilus influenzae type b (Hib) infections, a major cause of bacterial illness in children, due to a shortage of the vaccine. (infectioncontroltoday.com)
Therefore, the vaccine isn't approved for the prevention of head and neck cancers. (mdanderson.org)
To compare the clinical impact of a prophylactic treatment with sublingual immunostimulation in the prevention of recurrent urinary tract infections (rUTIs) with the use of antibiotics. (frontiersin.org)
Dr. Thomas Frieden, director of the Centers for Disease Control and Prevention, acknowledges that the number of girls who have gotten the HPV vaccine is "very disappointing" and "certainly not good enough. (keranews.org)
2 Results showed that among 43,448 patients, the vaccine showcased a 95% efficacy with regard to COVID-19 infection prevention in those who did not have prior infection 7 days or longer following the second vaccine dose. (onclive.com)
Prevention of opportunistic infections (OI) in patients with HIV has since significantly reduced morbidity and mortality in these patients. (medscape.com)

To date, the age and sex distribution of reported vaccine breakthrough infections reflects the fully vaccinated U.S. population. (cdc.gov)
Seventy-three percent of SARS-CoV-2 infections and 79% of COVID-19-related hospitalizations and deaths averted stemmed from the protective effects in fully vaccinated persons. (ssrn.com)
WASHINGTON) - With more than 161 million people now fully vaccinated in the U.S., experts say we are bound to see reports of breakthrough infections, meaning people test positive for COVID-19 while fully vaccinated. (850wftl.com)

The vaccine continues to offer strong protection against severe disease. (bmj.com)
The vaccine brings a threefold reduction in risk of infection, an eightfold reduction in risk of symptomatic disease, and a 25-fold reduction in risk of hospital admission or death, the agency estimates. (bmj.com)
A variant bringing more severe disease with mortality like SARS-CoV (10%) or MERS-CoV (~35%) was a "realistic possibility," as was a variant that finds an animal reservoir then returns to strike humans in an evolved, vaccine resistant form. (bmj.com)
Therefore, a vaccine that blocks the parasites from entering the RBC could prevent disease. (nature.com)
Such a vaccine will have an enormous impact on reducing mortality and disease severity in children and pregnant women. (nature.com)
The North American Emerging Infections Network reported that about 80 percent of responding infectious disease physicians had treated a UTI caused by the most resistant bacteria, carbapenem-resistant Enterobacteriaceae (CRE). (prnewswire.com)
For more information, see the Centers for Disease Control and Prevention's (CDC) Meningococcal vaccine . (msdmanuals.com)
FDA approval could make Pfizer's shot the first maternal vaccine available to prevent the disease in infants. (cbc.ca)
KENILWORTH, N.J.-( BUSINESS WIRE )-Merck (NYSE:MRK), known as MSD outside the United States and Canada, and Instituto Butantan, Sao Paulo, Brazil, a non-profit producer of immunobiologic products for Brazil today announced a collaboration agreement to develop vaccines to protect against dengue virus disease, the mosquito-borne infection. (merck.com)
It is a severe disease and not mild infection that makes a pandemic, and so far vaccines have substantially weakened the link between infection and death. (independent.co.uk)
The available studies of the Oxford-AstraZeneca vaccine only tell us about mild infection with Beta as severe disease has not been studied. (independent.co.uk)
Unfortunately, explains Gillison, no clinical trials have prospectively evaluated whether the existing FDA-approved HPV vaccines will prevent oral infections that lead to the disease. (mdanderson.org)
This is one of the most highly-effective vaccines we have in our infectious disease arsenal. (theepochtimes.com)
The vaccines continue to protect against severe disease and hospitalization, Birx said on Friday. (theepochtimes.com)
5. So the vaccine does protect some people, not 95 percent, from getting infected, from getting symptoms, and getting severe disease. (theepochtimes.com)
The neglected tropical disease Buruli ulcer (BU) is an infection of subcutaneous tissue with Mycobacterium ulcerans There is no effective vaccine. (nih.gov)
HCV is also a viral infection that mostly targets the liver, resulting in symptoms of fever, dark urine, stomach pain, and eventually liver disease, cirrhosis (scarring of the liver), or liver failure. (medicaldaily.com)
FRIDAY, Feb. 17, 2023 (HealthDay News) -- A single dose of an AS01 E -adjuvanted respiratory syncytial virus (RSV) prefusion F protein-based candidate vaccine (RSVPreF3 OA) prevents RSV-related acute respiratory infection and lower respiratory tract disease in adults aged 60 years and older, according to a study published in the Feb. 16 issue of the New England Journal of Medicine . (healthday.com)
Vaccine efficacy was 94.1 and 71.7 percent against severe RSV-related lower respiratory tract disease and RSV-related acute respiratory infection, respectively. (healthday.com)
The RSVPreF3 OA vaccine provided protection across the clinical spectrum of RSV disease, from mild upper respiratory tract infection to severe lower respiratory tract disease,' the authors write. (healthday.com)
I think people need to appreciate when you talk about breakthrough infections that the original data from the clinical trial - the efficacy data was based on preventing clinically apparent disease, not preventing infection, such as a symptomatic infection," Fauci said. (850wftl.com)
Of course we will see some breakthrough infections that lead to severe illness, more in vulnerable populations with underlying chronic conditions who couldn't mount a response to vaccines because they couldn't," Dr. John Brownstein, an infectious disease epidemiologist at Boston's Children's Hospital and an ABC News contributor, told ABC News. (850wftl.com)
The overall number of breakthrough infections is rising, but that could be because more people overall are getting vaccinated, resulting in more breakthrough cases, Dr. Shobha Swaminathan, an associate professor and infectious disease expert at the Rutgers New Jersey Medical School, told ABC News. (850wftl.com)
What's more, the DTaP vaccine, along with many other vaccines, fails to provide permanent protection against disease - assuming they provide any protection at all. (naturalnews.com)
It would be better if children weren't vaccinated with DTaP vaccines at all because research shows that they actually increase susceptibility to disease after the antigens have all worn off. (naturalnews.com)
Acellular pertussis (aP) vaccines, this particularly study denotes, might block symptomatic disease but not asymptomatic transmission, which could account "for the observed increase in B. pertussis incidence. (naturalnews.com)
Likewise, aP vaccines fail to protect against transmission of disease, which means people vaccinated with them are a serious public health risk. (naturalnews.com)
At worst, it's a mass deception that's triggering disease outbreaks that are being erroneously blamed on the unvaccinated and used as an excuse to censor vaccine truth online while simultaneously eliminating vaccine exemption laws in as many states as possible. (naturalnews.com)
The study found that the vaccine had an overall efficacy rate of 90% and was 100% effective against moderate or severe disease in people who got the vaccine. (wdet.org)
This document updates previously published CDC recommendations for infection-control practices for dentistry (1-3) and offers guidance for reducing the risks of disease transmission among dental health-care workers (DHCWs) and their patients. (cdc.gov)
Inactivated bacterial vaccines have been used since 1890 but are less effective against the pneumonic plague, so live, attenuated vaccines and recombinant protein vaccines have been developed to prevent the disease. (wikipedia.org)

With the omnipresent threat of undiscovered pathogens, scientists have been investigating methods to jumpstart vaccine and monoclonal antibody development before an outbreak occurs, shifting containment efforts from preventive to compulsory. (asm.org)
Preliminary evidence also shows that existing ear infection vaccines are changing colonization patterns among otitis media pathogens, possibly increasing the prevalence of M. catarrhalis infections. (hearingreview.com)
In contrast with antibodies, which are immune-generated proteins that can prevent a virus from getting inside our cells and kicking off infections, killer T cells roam through our bodies' tissues, inspect cells' surfaces for telltale traces of infectious pathogens and kill infected cells. (stanford.edu)
A set of infection-control strategies common to all health-care delivery settings should reduce the risk of transmission of infectious diseases caused by bloodborne pathogens such as HBV and HIV (2,5-10). (cdc.gov)

A total of 10,262 SARS-CoV-2 vaccine breakthrough infections had been reported from 46 U.S. states and territories as of April 30, 2021. (cdc.gov)

Among the vaccinated with breakthrough infections, the difficulty of detecting virus in the nasal passages, known as the cycle threshold value, was almost identical to that seen in the unvaccinated. (bmj.com)
On social media, especially TikTok, people have been making links between nasal flu vaccines given to children and the rise in Strep A infections this winter. (euronews.com)
The COVID-19 pandemic has resulted in over 275 million of infections with nearly 5.36 million deaths by now, yet few vaccines approved for emergency use can induce sufficient mucosal protection for preventing robust SARS-CoV-2 nasal infection. (hku.hk)
We are currently testing the influenza-based nasal spray vaccine and the DNA vaccine in humans,' remarked Professor Yuen Kwok-yung, Henry Fok Professor in Infectious Diseases and Chair of Infectious Diseases, Department of Microbiology, HKUMed, who is currently leading the clinical trials of these two vaccines in Hong Kong. (hku.hk)

Influenza (Flu) Influenza (flu) is a viral infection of the lungs and airways with one of the influenza viruses. (msdmanuals.com)
Bird Flu Bird flu is a viral infection with strains of influenza virus that normally occur in wild birds and domestic poultry. (msdmanuals.com)
As the B.1.617.1 variant continues to evolve, it will be important to monitor how additional mutations within the spike impact antibody resistance, viral transmission and vaccine efficacy. (biorxiv.org)

The Plasmodium falciparum protein, apical membrane antigen 1 forms a complex with another parasite protein, rhoptry neck protein 2, to initiate junction formation with the erythrocyte and is essential for merozoite invasion during the blood stage of infection. (nature.com)
That work was built before they had all the tools you would want to develop a vaccine antigen because they couldn't empirically test this at the time they were designing it. (asm.org)
What Dr. Corbett and Dr. Graham have advocated for is a pandemic pathogen model antigen system, where they learn the biology of a type of pathogen-what it requires for entry or completion of its initial infection of a cell-and [then] design vaccine approaches around the critical steps in the entry program," Ray said. (asm.org)
The goal of the current research, funded by the NIH's National Institute on Deafness and Other Communication Disorders (NIDCD), is to identify new virulence mechanisms for this understudied pathogen, identify the structure of a candidate antigen for a new vaccine, and develop a new vaccine. (hearingreview.com)

mRNA vaccines are the future," Shah added. (asm.org)

SARS-CoV-2) breakthrough infection among recipients of 4 different vaccines in South Korea. (cdc.gov)
The CDC has investigated 42 reports of deaths among HPV vaccine recipients. (keranews.org)
Moreover, among patients with and without evidence of prior SARS-CoV-2 infection, COVID-19 was observed in 9 vaccine recipients and 169 placebo recipients, translating to a 94.6% vaccine efficacy (95% CI, 89.9-97.3). (onclive.com)

The World Health Organization has estimated that up to 400 million dengue infections occur annually, resulting in 500,000 hospitalizations. (merck.com)

ST. LOUIS , July 26, 2017 /PRNewswire/ -- Sequoia Sciences announced it has received Fast Track Designation from the U.S. Food and Drug Administration (FDA) for its novel, investigational vaccine designed to treat recurrent urinary tract infections (UTI) caused by multidrug-resistant bacteria. (prnewswire.com)
Sequoia's investigational vaccine, if approved by the FDA, may help reduce the use of antibiotics and address this growing health threat. (prnewswire.com)
Instituto Butantan will receive a $26 million upfront payment from Merck and is eligible to receive up to $75 million for the achievement of certain milestones related to the development and commercialization of Merck's investigational vaccine as well as potential royalties on sales. (merck.com)
Instituto Butantan will retain responsibility for the manufacturing and commercialization of their investigational vaccine, TV003, in Brazil. (merck.com)
This agreement recognizes the tremendous progress that scientists and clinicians at the Instituto Butantan have made in developing their investigational dengue virus vaccine," said Dr. Roger M. Perlmutter, president, Merck Research Laboratories. (merck.com)
In their study, they gathered 32 healthy participants and divided them into three groups: The first group received only HCV investigational vaccines the first and eighth weeks. (medicaldaily.com)
The second group received only HIV investigational vaccines during the same time period, and the last group received the combined vaccine for HIV/HCV. (medicaldaily.com)

It also pointed to studies from Canada, Scotland, and Singapore suggesting that delta infection is about twice as likely as ancestral strains to result in pneumonia or hospital admission. (bmj.com)
Each year's vaccine is directed against the 3 or 4 strains that scientists predict will be most common in the coming year. (msdmanuals.com)
Data shows the vaccines did prevent infection from early strains of the CCP (Chinese Communist Party) virus , which causes COVID-19, but that the protection waned over time. (theepochtimes.com)
There are signs the protection from vaccines against severe illness is also dropping quickly as new strains emerge. (theepochtimes.com)
The study didn't find a decrease in the HPV strains covered by the vaccine in other age groups, a clue that the vaccine is responsible for the decrease among teenagers. (keranews.org)

2020) Immunotherapy With the PreS-based Grass Pollen Allergy Vaccine BM32 Induces Antibody Responses Protecting Against Hepatitis B Infection. (news-medical.net)
The [authorization] of the COVID-19 vaccine today is one of the brightest news of 2020. (onclive.com)
Ahead of World Immunization Week 2020, WHO hosted a live Q&A on vaccines who Dr Katherine O'Brien WHO Director of Immunization, Viaccines and Biologicals. (bvsalud.org)

Diseases (NIAID), part of the United States National Institutes of Health (NIH), for the development of live attenuated tetravalent vaccines (LATV). (merck.com)
Scientists in the Laboratory of Infectious Diseases at the NIAID of the NIH engineered a candidate live attenuated tetravalent vaccine against the dengue virus. (merck.com)
A paper has been circulating with an eye-catching title: 'Live Attenuated Influenza Vaccine Enhances Colonization of Streptococcus pneumoniae and Staphylococcus aureus in Mice. (euronews.com)

The goal of the trial is to determine the efficacy of the vaccine for preventing dengue, and importantly to provide additional information about its safety. (merck.com)
In phase 1 of the research, investigators sought to determine preferred vaccine candidates and dose levels, while in phase 2/3, they assessed the efficacy of the vaccine in an expanded patient. (onclive.com)

But he warned PNG was not out of the woods yet, and frontline health workers would need a second vaccine dose 12 weeks after their first. (abc.net.au)

Take 5 minutes to catch up on Infection Control Today®'s highlights for the week ending September 24, 2023. (infectioncontroltoday.com)

If approved, the vaccine could change the standard of care for recurrent UTI," said Gary Eldridge , president and CEO, Sequoia Sciences. (prnewswire.com)
Many of my patients with multidrug-resistant recurrent urinary tract infections have tried multiple antibiotics for years without success," said Liz D'Antonio, CRNP, director of clinical research Anne Arundel Urology. (prnewswire.com)
Twenty two percent will have recurrent urinary tract infections (rUTIs). (frontiersin.org)
Now, University at Buffalo (UB) scientists have received a $1.5 million National Institutes of Health (NIH) grant to develop a vaccine against recurrent ear infections. (hearingreview.com)

Many persons with vaccine breakthrough infections, especially those who are asymptomatic or who experience mild illness, might not seek testing. (cdc.gov)
Most adverse events reported were transient, with mild-to-moderate severity, although the vaccine was more reactogenic than placebo. (healthday.com)
The most frequently reported toxicities with the vaccine included transient, mild to moderate pain at the injection site, fatigue, and headache. (onclive.com)
Despite many high-profile cases of breakthrough infections with mild or no symptoms, including among Olympic athletes and some politicians, the overall number is very low compared to the number of people vaccinated. (850wftl.com)
Crow also said he had been vaccinated and boosted, and reported only mild symptoms - "the vaccine is safe and effective," he added. (northernpublicradio.org)
Decreased antibody responses in Omicron breakthrough infections relative to Delta were potentially related to a higher proportion of asymptomatic or mild breakthrough infections (55.0% versus 28.6%, respectively), which exhibited 12.3-fold lower titers against WT compared with moderate to severe infections (p = 0.020). (bvsalud.org)

The initial response may include a rush to develop vaccines and therapeutics, but even conducting this clinical research at an expedited rate can take months. (asm.org)

Germany is moving toward offering vaccine boosters to virtually all who want them, according to a draft decision for a meeting of state and federal health ministers this week. (dailymaverick.co.za)

Corbett and Graham's team developed a model pathogen vaccine design years before the COVID-19 pandemic began. (asm.org)
The findings suggested that the clinical development of our two HKU vaccines remains a top priority for eliminating the uncontrolled spread of COVID-19 pandemic. (hku.hk)

San Diego, CA - The introduction of pneumococcal vaccines for treating otitis media in children has not prevented complications from occurring, according to new research presented at the 2009 American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting & OTO EXPO, in San Diego, CA. In fact, the research suggests that the focus has changed on what complications may arise. (scienceblog.com)
While it does cause milder cases of middle ear infections (otitis media) than other bacteria, Murphy said it is becoming more prevalent. (hearingreview.com)

Importantly, we show that antibodies from animals vaccinated with the complex have significantly higher neutralization activity against non-vaccine type parasites. (nature.com)
The high antibody titers against AMA1 in malaria-exposed individuals, its surface expression and ability of anti-AMA1 antibodies to block invasion in vitro led to AMA1 being a leading vaccine candidate. (nature.com)
Using data from 128 people vaccinated against grass pollen allergy, a research group led by Rudolf Valenta from MedUni Vienna's Center for Pathophysiology, Infectiology and Immunology has now shown that this BM32 vaccine induces antibodies exactly at the site where the virus binds to the liver cell, thus preventing infection. (news-medical.net)
High titers of ER-specific IgG serum antibodies together with IL-2 and IL-4 in the draining lymph node (DLN) were associated with protection induced by the ER vaccine. (nih.gov)

NIAID then supported the development of the candidate vaccine through a series of clinical trials. (merck.com)

Meningococcal group B vaccine (MenB) is available to prevent infection by one type of meningitis bacteria that has become common in outbreaks among college students (see CDC: Meningococcal B vaccine information statement ). (msdmanuals.com)
Vaccines Before Outbreaks? (asm.org)

Today, a long-sought-after goal to deliver a maternal vaccine that will help protect infants six months of age or younger - when they are at greatest risk of possible serious consequences from RSV - has been achieved. (wboy.com)

Wikimedia Commons has media related to Plague vaccine. (wikipedia.org)

The recent development of resistance to front-line antimalarial drugs underscores the urgent need to develop an effective vaccine. (nature.com)
Pfizer's experimental RSV vaccine was 82 per cent effective in preventing severe infections in infants when given to expecting mothers in the second half of their pregnancy, according to new trial data. (cbc.ca)
Pfizer's experimental respiratory syncytial virus (RSV) vaccine was 82 per cent effective in preventing severe infections in infants when given to expecting mothers in the second half of their pregnancy, according to trial details published on Wednesday that confirm preliminary data from the study. (cbc.ca)
Final data from the study that was halted early when it became clear the vaccine was effective was published in the New England Journal of Medicine . (cbc.ca)
The shot was 69.4 per cent effective in preventing severe infections in the first 180 days. (cbc.ca)
Clement Beaune, the French Europe minister, publicly criticised the restrictions placed upon travellers from France to England by the UK government because of UK fears that the Beta variant, first identified in South Africa, might spread to the UK and that the vaccines would be less effective. (independent.co.uk)
This study suggests that an effective BU vaccine must induce localized, tissue-specific immune profiles with controlled inflammatory responses at the site of infection. (nih.gov)
They found that the combined vaccine didn't impair the immune response compared to the individual vaccines, hinting that with more research, they may develop an equally effective combined vaccine. (medicaldaily.com)
For many years before the development of effective antiretroviral therapy (ART), these infections inflicted significant morbidity and mortality on patients living with AIDS. (medscape.com)
Effective infection-control strategies are intended to break one or more of these 'links' in the chain, thereby preventing infection. (cdc.gov)

COVID-19 mRNA (messenger ribonucleic acid) vaccines use a lipid nanoparticle to deliver mRNA encoding SARS-CoV-2 spike proteins to the cytoplasm of the cell. (asm.org)
Pharmaceutical companies dedicated to rolling out a COVID-19 mRNA vaccine all committed to using the same spike protein sequence (all including the 2 proline changes) when developing the shot. (asm.org)
We found that the GD of the receptor-binding domain of the SARS-CoV-2 spike protein is highly predictive of vaccine protection and accounted for 86.3% ( P = 0.038) of the VE change in a vaccine platform-based mixed-effects model and 87.9% ( P = 0.006) in a manufacturer-based model. (nature.com)

The direct effects of the immunization program were estimated for all susceptible individuals (i.e., no previous evidence of laboratory-confirmed SARS-CoV-2 infection) who were at least partially vaccinated (defined as receipt of at least one dose with ≥14 days after the first dose). (ssrn.com)

The study of more than 2,600 young adults in the United States found that the prevalence of oral infection with four HPV types, including two high-risk, or cancer-causing, types, was 88% lower in those who reported receiving at least one dose of an HPV vaccine than in those who said they were not vaccinated. (cancer.gov)
Among men, the prevalence of oral infection with the four HPV types was 2.1% in unvaccinated individuals and 0.0% in vaccinated individuals. (cancer.gov)

However, vaccine breakthrough infections occur in only a small fraction of all vaccinated persons and account for a small percentage of all COVID-19 cases ( 5 - 8 ). (cdc.gov)

Natural News ) A new peer-reviewed scientific paper published in the journal Tropical Diseases, Travel Medicine and Vaccines has found that the DTaP vaccine for diphtheria, tetanus, and pertussis (whooping cough) is causing children who receive it to become more prone to contracting whooping cough later on in life. (naturalnews.com)

Severe illness occurred within six months in 19 infants born to mothers in the vaccine group, compared with 62 infants in the placebo group. (cbc.ca)
A total of 24,966 participants were randomly assigned to one dose of vaccine (12,467 participants) or placebo (12,499 participants). (healthday.com)
In the observer-blind study, participants were randomized in a 1:1 fashion to either the vaccine or placebo. (onclive.com)

HIV-related infections and malignancies escalate in frequency and severity as the absolute CD4 T cell count falls toward 200 cells/μL and below. (medscape.com)

Clinical trials have shown that FDA-approved HPV vaccines can prevent anogenital HPV infections and precancerous lesions that lead to HPV-associated cancers, including cervical and anal cancer. (cancer.gov)
However, Dr. Gillison said, the potential impact of current HPV vaccines on oral HPV infections that lead to cancer has not yet been rigorously tested in clinical trials, and thus the vaccines are not specifically approved for preventing cancers of the oropharynx. (cancer.gov)

Sequoia's vaccine is designed to create an immune response preventing bacteria from colonizing the urinary tract, and it recently completed its first clinical trial in women. (prnewswire.com)
The vaccine was well-tolerated and generated a strong immune response. (prnewswire.com)
The second wave in South Africa was dominated by the notorious Beta variant, which sparked much concern because of its ability to escape immune responses and cause infections in vaccinated individuals, but it hasn't taken off here in the UK. (independent.co.uk)
I have patients that say, 'Well, I got the vaccine and I felt like garbage the next day," Well, a side effect is to make you feel kind of crummy for a day or two because it's developing this wonderful immune response," said Susan Bailey, president of the American Medical Association. (wcpo.com)
The various vaccine technology strategies generated non-identical immune responses to provide protection against SARS-CoV-2 infection 4 . (nature.com)
Although the mechanisms of immune escape caused by the new mutations are being elucidated in experimental studies, an integrative framework to quantify the effect of genetic mismatch on VE would be instrumental for efficient evaluation of vaccine protection for any country in real time. (nature.com)
For that reason, an infection by one particular virus won't generate an exhaustive - and exhausting - immune response to every microbial invader under the sun. (stanford.edu)
That doesn't mean severe illness as the result of an infection isn't possible, but this tends to happen in people who are elderly or otherwise immune-compromised, experts said. (850wftl.com)
Immunosuppression resulting from HIV places a patient at risk for infection from organisms that are otherwise relatively mildly hazardous and that would normally be cleared by a competent immune system. (medscape.com)

The agency found the manufacturing quality and consistency associated with BNT162b2 to be acceptable for approval and stated that they would be working with the vaccine sponsors to work toward finalization and issuance of an emergency use authorization of the product. (onclive.com)

The first vaccine against HPV, Merck's Gardasil , was approved by the Food and Drug Administration in 2006. (keranews.org)

When you hear about a breakthrough infection, that doesn't necessarily mean the vaccine is failing," Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases, said before Congress on Tuesday. (850wftl.com)

The Hill ) - The Food and Drug Administration (FDA) on Monday approved the first vaccine meant to prevent infections in infants, with the new drug designed to be administered to pregnant mothers in their third trimester so their newborn infants can have protection from the moment they're born. (wboy.com)
Limited treatment options and no vaccines exist to treat or prevent a leading cause of severe diarrhea in infants and young children in the developing world: Cryptosporidium, a single-celled intestinal parasite found in soil, food and water that also causes significant illness and death in immunocompromised individuals. (uvm.edu)
Additionally, investigators are examining whether the vaccine is also able to prevent SARS-CoV-2 infection. (onclive.com)
Doctor holding COVID-19, сoronavirus vaccine in the syringe using for prevent infection in ultraviolet neon light. (photocase.com)
Plague vaccine is a vaccine used against Yersinia pestis to prevent the plague. (wikipedia.org)

Sequoia Sciences is a pharmaceutical company discovering and developing new medicines targeting bacterial infections and cancers. (prnewswire.com)

Moderna is banking on a combined COVID, flu and RSV vaccine. (cbc.ca)
No equivalent analysis was performed on the Moderna vaccine. (stanford.edu)

Anatomy11

Organisms38

Diseases35

Chemicals and Drugs105

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes22

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture2

Information Science3

Named Groups1

Health Care11

Geographicals1

Vaccination33

Doses11

COVID-19 Vaccines12

Human papillomavirus3

Immunity17

Randomized-contro1

Pfizer11

Variants18

Effectiveness5

Reported COVID-19 vaccine1

20192

Researchers12

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Fully vaccinated3

Disease31

Pathogens4

20211

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Strains5

20203

Live attenuated3

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Second vaccine dose1

20231

Recurrent4

Mild6

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Boosters1

Pandemic2

Otitis media2

Antibodies4

Candidate vaccine1

Outbreaks2

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Wikimedia Commons1

Effective10

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Occur1

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Emergency use authorization1

Merck's1

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Bacterial infections1

Moderna2