Infection with dengue viruses. Medical search. Frequent questions

Dengue is caused by infection with any of four mosquito-transmitted dengue viruses (DENV-1-4) and is characterized by fever, headache, myalgia, and leukopenia ( 1 ). (cdc.gov)
Dengue fever has risen dramatically over recent decades and the virus is thought to cause around 390 million infections each year - with 40 per cent of the world's population living in areas of risk. (imperial.ac.uk)
This has been previously identified in dengue fever, and is thought to be why a second infection with dengue is often more serious than the first. (imperial.ac.uk)
Colombia is an endemic country for dengue fever where the four serotypes of virus dengue (DENV1-4) circulate simultaneously, and all types are responsible for dengue cases in the country. (mdpi.com)
Dengue virus (DV) is a mosquito-borne flavivirus that causes hemorrhagic fever in humans. (unboundmedicine.com)
Increased blood vessel permeability, which occurs in dengue haemorrhagic fever and dengue shock syndrome patients, has been correlated with secondary heterotypic infections and has been postulated to arise from antibody-enhanced infection of monocytes. (microbiologyresearch.org)
Hemostatic defects in dengue hemorrhagic fever. (microbiologyresearch.org)
The term "Chikungunya" often refers to both the virus (CHIKV) and the illness or fever (CHIKF) caused by this virus. (medscape.com)
Chikungunya virus infection has a clinical presentation that overlaps with that of Ross River virus infection (fever, rash, polyarthritis) and dengue fever transmitted by the same mosquitoes. (medscape.com)
Dengue Hemorrhagic Fever 10 cases and 32 cases of Dengue Fever. (unair.ac.id)
Until now spectrum of clinical illness dengue virus infection from an asymptomatic or mild febrile illness to classical dengue fever (DF) and then to the most severe illness for example dengue hemorrhagic fever (DHF) are always found in Indonesia town. (unair.ac.id)
CONCLUSIONS: To prevent the outbreak of dengue hemorrhagic fever the Health Center doctor should give health education to community for decreasing Aedes aegeypti Mosquito around their houses. (unair.ac.id)
Dengue fever is an arthropod -borne viral infection that has become endemic in several parts of India including Delhi. (bvsalud.org)
Dengue virus (DENV) is the cause of dengue fever. (wikipedia.org)
Interestingly, increased levels of NET components were found in the serum of patients with more severe disease form-dengue hemorrhagic fever (DHF), but not uncomplicated dengue fever, during the acute phase of the infection. (ox.ac.uk)
The dengue virus, which is responsible for dengue fever and is widely spread across Latin America, was suspected to be one such cofactor. (charite.de)
The study was conducted to assess the role of Nitric Oxide (NO) in the pathogenesis of Dengue fever (DF). (ijmm.ir)
The model aims to capture the relevant physiological processes to provide researchers a tool to develop more effective antiviral drugs and treatments in the fight against Dengue Fever. (loyno.edu)
Significantly higher TNF-alpha levels were found in Afro-Colombians than in Mestizos in both dengue fever (DF) and dengue hemorrhagic fever (DHF). (qxmd.com)
Zika virus is transmitted to humans by infected mosquitoes which causes mild fever with maculopapular rash. (medindia.net)
18649 - the veteran has established the causal connection between infection with dengue viruses types 1, 2, 3, or 4 and VEA service for the clinical onset of dengue fever. (dva.gov.au)
on operational service, the veteran was infected with dengue viruses types 1, 2, 3, or 4 within the 14 days immediately before the clinical onset of dengue fever. (dva.gov.au)
the veteran's dengue fever is dengue haemorrhagic fever. (dva.gov.au)
Dengue fever is the most common viral disease transmitted by arthropods. (infectiousjournal.com)
The aim of this work is to investigate the clinical presentation, laboratory characteristics and diagnostic procedures of Dengue fever. (infectiousjournal.com)
The clinical suspicion of Dengue fever should be supported by epidemiological criteria and serology results in order to correctly diagnose the infection in its early stage. (infectiousjournal.com)
Given the recent increase in the incidence in the last decades, the geographical expansion of Dengue fever and the flow of migrants from Africa to Italy, surveillance systems based on laboratory tests are becoming crucial. (infectiousjournal.com)
The Ltc 1 peptide showed a significantly inhibitory effect against the dengue protease NS2B-NS3pro at 37°C, a physiological human temperature, (IC 50 , 12.68 ± 3.2 μM), and greater inhibitory effect was observed at 40°C, a temperature similar to a high fever (IC 50 , 6.58 ± 4.1 μM). (biomedcentral.com)
Its mild Dengue-like symptoms include fever, rash, headaches and Arthralgia. (bvsalud.org)
Use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with unconfirmed Zika virus infection should be avoided since the use of such drugs in dengue fever is associated with hemorrhagic risk and risk for Reye syndrome in the pediatric population. (medscape.com)
Dengue fever may be present in this country. (jeancoutu.com)
Infection initially produces fever and malaise followed by hyperactivity, aggression, convulsion and change in behavior. (stanford.edu)
HHV-6B infection causes high fever, irritability, malaise and roseola-like rash. (stanford.edu)
Dengue 2 causes encephalitis and/or a fever, rash and arthritis. (stanford.edu)
Dengue fever is present in this country. (uniprix.com)
DENV varies in presentation from asymptomatic infections to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS), which are the most serious forms of the disease. (who.int)
CHIKV infection is characterized by an abrupt onset of fever, frequently accompanied by debilitating joint pain. (who.int)

On November 7, 2022, dengue virus (DENV), which is not endemic in the continental United States, [ 1 ] was identified in a Maricopa County, Arizona resident by reverse transcription-polymerase chain reaction (RT-PCR) testing at Arizona State Public Health Laboratory (ASPHL). (medscape.com)
Whole genome sequencing by CDC's Dengue Branch later revealed that closely related DENV-3 strains not known to be circulating in the patient's travel region were identified in both patient A and pool A, suggesting local DENV transmission. (medscape.com)
This report describes a fatal case of acquired HLH that was apparently triggered by infection with DENV-3. (cdc.gov)
The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. (mdpi.com)
In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the 'vascular-leak' syndrome seen in severe dengue in humans. (mdpi.com)
however, a new model using high doses of DENV has recently been shown to develop hemorrhagic signs after infection. (mdpi.com)
DENV are major re-emerging pathogens that are endemic in all continents except Europe and Antarctica with over half of the world's population at risk of infection. (dovepress.com)
DENV is the most common human arboviral infection and the most important public health threat. (dovepress.com)
These findings provide a new foundation upon which our understanding of DENV infection and evolution may be built, and may provide new insights for treatment of this terrible disease,' explains Dr. Jonathan Dinman, editor-in-cheif, Virus Adaptation and Treatment journal. (dovepress.com)
Vertical transmission in Aedes aegypti and Aedes albopictus is considered a maintenance mechanism for dengue virus (DENV) during unfavorable conditions and may be implicated in dengue outbreaks. (nature.com)
Since DENV infection dynamics vary among wild-type viruses and vector populations, vertical transmission rates can also vary between regions. (nature.com)
Dengue virus (DENV) is the most geographically widespread arbovirus causing dengue disease epidemics in tropical and subtropical regions. (ugm.ac.id)
Nature provides abundant plants as a source for lead molecules against various diseases including DENV infection. (ugm.ac.id)
In conclusion, curcumin and 6‐gingerol exhibit antiviral properties against DENV infection and could provide a new therapeutic approach for dengue disease treatment strategies. (ugm.ac.id)
The virus isolation rate was only (4.5%: 1/22) from all patient sera, serotyping showed the presence of DENV-3 serotypes. (unair.ac.id)
The involvement of the immune system in the protection and pathology of natural dengue virus (DENV) has been extensively studied. (ox.ac.uk)
However, despite studies that have referred to activation of neutrophils in DENV infections, the exact roles of neutrophils remain elusive. (ox.ac.uk)
this confirmed in vivo neutrophil activation during DENV infection. (ox.ac.uk)
Spontaneous decondensation of nuclei, an early event of neutrophil extracellular trap (NET) formation, was also markedly increased in cells isolated from DENV-infected patients during the acute phase of the infection. (ox.ac.uk)
In vitro incubation of NETs with DENV-2 virus significantly decreased DENV infectivity. (ox.ac.uk)
This suggested that NETs may play dual roles during DENV infection. (ox.ac.uk)
The increased ability for NET formation during acute DENV infection appeared to be independent of PAD4-mediated histone H3 hyper-citrullination. (ox.ac.uk)
Our study suggests that neutrophils are involved in immunological responses to DENV infection. (ox.ac.uk)
We identified 3 serotypes of dengue virus (DENV-1, -2, and -3), as well as co-infection with 2 or 3 serotypes. (fiocruz.br)
Our goal is to find the active constituents of A. calamus to treat dengue virus (DENV) infections, and to study the effects and mechanisms of these active substances. (diva-portal.org)
A phase 1 study of 12 healthy adult volunteers using a challenge virus, DENV-1-LVHC strain 45AZ5, was performed. (nih.gov)
We conclude that DENV-1-LVHC was well-tolerated, resulted in an uncomplicated dengue illness, and may be a suitable DHIM for therapeutic and prophylactic product testing. (nih.gov)
The four dengue virus (DENV) serotypes (1-4) cause the most common mosquito-borne viral disease of humans, with 3 billion people at risk for infection and up to 100 million cases each year, most often affecting children. (ytiancompbio.com)
The goal of this study was to systematically review the published data on dengue virus (DENV) seroprevalence in Sudan and to estimate disease burden through meta-analysis. (utmb.edu)
DENV is an enveloped virus with a positive stranded RNA genome of approximately 11 kb in length that encodes a single polypeptide. (biomedcentral.com)
Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia. (broadinstitute.org)
Eleven (17.46%) of the confirmed cases were DENV, 49 (77.77%) were CHIKV, and 3 (4.76%) were DENV and CHIKV co-infections. (who.int)
Dengue virus (DENV) and Chikungunya (CHIKV) infections are fast-growing mosquito-borne arboviral diseases. (who.int)

The two arrived at the very beginning of what would become a massive epidemic of dengue virus Type 2, one of the more severe of the four flavors, or serotypes, of dengue, and the first major outbreak of dengue since the Zika epidemic in 2016. (sciencedaily.com)
According to Dr. Kelli L. Barr, author of Dengue Serotypes 1-4 Exhibit Unique Host Specificity In Vitro, 'The central message of our work is that if some dengue viruses grow well in various animal tissues (cell lines) then perhaps animals play a bigger role than we now believe in the preservation and spread of dengue viruses. (dovepress.com)
Our data support other reports that show that bats may serve as hosts for dengue virus and that dengue serotypes exploit unique cell entry pathways. (dovepress.com)
Four serotypes of the virus have been found, and a reported fifth has yet to be confirmed, all of which can cause the full spectrum of disease. (wikipedia.org)
Dengue is a viral disease caused by four serotypes of the Flavivirus genus [ 1 ] and is prevalent in tropical and subtropical countries, ranging from Southeast Asia to the Americas [ 2 ]. (biomedcentral.com)

A new study finds that people who have antibodies to the mosquito-borne Zika virus are more vulnerable to developing dengue disease. (sciencedaily.com)
This immune interaction, called antibody-dependent enhancement, could complicate the search for a safe and effective vaccine that protects against Zika without also increasing the risk of dengue. (sciencedaily.com)
Getting sick with the mosquito-borne Zika virus makes people more vulnerable to developing dengue disease later on, and to suffering from more severe symptoms when they do get sick from dengue, finds a new study published online today (Thursday, Aug. 27) in the journal Science . (sciencedaily.com)
The study, which drew on data from two cohorts of Nicaraguan children who lived through a Zika epidemic in 2016 and a dengue epidemic in 2019, is the first to investigate the impacts of Zika immunity on dengue disease in humans. (sciencedaily.com)
Its findings confirm earlier suspicions that some antibodies to the Zika virus, which usually serve to protect the body from infection, may actually interact with dengue viruses in ways that can make dengue infection worse. (sciencedaily.com)
This interaction, known as antibody-dependent enhancement, could make it harder for researchers to design a safe and effective vaccine that protects against Zika without also increasing the risk of dengue. (sciencedaily.com)
The key thing that our study establishes is that prior Zika infection does significantly increase your risk of both symptomatic and more severe forms of dengue disease," said study first author Leah Katzelnick, who performed the research as postdoctoral scholar at the University of California, Berkeley's School of Public Health. (sciencedaily.com)
That finding raises the questions: Could a vaccine only targeted at Zika actually put people at increased risk of more severe dengue disease? (sciencedaily.com)
When Zika first emerged in Latin America in late 2015, many speculated whether the flavivirus, a close cousin to the dengue viruses, might interact with the dengue viruses in a similar way. (sciencedaily.com)
The first question was, 'How will prior dengue virus infection affect Zika? (sciencedaily.com)
When chikungunya, another mosquito-borne virus, and Zika appeared in Nicaragua in 2014 and 2016, respectively, the cohort was expanded to capture cases of these emerging pathogens. (sciencedaily.com)
Using data from the cohort, Harris published a 2019 study showing that prior dengue virus infection can grant a small amount of protection against Zika, and other studies now support this conclusion. (sciencedaily.com)
But the inverse question, whether Zika antibodies protect against future dengue disease, or potentially enhance it, remained a mystery. (sciencedaily.com)
I wonder if previous infection with Zika is pushing people into symptomatic disease? (sciencedaily.com)
By mid-autumn, the researchers had enough evidence to prove that having a prior Zika infection made a person more likely to have a symptomatic dengue infection. (sciencedaily.com)
Previous exposure to the dengue virus may increase the potency of Zika infection, according to research from Imperial College London. (imperial.ac.uk)
The early-stage laboratory findings, published in the journal Nature Immunology , suggests the recent explosive outbreak of Zika may have been driven in part by previous exposure to the dengue virus. (imperial.ac.uk)
The study, which included scientists from Institut Pasteur in Paris and Mahidol University in Bangkok, suggests the Zika virus uses the body's own defences as a 'Trojan horse', allowing it to enter a human cell undetected. (imperial.ac.uk)
Professor Gavin Screaton , senior author of the research and Dean of the Faculty of Medicine at Imperial, said: "Although this work is at a very early stage, it suggests previous exposure to dengue virus may enhance Zika infection. (imperial.ac.uk)
A second study by the same team, published in Nature , suggests an antibody that works against the dengue virus may also neutralise Zika - providing a potential target for a vaccine. (imperial.ac.uk)
The dengue virus is similar to the Zika virus - they belong to the same viral family, called the Flaviviridae, and both are transmitted by the Aedes mosquito. (imperial.ac.uk)
The team, who were also supported by the National Institute for Health Research Imperial Biomedical Research Centre , added them to human cell cultures, together with the Zika virus. (imperial.ac.uk)
Their results suggest dengue antibodies can recognise and bind to Zika, due to the similarities between the viruses. (imperial.ac.uk)
Crucially, they also suggest that pre-existing dengue antibodies can amplify a Zika infection through a phenomenon called antibody-dependent enhancement (ADE). (imperial.ac.uk)
The new study suggests the same phenomenon occurs when a person who has previously been exposed to dengue encounters Zika. (imperial.ac.uk)
The existing dengue antibodies latch onto Zika, due to similarity between the viruses. (imperial.ac.uk)
In the current study, the team found a group of antibodies that bind to a certain site on the dengue virus - called EDE1 antibodies - were able to prevent the Zika virus from entering the immune cell. (imperial.ac.uk)
In a second study, published in Nature and co-authored by Professor Felix Rey from the Institut Pasteur and Professor Screaton from Imperial, the team confirmed that EDE1 antibodies bind efficiently to the Zika virus and potently neutralise infection. (imperial.ac.uk)
Women who have previously been infected with dengue virus may be at risk for increased damage to their fetuses and placentas if they should later become infected with the Zika virus, researchers from the Department of Microbiology at the Icahn School of Medicine at Mount Sinai report. (infectioncontroltoday.com)
This study is the first to report a possible mechanism for the enhancement of Zika virus progression during pregnancy in an animal model. (infectioncontroltoday.com)
Results of the study, 'Dengue virus immunity increases Zika virus-induced damage during pregnancy,' were published in the February issue of Immunity, a journal published by Cell Press. (infectioncontroltoday.com)
Zika virus outbreaks were first found to be associated with birth defects including microcephaly, in which the baby is born with an abnormally small head and brain, in 2015 in Brazil, where dengue virus, a virus closely related to Zika virus, is endemic. (infectioncontroltoday.com)
The research team led by Jean Lim, PhD, associate professor of microbiology and co-director of microbiology multidisciplinary training in the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai, transferred dengue virus-specific antibodies into mice prior to infection with Zika virus during pregnancy. (infectioncontroltoday.com)
Zika-infected human placental tissues also showed increased replication in the presence of dengue antibodies. (infectioncontroltoday.com)
Our data demonstrate that antibodies generated from a previous dengue virus infection can enhance the severity of Zika virus infection during pregnancy,' said Dr. Lim. (infectioncontroltoday.com)
Our research may explain the high rate of microcephaly and birth defects observed in the recent Zika virus outbreak in South America. (infectioncontroltoday.com)
Additionally, coinfection with and lack of rapid tests for Zika virus and chikungunya complicate matters in real-world infections. (wikipedia.org)
The Zika virus outbreak in Latin America has so far affected more than 60 million people. (charite.de)
Prior infection with the genetically related dengue virus had been assumed to enhance the effects of subsequent Zika virus infection. (charite.de)
Researchers from Charité - Universitätsmedizin Berlin and the German Centre for Infection Research (DZIF) have now shown that prior dengue infection protects against damage associated with Zika. (charite.de)
We already know that Zika virus infection during pregnancy can damage the fetus, leading to microcephaly and other potentially serious symptoms," explains the study's lead investigator, Prof. Dr. Felix Drexler of Charité's Institute of Virology. (charite.de)
Prof. Drexler has been working with the DZIF for many years, developing diagnostic tests for Zika and other viruses. (charite.de)
The international team of researchers set out to look for cofactors which might be responsible for determining whether a Zika virus infection during pregnancy will have devastating consequences. (charite.de)
Initially, the researchers assumed that it was the human antibodies produced in response to prior dengue virus infection which might contribute to the fetal damage caused during subsequent infection with the Zika virus. (charite.de)
Surprisingly, our study shows that previous dengue infection protects against Zika-associated damage," emphasizes Prof. Drexler. (charite.de)
In order to study interactions between dengue and Zika viruses, the researchers first compared the genomes of all known dengue viruses currently found in Brazil. (charite.de)
They also conducted tests on 29 mothers who had developed Zika virus infection during pregnancy and whose babies were later born with microcephaly. (charite.de)
108 mothers who were seropositive for Zika virus infection but whose children were born healthy served as controls. (charite.de)
Summarizing the findings of the study, Prof. Drexler says: "The results show that preexisting immunity against dengue virus significantly reduces the risk of Zika virus infection resulting in serious consequences for the unborn child. (charite.de)
People with prior dengue infection therefore need not worry about subsequently developing more severe forms of Zika infection. (charite.de)
It means that the researchers' initial suspicion - that the dengue virus might act as a cofactor for severe Zika virus infection in the unborn child - could not be confirmed. (charite.de)
Cross-Protection of Dengue Virus Infection against Congenital Zika Syndrome, Northeastern Brazil. (charite.de)
New study throws light on the circulation of the Zika virus in Thailand. (medindia.net)
In an attempt to shed light on Zika circulation, scientists from the Institut Pasteur and the CNRS, in collaboration with US teams and the Thai National Institute of Health, decided to investigate the history of the Zika virus in Thailand. (medindia.net)
Zika virus has been silently circulating in Thailand for at least 16 years and probably longer. (medindia.net)
The Aedes mosquito - potentially together with flaviviruses like dengue and Zika - is found in most tropical and subtropical countries, and South-East Asia is no exception. (medindia.net)
Dengue and Zika virus infection has been found to up against a human and mosquito immune defense mechanism and highjack specific host proteins for virus replication. (medindia.net)
By producing a phylogenetic tree of the Zika virus in Thailand, the scientists discovered that the viral strains within Thailand were genetically very different from each other, and their ancestor seems to have appeared in the country in 2002. (medindia.net)
The first is that changes may have occurred to the Zika virus - and its transmissibility - when the virus migrated to South America. (medindia.net)
Author Correction: Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection. (ox.ac.uk)
A viral disease transmitted by the bite of Aedes mosquitoes infected with Zika Virus. (bvsalud.org)
The Zika virus is transmitted to humans through the bite of an infected mosquito of the genus Aedes , mainly Aedes aegypti . (bvsalud.org)
Transmission associated with blood transfusion is possible, since the RNA of Zika virus was identified in asymptomatic blood donors during a current surge. (bvsalud.org)
There is strong evidence of a possible association of infection by Zika virus in pregnant women in Brazil and the occurrence of microcephaly in newborn infants. (bvsalud.org)
About 1 in 5 people infected with the Zika virus become symptomatic. (bvsalud.org)
Based on the typical clinical features, differential diagnosis for infection by Zika virus is widespread. (bvsalud.org)
There is no vaccine and no specific antiviral treatment available for the condition of the Zika virus. (bvsalud.org)
Aspirin and other nonsteroidal anti-inflammatory drugs, non-steroidal should be avoided until dengue can be discarded to reduce the risk of hemorrhage.When traveling to countries where the Zika virus or other viruses transmitted by mosquitoes have been reported, the recommendation is to use insect repellent, long sleeves and pants, and stay in places with air conditioning or window and door fitted with insect screens. (bvsalud.org)
The fact that the species of Aedes mosquitoes that transmit the Zika virus are found throughout the world, it is likely that the outbreak from spreading to other countries. (bvsalud.org)
Zika virus (ZIKV) infection usually is mild and self-limited. (medscape.com)
There are no specific FDA-approved treatment options or vaccines for treatment and prevention of Zika virus infection. (medscape.com)
Expert consultation with a maternal-fetal medicine and infectious diseases specialists is advised for management of Zika virus infection during pregnancy. (medscape.com)
Patients infected with arboviruses such as Zika virus should be advised to limit activity during symptomatic illness in order to avoid exposure to mosquitoes and potential risk for human-to-arthropod transmission and subsequent local spread of disease. (medscape.com)
The best method for preventing Zika virus infection is to avoid travel to areas with active Zika virus transmission. (medscape.com)
Zika virus is capable of infecting the eye, according to a new study. (sciencedaily.com)
The study, in mice, helps explain why some people with Zika virus develop eye disease, and suggests that contact with infected eyes may play a role in spreading the disease. (sciencedaily.com)
Researchers have found that Zika virus can live in eyes and have identified genetic material from the virus in tears, according to a study from Washington University School of Medicine in St. Louis. (sciencedaily.com)
The study, published Sept. 6 in Cell Reports , describes the effect of Zika virus infection in the eyes of mouse fetuses, newborns and adults. (sciencedaily.com)
Our study suggests that the eye could be a reservoir for Zika virus," said Michael S. Diamond, MD, PhD, the Herbert S. Gasser Professor of Medicine and one of the study's senior authors. (sciencedaily.com)
We need to consider whether people with Zika have infectious virus in their eyes and how long it actually persists. (sciencedaily.com)
Zika virus causes mild disease in most adults but can cause brain damage and death in fetuses. (sciencedaily.com)
To determine what effect Zika infection has on the eye, the researchers infected adult mice under the skin -- similar to the way humans are infected by mosquitoes -- and found live virus in the eyes seven days later. (sciencedaily.com)
Eye infection raises the possibility that people could acquire Zika infection through contact with tears from infected people. (sciencedaily.com)
Zika researchers are increasingly considering alternative routes of transmission because the virus is spreading more quickly than would be expected by mosquito-borne transmission alone. (sciencedaily.com)
The Zika epidemic has been very explosive, more explosive than we can account for by just mosquitoes and the level of Zika virus in human blood. (sciencedaily.com)
Human tears potentially could be tested for viral RNA or antibodies, a less painful way to diagnose recent Zika infection than drawing blood. (sciencedaily.com)

because everyone in Latin America, to some degree or another, is eventually dengue immune and has dengue antibodies," said study senior author Eva Harris, a professor of infectious diseases and vaccinology at UC Berkeley. (sciencedaily.com)
Since 2004, Harris and her colleagues in Nicaragua have monitored a cohort of approximately 3,800 children living in Managua, the country's capital, tracking any signs of dengue disease and collecting annual blood samples to test for the virus and its antibodies. (sciencedaily.com)
In the new Nature Immunology paper, supported by the Wellcome Trust and the Medical Research Council , the researchers used antibodies that recognise the dengue virus collected from individuals who had been infected with dengue. (imperial.ac.uk)
When dengue first infects the body, the immune system makes antibodies against the virus. (imperial.ac.uk)
Antibodies are large proteins that latch onto invading bacteria or viruses, neutralising them and enabling the immune system to destroy the pathogens. (imperial.ac.uk)
If someone is infected a second time by a different strain, the antibodies from the first attack can only partially bind to the virus, and are unable to prevent infection. (imperial.ac.uk)
Previous work from the team has shown the immune system generates different types of antibodies to dengue that bind to various areas of the virus. (imperial.ac.uk)
A panel of 11 murine monoclonal antibodies directed against dengue type 2 was evaluated for antigen specificity by dot immunobinding assay and Western blot analysis and for in vitro and in vivo biological activities. (ajtmh.org)
The nine E-glycoprotein-reactive monoclonal antibodies also neutralized dengue 2 virus in a plaque reduction assay. (ajtmh.org)
Of the neutralizing monoclonal antibodies, five passively protected mice in vivo against lethal intracerebral dengue 2 challenge. (ajtmh.org)
Infection enhancement of dengue type 2 virus in the human U-937 monocyte line by antibodies to Flavivirus cross-reactive determinants. (microbiologyresearch.org)
Monoclonal antibodies to Sindbis virus glycoprotein El can neutralize, enhance infectivity, and independently inhibit haemag-glutination or haemolysis. (microbiologyresearch.org)
Using a murine model, Lum et al showed that anti-Chikungunya virus antibodies were elicited early in the course of the illness and were directed against the C-terminus of the viral E2 glycoprotein. (medscape.com)
Both natural and Chikungunya virus infection-induced specific antibodies were essential for controlling Chikungunya virus infections. (medscape.com)
Recombinant domains of the E protein are used as well-defined antigens in the serological detection of antibodies directed against dengue virus and as immunogens in vaccine candidates. (wikipedia.org)
It had been known for some time that, under certain conditions, these antibodies are capable of enhancing the effects of subsequent dengue infections with a different dengue virus serotype. (charite.de)
These tests were conducted to determine whether these women had antibodies against the four types of dengue virus found in the area. (charite.de)
Curiously, length of residence in Santa Clara was negatively associated with DEN virus antibodies. (edu.pe)
The laboratory diagnosis is usually performed by testing the plasma or serum to detect the virus, viral nucleic acid or virus specific immunoglobulin M and neutralizing antibodies. (bvsalud.org)

The recent re-emergence and travel-related spread of Chikungunya infection to Europe and the United States has drawn global attention. (medscape.com)
The exact pathophysiology of Chikungunya virus remains to be investigated. (medscape.com)
Chikungunya virus infection elicited strong innate immunity with an abundant production of proinflammatory markers and cytokines, including high levels of alpha interferon, interleukin (IL)-4, IL10, and gamma interferon. (medscape.com)
A 2017 study reported that Chikungunya infection activates toll-like receptors (TLR), triggering the innate immune system. (medscape.com)
[ 23 , 24 ] Bernard et al evaluated this mechanism and found that Chikungunya virus enters mammalian epithelial cells via a clathrin-independent, Esp-15-dependent, dynamin 2-dependent route and requires an endocytic pathway in combination with other unknown pathways. (medscape.com)
The authors speculate that Chikungunya virus is capable of undergoing genetic drifts and could acquire alternate entry mechanisms. (medscape.com)
Several murine models with Chikungunya virus-related joint and neurological diseases are being investigated. (medscape.com)
Opsoclonus-myoclonus-ataxia syndrome associated with chikungunya and dengue virus co-infection. (ox.ac.uk)
This article reports the first case of OMAS in association with chikungunya and dengue virus co-infection. (ox.ac.uk)
The genetic analysis identified chikungunya virus of East/Central/South African genotype and dengue serotype 4 virus of genotype II. (ox.ac.uk)
Currently, our primary goal is to identify points of control in inflammation in the course of dengue virus, chikungunya virus and SARS-CoV-2 infection. (rug.nl)
Dengue and chikungunya are mosquito-borne infections that are spreading rapidly worldwide. (who.int)
To describe the magnitude of the first outbreak of dengue and chikungunya infections in Tandalti Town, White Nile State, southern part of Sudan. (who.int)
White Nile State may experience larger outbreaks of dengue and chikungunya in the future, there is, therefore, an urgent need for proper vector control interventions in the state and nearby states. (who.int)

abstract = "BACKGROUND: Since 1968 dengue virus infection has been found in several cities in Indonesia, especially Surabaya and Jakarta, this event occurs due to the changing of the hot weather to rainy season. (unair.ac.id)

Until a few hundred years ago, dengue virus was transmitted in sylvatic cycles in Africa, Southeast Asia and South Asia between mosquitoes of the genus Aedes and nonhuman primates, with rare emergences into human populations. (wikipedia.org)
The global spread of dengue virus, however, has followed its emergence from sylvatic cycles and the primary lifecycle now exclusively involves transmission between humans and Aedes mosquitoes. (wikipedia.org)
Dengue virus is transmitted by species of the mosquito genus Aedes. (wikipedia.org)

Unlike humans, viruses do not have a genetic repair system," says Henrik Salje. (medindia.net)
Although there have been considerable advances in the study of dengue virus, no vaccines or anti-dengue drugs are currently available for humans. (biomedcentral.com)
Nonhuman primates and humans are probably the main reservoirs of the virus, and anthroponotic transmission (man-vector-man) occurs during outbreaks. (bvsalud.org)
Even though we didn't find live virus in mouse tears, that doesn't mean that it couldn't be infectious in humans," said Jonathan J. Miner, MD, PhD, an instructor in medicine and the study's lead author. (sciencedaily.com)

Getting sick with one type of dengue virus can increase the likelihood that a person will develop a second, more severe illness when infected with a separate type of dengue virus. (sciencedaily.com)
This may be why the current outbreak has been so severe, and why it has been in areas where dengue is prevalent. (imperial.ac.uk)
Hence, severe or chronic infections could be attributed to an absence or deregulation of 1 of these pathways. (medscape.com)
The two main problems with this virus are that, occasionally, it can lead to neurological complications, such as Guillain-Barr syndrome, or severe fetal brain developmental defects. (medindia.net)

However, it has been unclear whether there represented a true absence of the virus in the region or if outbreaks have simply not been detected. (medindia.net)
Outbreaks of Ebola and Marburg virus infections started in Central and West Africa, probably because the infections are common in wild animals there. (msdmanuals.com)
A phylogenetic analysis using full-length viral genomes of South American dengue serotype 3 in consecutive Venezuelan outbreaks reveals a novel NS5 mutation. (broadinstitute.org)
The history of arboviral infections in Sudan dates back to the past century with noticeably increased outbreaks of viral haemorrhagic fevers since the 1970s (2). (who.int)

In 2022 Sudan encountered the most widespread infection of both diseases. (who.int)

However, there are four different types of dengue virus. (imperial.ac.uk)

Replication of dengue and Junin viruses in cultured rabbit and human endothelial cells. (microbiologyresearch.org)
These results demonstrated the anti-DENV2 effect of tatanan A, in inhibiting DENV2 RNA replication and infections. (diva-portal.org)
We can use the little errors that emerge during viral replication to piece together the historical spread of viruses. (medindia.net)
Many human viruses utilise or suppress ubiquitin and ubiquitin-like pathways during infection, enhancing their replication. (gla.ac.uk)
We performed this study to identify and characterise the inhibitory potential of the latarcin peptide (Ltc 1, SMWSGMWRRKLKKLRNALKKKLKGE) against dengue virus replication in infected cells. (biomedcentral.com)
The Ltc 1 peptide exhibited significant inhibitory effects against dengue NS2B-NS3pro and virus replication in the infected cells. (biomedcentral.com)
Immunosuppression reactivates BK virus replication and is linked to hemorrhagic cystis in bone marrow transplants. (stanford.edu)

In the natural infection, DV is introduced into human skin by an infected mosquito vector where it is believed to target immature dendritic cells (DCs) and Langerhans cells (LCs). (unboundmedicine.com)

It can cause an outbreak of dengue virus infection. (unair.ac.id)
We studied occurrence of co-infection with dengue viruses during an outbreak in New Delhi, India in 2014. (bvsalud.org)
In December 2013, a large Zaire Ebola virus outbreak began in rural Guinea (West Africa), then spread to densely populated urban regions in Guinea and to neighboring Liberia and Sierra Leone. (msdmanuals.com)
Because the original animal source of these viruses has not yet been identified precisely, doctors are not sure how the virus infects the first person in an outbreak. (msdmanuals.com)

Concurrent infection with more than one serotype was identified in 43% of the positive samples. (bvsalud.org)
Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity. (broadinstitute.org)
High-resolution analysis of intrahost genetic diversity in dengue virus serotype 1 infection identifies mixed infections. (broadinstitute.org)
Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East Asia. (broadinstitute.org)

It causes an estimated 50 million cases of dengue infection, half a million hospitalizations, and approximately 15,000 deaths. (dovepress.com)
Focusing this study evaluation all the cases of dengue virus infection, the diagnosis of cases was based on WHO 2009. (unair.ac.id)

In Japan, although dengue cases are currently seen only among travellers returning from endemic areas, the number of reported cases is rising according to the national case-based surveillance system. (who.int)
The number of reported cases per number of Japanese travellers to a dengue-endemic country was calculated to estimate the country-specific incidence of imported dengue virus infection. (who.int)
Travellers planning to visit dengue-endemic countries should be aware of historic dengue seasonality and the current dengue situation. (who.int)
Endemic dengue associated with the co-circulation of multiple viral lineages and localized density-dependent transmission. (broadinstitute.org)

Overall, each model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or pre-clinical testing of antiviral drugs and vaccines. (mdpi.com)
Infectious virus titres increased in undifferentiated U937 cells following infection with clinical isolates but only when the cells were infected via their Fc receptors. (microbiologyresearch.org)
Three different single-nucleotide polymorphisms (SNPs) in human TLR-7 (rs179010, rs5741880, rs3853839) and 1 SNP in TLR-8 (rs3764879) were associated with increased susceptibility to infection and related clinical manifestations. (medscape.com)
Based on this event, the clinical manifestation of dengue virus infection should be studied. (unair.ac.id)
This report represents an unusual clinical syndrome associated with viral co-infection and reinforces the need for clinical vigilance with regard to neurological syndromes in the context of emergent arboviruses. (ox.ac.uk)
Developing high throughput methods for generating and analysing virus genomic sequences from clinical samples. (gla.ac.uk)
Importantly, through national and international collaborations with basic and clinical scientists, we foster the multidisciplinary approach to these infections. (rug.nl)
A relativiely quick virus, clinical manifestations of Nipah infection occur shortly after handling infected pigs. (stanford.edu)
Clinical manifestations typically occur 14-90 days after infection but can also occur up to 6 years later. (stanford.edu)

Virus Adaptation and Treatment is an international, peer-reviewed, open access journal focusing on the study of virology, viral adaptation and the development and use of antiviral drugs and vaccines to achieve improved outcomes in infection control and treatment. (dovepress.com)
Immunosuppressives may diminish therapeutic effects of vaccines and increase risk of adverse effects (increased risk of infection). (medscape.com)
Immunosuppressants also increase risk of infection with concomitant live vaccines. (medscape.com)

Current estimates indicate that as many as 390 million infections occur each year, and many dengue infections are increasingly understood to be asymptomatic or subclinical. (wikipedia.org)

As an Honorary Consultant in Infectious Diseases, my research focuses on the epidemiology of influenza and other respiratory viruses in the UK and sub-Saharan Africa including COVID-19. (gla.ac.uk)

2013. Performance of commercial dengue NS1 ELISA and molecular analysis of NS1 gene of dengue viruses obtained during surveillance in Indonesia. (ugm.ac.id)
Sera that had been collected previously by the Peruvian Ministry of Health from residents were tested by an enzyme-linked immunosorbent assay (ELISA) for DEN virus IgG antibody. (edu.pe)
Diagnostic test for Dengue infections included serology (ELISA) and PCR on blood samples. (infectiousjournal.com)
The samples were tested for major arboviral infections using arboviral-speciﬁc enzyme-linked immunosorbent assays (IgM capture ELISA), and serologically positive samples were conﬁrmed using commercially available Real Time RT-PCR Kits. (who.int)

However, even though São Paulo is the most populous city in the Americas and has experienced major dengue epidemics, natural vertical transmission had never been detected in this area before. (nature.com)
Despite the fact that São Paulo, the capital of the state, is the most populous city in Brazil and Latin America 22 and in recent years has experienced major dengue epidemics, such as those in 2014 and 2015 23 , natural vertical transmission has never been detected in the city 15 . (nature.com)
To determine the causes of viral meningitis, we analyzed 22 cerebrospinal fluid samples collected during the 2014-2015 dengue epidemics in Brazil. (fiocruz.br)

They did so to establish whether, over the past few decades, the Northeast of Brazil had been exposed to different dengue viruses than those found in other regions, and whether people in the Northeast had developed different immunity as a result. (charite.de)
I'm interested in how viruses engage with these pathways with respect to cellular antiviral immunity, to develop novel avenues for therapeutic intervention. (gla.ac.uk)
My research focuses on companion animal virology and immunology with a view to understanding disease pathogenesis, correlates of immunity to infection and the development of novel approaches to the diagnosis, prevention and treatment of viral diseases. (gla.ac.uk)

Dengue disease is caused by not one but four closely related types of flaviviruses, each of which can strike with a slightly different set of symptoms and severity. (sciencedaily.com)
However, after a person has been infected with two types of dengue viruses, they usually gain some degree of immune protection against future dengue disease severity. (sciencedaily.com)
Whether the concurrent dengue viral infection is correlated with disease severity in a given population is another aspect to be pursued. (bvsalud.org)

Take 5 minutes to catch up on Infection Control Today®'s highlights for the week ending December 10, 2023. (infectioncontroltoday.com)

Hemorrhagic Fevers Overview Hemorrhagic fevers are serious viral infections characterized by bleeding (hemorrhage). (msdmanuals.com)
Hemorrhagic fevers can be caused by many different types of virus. (msdmanuals.com)

To determine risk factors associated with dengue (DEN) virus infection among residents of Santa Clara, Peru, a rural Amazonian village near Iquitos, a cross-sectional serological, epidemiological and environmental survey was conducted. (edu.pe)

Therefore, further investigation is necessary to develop the Ltc 1 peptide as a new anti-dengue therapeutic. (biomedcentral.com)

The antibody, with the virus loosely attached, then shuttles into an immune cell. (imperial.ac.uk)
This immune cell would normally then kill the virus, but because the virus is not properly attached, it breaks free once it gains entry to the human immune cell. (imperial.ac.uk)
Here it hijacks the immune cell's machinery to replicate more viral particles, enhancing the infection. (imperial.ac.uk)
he added that the team also found that a type of antibody may help protect against the phenomenon of ADE, and prevent the virus from hijacking the immune cells. (imperial.ac.uk)
trypsin-sensitive virus receptors and trypsin-resistant immune complex receptors. (microbiologyresearch.org)
These results suggest that ethnicity may contribute to differences in immune responses to dengue infections. (qxmd.com)
We explore the intricate structural interactions between viruses and host complexes during virus infection and immune response, which is crucial for exploiting them and uncovering new avenues for the development of therapeutics. (gla.ac.uk)
My team within the Experimental Virology Group focuses on immune mechanisms triggered by acute viral infections. (rug.nl)
The eye is an immune privileged site, meaning the immune system is less active there, to avoid accidentally damaging sensitive tissues responsible for vision in the process of fighting infection. (sciencedaily.com)

Filoviruses Arbovirus, arenavirus, and filovirus are viruses that are spread from animals to people and, with some viruses, from people to people. (msdmanuals.com)
Dengue is the most important human arbovirus. (stanford.edu)

The study had been done in all cases Dengue Virus Infection who had been cared in Mother and Child Health of SOERYA Hospital Sepanjang, Indonesia, since January 1/June 30, 2018. (unair.ac.id)

The role and responsibility of executive-level oversight in infection prevention is growing. (infectioncontroltoday.com)
Dengue guidelines for diagnosis, treatment, prevention and control 2009. (ijmm.ir)
Dengue Guidelines for Diagnosis Treatment, Prevention and Control A joint publication of the World Health Organization (WHO) and the Special Programme for Research and Training in Tropical Diseases (TDR) 2009. (ijmm.ir)

Power level is low in healthy children in whom the viral infection is subclinical or produces mild respiratory disease. (stanford.edu)

ifosfamide decreases effects of influenza virus vaccine quadrivalent by pharmacodynamic antagonism. (medscape.com)
adalimumab decreases effects of influenza virus vaccine quadrivalent by pharmacodynamic antagonism. (medscape.com)
A post-exposure rabies vaccine can be given after infection. (stanford.edu)

Also, mosquito protection may lower the risk of contracting mosquito-borne infections such as malaria. (jeancoutu.com)

I. Epidemiology of Symptomatic Acute Dengue Infection in Children, 2006-2009. (ijmm.ir)

Dengue is considered the most serious re-emergent viral disease transmitted by arthropods, with approximately 390 million infections worldwide each year, 7% of which occur in Brazil 1 , 2 . (nature.com)
These results strongly suggested that recent DEN virus transmission did not occur in the village and that most infections of residents of this rural village were acquired while visiting the city of Iquitos. (edu.pe)

This study describes the susceptibility to dengue virus infection of a monocytic cell line at different states of differentiation. (microbiologyresearch.org)
This same study identified 47 strains of dengue virus. (wikipedia.org)
A total of 150 patients with positive Dengue serology and 50 candidates as controls in the age group of 15-65 years were included in the study. (ijmm.ir)
Dengue Infection in Children in Ratchaburi, Thailand: A Cohort Study. (ijmm.ir)
Mouse kidney fibroblast cells (BHK-21) were used as a host cell to study the infection ability of the virus. (diva-portal.org)
This study compared the serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interferon gamma (IFN-gamma) in 78 Colombian patients, from two ethnic groups, with dengue virus infection. (qxmd.com)
My group apply the techniques of elecrton-cryomicroscopy and image analysis to the study of viruses, providing an exciting opportunity to visualise the process of virus infection at cellular scale and at macromoleculr resolution. (gla.ac.uk)
However, this gap in data and knowledge highlights the urgent need for a country-wide surveillance system and continued study of dengue burden in Sudan to accurately estimate the disease prevalence and determine the associated risk factors. (utmb.edu)
Index cluster study of dengue virus infection in Nicaragua. (broadinstitute.org)

Next to research, I enjoy teaching biology of viral infections. (rug.nl)

Nipah virus infection causes febrile encephalitis and aseptic meningitis. (stanford.edu)

Multiple antiviral drugs are under investigation for treatment of ZIKV infection. (medscape.com)

Even when they do get sick, the symptoms can easily be confused with other diseases such as the flu or dengue. (medindia.net)

However, travelers from those areas sometimes carry the infection to nearby areas or, rarely, outside of Africa. (msdmanuals.com)

Recent findings suggest that as the virus infects human cells, host homeostatic processes such as autophagy and ER stress response, not to mention apoptosis, are triggered depending on the infected cell type. (wikipedia.org)

Anatomy5

Organisms51

Diseases10

Chemicals and Drugs26

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes27

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science3

Health Care7

Geographicals7

Fever37

DENV33

Serotypes5

Zika86

Antibodies19

Chikungunya14

Abstract1

Aedes3

Humans4

Severe4

Outbreaks4

20221

Types of dengue virus1

Replication7

Infected mosquito1

Outbreak4

Serotype4

Cases of dengue2

Endemic4

Clinical9

Vaccines3

Asymptomatic1

Infectious Diseases1

ELISA4

Epidemics3

Immunity3

Severity3

20231

Fevers2

Epidemiological1

Therapeutic1

Immune9

Arbovirus2

20181

Prevention3

Mild1

Vaccine3

Mosquito-borne infections1

Symptomatic1

Occur2

Study9

Viral Infections1

Febrile1

Antiviral1

Diseases1

Africa1

Infects1