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  • Apoptosis
  • We also probed the mechanism linking Abcc6 deficiency and the difference in infarct size following I/R, examining the transforming growth factor-β and bone morphogenetic protein (BMP) signaling pathways, and using terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining to quantify apoptosis. (ahajournals.org)
  • ligation
  • 12-week-old C57BL/six mice at four different time-points during the day using either permanent ligation (PL) or 30-min of ischemia followed by reperfusion (IR), with a control group wherein no ligation was applied. (uu.nl)
  • Because H₂ is reported to eliminate peroxynitrite, it was expected to reduce the adverse effects of NO. In mice, left anterior descending coronary artery ligation for 60 min followed by reperfusion was performed with inhaled NO [80 parts per million (ppm)], H₂ (2%), or NO + H₂, starting 5 min before reperfusion for 35 min. (nih.gov)
  • functional
  • Rhythmicity in infarct size was present in the PL group at the functional and histological level, with maximal damage occurring when the infarct was induced at noon. (uu.nl)
  • however
  • however, that of miRNA-1, -24, -208b, and -499 was already increased at 60 min ischemia and probably reflects falsely positive results. (springer.com)
  • hearts
  • At the end of the reperfusion, the hearts stained by Evans blue solution then incubated by triphenyltetrazolium chloride. (ac.ir)