Infants from clinical bronchiolitis. Medical search. Frequent questions

This study evaluated the lower respiratory tract distribution characteristics of nebulized bronchodilators in infants with acute bronchiolitis. (snmjournals.org)
Twelve infants (mean age ± SD, 8 mo ± 4 mo) who were admitted for acute respiratory syncytial virus bronchiolitis were treated with 99m Tc-albuterol aerosol. (snmjournals.org)
This study evaluated the dose and distribution of the inhaled β-agonist bronchodilator 99m Tc-albuterol in acute RSV bronchiolitis. (snmjournals.org)
mean age ± SD, 8 ± 4 mo) ( Table 1 ) spontaneously breathing, wheezy infants, who were hospitalized with a diagnosis of acute bronchiolitis, were enrolled in the study. (snmjournals.org)
The diagnosis of bronchiolitis was made in the presence of a history of upper respiratory tract infection followed by the acute onset of respiratory distress with cough, breathlessness, and wheeze and clinical signs of chest hyperinflation, tachypnea, rhonchi, or crepitations occurring during a winter epidemic of bronchiolitis attributed to RSV ( 12 ). (snmjournals.org)
Acute bronchiolitis is due to a viral infection usually affecting children younger than two years of age. (wikipedia.org)
Acute bronchiolitis is usually the result of infection by respiratory syncytial virus (72% of cases) or human rhinovirus (26% of cases). (wikipedia.org)
Acute bronchiolitis is the one of the most common respiratory infections in infants. (thennt.com)
Administration of nebulized 3% saline in the emergency department did not result in a statistically significant decrease in the rate of admission for infants presenting with acute bronchiolitis, though there was a trend towards decreased admissions in both outpatient studies. (thennt.com)
In critically ill adults, most studies have focused on acute respiratory parameters and short-term physiologic outcomes with limited investigations focusing on clinical outcomes such as duration of therapy and need for escalation of ventilatory support. (nih.gov)
The term ALRI included: acute broncho-pneumonia for bacterial infections, bronchiolitis for viral infections, pneumonia and pleuro-pneumonia. (scirp.org)
Acute bronchiolitis is the most frequent lower respiratory infection in infancy, yet no therapy has shown consistent benefit. (bmj.com)
Bronchiolitis remains the most common acute lower respiratory tract infection (ALRTI) in infants. (edu.au)
Severity scoring systems: Are they internally valid, reliable and predictive of oxygen use in children with acute bronchiolitis? (edu.au)
Given the increased interest for novel HRV strain identification and their worldwide distribution, we have carried out clinical and molecular diagnosis of HRV strains in a 2-year study of children with acute respiratory infection visiting one district hospital in Shanghai. (plos.org)
Acute respiratory infection (ARI) surveillance was conducted from 0 to 6 months of age among 1060 infants of women randomized to one of four pre/post-partum vitamin D dose combinations or placebo. (biomedcentral.com)
1. To analyze the clinical presentation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the paediatric population in the third wave. (pediatriconcall.com)
RSV remains important viral etiological agent causing influenza-like illness and severe acute respiratory infections especially among infants in Morocco. (who.int)

RSV vaccines (administered during pregnancy) and monoclonal antibody products (administered to the infant) are available to protect infants and young children from severe RSV. (cdc.gov)
Nirsevimab (Beyfortus) is a monoclonal antibody product that can protect infants and some young children from severe RSV disease. (cdc.gov)
Children are at an increased risk for progression to severe respiratory disease if they have any of the following additional factors: Preterm infant (gestational age less than 37 weeks) Younger age at onset of illness (less than 3 months of age) Congenital heart disease Immunodeficiency Chronic lung disease Neurological disorders Tobacco smoke exposure Wheezing Wheezing heard in the lungs of an adult using a stethoscope. (wikipedia.org)
These results suggest that early and aggressive treatment action should be taken in patients with a high clinical suspicion of severe influenza infection. (medscape.com)
It is estimated that nearly all infants are infected with RSV and that between 1 and 2% of these develop symptoms severe enough to warrant admission. (thennt.com)
However, HFNC has not been demonstrated to be equivalent or superior to non-invasive positive pressure ventilation, and further studies are needed to identify clinical indications for HFNC in patients with moderate to severe respiratory distress. (nih.gov)
However, in vulnerable populations, such as newborns, infants, the elderly and immune-compromised individuals, these opportunistic pathogens can also affect the lower respiratory tract, causing a more severe disease (e.g., pneumonia). (mdpi.com)
To date, studies addressing the incidence of asthma after bronchiolitis severe enough to warrant hospitalization have focused almost exclusively on RSV, but a number of recent studies suggest that other respiratory pathogens, including RV, may contribute as well. (atsjournals.org)
Infants with bronchiolitis who develop symptoms severe enough to warrant hospitalization are at increased risk of developing recurrent wheezing or childhood asthma ( 1 - 6 ). (atsjournals.org)
Although this association has been widely reported, the mechanisms underlying this increased incidence of wheezing after severe bronchiolitis are unclear. (atsjournals.org)
Bronchiolitis typically affects infants aged under 12 months, with young infants or those born premature at greater risk of severe illness. (bpac.org.nz)
Infants with more severe symptoms or underlying conditions which predispose them to deterioration may require referral to hospital. (bpac.org.nz)
3, 5 In more severe cases, infants can have signs of increased respiratory effort such as nasal flaring and the use of accessory breathing muscles, as well as reduced oxygen saturation and cyanosis ( Table 1 ). (bpac.org.nz)
Increased respiratory effort in infants with more severe bronchiolitis can result in difficulty feeding, reduced fluid intake and dehydration. (bpac.org.nz)
In the Northern Territory (NT), Indigenous infants present to hospital more often and with more severe bronchiolitis than non Indigenous infants. (edu.au)
According to our clinical score, 74 infants had mild bronchiolitis, 30 had moderate bronchiolitis and two had severe bronchiolitis. (biomedcentral.com)
There is an increased risk of severe disease in premature infants, the immune-compromised, individuals with chronic obstructive pulmonary disease (COPD) and asthma, and the elderly. (gilead.com)
RSV is a common virus that usually causes mild, cold-like symptoms, but in serious cases can lead to severe lung infections, including bronchiolitis and pneumonia, which ultimately can lead to death. (pipelinereview.com)
Passive immunoprophylaxis with a monoclonal antibody against RSV, when given intramuscularly and monthly during winter, is effective in preventing severe RSV bronchiolitis in high-risk children who are born prematurely and in children under 2 years with chronic lung disease or hemodynamically significant congenital heart disease. (benthamscience.com)
On July 17, the FDA approved the monoclonal antibody injection, Beyfortus, for newborns and infants in their first RSV season and for children at risk of severe disease in their second RSV season, up to 24 months of age. (factcheck.org)
Young and premature babies and infants with heart or lung disease, or weakened immune systems, are particularly susceptible to severe infection due to RSV. (factcheck.org)
Infection by the respiratory syncytial virus may lead to severe respiratory diseases such as bronchiolitis and pneumonia, which can further progress into respiratory failure or death in rare cases. (persistencemarketresearch.com)

Although RSV typically results in mild, cold-like symptoms in most infants and young children, some develop lower respiratory tract disease such as pneumonia and bronchiolitis (swelling of the small airway passages in the lungs) . (everydayhealth.com)
This is important because respiratory syncytial virus infection can lead to serious health complications, such as pneumonia and bronchiolitis, especially in young children. (consultantlive.com)
The virus is the leading cause of pneumonia and bronchiolitis - infection and inflammation of the lungs, respectively - in kids younger than 1, the CDC says . (factcheck.org)

The diagnosis is typically made by clinical examination. (wikipedia.org)
Diagnosis is clinical. (msdmanuals.com)
The age at diagnosis varies widely, however, as do the clinical presentation, severity of symptoms, and rate of disease progression in the organs involved. (medscape.com)
During a clinical examination, clinicians will be forming a diagnosis and simultaneously assessing severity based on the presence and extent of symptoms and signs. (bpac.org.nz)
Age is also a key factor in establishing a diagnosis of bronchiolitis, as 85% of cases in New Zealand are in infants aged under 12 months. (bpac.org.nz)
2 Clinicians should consider a diagnosis of bronchiolitis in an infant aged under 12 months with symptoms of lower respiratory tract infection during winter. (bpac.org.nz)
In paediatrics, bronchiolitis is a clinical diagnosis characterised by tachypnoea, wheeze and/or crepitations in infants following a preceding upper respiratory illness. (edu.au)
Clinical assessment is the gold standard for diagnosis of bronchiolitis. (biomedcentral.com)
To date, only one study found LUS (Lung Ultrasound) to be a valuable tool in the diagnosis of bronchiolitis. (biomedcentral.com)
Aim of this study is to evaluate the accuracy of lung ultrasonography in the diagnosis and management of bronchiolitis in infants. (biomedcentral.com)
Diagnosis and grading of bronchiolitis was assessed according to a clinical and a ultrasound score. (biomedcentral.com)
The diagnosis of bronchiolitis should be made on the basis of medical history and a clinical examination. (biomedcentral.com)
e influenza activity has been documented in the community or geographic area, a clinical diagnosis of influenza can be made for outpatients with signs and symptoms consistent with suspected influenza, especially during periods of peak influenza activity in the community. (cdc.gov)
Objective: This article provides readers with an update on the evaluation, diagnosis, and treatment of viral bronchiolitis, primarily due to RSV. (benthamscience.com)
Diagnosis is based on clinical manifestation. (benthamscience.com)
Bronchiolitis in children: The Saudi initiative of bronchiolitis diagnosis, management, and prevention (SIBRO). (benthamscience.com)
Objectives: Universal implementation of cystic fibrosis (CF) newborn screening (NBS) has led to the diagnostic dilemma of infants with CF screen positive, inconclusive diagnosis (CFSPID), for which there is limited guidance regarding prognosis and standardized care. (authorea.com)
We investigated whether clinical characteristics are associated with risk of reclassification from CFSPID to a CF diagnosis. (authorea.com)
METHODS: We conducted a randomized, double-blind, controlled trial comparing nebulized singleisomer epinephrine with placebo in 194 infants admitted to four hospitals in Queensland, Australia, with a clinical diagnosis of bronchiolitis. (edu.au)

Thus, many possible determinants exist that may contribute to the severity of bronchiolitis and the subsequent development of asthma. (atsjournals.org)
Any intervention that is efficacious in reducing the severity of bronchiolitis and or re-admission for bronchiolitis in particular for Indigenous children would be beneficial in the short and long term. (edu.au)
Scans of the posterior area are more indicative in ascertaining the severity of bronchiolitis. (biomedcentral.com)

Viral infections are important causes of asthma exacerbations in children, and lower respiratory tract infections (LRTIs), caused by viruses such as respiratory syncytial virus (RSV) and rhinovirus (RV), are a leading cause of bronchiolitis in infants. (atsjournals.org)
Human respiratory syncytial virus (RSV) is a ubiquitous virus of worldwide distribution and is the leading cause of infant morbidity from respiratory infections. (intechopen.com)
Double or triple infections with HRV-C and respiratory syncytial virus and/or bocavirus were diagnosed in 33.3% of the HRV-infected patients, but no correlation with severity of clinical outcome was observed. (plos.org)
RSV is a pathogen that infects the human respiratory tract, potentially leading to infections such as bronchiolitis and pneumonia. (gilead.com)
The most noticeable connection of RSV infections with respiratory infections and specific clinical syndromes was detected in infants up to 6 months of age with bronchiolitis or pneumonia. (rapidtest.com)
In the subjects vaccinated with MVA-BN RSV, clinical symptoms typically associated with RSV infections were significantly reduced. (pipelinereview.com)
While we do not want to miss urinary tract infections, bacteremia, or bacterial meningitis in these young infants, we also do not want to expose this population to unnecessary procedures ( lumbar puncture ), antimicrobial therapy, or hospitalisation. (dontforgetthebubbles.com)
Pneumococcus is not a common cause of neonatal infection in high-income countries, but a study of neonatal infections in South Asia identified pneumococcus as a culture-confirmed cause of neonatal sepsis almost as commonly as Streptococcus agalactiae (group B streptococcus) in infants 0-59 days of age [ 2 ]. (biomedcentral.com)
In more serious cases, RSV infections can lead to bronchiolitis or pneumonia. (healthline.com)
Vitamin D is likely to play a role in early infant immune health, with emerging evidence that early life vitamin D deficiency increases the risk of developing childhood diseases such as food allergy 1 lower respiratory infections (LRIs) 2 and eczema. (bmj.com)

Given the prevalence of bronchiolitis, the cost and morbidity associated with hospitalization, and the emotion and stress involved for the admitted infants and their families, we feel this is a meaningful reduction. (thennt.com)
In order to contribute to the reduction of the morbidity and the mortality relative to the ALRIs of children in Brazzaville, this study set itself the objective of determining their epidemiological, clinical and evolutionary profiles and to identify the favoring factors and those associated with the risk of death. (scirp.org)
It is usually caused by a viral infection with a peak of incidence and morbidity among infants of 1-3 months of age [ 1 ]. (biomedcentral.com)
Invasive pneumococcal disease is a major cause of infant morbidity and death worldwide. (biomedcentral.com)
Furthermore, RSV is a major cause of morbidity and mortality in premature infants and infants with bronchopulmonary dysplasia. (persistencemarketresearch.com)
ABSTRACT Respiratory syncytial virus (RSV) is a leading cause of mortality and morbidity in young infants, little was known on its circulation types and patterns in Morocco. (who.int)

1 The putative effect of hypertonic saline (HTS) in bronchiolitis is to absorb mucosal water, hydrate the airway-surface liquid in the bronchioles and enhance mucociliary clearance. (bmj.com)

Patients and Methods: We studied previously healthy infants hospitalized for bronchiolitis during the fall-winter period of2009 and 2010. (uchile.cl)
Methods nd analysis Infants (n=3012) who are fully breastfed and not receiving vitamin D supplementation will be recruited at the time of their first immunisation, from council-led immunisation clinics throughout metropolitan Melbourne, Australia. (bmj.com)

In an invited commentary, Dr Alan R. Shroeder of Stanford University School of Medicine, Stanford, California, and colleagues wrote, "If affordability is an issue, clinicians and parents can be comforted by the findings in this trial that the most expensive device does not appear to confer meaningful clinical outcomes over the cheapest. (medscape.com)
They added further, "Parents are less satisfied with minimal suctioning and may be more likely to try something else, but there is no evidence that the more expensive approach leads to better outcomes for their infants. (medscape.com)
The administration of nebulized 3% saline had been proposed as an intervention that may help improve mucous clearance and therefore clinical outcomes through various mechanisms. (thennt.com)
To test 200 hospitalised Indigenous children with bronchiolitis to deterimine if oral Azithromycin, compared to placebo 30 mg/kg per dose, or oral placebo, improves clinical outcomes. (edu.au)
To compare oral Azithromycin to oral placebo given in three doses, seven days apart, to determine which improves the clinical outcomes of length of stay in hospital and duration of oxygen supplementation. (edu.au)
Most studies of the use of bronchodilators have enrolled small numbers of subjects and have examined only short-term outcomes, such as clinical scores. (edu.au)
Identify the epidemiological profile and clinical outcomes of hospitalised children and adolescents in the Paediatric Intensive Care Unit of Hospital Vitória, Espirito Santo, Brazil. (bvsalud.org)
Frequently, emergency department disposition decisions (to discharge or hospitalize) are made subjectively because of the lack of evidence and objective criteria for bronchiolitis management, leading to significant practice variation, wasted health care use, and suboptimal outcomes. (jmir.org)

Clinical neonatal studies are limited to premature infants. (nih.gov)
Premature infants and those with chronic lung disease or significant congenital heart disease are at highest risk from RSV. (everydayhealth.com)

Bronchiolitis typically presents in children under two years old and is characterized by a constellation of respiratory symptoms that consists of fever, rhinorrhea, cough, wheeze, tachypnea and increased work of breathing such as nasal flaring or grunting that develops over one to three days. (wikipedia.org)
Infants can have an ongoing cough for up to three weeks. (bpac.org.nz)
Infants with mild bronchiolitis characteristically have cough, wheezing, nasal discharge, and chest recession with wheeze and crackles audible on chest auscultation. (bpac.org.nz)
In HCoV-HKU1-infected patients, the predominant clinical symptoms were cough, fever, and expectoration. (hindawi.com)

In 2013, a Cochrane meta-analysis concluded that HS may significantly reduce the hospital length of stay among infants hospitalised with mild-to-moderate bronchiolitis and also improve clinical severity scores. (bmj.com)
Among infants who required supplemental oxygen and intravenous fluids, the time until the infant was ready for discharge was significantly longer in the epinephrine group than in the placebo group (P=0.02). (edu.au)
CONCLUSIONS: The use of nebulized epinephrine did not significantly reduce the length of the hospital stay or the time until the infant was ready for discharge among infants admitted to the hospital with bronchiolitis. (edu.au)

In 2005, a parvovirus, subsequently named human bocavirus (HBoV), was discovered in respiratory samples taken from infants and children hospitalized at Karolinksa University Hospital, Sweden, with lower respiratory tract infection ( 1 ). (cdc.gov)
There are two safe and effective immunizations to prevent RSV lower respiratory tract infection in infants. (cdc.gov)
Bronchiolitis is a lower respiratory tract infection, most often caused by Respiratory Syncytial Virus (RSV). (bpac.org.nz)

Dr. Schroeder is currently involved in multiple projects involving common conditions in pediatrics such as head trauma, bronchiolitis, UTI, meningitis, and febrile infant management. (stanford.edu)
Earlier this month, The American Academy of Pediatrics (AAP) published new guidelines on the evaluation and management of well-appearing febrile infants 8-60 days old. (dontforgetthebubbles.com)

Respiratory syncytial virus (RSV) is recognized as one of the most common causes of childhood illness and is the most common cause of hospitalization in infants. (cdc.gov)
For infants with mild illness and without risk factors for deterioration, caregivers can be reassured that conservative treatment is appropriate. (bpac.org.nz)
The course of illness in infants with bronchiolitis can vary, although it often begins with symptoms similar to a cold, lasting approximately three days, which worsen as the infection spreads into the lower respiratory tract. (bpac.org.nz)
Despite reducing nasopharyngeal bacterial carriage, three large once-weekly doses of azithromycin did not confer any benefit over placebo during the bronchiolitis illness or 6 months post hospitalization. (edu.au)
In clinical trials of babies entering their first RSV season, nirsevimab reduced the risk of RSV-associated illness requiring medical attention by 70% to 75% during the first five months after the injection. (washingtoninformer.com)
But infants and older adults can experience serious and dangerous illness. (factcheck.org)
Meanwhile, Sanofi and AstraZeneca have asked the FDA to approve a monoclonal antibody injection for newborns and infants, which, while not a vaccine, would act like one in preventively protecting babies from RSV illness. (factcheck.org)

In clinical trials, single-dose baloxavir is safe and effective in treating patients with uncomplicated influenza. (medscape.com)
and (4) review ongoing and planned trials studying the utility of HFNC in various clinical settings. (nih.gov)
Ongoing research and clinical trials confirm that there is no role for bronchodilators, corticosteroids or antibiotics. (bpac.org.nz)
In clinical trials, a single dose of Beyfortus, administered as a single injection, protected against RSV for about five months, the duration of a typical RSV season (typically the fall to the end of spring). (everydayhealth.com)
So far, AstraZeneca says, clinical trials with infants have demonstrated that Beyfortus lowers the incidence of RSV-caused lower respiratory tract disease (such as bronchiolitis or pneumonia ) by 70 to 75 percent compared with placebo. (everydayhealth.com)
Under the terms of the agreement, Gilead will pay MicroDose an upfront payment and provide research funding to support MicroDose's continued development of MDT-637 through Phase IIa clinical trials. (gilead.com)
Evidence-based research from epidemiological and interventional/clinical trials as published in peer-reviewed journals which evaluated the health benefits of dietary LCPUFA as ingested by infants from breast milk or infant formula will be addressed. (dhaomega3.org)
After analyzing data from 15 randomized clinical trials involving 18,395 participants, results showed no significant differences in all-cause mortality or drug-related adverse events between the monoclonal antibody treatments and placebo. (consultantlive.com)
Investigators systematically searched several databases for trials that enrolled infants who showed high risk of respiratory syncytial virus infection to receive a monoclonal antibody or a placebo. (consultantlive.com)
The search utilized keywords and vocabulary related to monoclonal antibodies, respiratory syncytial virus, and randomized clinical trials to ensure all relevant studies were considered. (consultantlive.com)
The drug also showed an "overall favorable safety profile," according to an FDA briefing document, and deaths of children who received nirsevimab in clinical trials were not likely to be related to the monoclonal antibody. (washingtoninformer.com)
In clinical trials, 12 out of 3,710 children who received nirsevimab and four out of 1,797 in the control groups died of various causes. (washingtoninformer.com)
Countries in the Northern hemisphere recommend universal infant vitamin D supplementation to optimise early vitamin D levels, despite the absence of large trials proving safety or efficacy for any disease outcome. (bmj.com)

Management of diuretics in infants with bronchopulmonary dysplasia discharged on home. (authorea.com)
Background: Infants with Bronchopulmonary Dysplasia (BPD) are often prescribed diuretics before the neonatal intensive care unit (NICU) discharge. (authorea.com)

Background: Respiratory syncytial virus infection (RSV) alone or associated to rhinovirus (RV) in the infant has been linked with more likelihood to develop asthma and atopy. (uchile.cl)
Infants hospitalized with bronchiolitis are at significantly increased risk for both recurrent wheezing and childhood asthma. (atsjournals.org)
It is not known whether viral bronchiolitis directly contributes to asthma causation or simply identifies infants at risk for subsequent wheezing, as from an atopic predisposition or preexisting abnormal lung function. (atsjournals.org)
One such determinant is the potential involvement of genetic susceptibility loci to asthma after viral bronchiolitis, a critical area that is just beginning to be evaluated. (atsjournals.org)
It is also not known whether viral bronchiolitis (both inpatient and outpatient illnesses) contributes to asthma inception or simply identifies infants who are at increased risk for subsequent wheezing ( 2 , 7 - 10 ). (atsjournals.org)
This study's objective is to identify and test pragmatic and sustainable strategies for implementing a multi-condition clinical pathway intervention for children hospitalized with asthma, pneumonia, or bronchiolitis in community hospitals. (nih.gov)
The use of high-flow nasal cannula and noninvasive ventilation has become increasingly common in emergency medicine as a first-line treatment of pediatric patients with respiratory distress secondary to asthma and bronchiolitis. (ebmedicine.net)
Children with viral bronchiolitis in early life are at increased risk of developing asthma later in childhood. (benthamscience.com)
Viral bronchiolitis in early life predisposes asthma development later in childhood. (benthamscience.com)
The leading causes of hospitalisation were respiratory disease (pneumonia, bronchiolitis, and asthma), sepsis, and head injury, which was the major cause of the trauma motivated by violence. (bvsalud.org)

Its use as aerosol reduces hospitalization rates for bronchiolitis in children. (springer.com)

Bronchiolitis is inflammation of the small airways in the lungs. (wikipedia.org)

Enhanced battery-operated nasal suctioning in infants with bronchiolitis discharged from the emergency department (ED) lacked incremental benefits over minimal bulb suctioning. (medscape.com)
Infants were randomly assigned to minimal bulb suctioning (n=185) or enhanced battery-operated nasal suctioning (n=187) before feeding for 72 hours. (medscape.com)
Cite this: Enhanced Nasal Suction Makes Little Difference in Infant Bronchiolitis - Medscape - Nov 06, 2023. (medscape.com)
Clinical/baseline data will be collected along with details of types of breathing support received (including weaning, switches and escalations from Humidified Standard Oxygen (HSO), High Flow Nasal Cannula (HFNC), Continuous Positive Airway Pressure (CPAP)) and patient comfort (FLACC score). (who.int)
Vitamin D promotes anti-pneumococcal immune responses in vitro, but whether improvements in infant vitamin D status modify risks of nasal pneumococcal acquisition in early life is not known. (biomedcentral.com)

Rates of hospitalisation for bronchiolitis in New Zealand have increased by approximately 50% since 2000. (bpac.org.nz)
Bronchiolitis is common in children below 2 years of age and is a leading cause of infant hospitalisation, accounting for $1.73 billion in hospital charges in the USA annually. (bmj.com)
The RDAI has poor discriminative and construct validity in predicting hospitalisation and LOS in bronchiolitis, in part because it does not include respiratory rate or O 2 saturation, both important variables for a clinician to determine disposition. (bmj.com)

The use of HFNC as a respiratory support modality is increasing in the infant, pediatric, and adult populations as an alternative to non-invasive positive pressure ventilation. (nih.gov)
Only a few pediatric studies have examined the use of HFNC, with most focusing on this modality for viral bronchiolitis. (nih.gov)

In some patients, especially infants, a more widespread papular or vesicular exanthem appears principally on the buttocks, although it may occasionally generalize. (medscape.com)
A recent survey found that nearly all centers administer bronchodilators to most respiratory syncytial virus (RSV) bronchiolitis patients, with the β-agonist drug albuterol being prescribed most commonly ( 2 ). (snmjournals.org)
Aim: Analyze clinical and immunological markers of patients with RSV or RV bronchiolitis that determine their evolution. (uchile.cl)
One study analyzed the clinical data of adult patients with pandemic H1N1 2009 infection admitted to the ICU. (medscape.com)
In all patients clinical improvement at discharge was associated with disappearance of the previous LUS findings. (biomedcentral.com)
RIDTs may be used to help with diagnostic and treatment decisions for patients in clinical settings, such as whether to prescribe antiviral medications. (cdc.gov)
Demographic data, clinical details and epidemiological factors, were collected from the parents of the patients through a structured interview. (pediatriconcall.com)
Batista NOW, Coelho MCR,Trugilho SM, Pinasco GC, Santos EFSS, Ramos-Silva V. Clinical-epidemiological profile of hospitalised patients in paediatric intensive care unit. (bvsalud.org)
At Mass General, the brightest minds in medicine collaborate on behalf of our patients to bridge innovation science with state-of-the-art clinical medicine. (massgeneral.org)
At present, no operational definition of appropriate hospital admission for emergency department patients with bronchiolitis exists. (jmir.org)
We completed the first operational definition of appropriate hospital admission for emergency department patients with bronchiolitis. (jmir.org)
RÉSUMÉ Cette étude présente les agents étiologiques, les données démographiques des patients, la saisonnalité et les pathologies sous-jacentes chez des patients hospitalisés en raison d'infections respiratoires aiguës sévères (IRAS) au Yémen. (who.int)
Nous avons réalisé une étude prospective en recourant à la surveillance de la grippe basée sur des sites sentinelles dans le but de dépister le VRS grâce à la PCR en temps réel chez des patients souffrant d'infections respiratoires aiguës recrutés au cours de deux saisons (2014-2015 et 2015-2016). (who.int)
La proportion d'infections positives au VRS était plus élevée chez les patients hospitalisés pour une infection respiratoire aiguë que chez les patients en consultation externe souffrant de légers symptômes. (who.int)

Prolonged symptoms of bronchiolitis occur in infants. (medscape.com)
Clinical signs and symptoms consistent with influenza o Having clinical signs and symptoms consistent with influenza increases the pre-test probability of influenza virus infection, which increases the reliability of a positive RIDT result. (cdc.gov)

The purpose of this study is to identify the optimal deimplementation strategies for an overused practice: continuous pulse oximetry monitoring of children hospitalized with bronchiolitis who are not receiving supplemental oxygen. (nih.gov)
When implemented in clinical practice, close monitoring of vital signs and ventilation parameters is warranted to identify possible signs of respiratory failure. (ebmedicine.net)
Currently, there still exists much practice variation among clinicians in the care of young febrile infants. (dontforgetthebubbles.com)
There is a lot of information and nuance in this clinical practice guideline that is difficult to unpack in a blog post, including weighing the risks and benefits of each key action statement and discussion of future directions and limitations. (dontforgetthebubbles.com)

In 5 HBoV-positive infants no other pathogens were identified, but RSV was detected in 3 ( Table ). (cdc.gov)
To examine whether macrolide-resistant respiratory pathogens present in nasopharyngeal swabs (NPS) influence clinical severity. (edu.au)
In China, several groups have demonstrated the existence of HCoV-NL63 and HCoV-HKU1 as potential respiratory pathogens of infants and the elderly [ 3 - 5 ]. (hindawi.com)

The clinical status on admission was scored according to the respiratory rate (RR), oxygen saturation (SatO 2 ), subcostal indrawing, chest auscultation, and general evaluation, with each parameter graded on a scale of 0-2. (snmjournals.org)
Oxygen requirement was determined to be the best measure of bronchiolitis severity ( 2 ). (cdc.gov)
and infants who were hospitalized but did not require supplemental oxygen, mild. (cdc.gov)
Subpleural lung consolidation of 1 cm or more in the posterior area scan and a quantitative classification of interstitial syndrome based on intercostal spaces involved bilaterally, good correlate with bronchiolitis severity and oxygen use. (biomedcentral.com)
The lung ultrasound findings strictly correlate with the clinical evaluations in infants with bronchiolitis and permit the identification of infants who are in need of supplementary oxygen with high specificity. (biomedcentral.com)
there were no differences in home oxygen duration in infants actively weaned (median 13 weeks, IQR 10-26) versus not on diuretics (median 22 weeks, IQR 12-30, p=0.285). (authorea.com)
Conclusions: Active weaning of diuretics did not prolong duration of home oxygen, in the setting of a standardized clinical guideline for weaning home oxygen in infants with BPD. (authorea.com)

The FDA has already approved another monoclonal antibody injection called Synagis (palivizumab), but that is only for high-risk infants who were born severely premature. (everydayhealth.com)
Despite these limitations, this study provided valuable insights into potential preventive strategies for respiratory syncytial virus and can inform clinical decision-making for high-risk infants and children. (consultantlive.com)

The most recent meta-analysis on HTS in bronchiolitis seems promising in terms of LOS reduction for mild-to-moderate disease (mean=1.15 days, 95% CI 1.49 to 0.82). (bmj.com)

We have been trying to decipher the riddle of the young febrile infant for more than four decades. (dontforgetthebubbles.com)
This is not to say that infants are purposely facetious, but rather it is sometimes difficult to distinguish a sick versus not sick febrile infant based on physical exam alone. (dontforgetthebubbles.com)

This was an observational cohort study of infants admitted to our Pediatric Unit with suspected bronchiolitis. (biomedcentral.com)

Primary outcome was the use of additional resources, including any unscheduled family- or healthcare practitioner-initiated bronchiolitis-related visit to any medical facility within 72 hours of ED discharge or use of any unassigned suctioning devices for feeding or breathing concerns. (medscape.com)
The proportion of bronchiolitis-related and ED revisits, parental satisfaction with care at home, and changes in normal infant feeding and sleeping within 72 hours of discharge were not significantly different between the groups. (medscape.com)
The primary outcome measures were the length of the hospital stay and the time until the infant was ready for discharge. (edu.au)
RESULTS: There were no significant overall differences between the groups in the length of the hospital stay (P=0.16) or the time until the infant was ready for discharge (P=0.86). (edu.au)

In 2021, Bavarian Nordic reported results from a clinical Phase 2 double-blinded, placebo-controlled human challenge trial (n=61), which enrolled healthy adult volunteers, who were randomized to receive either a single vaccination of MVA-BN RSV or placebo. (pipelinereview.com)
Well appearing febrile infants, Don't Forget the Bubbles, 2021. (dontforgetthebubbles.com)

This pathogen may cause bronchiolitis or, in infants up to 4 months of age, pneumonias. (rapidtest.com)

Either a maternal vaccination or a monoclonal antibody is recommended, but administration of both is not needed for most infants. (cdc.gov)
Healthcare providers of pregnant people should provide information on both maternal vaccines and infant monoclonal antibody products and consider patient preferences when determining whether to vaccinate the pregnant patient or to not vaccinate and rely on administration of nirsevimab to the infant after birth. (cdc.gov)
The new monoclonal antibody treatment defends against serious, potentially life-threatening disease in infants and vulnerable children up to age 2. (everydayhealth.com)
Monoclonal Antibody for the Prevention of Respiratory Syncytial Virus in Infants and Children: A Systematic Review and Network Meta-analysis. (consultantlive.com)
But the Food and Drug Administration is now considering approval of a vaccine and a monoclonal antibody aimed at protecting infants from this common virus. (factcheck.org)
Any detectable titer of neutralizing antibody against poliovirus is considered protective against clinical paralytic diseases. (who.int)

abstract = "BACKGROUND: The treatment of infants with bronchiolitis is largely supportive. (edu.au)

Eight (3.5%) of 230 samples, collected from infants hospitalized with bronchiolitis during the 2003-2005 winter epidemic seasons, were positive for HBoV. (cdc.gov)

Sharon Chen, MD, MS, is a Clinical Associate Professor in Pediatric Cardiology and her clinical focus include single ventricle heart disease, mechanical circulatory support, heart failure, heart transplantation, and pediatric cardiology. (stanford.edu)
Alan Schroeder, MD, is the associate chief for research in the division of pediatric hospital medicine at Lucile Packard Children's Hospital Stanford, and an associate clinical professor in the division of hospital medicine and the division of critical care. (stanford.edu)
Dr. Schroeder provides clinical care for children in the PICU and the pediatric ward. (stanford.edu)
Describe clinical care and interventions for pediatric respiratory illnesses. (ceufast.com)

2015). Three-weekly doses of azithromycin for Indigenous infants hospitalised with bronchiolitis: A multicentre, randomised, placebo-controlled trial. (edu.au)

Because of this, Mingyao Sun Department of Intensive Care Unit, The First Hospital of Lanzhou University, and a team of investigators, compared the efficacy and safety of monoclonal antibodies for the prevention of respiratory syncytial virus infection in infants and children. (consultantlive.com)
Pfizer's vaccine also has been administered to pregnant people in a clinical trial to determine whether the antibodies they develop in response to vaccination can then protect their babies up to 6 months of age. (factcheck.org)
In infants, RSV antibodies that have been passed from mother to baby may also be detected. (medlineplus.gov)
Infants may have a positive test because antibodies were passed from their mother to them before they were born. (medlineplus.gov)

The Suctioning of Nose Therapy in Bronchiolitis Trial included 372 infants (age, 4 weeks to 11 months) with bronchiolitis discharged from the ED. (medscape.com)
The 8 HBoV-positive infants had a median age of 9.5 months, and the male:female ratio was 1:1. (cdc.gov)
Infants with bronchiolitis between the age of two and three months have a second infection by bacteria (usually a urinary tract infection) less than 6% of the time. (wikipedia.org)
Each year during the winter months, RS viruses spread heavily amongst children and infants. (rapidtest.com)
With the aim of determining the clinical and cost-effectiveness of daily vitamin D supplementation in breastfed infants from age 6-8 weeks to 12 months of age, we have started a double-blind, randomised, placebo-controlled trial of daily 400 IU vitamin D supplementation during the first year of life, VITALITY. (bmj.com)
25(2): 182-193 related to the experience of the care team, health analysis, we adopted the following stratification assistance, the availability of material resources, proposed by the Brazilian Society of Pae- and the use of clinical care protocols, among diatrics5: infants (29 days to 24 months others. (bvsalud.org)

CDC recommends that adults 60 and older may receive a single dose of RSV vaccine, using shared clinical decision-making. (cdc.gov)
Chronic bronchiolitis is the general term used for small airways disease in adults, notably in chronic obstructive pulmonary disease. (wikipedia.org)
COPENHAGEN, Denmark I April 20, 2022 I Bavarian Nordic A/S (OMX: BAVA) announced today the dosing of the first subject in the Phase 3 VANIR clinical trial of its investigational respiratory syncytial virus (RSV) vaccine candidate, MVA-BN ® RSV in older adults. (pipelinereview.com)
At-risk individuals typically include infants and older adults as well as immunocompromised individuals. (pipelinereview.com)
We don't know if the products - both those for older adults and those for infants - will be approved by the FDA. (factcheck.org)
As such, increasing rate of premature births is contributing toward the rising demand for RSV prophylaxis owing to RSV being more commonly found in infants as compared to adults. (persistencemarketresearch.com)

Bronchiolitis is the inflammation of the bronchioles, the smallest air passages in the lungs, mainly seen in children under 2 years of age in response to viral respiratory infection. (jmir.org)

Consider glucose and electrolyte monitoring in young infants, and those with ongoing significant losses or nasogastric fluid support requirement beyond the initial 4-6 hour rehydration phase. (rch.org.au)
There are two ANC cutoffs included based on the PECARN study and the Febrile Young Infant Research Collaborative study. (dontforgetthebubbles.com)
Background: Viral bronchiolitis is a common condition and a leading cause of hospitalization in young children. (benthamscience.com)
Results: Respiratory syncytial virus (RSV) is the most common viral bronchiolitis in young children. (benthamscience.com)

Greater lung deposition, if appropriately targeted to the airways, should lead to greater clinical benefit. (snmjournals.org)
Therefore, knowledge of the lung dose, its regional distribution, and the manner in which pulmonary drug targeting may be affected by large and small airway obstruction in bronchiolitis is very important if aerosol therapy is to be optimized. (snmjournals.org)
However, to our knowledge, no studies have been conducted to investigate the airway dose and distribution of aerosolized medications in bronchiolitis to determine if medications are capable of being delivered to affected lung regions. (snmjournals.org)
An exploratory analysis was used to assess correspondence between the lung ultrasound findings and the clinical evaluation and to evaluate the inter-observer concordance between the two different sonographs. (biomedcentral.com)
An aberrant ultrasound lung pattern in posterior chest area was collected in 86 % of infants with bronchiolitis. (biomedcentral.com)

We also looked at a recently completed emergency department study (Kuzik et al 2010) that randomized infants to 3% or 0.9% saline and examined whether there was a significant change in the rate of admission (n = 81). (thennt.com)
Subjects receiving 3% saline were also noted to have improved clinical severity scores, especially on the first day of admission, when compared to the groups receiving 0.9% saline. (thennt.com)
in the PICU are influenced by intrinsic factors to The improvement of specialised care the patient, such as pre-existing comorbidities, for seriously ill children began in 1980 and the clinical severity on admission, and number of these units growth throughout the age. (bvsalud.org)
Appropriate hospital admissions include actual admissions with exposure to major medical interventions for more than 6 hours, as well as actual emergency department discharges, followed by an emergency department return within 12 hours ending in admission for bronchiolitis. (jmir.org)

Anatomy6

Organisms4

Diseases29

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Psychiatry and Psychology6

Phenomena and Processes13

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture5

Information Science1

Named Groups9

Health Care16

Geographicals1

Acute18

Severe22

Pneumonia and bronchiolitis3

Diagnosis19

Severity of bronchiolitis3

Infections10

Morbidity6

Hypertonic Saline1

Methods2

Outcomes8

Premature infants2

Cough4

Among infants3

Lower respirato3

Pediatrics2

Illness7

Trials13

Bronchopulmonary Dysplasia2

Asthma10

Hospitalization rates1

Inflammation of the small airways1

Nasal5

Hospitalisation3

HFNC2

Patients14

Symptoms2

Practice4

Pathogens3

Oxygen7

High-risk infants2

Moderate1

Febrile infant2

Observational1

Discharge4

20212

Pathogen1

Antibody6

Abstract1

Winter epidemic1

Pediatric4

Multicentre1

Antibodies4

Months6

Adults6

Lungs1

Young4

Lung5

Admission4