Cell AgingCyclin-Dependent Kinase Inhibitor p16TelomereAging, Prematurebeta-GalactosidaseTumor Suppressor Protein p53Cyclin-Dependent Kinase Inhibitor p21FibroblastsTelomeraseTelomere ShorteningAgingCells, CulturedDNA DamageCell ProliferationSignal TransductionRetinoblastoma ProteinOxidative StressCell Line, TumorCell CycleApoptosisReactive Oxygen SpeciesBiological ProcessesCell LineGene Expression RegulationEnzyme InductionRNA, Small InterferingPhenotypeRNA InterferenceDown-RegulationCell DivisionUp-RegulationEndothelial CellsCell Cycle CheckpointsDNA-Binding ProteinsCell Transformation, NeoplasticTOR Serine-Threonine KinasesBlotting, WesternTumor Suppressor Protein p14ARFTumor Suppressor ProteinsPlant LeavesRNA, MessengerMice, KnockoutMice, Inbred C57BLTime FactorsSirtuin 1HistonesReverse Transcriptase Polymerase Chain ReactionLongevityNuclear ProteinsCell Cycle ProteinsNeoplasmsGene Expression Regulation, NeoplasticProgeriaTelomeric Repeat Binding Protein 2TransfectionDiploidyp38 Mitogen-Activated Protein KinasesTranscription FactorsCell DifferentiationGenes, p16Models, BiologicalPhosphorylationStem CellsHydrogen PeroxideFlow CytometryGene Knockdown TechniquesBiological Markersras ProteinsMutationRepressor ProteinsHeterochromatinImmunohistochemistryEnzyme ActivationWerner SyndromePromoter Regions, GeneticDose-Response Relationship, DrugAtherosclerosisTranscription, GeneticEndothelium, VascularOncogenesOxidantsCell Line, TransformedGenes, rasForeskinMolecular Sequence DataGene SilencingHCT116 CellsBase SequenceGene Expression Regulation, PlantGene ExpressionProtein-Serine-Threonine KinasesProto-Oncogene Proteins c-mycCyclin-Dependent Kinase Inhibitor p15EthylenesNevus, PigmentedChlorophyllGenes, p53Polycomb Repressive Complex 1Epithelial CellsCell Survival