These results establish HO-1 as a mediator of ATF4-dependent anoikis resistance and tumor metastasis and suggest ATF4 and HO-1 as potential targets for therapeutic intervention in solid tumors. (jci.org)
In cancer, EMT plays various roles in the maintenance of cancer stemness and induction of metastasis, and is inducible by different growth factors, hormones, and intracellular molecules. (microrna21.com)
Whereas the disruption of cell-cell contacts alone does not enable metastasis, the loss of E-cadherin protein does, through induction of an epithelial-to-mesenchymal transition, invasiveness, and anoikis resistance. (gsea-msigdb.org)
In addition, gene expression analysis shows that E-cadherin loss results in the induction of multiple transcription factors, at least one of which, Twist, is necessary for E-cadherin loss-induced metastasis. (gsea-msigdb.org)
In this study, we found that the induction of NOX4, followed by the increased ROS was essential for oleic acid (OA)-promoted CRC cell metastasis. (thno.org)
However despite such obvious evidence suggesting the induction of c-kit manifestation is triggered by the osseous microenvironment Rotigotine as a result of an Rotigotine adaptation of the PCa bone colonizing cells the contribution of c-kit manifestation and activation in PCa cells to bone metastasis has not been confirmed up to date. (acancerjourney.info)
Nitrosothiol signaling in anoikis resistance and cancer metastasis. (siscr.org)
Resistance and tumor1
Loss of calponin h1 confers anoikis resistance and tumor progression in the development of high-grade serous carcinoma originating from the fallopian tube epithelium. (biossantibodies.com)
Apoptosis3
Here, we have shown that activating transcription factor 4 (ATF4), a master transcriptional effector of the ISR, protects transformed cells against anoikis - a specialized form of apoptosis - following matrix detachment and also contributes to tumor metastatic properties. (jci.org)
Downregulation of VSNL1 in CW-2 and HCT116 cells suppressed their proliferation through induction of apoptosis. (bvsalud.org)
The results demonstrated that JIB extract combined with cisplatin enhanced the inhibition of cell growth, proliferation, and survival through the obstruction of cell cycle progression and AKT/mTOR and MAPK signaling as well as the induction of cell apoptosis. (medsci.org)
Tumor2
ATF4-deficient human fibrosarcoma cells were unable to colonize the lungs in a murine model, and reconstitution of ATF4 or HO-1 expression in ATF4-deficient cells blocked anoikis and rescued tumor lung colonization. (jci.org)
Newer induction immunosuppressive agent combinations [T-cell-depleting antibody (anti-CD3 antibody, alemtuzumab, or antithymocyte globulin) and a tumor necrosis factor alpha (TNF- α ) inhibitor (etanercept or infliximab)] have improved long-term diabetes reversal rates (~50% in 5 years at the most experienced centers) [ 9 ], presumably by preserving transplanted β -cell mass. (hindawi.com)
Proliferation1
Cell Proliferation Migration Invasion and Anoikis Cell viability and proliferation of PCa cells stably transfected using the vector expressing c-kit or the unfilled vector were examined utilizing the WST-1 assay within the existence or lack of 100 ng/ml SCF (PeproTech). (acancerjourney.info)
PI3K2
Further analysis showed that higher expression of plakoglobin was able to promote activation of the PI3K/Akt/Bcl-2 pathway, which might protect the clusters from anoikis. (jcancer.org)
Induction of canonical autophagy is mainly controlled by the AKT/mTOR and AMPK signaling pathways and relies on the activation and assembly of two macromolecular complexes, the ATG1/ULK1 and the Class III phosphatidylinositol 3-kinase (PI3K) complex (Figure 1 ) [ 5 ]. (hindawi.com)
Autophagy1
Autophagy usually serves as a survival mechanism in response to stress conditions, but excessive induction of autophagy results in cell death. (biomedcentral.com)
Lung3
Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotubes. (siscr.org)
Caveolin-1 regulates p53 inactivation and stem-like induction of carbon nanotube-driven lung tumorigenesis. (siscr.org)
Acquisition of anoikis resistance up-regulates caveolin-1 expression in human non-small cell lung cancer cells. (siscr.org)
Gene1
Before using transduced PCa cells gene induction was verified using cocultures of Rotigotine Computer3 and bone tissue marrow (BM) cells inserted in Matrigel (BD Biosciences) which imitate c-kit induction seen in intraosseous PCa tumors or metastases6. (acancerjourney.info)
Cells3
Conversely, overexpression of VSNL1 in SNU-C5 cells enhanced resistance to anoikis. (bvsalud.org)
Re sistance against anoikis induced upon cell detach ment from the extracellular matrix, might also be involved in survival of migrating cancer cells. (microrna21.com)
Induction of stem-like cells with fibrogenic properties by carbon nanotubes and its role in fibrogenesis. (siscr.org)
Pancreas1
Development of gastrulation, neural systems and various internal Inhibitors,Modulators,Libraries organs, such as pancreas and liver, are required from induction of EMT. (microrna21.com)
Growth1
A few reports have suggested that induction of resistance against anoikis is also derived from ac tivation of the PI3Kinase signaling and extracellular signaling receptor kinase via various proteins involving TrkB, its ligand brain derived neurotrophic factor, and hepatocyte growth factor. (microrna21.com)
Expression1
Hepatitis B Virus X Protein Induces SATB1 Expression Through Activation of ERK and p38MAPK Pathways to Suppress Anoikis. (arigobio.com)
Resistance10
To find al ternative cell death pathways that can bypass the apoptotic resistance of pancreatic cancer cells, we examined the role of the novel anoikis effector Bit1 (Bcl-2 inhibitor of transcription) in the survival and apoptotic resistance of pancreatic cancer cells. (scirp.org)
Conversely, downregulation of endogenous Bit1 in PANC-1 cells further enhanced their anoikis resistance. (scirp.org)
To identify potential therapies, we developed in vitro models of peritoneal carcinomatosis/peritoneal sarcomatosis using tumor cell lines and patient-derived spheroids (PDS) that recapitulate anoikis resistance and spheroid proliferation across multiple cancer types. (elsevierpure.com)
For successful distant metastasis, circulating tumor cells (CTCs) that have lost matrix attachment need to acquire anoikis resistance in order to survive. (nih.gov)
These findings suggest that the viability difference between cells incubated with fibronectin and those with BSA is due to acquired resistance to anoikis by the former cells, not to different proliferation rates. (medscape.com)
To determine whether VLA-4 or VLA-5 interact with fibronectin in acquired anoikis resistance, we examined the viability and annexin-V positive staining of U937 cells in the presence of antibodies to each ß 1 integrin (10 µg/ml). (medscape.com)
To this end, we tested the tumorigenicity and anoikis resistance of OS cell lines both in vitro and in vivo. (nature.com)
We detected anoikis resistance in transformed OS cells. (nature.com)
9 Transformed growth or anoikis resistance refers to a state in which malignant tumor cells can evade context-dependent conditions and survive. (nature.com)
10 Earlier studies have suggested that the absence of normal signaling produced by attachment to the ECM could lead to anoikis resistance in human OS cells. (nature.com)
Decreasing the induction of apoptosis1
Pharmacologic induction of autophagy with rapamycin significantly increased spheroid formation and survival while decreasing the induction of apoptosis. (elsevierpure.com)
Induces3
Bit1 is a mitochondrial protein that induces a caspase-independent apoptosis upon its release into the cyto sol following loss of integrin-mediated attachment to extracellular matrix (anoikis). (scirp.org)
Our previous study demonstrated that arecoline induces anoikis of HA22T/VGH hepatoma cells. (jcancer.org)
Detachment1
Addition of 2-deoxy-d-glucose, a glucose competitor that interferes with glycolysis, attenuated arecoline induction of lactate [Ca 2+ ]i, ROS and cell detachment. (jcancer.org)
Integrin1
Moreover, we reported that FxOH rapidly detached human CRC cells (DLD-1 cell line) from a culture dish and induced anoikis-like cell death through the suppression of integrin β1 and inactivation of focal adhesion kinase [ 10 ]. (biomedcentral.com)
Endogenous1
Other lines of treatment including induction of endogenous tissue inhibitors of metalloproteinases and administration of exogenous synthetic inhibitors of MMPs are being explored, and could provide alternative strategies in the treatment of CVD. (oaepublish.com)
Protein1
Mecha nistically, we found that the Bit1 apoptosis function is in part dependent on the groucho related Amino-terminal En hancer of Split (AES) expression and is abrogated by the transcriptional corepressor TLE1 protein. (scirp.org)
Prevents1
10. Fucoxanthin potentiates anoikis in colon mucosa and prevents carcinogenesis in AOM/DSS model mice. (nih.gov)
From the current examine we evaluated the antitumor activity of sorafenib, and also the en hancement of gemcitabine response by addition of sorafenib plus the antiangiogenic agent EMAP in experi psychological pancreatic cancer. (peptidesprice.com)
Agent1
This study suggested that FxOH is a more potent apoptosis-inducing agent than FX and that its induction of apoptosis is enhanced by inhibiting NF-κB transcriptional activity via suppression of IAP family genes. (biomedcentral.com)