Endothelium, VascularVasodilationVasodilator AgentsAcetylcholineNitroglycerinNitroprussideNitric OxideEndotheliumVasoconstrictionBrachial ArteryVasoconstrictor AgentsRegional Blood FlowArteriesMuscle, Smooth, VascularNitric Oxide SynthaseDose-Response Relationship, DrugEndothelium, CornealEnzyme InductionCells, CulturedSignal TransductionRNA, MessengerCell LineMice, Inbred C57BLMolecular Sequence DataEndothelial CellsCell AdhesionEndothelium, LymphaticGene Expression RegulationTime FactorsApoptosisBase SequenceMice, KnockoutTranscription, GeneticEnzyme InhibitorsTranscription FactorsPromoter Regions, GeneticDNA-Binding ProteinsKineticsBlotting, WesternCalciumPhosphorylationRats, Sprague-DawleyRabbitsAmino Acid SequenceMutationAortaTransfectionUmbilical VeinsUp-RegulationCell Line, TumorEmbryonic InductionCell DifferentiationCell MovementEnzyme ActivationTumor Cells, CulturedMice, Inbred BALB CReverse Transcriptase Polymerase Chain ReactionGene ExpressionImmunohistochemistryProtein BindingIntercellular Adhesion Molecule-1Cell DivisionTumor Necrosis Factor-alphaMembrane ProteinsCell Adhesion MoleculesAorta, ThoracicRecombinant ProteinsRats, WistarMice, TransgenicModels, BiologicalVascular Cell Adhesion Molecule-1Disease Models, AnimalLeukocytesFlow CytometryCattleCell SurvivalAntibodies, MonoclonalLiverCapillariesTranscriptional ActivationNF-kappa BCarrier ProteinsMonocytesMicrocirculationE-SelectinCell ProliferationCytokinesMacrophagesMembrane GlycoproteinsFibroblastsLungRecombinant Fusion ProteinsNitric Oxide Synthase Type IIILipopolysaccharidesT-LymphocytesRNA, Small InterferingTrans-ActivatorsCorneaGene Expression Regulation, EnzymologicInflammation