ConcurrentConcomitant chemoradiotherapyFollowed by radiotherapyCisplatinComparing induction chemotherapy followedCCRTCarboplatinMainstayChemotherapy followed by chemoradiationPancreatic cancerOutcomesToxicityUnresectablePatientsEfficacySecondaryDefinitiveFavorablePelvicPreservationOBJECTIVETreatmentSurvivalPartialMethodsComplete responseResponseNeoadjuvantTrialsSystemicDiseaseNeck
Concurrent18
- What about induction chemotherapy followed by CRT, would that give better systemic control without losing the advantage of better locoregional provided by concurrent CRT? (oncolink.org)
- Concurrent chemoradiotherapy (CCRT) is the standard treatment for patients with unresectable, nonmetastatic locoregionally advanced squamous-cell carcinoma of the head and neck (LASCCHN). (h12o.es)
- Our findings demonstrate that a non-operative approach with high-dose radiotherapy and concurrent chemoradiotherapy can result in favorable outcomes. (mskcc.org)
- In the absence of similar research, we endeavored to investigate the prognostic usefulness of posttreatment neutrophil-to-lymphocyte ratio (NLR) in patients treated with definitive concurrent chemoradiotherapy (CCRT) for locally advanced pancreatic adenocarcinoma (LAPAC). (hindawi.com)
- however, chemotherapy (CT), concurrent chemoradiotherapy (CCRT), and induction CT followed by CCRT are the most often utilized alternatives [ 6 ]. (hindawi.com)
- In recent years, as most evidence solidified the role of concurrent chemotherapy and radiation as either primary or postoperative therapy for locally advanced head and neck cancer, induction chemotherapy fell out of scope and practice. (jnccn.org)
- Locoregional control has dramatically improved with concurrent chemoradiotherapy. (jnccn.org)
- Of note is that none of the previously conducted randomized trials of induction chemotherapy used concurrent chemoradiotherapy in the control arm. (jnccn.org)
- A number of randomized trials are planned or currently ongoing to investigate concurrent chemoradiotherapy with or without induction. (jnccn.org)
- Concurrent chemoradiotherapy with 3x-weekly cisplatin is recommended if patient refuses surgery. (medscape.com)
- The decision to treat the patient with induction chemotherapy rather than concurrent chemoradiation or surgery, radiation, or chemotherapy alone should be made by a multidisciplinary tumor board (including a medical oncologist, a radiation therapist, and an ENT surgeon). (medscape.com)
- The purpose of this trial is to explore whether concurrent chemoradiotherapy is not inferior to induction chemotherapy combined with concurrent chemoradiotherapy in patients with locally advanced nasopharyngeal carcinoma. (centerwatch.com)
- Background: Induction chemotherapy (IC) adopted by concurrent chemoradiotherapy is the mainstay remedy for sufferers with locoregionally superior nasopharyngeal carcinoma. (stjosephs-hospital.com)
- Patients with nasopharyngeal carcinoma treated with concurrent chemoradiotherapy reported higher quality of life and were less likely to experience vomiting when receiving fosaprepitant every week as opposed to every three weeks. (curetoday.com)
- Patients with nasopharyngeal carcinoma (NPC) treated with concurrent chemoradiotherapy who received fosaprepitant every week were less likely to experience vomiting and had greater quality of life than those who received fosaprepitant every three weeks, according to the findings of a new study. (curetoday.com)
- Unlike substantial evidence in the prevention of chemotherapy-induced nausea and vomiting (CINV), research in the prevention of nausea and vomiting caused by concurrent chemoradiotherapy (CCRT) is currently lacking," Sun Yat-Sen University researchers wrote in the JAMA Network Open study, which they posited was to their knowledge, "the first study to assess the efficacy and safety of fosaprepitant during combined radiotherapy-HEC. (curetoday.com)
- Concurrent chemoradiotherapy is still the mainstay of HNSCCs treatment, especially in unresectable ones, which has been associated with variable individual clinical outcomes despite similar clinical-pathological features (Nogueira et al. (researchsquare.com)
- Over the decades Dr. Morrison has been involved in trials of fractionation, radiation protectors, induction and concurrent chemotherapy, and proton beam therapy. (mdanderson.org)
Concomitant chemoradiotherapy3
- For concomitant chemoradiotherapy with 3x-weekly cisplatin, several studies have demonstrated benefit in locoregional control and overall survival over radiotherapy alone with a significant increase in acute and chronic toxicity. (medscape.com)
- The MEND-IT study aims to evaluate the CR rate after intensified chemotherapy prior to concomitant chemoradiotherapy in a homogeneous group of patients with locally advanced rectal cancer and indisputably unfavourable characteristics, defined as hr-LARC, in order to improve their prognosis. (amsterdamumc.org)
- Five completed the scheduled induction chemotherapy and all patients completed the programmed concomitant chemoradiotherapy. (uniroma1.it)
Followed by radiotherapy3
- It is beneficial in the control of malignant lymphomas and head and neck squamous cell carcinomas when followed by radiotherapy or when treated concurrently with chemoradiotherapy. (wikipedia.org)
- Recommend surgical resection (total pharyngo-laryngectomy + neck dissection) followed by radiotherapy or chemoradiotherapy if there is high risk of recurrence of pathological factors, especially T4a. (medscape.com)
- surgery followed by radiotherapy or chemoradiotherapy. (medscape.com)
Cisplatin8
- For the induction treatment of locally advanced inoperable SCCHN, the recommended dose of TAXOTERE is 75 mg/m 2 as a 1-hour intravenous infusion followed by cisplatin 75 mg/m 2 intravenously over 1 hour, on day one, followed by fluorouracil as a continuous intravenous infusion at 750 mg/m 2 per day for five days. (drugs.com)
- For the induction treatment of patients with locally advanced (unresectable, low surgical cure, or organ preservation) SCCHN, the recommended dose of TAXOTERE is 75 mg/m 2 as a 1-hour intravenous infusion on day 1, followed by cisplatin 100 mg/m 2 administered as a 30-minute to 3 hour infusion, followed by fluorouracil 1000 mg/m 2 /day as a continuous infusion from day 1 to day 4. (drugs.com)
- radiotherapy (based on initial stage) ± cisplatin/cetuximab (based on induction chemotherapy [ICT] toxicity). (medscape.com)
- A randomized phase 3 trial of the treatment of squamous-cell carcinoma of the head and neck compared induction chemotherapy with docetaxel plus cisplatin and fluorouracil (TPF) with cisplatin and fluorouracil (PF), followed by chemoradiotherapy. (nih.gov)
- Patients with squamous-cell carcinoma of the head and neck who received docetaxel plus cisplatin and fluorouracil induction chemotherapy plus chemoradiotherapy had a significantly longer survival than did patients who received cisplatin and fluorouracil induction chemotherapy plus chemoradiotherapy. (nih.gov)
- She noted the study's premise starts with the recognition that for locally advanced nasopharyngeal cancer, gemcitabine/cisplatin induction chemotherapy is now accepted as a standard of care. (ascopost.com)
- So, the question of induction achemotherapy with gemcitabine/cisplatin had been previously answered, as had the question of immunotherapy plus gemcitabine/cisplatin. (ascopost.com)
- 1. Zhang Y, Chen L, Hu GQ, et al: Gemcitabine and cisplatin induction chemotherapy in nasopharyngeal carcinoma. (ascopost.com)
Comparing induction chemotherapy followed1
- Catálogo en línea Koha › Detalles para: A randomized phase III trial comparing induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as treatment of unresectable head and neck cancer. (h12o.es)
CCRT1
- This randomized, open-label, phase III clinical trial compared the efficacy between standard CCRT and two different induction chemotherapy (ICT) regimens followed by CCRT. (h12o.es)
Carboplatin1
- We randomly assigned 501 patients (all of whom had stage III or IV disease with no distant metastases and tumors considered to be unresectable or were candidates for organ preservation) to receive either TPF or PF induction chemotherapy, followed by chemoradiotherapy with weekly carboplatin therapy and radiotherapy for 5 days per week. (nih.gov)
Mainstay1
- INTRODUCTION: The mainstay of management for locally advanced rectal cancer is chemoradiotherapy followed by surgical resection. (lu.se)
Chemotherapy followed by chemoradiation2
- The CONTINUUM trial sought to answer that question by assessing 425 patients with advanced-stage disease who were randomly assigned between induction chemotherapy followed by chemoradiation or the same plus the incorporation of the PD-1 inhibitor sintilimab, with sintilimab continued for a total of 12 cycles. (ascopost.com)
- The Presidential 2 session will explore results from INTERLACE , which evaluated induction chemotherapy followed by chemoradiation vs chemoradiation alone in locally advanced cervical cancer. (medscape.com)
Pancreatic cancer1
- In a study appearing in the May 3 issue of JAMA, Pascal Hammel, M.D., of Beaujon Hospital, Clichy, France and colleagues assessed whether chemoradiotherapy improves overall survival of patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine-based induction chemotherapy, and assessed the effect of erlotinib on survival. (news-medical.net)
Outcomes2
- This meta-analysis aimed to compare the clinical outcomes between neoadjuvant CRT (nCRT) with induction CT and nCRT with consolidated CT in locally advanced rectal cancer (LARC) patients . (bvsalud.org)
- Background: Induction chemotherapy (IC) in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) often compromises compliance with subsequent chemoradiotherapy (CRT), which negatively affects outcomes. (elsevierpure.com)
Toxicity1
- Consider induction chemotherapy with TPF schedule only in those patients with N bulky and fast tumor growth, individualizing benefit and toxicity. (medscape.com)
Unresectable1
- Induction Chemotherapy Followed by Chemoradiotherapy Compared with Chemoradiotherapy Alone for Regionally Advanced Unresectable Stage III Non-Small. (oncolink.org)
Patients12
- In July 2022, a literature search was conducted using the following public databases PubMed , MEDLINE , Embase, the Cochrane Library , and Web of Science , retrieved all relevant articles comparing nCRT-combining induction CT with nCRT-combining-consolidated CT treatments for LARC patients . (bvsalud.org)
- Four eligible studies were identified, including a total of 995 LARC patients 473 in the nCRT with consolidated CT group and 522 in the nCRT with induction CT group. (bvsalud.org)
- Induction chemotherapy is typically given to patients with stage III-IVB disease in order to shrink a primary tumor to reduce its bulkiness in preparation for future surgery or radiation therapy. (medscape.com)
- Weekly fosaprepitant decreased vomiting in patients undergoing chemoradiotherapy, accoriding to a recnet study. (curetoday.com)
- RESULTS: Of 2572 patients undergoing rectal cancer surgery in 277 participating centres across 44 countries, 673 (26.2%) underwent chemoradiotherapy and surgery. (lu.se)
- The aim of this study is to evaluate whether or not intensified chemotherapy prior to neoadjuvant chemoradiotherapy improves the complete response (CR) rate in these patients. (amsterdamumc.org)
- All patients will be planned for six two-weekly cycles of FOLFOXIRI (5-fluorouracil, leucovorin, oxaliplatin and irinotecan) prior to chemoradiotherapy (25 × 2 Gy or 28 × 1.8 Gy with concomitant capecitabine). (amsterdamumc.org)
- Aim: To assess feasibility, complications and efficacy of induction chemotherapy followed by standard chemoradiotherapy in patients with bulky anal canal cancer. (uniroma1.it)
- Before standard chemoradiotherapy, patients received induction chemotherapy with 3 cycles of 75 mg/m2cisplatin and 750 mg/m25-fluorouracil. (uniroma1.it)
- The majority of patients (6/7) had tumor downsizing after induction treatment. (uniroma1.it)
- Six months after chemoradiotherapy, complete response was documented in three patients and salvage surgery was performed in two cases. (uniroma1.it)
- Conclusion: Induction chemotherapy has the potential to become a standard approach in patients with bulky human papillomavirus-negative anal canal cancer. (uniroma1.it)
Efficacy1
- Moreover, we witnessed the development of better combination regimens that improved efficacy in the induction setting. (jnccn.org)
Secondary1
- Philadelphia chromosome-positive acute lymphoblastic leukemia secondary to chemoradiotherapy for Ewing sarcoma. (who.int)
Definitive1
- Objectives/Hypothesis Local residual or recurrent pharyngeal cancer after definitive radiotherapy (RT) or chemoradiotherapy (CRT) is correlated to poor prognosis. (elsevierpure.com)
Favorable1
- Conclusion: Deep remission from induction CT was associated with favorable survivals in localized NKTCL receiving CT+RT, and an induction CT response-adapted individualized treatment strategy might be recommended in clinical practice. (aging-us.com)
Pelvic1
- Exclusion criteria are the presence of a homozygous DPD deficiency, distant metastases, any chemotherapy within the past 6 months, previous radiotherapy within the pelvic area precluding standard chemoradiotherapy, and any contraindication for the planned treatment. (amsterdamumc.org)
Preservation1
- In this meta-analysis of TNT regimens for rectal cancer , consolidative CT following nCRT was associated with similar PCR , 3-year DFS, LR, R0 resection, compliance , and grade 3-4 toxicities compared to induction CT prior to nCRT but a higher rate of organ preservation . (bvsalud.org)
OBJECTIVE2
- Despite high objective response rates, induction chemotherapy has not resulted in tangible benefit in multiple randomized trials. (jnccn.org)
- Objective: We aimed to assess the association between induction chemotherapy (CT) response and survivals and to explore an induction CT response-adapted treatment strategy for localized extranodal NK/T-cell lymphoma (NKTCL) receiving first-line sequential CT and radiation (RT). (aging-us.com)
Treatment5
- The long-term treatment results, the induction of second malignant tumors, and other long-term toxicities are not well defined. (uni-muenchen.de)
- Total neoadjuvant therapy ( TNT ) combining chemoradiotherapy (CRT) with chemotherapy (CT) was a novel pre-surgical approach to cancer treatment . (bvsalud.org)
- Induction chemotherapy is the first-line treatment of cancer with a chemotherapeutic drug. (wikipedia.org)
- Induction chemotherapy followed by locoregional treatment. (medscape.com)
- Drug treatment designed to further diminish the disease toward complete remission following INDUCTION CHEMOTHERAPY. (bvsalud.org)
Survival2
- The trial was designed to have 80% power to detect a 40% increase in median survival, from about 13mo to 18.2 mo with the addition of induction chemo using a one-tailed log-rank test conducted at a 0.025 level of significance. (oncolink.org)
- The failure of older randomized trials to show a survival benefit from induction chemotherapy can be attributed to several factors. (jnccn.org)
Partial1
- a partial response represented any regression from baseline staging following chemoradiotherapy. (lu.se)
Methods1
- Methods: Induction chemotherapy consisted of weekly CBDCA area under the plasma concentration-time curve = 1.5, PTX 80 mg/m 2 and Cmab with an initial dose of 400 mg/m 2 followed by 250 mg/m 2 for 8 weeks. (elsevierpure.com)
Complete response1
- Following chemoradiotherapy, a complete response may be detected clinically and radiologically (cCR) prior to surgery or pathologically after surgery (pCR). (lu.se)
Response2
- Responses after induction CT (initial response), RT (final response) and survivals were analyzed. (aging-us.com)
- The limited strength of agreement between basic conventional post-chemoradiotherapy imaging assessment techniques and pathology suggest alternative markers of response should be considered, in the context of controlled clinical trials. (lu.se)
Neoadjuvant1
- A Meta-analysis of Total Neoadjuvant Therapies Combining Chemoradiotherapy with Induction or Consolidated Chemotherapy for Locally Advanced Rectal Cancer. (bvsalud.org)
Trials1
- These trials are anticipated to redefine the role of induction chemotherapy for head and neck cancer. (jnccn.org)
Systemic1
- With the emergence of more efficacious systemic therapies, the role of induction therapy warrants reevaluation. (jnccn.org)
Disease1
- A resection will be performed following radiological confirmation of resectable disease after the completion of chemoradiotherapy. (amsterdamumc.org)
Neck1
- Induction Chemotherapy for Head and Neck Cancer: Will History Repeat Itself? (jnccn.org)