Inducing mast cell. Medical search. Frequent questions

Mercury induces inflammatory mediator release from human mast cells. (tufts.edu)
Mast cells are inflammatory immune cells that play an essential role in mediating allergic reactions in humans. (figshare.com)
In intestine of Ws/Ws rats, epithelial function and morphology were unchanged by chronic stress, bacterial-epithelial cell interaction was not demonstrated, and there was no evidence of inflammatory cell infiltration. (mcmaster.ca)
Chloroquine phosphate (CP) is an antimalarial medication that, upon injection subcutaneously, promotes a robust itch response thought to be primarily due to triggering mast cell degranulation and a subsequent elevation of inflammatory cytokines as well as other itch-producing mediators (Aghahowa et al. (gasyblog.com)
These cells can participate in inflammatory responses by releasing mediators that attract or activate other cells, contributing to the pathogenesis of allergic and non-allergic diseases. (mdpi.com)
Anti-Siglec-8 antibody administration in vivo to humanized and transgenic mice selectively expressing Siglec-8 on mouse eosinophils and mast cells confirmed the in vitro findings, and identified additional anti-inflammatory effects. (mdpi.com)
Exposure of the peripheral C-fiber terminals to inflammatory mediators such as bradykinin, serotonin, prostaglandins, leukotriences, and protons induces depolarization of the terminals as evidenced by the generation of action potentials and/or sensitization of the terminals ( Basbaum, 1991 ). (jneurosci.org)
The local action of these released peptides are known to increase tissue blood flow, capillary permeability, and inflammatory cell activities ( Holzer, 1988 ). (jneurosci.org)
Cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) can be generated by inflammatory and nonimmune cells in response to inflammation, tissue injury, microbial invasion, and immunological reactions ( Dinarello, 1994 ). (jneurosci.org)
The observed symptoms for MIS-C and KD are consistent with Mast Cell Activation Syndrome (MCAS) characterized by inflammatory molecules released from activated mast cells. (mit.edu)
Inflammatory cell infiltration was not affected by the racemate or the individual enantiomers. (ersjournals.com)
These adverse effects are thought to be caused by desensitisation of β 2 -adrenoceptors on airway smooth muscle as well as on inflammatory cells 5 - 7 . (ersjournals.com)
Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)
CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)
The body produces mast cells as an inflammatory and histamine response. (dogsnaturallymagazine.com)
The present study was aimed to assess the protective effect of aqueous extract of Spinacia oleracea leaves (AESO 250, 500, and 1,000 mg/kg, p.o.) in inflammatory bowel disease using acetic acid- and ethanol-induced colitis in mice and indomethacin-induced enterocolitis in rats. (springermedizin.de)
Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. (medscape.com)
Mast cells play an important role in a variety of biological processes and actively participate in the inflammatory response. (bvsalud.org)
In this investigation we sought to answer the question concerning the presence of mast cells in human and rat dental pulp tissues, under normal and inflammatory conditions. (bvsalud.org)
The role of mast cells in the inflammatory dental pulp response is not clear. (bvsalud.org)
Since mast cells are active during inflammatory responses it becomes crucial to find out if these cells are actually present and play a role in dental pulp under normal and inflammatory conditions either in humans or in rats. (bvsalud.org)
As reported previously by Medscape Medical News , evidence suggests that the inflammatory cytokines involved in ME/CFS are different from those that induce C-reactive protein. (medscape.com)
A spectrum of primary, secondary, and idiopathic disorders involving MAST CELLS and characterized by an aberrant release of mast cell mediators which result in multiple and variable inflammatory and allergic symptoms. (bvsalud.org)

Mast cells are involved in allergic reactions, but also in innate and acquired immunity, as well as in inflammation. (tufts.edu)
BACKGROUND & AIMS: Chronic psychological stress is an important factor in relapses of intestinal disorders, but it remains unclear if stress can induce primary gut inflammation in a previously healthy host. (mcmaster.ca)
CONCLUSIONS: These findings suggest that chronic psychological stress can be an initiating factor in intestinal inflammation by impairing mucosal defenses against luminal bacteria and highlight the importance of mast cells in this process. (mcmaster.ca)
Antigen presentation by the dendritic cell with the lymphocyte and cytokine response leading to airway inflammation and asthma symptoms. (medscape.com)
Previous work by our group has shown that the expression levels of some members of the Mas-related gene receptor (Mrgpr) family in both enteric neurons and mucosal mast cells change during intestinal inflammation. (uantwerpen.be)
Here we report that TcdB induces neurogenic inflammation by targeting gut-innervating afferent neurons and pericytes through receptors, including the Frizzled receptors (FZD1, FZD2 and FZD7) in neurons and chondroitin sulfate proteoglycan 4 (CSPG4) in pericytes. (nature.com)
Targeted delivery of the TcdB enzymatic domain, through fusion with a detoxified diphtheria toxin, into peptidergic sensory neurons that express exogeneous diphtheria toxin receptor (an approach we term toxogenetics) is sufficient to induce neurogenic inflammation and recapitulates major colonic histopathology associated with CDI. (nature.com)
Fig. 3: Delivery of TcdB-GTD into peptidergic sensory neurons using the toxogenetic approach is sufficient to induce neurogenic inflammation. (nature.com)
To date, the effects of the individual salbutamol enantiomers on allergen-induced early (EAR) and late (LAR) asthmatic reactions, AHR and airway inflammation have not been established. (ersjournals.com)
The principal injury responsible for sunburn is direct damage to DNA by UVR, resulting in inflammation and apoptosis of skin cells. (medscape.com)
Our aims were to prove that crowding stress induces mucosal inflammation and intestinal dysfunction, to characterize dynamics in time, and to evaluate the implication of stress-induced mast cell activation on intestinal dysfunction. (nih.gov)
Stress-induced intestinal chrono-pathobiology was determined by measuring intestinal inflammation, epithelial damage, mast cell activation and infiltration, and intestinal barrier function. (nih.gov)
Stress-induced mild inflammation, manifested earlier in the ileum and the colon than in the jejunum. (nih.gov)
Taken together, we have provided evidences that long-term exposure to psychosocial stress promotes mucosal inflammation and mast cell-mediated barrier dysfunction in the rat bowel. (nih.gov)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)
Mast cells play an important role in a variety of biological processes including allergic reactions, atherosclerosis and inflammation 7,8 . (bvsalud.org)

Mast cells are found frequently in close proximity to blood vessels, and endothelial cells are likely to be exposed to high concentrations of their granule mediators. (eurekamag.com)
Recent evidence indicates that RFamides act as mediators in mast cell-sensory nerve communications related to allergic disease. (uantwerpen.be)
Within an hour of UVR exposure, mast cells release preformed mediators including histamine, serotonin, and tumor necrosis factor, leading to prostaglandin and leukotriene synthesis. (medscape.com)
12 However, the antagonism of histamine or serotonin, two important mast cell mediators, only partially reduce postoperative nociception, indicating that other mast cell components must be involved. (asahq.org)
Oxidative and dicarbonyl stress, driven by excess accumulation of glycolytic intermediates in cells that are highly permeable to glucose in the absence of effective insulin activity, appear to be the chief mediators of the complications of diabetes. (bvsalud.org)
The activation of these cells leads to the release of chemical mediators such as histamine and arachidonic acid metabolites, which increase vascular permeability and tissue swelling 9 . (bvsalud.org)

The results suggest that, if an influx of Ca2+ is the mechanism for initiating mast cell degranulation, then the opening of Ca2+ channels in the plasma membrane of activated mast cells is a localized event and that Ca2+ acts locally within the cell to initiate exocytosis. (rupress.org)

ET-1 is released endogenously by several cell-types found in the skin, including macrophages and keratinocytes. (iasp-pain.org)
Immunofluorescence revealed more β-glucan-uptake and higher percentage of macrophages and dendritic cells close to β-glucan in VE of CD compared to controls. (azurewebsites.net)
Double IHC showed that the distribution of FcεRI + cells was tryptase + mast cells (33%), CD68 + macrophages (36%), EG2 + eosinophils (20%), CD1a + Langerhans' cells (4%) and unidentified cells (7%), at the 24-hr allergen-challenged sites. (utmb.edu)
These observations suggest that the cutaneous late-phase reaction in man is associated with up-regulation of FcεRI on eosinophils, macrophages, mast cells and Langerhans' cells. (utmb.edu)
IL-3 is a highly species-specific pleiotropic factor produced primarily by activated T cells though also by mast cells keratinocytes, and astrocytes, which stimulates colony formation of megakaryocytes, neutrophils, and macrophages from bone marrow cultures. (biolegend.com)

Concanavalin A (Con A) covalently linked to Sepharose 4B beads induced localized degranulation of sensitized rat peritoneal mast cells in regions of contact between beads and cells. (rupress.org)

Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1. (iasp-pain.org)
The mouse mast cell proteases (mMCPs) mMCP4 (chymase), mMCP6 (tryptase), and CPA3 are found in connective tissue type mast cells and are the closest functional homologs to human mast cell proteases, but little is known about their role in endothelin-induced itch. (iasp-pain.org)
We have investigated the proinflammatory actions of the major mast cell product tryptase on HUVEC. (eurekamag.com)
Addition of purified tryptase was found to stimulate thymidine incorporation, but induced little alteration in cell numbers, suggesting it is not a growth factor for HUVEC. (eurekamag.com)
However, tryptase was a more selective stimulus than TNF-alpha and did not induce increased expression of mRNA for granulocyte-macrophage CSF or stimulate the release of this cytokine. (eurekamag.com)
Leukocyte accumulation in response to tryptase may be mediated in part through the selective secretion of IL-8 from endothelial cells. (eurekamag.com)
In addition to histamine and serotonin, mast cell degranulation releases tryptase, which has been demonstrated to be an important pronociceptive protease related to some painful diseases such as irritable bowel syndrome. (asahq.org)
16 , 17 Tryptase works by cleaving a specific site on the extracellular N-terminal domain of the receptor and releases a new N-terminal domain for the receptor, which acts as a tethered ligand by binding to the second extracellular loop of the receptor to induce intracellular signaling. (asahq.org)
The close association between mast cells and nerves in peripheral tissues, and the fact that large amounts of tryptase are released upon mast cell degranulation, makes tryptase an ideal candidate to activate PAR-2 on peripheral neurons. (asahq.org)
Tryptase levels of 11.5 ng/mL or greater are indicative of either mast cell activation (as in anaphylaxis) or increased total mast cell levels (as in mastocytosis). (medscape.com)
As such, determinations of tryptase levels are contingent on both the size and activation status of an individual's mast cell population but is not informative of the specific contribution of either of these factors. (medscape.com)
Tryptase is a trypsin-like proteinase that is found most abundantly in mast cells and basophils, with the former containing almost 300 times more tryptase. (medscape.com)
[ 8 ] As such, tryptase is specific to mast cell granules and can provide information about mast cell number, distribution, and activation depending on the clinical context. (medscape.com)
Of the four isoenzymes, beta tryptase is the predominant form stored in the mast cell granule where it is complexed as a tetramer stabilized by proteoglycans namely heparin. (medscape.com)

METHODS: Mast cell-deficient (Ws/Ws) rats and wild-type control (+/+) rats were submitted to water avoidance stress or sham stress (1 h/day) for 10 consecutive days, as a model of ongoing life stress. (mcmaster.ca)
In +/+ rats, chronic stress induced barrier dysfunction in the ileum and colon (increased macromolecular permeability and depletion of mucus) and ultrastructural changes in epithelial cells (enlarged mitochondria and presence of autophagosomes) associated with bacterial adhesion and penetration into enterocytes. (mcmaster.ca)
Crude peritoneal mast cells were obtained from male Sprague-Dawley rats, washed and suspended in Locke's solution, and purified by sedimentation. (llu.edu)
Systemic injection of LPS (0.75 mg/kg, i.p.) in adult rats induced an increase in body temperature followed by hypothermia, indicating ongoing infection. (jneurosci.org)
Capsaicin attenuates excitotoxic-induced neonatal brain injury and brain mast cell-mediated neuroinflammation in newborn rats. (cabi.org)
Zurück zum Zitat Cetinkaya A, Bulbuloglu E, Kurutas EB, Ciralik H, Kantarcekan B, Buyukbese MA (2005) Beneficial effects of N-acetylcysteine on acetic acid induced colitis in rats. (springermedizin.de)
After treatment, rats were euthanized, and tail tissues were chemically fixed for histological analysis of nerves (PGP9.5, neuropeptide Y, calcitonin gene related protein) and mast cells (avidin, Alcian Blue/Safranin O).2 Single sections were doublestained for nerve fibers and mast cells to permit assessment of the degree of physical overlap. (cdc.gov)
Our results showed that inflamed and non-inflamed dental pulps neither from humans nor from rats presented mast cells. (bvsalud.org)
In addition there is a lack of information regarding the presence of mast cells in dental pulp of rats, which are animals used to study important aspects of the pathophysiology of dental pulp in vivo 6 . (bvsalud.org)
Therefore, the purpose of the present work was, under the same experimental conditions, to identify mast cells in healthy and inflamed dental pulp from rats and humans using toluidine blue histochemistry and immunohistochemistry techniques. (bvsalud.org)

Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that also has the ability to induce a burning, non-histaminergic pruritus when exogenously administered, by activating the endothelin A receptor (ETR) on primary afferents. (iasp-pain.org)
Previous reports showed that store-operated Ca 2+ entry (SOCE) via the calcium sensor, stromal interaction molecule 1 (STIM1), regulates mast cell response induced by the high-affinity IgE receptor (FcεRI). (figshare.com)
This mouse model is based on the cell type-specific expression of Cre recombinase in connective tissue-type MCs under control of the Mcpt5 promoter and the Cre-inducible diphtheria toxin receptor-mediated cell lineage ablation by diphtheria toxin. (uni-luebeck.de)
This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. (nih.gov)
Based on the associations of KD with multiple viral and bacterial pathogens, we put forward the hypothesis that KD and MIS-C result from antibody activation of mast cells by Fc receptor-bound pathogen antibodies causing a hyperinflammatory response upon second pathogen exposure. (mit.edu)
The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)
Estos trastornos se asocian a diversas mutaciones en el receptor tirosina-cinasa KIT (PROTEÍNAS PROTOONCOGÉNICAS C-KIT) y en otros genes, afecciones subyacentes y respuestas a desencadenantes alérgicos o no alérgicos de la estimulación y la desgranulación de los mastocitos, tales como anestésicos locales, antibióticos lactámicos, relajantes musculares, alimentos específicos, toxinas ambientales y situaciones físicas tales como la vibración, el frío, la presión y el estrés. (bvsalud.org)

Localized mast cell degranulation induced by concanavalin A-sepharose beads. (rupress.org)
BMMCs were found to express MrgprA4 and A1, and functional analysis of the effects of NPAF by means of a beta-hexosaminidase assay, mMCP-1 ELISA, electron microscopy and live cell calcium imaging revealed a piecemeal degranulation induced by NPAF. (uantwerpen.be)

We extend the mast cell hypothesis that increased histamine levels are inducing contraction of effector cells with impeded blood flow through cardiac capillaries. (mit.edu)
It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. (abcam.com)

We, therefore, investigated the effect of mercuric chloride (HgCl2) on human mast cell activation. (tufts.edu)
It is well-known that mast cell activation is critically regulated by intracellular calcium ion (Ca 2+ ) concentrations. (figshare.com)
Collectively, our data suggests that MRGPRX2/MrgprB2 activation of mast cells is dependent on SOCE via STIM1, and further characterization of the MRGPRX2-SOCE-STIM1 pathway will lead to the identification of novel targets for the treatment of pseudo-allergic reactions in humans. (figshare.com)
Moreover, hyperplasia and activation of mast cells, infiltration of neutrophils and mononuclear cells, and increased myeloperoxidase (MPO) activity were documented in the mucosa. (mcmaster.ca)
Three distinct diagnostic outcomes including systemic mastocytosis, monoclonal mast cell activation syndrome and non-clonal HVA were revealed. (biomedcentral.com)
T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. (nih.gov)
The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of "mast cell activation syndrome" (MCAS) grown significantly. (degruyter.com)
Subsequent literature regarding this newly recognized (but of course not truly new) "mast cell activation syndrome" (MCAS) included case reports as well as formal studies (mostly relatively small scale), reviews, and various proposals for formal diagnostic criteria. (degruyter.com)
Stress-induced mitochondrial injury and increased jejunal permeability, both events strongly correlated with mast cell activation at day 15. (nih.gov)
After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. (abcam.com)
A lot of the testing we do is the differential diagnosis, and we're looking for comorbid conditions, treatment targets, and subgroups, like people with [small intestinal bacterial overgrowth] or mast cell activation. (medscape.com)

The finding that sensitized mast cells which had adhered to Con A-Sepharose beads degranulated in regions of the cell away from the area of bead contact if exposed to soluble Con A excluded the possibility that the localized release was due to a redistribution of the IgE receptors or putative Ca2+ channels to the region of bead contact. (rupress.org)
These integrin receptors are present on a number of immune cells such as mast cells, neutrophils, and T cells. (wikipedia.org)
Upon binding these receptors, cells use several signal transduction pathways to elicit immune responses in these cells. (wikipedia.org)
Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. (mdpi.com)
The aim of the present study was to investigate whether RFamides of the NPFF group are expressed in the gastrointestinal tract and to identify possible targets and receptors that might be involved in RFamide-associated mast cell modulation. (uantwerpen.be)
To this end, the expression and distribution patterns of NPFF/AF receptors and the NPFF precursor protein were determined in bone marrow-derived mucosal mast cells (BMMCs) by immunocytochemistry and (RT-) PCR. (uantwerpen.be)
MCs express receptors for both estrogen and progesterone that induce degranulation upon binding. (frontiersin.org)
Mast cells secrete histamine that inhibits vasoconstriction via H2 receptors on smooth muscle cells. (cdc.gov)

Although β 2 -agonists, including salbutamol, are the most effective bronchodilators available for the treatment of asthma, long-term use of these drugs has been associated with adverse effects, including the development of airway hyperreactivity (AHR) and tolerance to β 2 -agonist-induced bronchoprotection against allergic and pharmacological stimuli 1 - 4 . (ersjournals.com)

In addition, the acute protective effects against histamine-induced bronchoconstriction were assessed in both normoreactive and hyperreactive airways, after both the EAR and the LAR. (ersjournals.com)
Fewer mast cells means less histamine-induced vasodilation and protease inactivation of NPY and endothelin-1, favoring vasospasm. (cdc.gov)

Translocation of β-glucan and colocalization with immune cells were studied by immunofluorescence. (azurewebsites.net)
little attention has been devoted to the mechanisms and other immune cells. (hindawi.com)
There were also significant differences in microbial composition in dust samples and in innate immune cells between the two groups of children. (medscape.com)

Chronic visceral pain is a classic example of gene × environment interaction which results from maladaptive changes in neuronal circuitry leading to neuroplasticity and aberrant neuronal activity-induced signaling. (frontiersin.org)

Exercise-induced asthma is generally a clinical diagnosis. (medscape.com)
Imaging studies are often not indicated in the evaluation of routine exercise-induced asthma. (medscape.com)
Postexercise laryngoscopy can be used to evaluate for vocal cord dysfunction, a condition often mistaken for exercise-induced asthma. (medscape.com)
Treatment of the athlete who is experiencing an acute attack of exercise-induced asthma is the same as in any asthma attack situation and includes immediately removing the patient from competition or play. (medscape.com)
Traditional asthma medications (eg, corticosteroids, theophylline) have less of a role in the treatment of pure exercise-induced asthma (EIA). (medscape.com)
As discussed earlier, the optimal treatment for exercise-induced asthma (EIA) is to prevent the onset of symptoms. (medscape.com)
Go to Pediatric Asthma , Status Asthmaticus , Exercise-Induced Asthma , and Asthma in Pregnancy for complete information on these topics. (medscape.com)

It is concluded that Physalia venom induces the release of both histamine and lactate dehydrogenase from isolated rat peritoneal mast cells by a cytolytic mechanism. (llu.edu)

Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosinophils, and at low levels on basophils. (mdpi.com)
Since its discovery in 2000, initial in vitro studies have found that the engagement of Siglec-8 with a monoclonal antibody or with selective polyvalent sialoglycan ligands induced the cell death of eosinophils and inhibited mast cell degranulation. (mdpi.com)

with mastocytosis, characterized by numerous hyperactive mast cells in most tissues, is 10-fold higher than the general population suggesting mast cell involvement. (tufts.edu)

arr2-KO mice display less of a response to KOR antagonist-induced itch compared to wild types, however no genotype differences are observed from chloroquine phosphate (CP)-induced itch, suggesting that the antagonists may utilize a KOR-arrestin2 dependent mechanism. (gasyblog.com)
The Spiramycin KOR agonist U50,488H was equally effective in both WT and arr2-KO mice in suppressing CP-induced itch. (gasyblog.com)
Furthermore, the G protein biased agonist, Isoquinolinone 2.1 was as effective as U50,488H in suppressing the itch response induced by KOR antagonist NorBNI or CP in C57BL/6J mice. (gasyblog.com)
3.3 Chloroquine phosphate-induced pruritus Spiramycin results in no genotype differences in arr2-WT and arr2-KO mice To test whether the WT and arr2-KO mice are equally capable of expressing an itch response, we tested a general pruritic agent that is not known to be an antagonist at the KOR. (gasyblog.com)
it is often used to induce a model of pruritus in mice (Akiyama et al. (gasyblog.com)
Collectively, our findings strongly suggest that significant reduction of MC numbers does not affect skin wound healing and bleomycin-induced fibrosis in mice, and provide to our knowledge previously unreported insight in the long-debated contribution of MCs in skin regenerative processes. (uni-luebeck.de)
Zurück zum Zitat Andrade MC, Vaz NM, Faria AMC (2003) Ethanol induced colitis prevents oral tolerance induction in mice. (springermedizin.de)
Previous studies in mice demonstrated that mast cells (MCs) not only contribute to P. aeruginosa eradication but also promote wound healing via an unknown mechanism. (listlabs.com)

We have used in situ hybridization (ISH) and immunohistochemistry (IHC) to investigate the kinetics of the expression for FcεRI mRNA (α-, β- and γ-chains), the α-chain protein product, as well as the phenotype of the mRNA- or protein-positive cells in allergen-induced late-phase skin reactions in atopic subjects. (utmb.edu)
Cell-fate-determinant molecule NUMB-interacting protein (TBC1D15) is overexpressed and contributes to p53 degradation in TICs. (nature.com)
This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. (nih.gov)
As a PhD student with Alex Brand in the Aberdeen Fungal Group and a post-doc with Rob Arkowitz in Nice, I generated novel techniques via cross-faculty approaches to define previously-impossible-to-measure live-cell applied-forces and fluorescent protein dynamics within invasive pathogenic fungi against tissue-soft substrates. (exeter.ac.uk)
Murepavadin also caused degranulation in RBL-2H3 cells expressing MRGPRX2 but this response was significantly reduced in cells expressing missense variants within the receptor's ligand binding (G165E) or G protein coupling (V282M) domains. (listlabs.com)

UVR exposure also suppresses cutaneous cell-mediated immunity, which might contribute to nonmelanoma skin cancer and certain infections. (medscape.com)

Both epidermal keratinocytes ("sunburn cells") and Langerhans cells undergo apoptotic changes as a consequence of UVR-induced DNA damage. (medscape.com)

Neuropeptide AF induces piecemeal degranulation in murine mucosal mast cells : a new mediator in neuro-immune communication in the intestinal lamina propria? (uantwerpen.be)

In animal tumor implant models, Gold-Coated Silicone Nanoparticle (GSN) and exposure of tumors to laser light (at 808nm) generated enough heat to cause tumor cell death. (fortunepublish.com)
Mast Cell Tumors (MCT) are the most common skin tumor in dogs, comprising an estimated 20% of canine skin tumors. (fortunepublish.com)
Tumor-initiating stem-like cells (TICs) are defective in maintaining asymmetric cell division and responsible for tumor recurrence. (nature.com)
If you suspect a mast cell tumor, take your dog to the vet for diagnosis so that you can decide on the best treatment option. (dogsnaturallymagazine.com)
Thanks to advancements in science, your vet can now test tumor cells to find out 2 important things: the "grade" and the "stage" of the tumor. (dogsnaturallymagazine.com)

In the other case, symptoms were consistent with chemically-induced cirrhosis. (cdc.gov)

While there are relatively few studies examining epigenetically mediated mechanisms involved in visceral nociception, stress-induced visceral pain has been linked to alterations in DNA methylation and histone acetylation patterns within the brain, leading to increased expression of pro-nociceptive neurotransmitters. (frontiersin.org)
This review will discuss the potential neuronal pathways and mechanisms responsible for stress-induced exacerbation of chronic visceral pain. (frontiersin.org)
We will provide an evidenced-based argument for the use of specific experimental models to advance the understanding of stress-induced chronic pain. (frontiersin.org)
We will explain the unique aspects of these models that allows for a carefully crafted investigation of the female vulnerability to stress-induced chronic visceral pain. (frontiersin.org)

We observed that capsaicin-induced (0.1 μ m ) tracheal CGRP release was significantly enhanced in the LPS-treated animals after 5 hr. (jneurosci.org)
IL-1β-induced augmentation of CGRP release was blocked by Lys- d -Pro-Thr. (jneurosci.org)
Discussion: PGP9.5, NPY and CGRP staining of nerve fibers and avidin-positive mast cells is feasible in rat tail sections. (cdc.gov)
The present study shows CGRP in some mast cells, but it is unknown whether this represents associated nerve fibers and/ or uptake with re-release during vasoregulation. (cdc.gov)

In vitro , S -salbutamol was shown to increase the contractile response to carbachol in guinea pig tracheal smooth muscle preparations 12 , intracellular calcium levels in bovine airway smooth muscle cells 13 , and histamine and interleukin-4 production in immunoglobulin (Ig)E-stimulated murine mast cells 14 . (ersjournals.com)

6. It is concluded that the fall in blood pressure induced by intravenous administration of pharmacological doses of nerve growth factor is mediated by vasoactive substances, particularly histamine, released from mast cells. (portlandpress.com)
Mast cells moderate vasoconstriction by releasing proteases that degrade vasoactive neuropeptides and endothelin-1. (cdc.gov)

While mast cell counts remained mostly unchanged, piecemeal degranulation increased along time, as the mucosal content and luminal release of rat mast cell protease-II. (nih.gov)

Inhalation of RS - and R -salbutamol 30 min before and 5.5 h after allergen challenge suppressed allergen-induced airway hyperreactivity to histamine after the early and late asthmatic reaction, completely inhibiting the early asthmatic reaction and tending to reduce the development of the late asthmatic reaction. (ersjournals.com)
Both basal airway reactivity and allergen-induced hyperreactivity were not affected by S -salbutamol. (ersjournals.com)
In conclusion, inhalation of therapeutically relevant doses of R - and RS -salbutamol effectively suppress allergen-induced airway reactivity after the early and late asthmatic reactions, the R -enantiomer being slightly more potent with respect to early airway reactivity than the racemate. (ersjournals.com)

For example, mammalian cells range in size from 2000 nm to 10,000 nm, cellular organelles are about 100 nm to 300 nm, and intracellular proteins and molecules range between 10 nm to 50 nm [23]. (fortunepublish.com)

We evaluated characteristics of the bone marrow mast cells by pathology, flow cytometry and detection of D816V mutation by using current WHO-criteria, which led to changes in the final diagnosis compared to the assessments done by classical allergy work-up and measurements of sBT. (biomedcentral.com)

T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)

Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)

The present study investigates the general mechanism whereby nematocyst venom causes the direct release of histamine from isolated mast cells. (llu.edu)
To characterize the requirements for Physalia venom-induced histamine release, mast cells and nematocyst venom were incubated together in the presence or absence of calcium, at different temperatures, and with ATP depleted and ATP supplied mast cells. (llu.edu)
ATP depletion increases the sensitivity of venom-induced lactate dehydrogenase release while having no effect on histamine release. (llu.edu)
The cells release those granules into the tissues to destroy the "invader. (dogsnaturallymagazine.com)

30 dogs with 36 mast cell tumors were treated in this retrospective study. (fortunepublish.com)
Unfortunately, the squished-nosed dogs of the world are not the only ones who get mast cell tumors. (dogsnaturallymagazine.com)
What Are Mast Cell Tumors? (dogsnaturallymagazine.com)
Mast cell tumors (MCTs) happen mostly on the skin but sometimes in the internal organs . (dogsnaturallymagazine.com)

[ 1 ] Long-acting β2-agonists, mast cell stabilizers, and antileukotriene drugs also have a role. (medscape.com)

Hymenoptera venom allergy (HVA) represents a particular risk for exceptionally severe anaphylactic sting reactions in patients with clonal mast cell disorders (CMD). (biomedcentral.com)
Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)

At the same time, dermicidin and antibacterial substances in sebum kill bacteria directly, and skin cells also secrete natural antibiotics, the defensins, that perforate and kill bacteria. (ernolaszlo.com)

Different cell types may differ in their regulatory mechanisms of the OPN gene. (wikipedia.org)
Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases. (nih.gov)

Mast cells express ETRs and can thereby be degranulated by ET-1, and mast cell proteases chymase and carboxypeptidase A3 (CPA3) are known to either generate or degrade ET-1, respectively, suggesting a role for mast cell proteases in the regulation of ET-1-induced itch. (iasp-pain.org)

In this study, using complementary pharmacologic and genetic ablation approaches we demonstrate that SOCE through STIM1 promotes MRGPRX2-induced human mast cell response in vitro. (figshare.com)
LAD2 cells) endogenously expressing MRGPRX2. (listlabs.com)

We discuss the current knowledge about sex differences in migraine and its comorbidities, and focus on the potential role of mast cells (MCs) in both. (frontiersin.org)
Th17 cell may have a role in severe asthma and chronic obstructive pulmonary disease (COPD). (cdc.gov)
We propose that the BPTI decamer, with a heparin chain threading the decamer channel, plays a functional role in the mast cell. (lu.se)

Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)

In cells exposed to hyperglycemia, glycine somehow up-regulates Nrf2 activity. (bvsalud.org)

Our aim was to investigate whether β-glucan could attenuate mast cell (MC)-induced hyperpermeability in follicle-associated epithelium (FAE) and villus epithelium (VE) of patients with Crohn's disease (CD) and in noninflammatory bowel disease (IBD)-controls. (azurewebsites.net)

Anatomy11

Organisms6

Diseases11

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes6

Inflammatory23

Inflammation17

Mediators6

Initiating mast cell degranulation1

Macrophages5

Sensitized rat peritoneal mast cells1

Tryptase14

Rats10

Receptor7

Degranulation induced2

Contraction2

Activation11

Receptors8

Allergic1

Histamine-induced2

Immune cells3

Aberrant1

Exercise-induce7

Peritoneal1

Eosinophils2

Mastocytosis1

Mice8

Protein5

Cutaneous1

Keratinocytes1

Mediator1

Tumor5

Chemically-induced1

Stress-induced4

CGRP4

Murine1

Vasoactive2

Piecemeal degranulation1

Airway3

Intracellular1

Diagnosis1

Effector1

Monoclonal1

Release4

Tumors4

Stabilizers1

Disorders2

Secrete1

Gene2

Regulation1

MRGPRX22

Role3

Adhesion1

Regulates1

Disease1