• Herein, chronic inflammation was induced by intraperitoneal injection of pristane into mice. (hindawi.com)
  • We found that the loss of IL-6 decreased macrophage recruitment to the spleen and the peritoneal cavity during pristane-induced inflammation. (hindawi.com)
  • These data provide insight into the development of chronic inflammation induced by noninfectious substances. (hindawi.com)
  • Noninfectious inflammation can be induced by persistent indigestible substances. (hindawi.com)
  • Pristane-induced chronic inflammation has been characterized by the continuous recruitment of leukocytes, including lymphocytes, neutrophils, and macrophages, to the peritoneal cavity and the spleen [ 6 - 8 ]. (hindawi.com)
  • Interleukin-6 (IL-6) seems to regulate both plasmacytoma development in BALB/c mice and oil granuloma formation in C57BL/6 mice during pristane-induced inflammation [ 10 , 12 ]. (hindawi.com)
  • Other cell-mediated mechanisms (especially inflammation induced by TNF-α). (cdc.gov)
  • We focused on early recruitment of neutrophils to wounds at 0.5-1h post wounding throughout this study because within this time frame the H2O2 burst occurs6 (Supplementary Movie 1) and neutrophil accumulation is usually roughly linear18 19 Addition of PP2 at 1h post wounding did not disturb resolution of inflammation which is usually mediated by neutrophil reverse migration from wounds16 19 (Supplementary Fig 3c.d). (cancerhugs.com)
  • Bleomycin (BLM)-induced inflammation and fibrosis represent an experimental model for IPF as well as ALI/ARDS. (ersjournals.com)
  • Cellular factors which play role in host defense mechanisms against HIV were identified and their role in HIV induced inflammation was established. (europa.eu)
  • One possible explanation is that HBoV infection may directly induce inflammation of tonsillar tissues or facilitate bacterial superinfection prompting surgical intervention. (cdc.gov)
  • Another possibility is that inflammation of mucosal lymphoid tissues enhances HBoV replication by recruitment of immune cells permissive for HBoV infection or by latent virus reactivation. (cdc.gov)
  • Tumor-necrosis-factor-alpha also appears to be an important mediator of cotton dust induced pulmonary inflammation. (cdc.gov)
  • Exposure to perfluorooctanesulfonic acid (PFOS) during 2,4,6-trinitro-benzene sulfonic acid (TNBS)-induced inflammation enhanced the expression of proinflammatory cytokines as. (lu.se)
  • Thus, our results indicate that PFOS worsens inflammation-induced intestinal damage with disruption of T-cell homeostasis beyond the gut and provides a novel in vivo toolbox to screen for pollutants affecting intestinal homeostasis. (lu.se)
  • Histopathological grading indicated that OVA + PM/OVA treatment induced significant inflammation compared to OVA/OVA. (cdc.gov)
  • The loss of TNF α receptor 1/2 resulted in reduced recruitment of neutrophils, macrophages, and dendritic cells into the spleen, but only neutrophil recruitment was inhibited in the peritoneal cavity. (hindawi.com)
  • We hypothesize that neutrophil recruitment could be exploited as a therapeutic approach to alleviate oral cancer pain in female mice. (frontiersin.org)
  • Inhibition of VE-PTP decreased neutrophil recruitment to granulomas in adult and larval zebrafish, and decreased the proportion of neutrophils that extravasated distal to granulomas. (duke.edu)
  • Paracrine signaling by hydrogen peroxide (H2O2) induces neutrophil wound attraction6. (cancerhugs.com)
  • However it is not known what sensor detects H2O2 and mediates neutrophil recruitment. (cancerhugs.com)
  • Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain. (ox.ac.uk)
  • The single-bolus microinjection of IL-1 into the central nervous system (CNS) parenchyma gives rise to delayed and localized neutrophil recruitment, transient blood-brain barrier (BBB) breakdown, but no overt damage to CNS integrity. (ox.ac.uk)
  • In the bleomycin-induced early-stage pulmonary fibrosis model, the neutrophil elastase level was increased in the lungs. (ersjournals.com)
  • We and others have discovered factors that control the recruitment of inflammatory leukocytes to the peritoneal mesentery in response to pristane [ 9 , 10 ]. (hindawi.com)
  • The migration of inflammatory leukocytes, including dendritic cells, neutrophils, and macrophages, to the peritoneal mesentery has been shown to be promoted in LAT −/− (lack mature T cells) mice but inhibited in μ MT (lack mature B cells) mice during the pristane-induced immune response [ 10 ]. (hindawi.com)
  • Neutrophils isolated from the cancer-induced inflammatory microenvironment contain β-endorphin protein and are identified by the Ly6G + immune marker. (frontiersin.org)
  • By contrast, addition of free fatty acids (FFA, oleic acid/palmitic acid 2:1) caused aggravation of LPS-induced inflammatory reaction and an increase of Srebp-1c relative to PPARα. (frontiersin.org)
  • These results suggest that sivelestat alleviated bleomycin-induced pulmonary fibrosis via inhibition of both TGF-β activation and inflammatory cell recruitment in the lung. (ersjournals.com)
  • Hypoxia was found to induce A498 cell invasion, migration, and the release of inflammatory cytokines, while repressing human solute carrier family 14 member 1 gene expression. (biomedcentral.com)
  • Overexpression of the solute carrier family 14 member 1 gene could abolish hypoxia-induced invasion, reduce the migration of A498 cells, inhibit the hypoxia-induced release of inflammatory cytokines, and arrest the cell cycle at the G1/S checkpoint. (biomedcentral.com)
  • We report here on the anti- inflammatory activity of the methanolic extract of Cissampelos pareira using the Carragenin-induced paw edema method (acute inflammatory model) in male albino rats. (pharmatutor.org)
  • Table 1: Acute anti-inflammatory activity of the methanolic extract of Cissampelos pareira , indomethacin (reference drug), ibuprofen (reference drug) on Carragenin induced paw edema in male albino rats. (pharmatutor.org)
  • A cochlear inflammatory response is also initiated in response to acoustic trauma and involves the recruitment of circulating leukocytes to the inner ear. (medscape.com)
  • UBE2N promotes degradation of cIAP1 induced by cIAP1 ligands and subsequent cancer cell apoptosis. (nature.com)
  • Fig. 2: UBE2N promotes degrader-induced cIAP1 degradation and apoptosis. (nature.com)
  • The NLRP3 inflammasome consists of the NLRP3 scaffold, the apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD) (ASC) adaptor and caspase-1 ( 5 , 6 ). (spandidos-publications.com)
  • We identified a novel mode of communication by which apoptotic cells induce additional apoptosis in the same tissue. (elifesciences.org)
  • We identified Eiger, the Drosophila tumor necrosis factor (TNF) homolog, as the signal responsible for apoptosis-induced apoptosis (AiA). (elifesciences.org)
  • Apoptosis is induced by different stimuli, among them triggering of the death receptor CD95, staurosporine, and chemotherapeutic drugs. (diva-portal.org)
  • These results suggest that chemotherapeutic drug-induced caspase activation is entirely controlled by a receptor-independent mitochondrial pathway, whereas CD95-induced apoptosis can be regulated by a separate pathway not requiring Apaf-1 function. (diva-portal.org)
  • Elevated levels of solute carrier family 14 member 1 expression induced mitochondrial reactive oxygen species accumulation, diminished the intracellular adenosine triphosphate level, and destroyed both mitochondrial membrane potential integrity and mitochondrial morphology. (biomedcentral.com)
  • Scholars@Duke publication: Inhibition of infection-induced vascular permeability modulates host leukocyte recruitment to Mycobacterium marinum granulomas in zebrafish. (duke.edu)
  • Using the zebrafish-Mycobacterium marinum infection model, we demonstrate that vascular normalization by inhibition of vascular endothelial protein tyrosine phosphatase (VE-PTP) decreases granuloma hypoxia, the opposite effect of hypoxia-inducing antiangiogenic therapy. (duke.edu)
  • Is neuronal inhibition in nucleus accumbens required for such pharmacologically-induced motivations? (jneurosci.org)
  • Here we demonstrate that neuronal inhibition is necessary to generate appetitive or defensive motivations, using local optogenetic excitations to oppose putative DNQX-induced inhibitions. (jneurosci.org)
  • During this process, ATX-LPA signaling induces production of proinflammatory cytokines. (hindawi.com)
  • In a review of acute organic dust induced reactions, development of animal models for the study of acute pulmonary responses to organic dust exposures was discussed, and pathological responses resulting from inhaling organic dusts were described. (cdc.gov)
  • Such organic dust-induced airway disease is often classified to occupational exposures would have major public health im- as an "asthma-like disorder" rather than as "true" asthma (3). (cdc.gov)
  • However, it remains unknown how leukocyte recruitment is regulated. (hindawi.com)
  • In vitro Modulation of the LPS-Induced Proinflammatory Profile of Hepatocytes and Macrophages- Approaches for Intervention in Obesity? (frontiersin.org)
  • Here, we show that successful treatment of cervical carcinoma in mouse models with synthetic long peptide (SLP) vaccines induced influx of cytokine-producing CD8 T cells that strongly altered the numbers and phenotype of intratumoral macrophages. (aacrjournals.org)
  • Strikingly, complete regressions of large established tumors depended on the tumor-infiltrating macrophages that were induced by this immunotherapy, because a small-molecule drug inhibitor targeting CSF-1R diminished the number of intratumoral macrophages and abrogated the complete remissions. (aacrjournals.org)
  • Here, we show that coinfection of the upper respiratory tract of mice with influenza virus and pneumococcus leads to synergistic stimulation of type I IFNs and that this impairs the recruitment of macrophages, which are required for pneumococcal clearance, due to decreased production of the chemokine CCL2. (nih.gov)
  • This enhanced type I IFN response inhibited production of the chemokine CCL2, which promotes the recruitment of macrophages and bacterial clearance. (nih.gov)
  • Previously, we identified inducible nitric oxide synthase (iNOS) as an essential enzyme for development and reversal of smoke-induced PH and emphysema, and showed that iNOS expression in bone-marrow-derived cells drives pulmonary vascular remodelling, but not parenchymal destruction. (ersjournals.com)
  • To elucidate the antifibrotic mechanisms of sivelestat, we examined a murine model of bleomycin-induced early-stage pulmonary fibrosis. (ersjournals.com)
  • Recent studies have suggested that increased collagen turnover and fibrotic changes are earlier events within 14 days in the BLM-induced fibrosis [ 8 - 11 ] and these changes were used commonly as a pulmonary fibrosis model. (ersjournals.com)
  • Recruitment of PMNs appears to play a critical role in determining the pulmonary responses. (cdc.gov)
  • In summary, although ropinirole cotreatment does not prevent L-DOPA-induced dyskinesia, it protects from maladaptive gliovascular changes otherwise associated with this disorder, with potential long-term benefits to striatal tissue homeostasis. (lu.se)
  • Tissue wounding induces the speedy recruitment of leukocytes1. (cancerhugs.com)
  • Insulin-induced vasodilation regulates muscle perfusion and increases the microvascular surface area (microvascular recruitment) available for solute exchange between blood and tissue interstitium. (jove.com)
  • To determine whether HMGB-1 signaling is necessary for stress-induced sensitization of microglia, the HMGB-1 antagonist BoxA was injected into the cisterna magna before IS. (jneurosci.org)
  • Hippocampal microglia were isolated 24 h later and stimulated with LPS ex vivo to probe for stress-induced sensitization of proinflammatory responses. (jneurosci.org)
  • We then evaluated the efficacy of chronic rG-CSF administration to attenuate oral cancer-induced nociception using a tongue xenograft cancer model with the HSC-3 human oral cancer cell line. (frontiersin.org)
  • Saline-treated male mice with HSC-3 tumors exhibited less oral cancer-induced nociceptive behavior and had more β-endorphin protein in the cancer microenvironment than saline-treated female mice with HSC-3 tumors. (frontiersin.org)
  • A point-of-care pilot randomized intervention to connect patients with cancer-induced financial toxicity to telehealth financial counseling. (bvsalud.org)
  • A triple combination of the ferroptosis inducing natural compound withaferin A, the CXCR2 inhibitor SB225002 and α-PD-1 greatly improves survival of wild-type mice with liver tumours. (bmj.com)
  • As we previously hypothesized ( 6 ), co-virus-induced cellular damage resulting in high levels of cellular division and differentiation may stimulate HBoV reactivation and replication, as has been shown for polyomavirus following induced kidney damage in newborn mice ( 8 ). (cdc.gov)
  • Hearing loss due to injurious noise at workplace is referred to as occupational noise-induced hearing loss (ONIHL). (medscape.com)
  • ONIHL is a more common cause of noise-induced hearing loss (NIHL) and much more serious problem than socioacusis for the following 2 reasons: (1) The threat of loss of employment may convince people to remain in environments with noise levels higher than they would otherwise accept, and (2) in the workplace, high levels of noise may be sustained on a regular basis for many hours each day over many years. (medscape.com)
  • OBJECTIVE: Despite the use of hearing protection devices (HPDs), noise induced hearing loss (NIHL) remains one of the most prevalent occupational conditions. (cdc.gov)
  • It was our objective to study the role of mechanical stimulation on fibronectin (FN) reorganization and recruitment by exposing fibroblasts to shear fluid flow and equibiaxial stretch. (nature.com)
  • These results show that mechanical stimulation directly affected FN reorganization and recruitment, despite perturbation by chemical stimulation. (nature.com)
  • Thus a thorough understanding of both mechanical and chemical stimulation separately, as well as coupled together, is integral to gain insight into FN synthesis, function and the effects of various pathology-induced abnormalities that can perturb this multi-functional protein. (nature.com)
  • Electrical stimulation of the EZ induced seizures, in which early recruitment of ANT was confirmed. (biorxiv.org)
  • Stimulation of ANT did not induce a seizure. (biorxiv.org)
  • All these ROS induce tumor necrosis factor-alpha (TNF-α). (cdc.gov)
  • MK2 Regulates Macrophage Chemokine Activity and Recruitment to Promote Colon Tumor Growth. (nih.gov)
  • These changes of the intratumoral myeloid composition coincided with macrophage recruitment by chemokines, including CCL2 and CCL5, and were completely dependent on a vaccine-induced influx of tumor-specific CD8 T cells. (aacrjournals.org)
  • Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer. (rochester.edu)
  • the second stimulus is DAMPs that induce the activation of caspase-1 ( 3 , 5 , 8 , 9 ). (spandidos-publications.com)
  • One is mediated by recruitment of the proximal regulator caspase-8 to the death receptor complex. (diva-portal.org)
  • However, only macrophage recruitment was inhibited in the absence of T cells in the spleen. (hindawi.com)
  • Macrophage recruitment. (cdc.gov)
  • It has been reported that RNF4 negatively regulates TNF-α-induced activation of the nuclear factor-κB (NF-κB) through downregulation of transforming growth factor β-activated kinase 1 (TAK1) activity, indicating the possibility that RNF4-mediated TAK1 suppression results in enhanced sensitivity to cell death. (mdpi.com)
  • Thus, stressors must induce the release of an endogenous ligand within the CNS that signals via TLR2 and TLR4 to mediate neuroinflammatory sensitization produced by stressors. (jneurosci.org)
  • Plasticity of the cullin-RING ligase repertoire shapes sensitivity to ligand-induced protein degradation. (nature.com)
  • Here, high mobility group box-1 (HMGB-1) protein was explored as a potential mediator of stress-induced microglial priming and whether HMGB-1 does so via the nucleotide-binding domain, leucine-rich repeat, pyrin domain containing protein 3 (NLRP3) inflammasome. (jneurosci.org)
  • LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA 1-6 , to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. (hindawi.com)
  • Asbestos Toxicity: How Does Asbestos Induce Pathogenic Changes? (cdc.gov)
  • We assessed the feasibility of recruitment, randomization , retention, baseline and post-intervention COmprehensive Score for Financial Toxicity ( COST ), and Telehealth Usability Questionnaire (TUQ) scores. (bvsalud.org)
  • Asbestos induces pathological changes leading to such outcomes as fibrosis and malignancy. (cdc.gov)
  • Conclusion Our data highlight a context-specific ferroptosis-induced immune response that could be therapeutically exploited for the treatment of primary liver tumours and liver metastases. (bmj.com)
  • Local naloxone treatment restored the cancer mediator-induced nociceptive behavior. (frontiersin.org)
  • induced by CD4 + and CD8 + T cells stimulated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike epitopes (Ag2), levels were highest at 3 weeks after the second vaccination (6 W) and decreased by 37.4% at 3 months (4 M) and 60.0% at 6 months (7 M), the decline of which seemed slower than that of anti-spike antibody levels. (cdc.gov)
  • The purpose of this study was to investigate the role and mechanism of hypoxia-induced renal cell carcinoma and provide evidence-based medical proof for improvements to postoperative nursing of renal cell carcinoma patients. (biomedcentral.com)
  • The results elucidate a mechanism wherein the solute carrier family 14 member 1 gene participates in the occurrence and development of hypoxia-induced renal cell carcinoma in a mitochondria-dependent manner. (biomedcentral.com)
  • Lymphotoxin alpha (LT α ) and TNF α were shown to induce the expression of homing chemokines in B and T cell areas of the spleen [ 13 ]. (hindawi.com)
  • Although two E3s, CRL2 VHL and CRL4 CRBN , frequently assemble with proteolysis-targeting chimeras (PROTACs) to attach lysine-48 (K48)-linked ubiquitin chains, the diversity of the ubiquitin code used for chemically induced degradation is largely unknown. (nature.com)
  • These results reveal an unexpected role for K63-linked ubiquitin chains and UBE2N in degrader-induced proteasomal degradation and demonstrate the diversity of the ubiquitin code used for chemical hijacking. (nature.com)
  • SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence. (cdc.gov)
  • New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy. (rochester.edu)
  • Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplification. (musc.edu)
  • This "Chemotherapy Induced Neutropenia (CIN)- Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of the Chemotherapy Induced Neutropenia (CIN), historical and forecasted epidemiology as well as the Chemotherapy Induced Neutropenia (CIN) market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. (researchandmarkets.com)
  • The Chemotherapy Induced Neutropenia (CIN) epidemiology division provide insights about historical and current Chemotherapy Induced Neutropenia (CIN) patient pool and forecasted trend for every seven major countries. (researchandmarkets.com)
  • The disease epidemiology covered in the report provides historical as well as forecasted Chemotherapy Induced Neutropenia (CIN) epidemiology scenario in the 7MM covering the United States, EU5 countries (Germany, Spain, Italy, France, and the United Kingdom), and Japan from 2019 to 2032. (researchandmarkets.com)
  • The epidemiology segment also provides the Chemotherapy Induced Neutropenia (CIN) epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan. (researchandmarkets.com)
  • The Chemotherapy Induced Neutropenia (CIN) market report provides current treatment practices, emerging drugs, Chemotherapy Induced Neutropenia (CIN) market share of the individual therapies, current and forecasted Chemotherapy Induced Neutropenia (CIN) market Size from 2019 to 2032 segmented by seven major markets. (researchandmarkets.com)
  • It covers the details of conventional and current medical therapies available in the Chemotherapy Induced Neutropenia (CIN) market for the treatment of the condition. (researchandmarkets.com)
  • The report provides the details of the emerging therapies under the late and mid-stage of development for Chemotherapy Induced Neutropenia (CIN) treatment. (researchandmarkets.com)
  • The Chemotherapy Induced Neutropenia (CIN) market outlook of the report helps to build the detailed comprehension of the historic, current, and forecasted Chemotherapy Induced Neutropenia (CIN) market trends by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers and demand of better technology. (researchandmarkets.com)
  • Pristane administration induces macrophage activation [ 1 , 2 ]. (hindawi.com)
  • Blocking LTB4 secretion (with diverse specific inhibitors of the leukotriene pathway) prevented the recruitment of potential target cells, as well as the formation of cell-to-cell contacts. (biomedcentral.com)
  • Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway. (uchicago.edu)
  • The intervening decades have provided compelling experimental and model‐based evidence that fisheries‐induced evolution (FIE) can cause genetic changes in life history, behaviour and body shape, given sufficiently high trait heritability, selection intensity and time. (jyu.fi)
  • By cell transduction with lentiviral vectors encoding Tax, we suggest that HTLV-1 induced LTB4 secretion is a consequence of Tax-induced cytosolic phospholipase A2 (cPLA2) over expression. (biomedcentral.com)
  • Type I IFN expression was induced by pneumococcal colonization alone. (nih.gov)
  • Same-site NAc optogenetic excitations also attenuated recruitment of Fos expression in other limbic structures throughout the brain, which was otherwise elevated by NAc DNQX microinjections that generated motivation. (jneurosci.org)
  • Go to Pediatric Asthma , Status Asthmaticus , Exercise-Induced Asthma , and Asthma in Pregnancy for complete information on these topics. (medscape.com)
  • Epitope spreading refers to the recruitment of autoreactive lymphocytes against normally tolerated host antigens, which contributes to disease chronicity and course. (msdmanuals.com)
  • Using epileptogenicity index and line length, we computed the number of seizures that recruited the ANT (recruitment ratio), the recruitment latencies between the ANT and the epileptogenic zone (EZ), and latency of ANT recruitment to clinical manifestation for seventy-nine seizures. (biorxiv.org)
  • Recruitment latency was inversely correlated to seizure duration (r=-0.78, p=0.004). (biorxiv.org)
  • Triggers may induce an autoimmune reaction by mimicking molecular sequences in the epidermal basement membrane (molecular mimicry, as with drugs and possibly infections), by exposing or altering normally tolerated host antigens (as with physical triggers and certain disorders), or by other mechanisms. (msdmanuals.com)
  • this is called non-alcoholic steatohepatitis, to differentiate the disease from alcohol-induced liver injury, either of which can progress to cirrhosis. (frontiersin.org)
  • The RNA-induced silencing complex, or RISC, is a multiprotein complex, specifically a ribonucleoprotein, which functions in gene silencing via a variety of pathways at the transcriptional and translational levels. (wikipedia.org)
  • By posing a series of questions and responses, we illustrate how science advice pertaining to human‐induced evolution in fishes can be strengthened. (jyu.fi)
  • The authors examined whether baseline and past diagnoses of DSM-IV primary (independent) or substance-induced depression or other psychiatric syndromes predict 1-year course of depression in substance-dependent patients. (psychiatrist.com)