Drug-inducedAcquired Immune DAlcohol-induced deaths2020InflammationDegenerationAcuteMultiple systemLiverCardiacRatsColitisPluripotentMiceProteinEndogenousSepsisNifedipineApoptosisResponsesDysfunctionAutonomic nervouPulmonaryNervousHypertensionPatternsMechanismsAlpha-synucleinDeathsAlterationsFacilitatesRenalInsulinLungsImplicationsConclusion2019HypothesesIdentifiesImmune system to recognizeInvestigateCalciumArticleLipidVital Statistics SystemContextVaccinesEvaluateModel

Drug-induced14

• This work also highlights the value of using a mouse diversity panel to investigate drug-induced responses across a diverse population. (nih.gov)
• Drug-induced diarrhea is loose, watery stools that occurs when you take certain medicines. (medlineplus.gov)
• To minimize the potential morbidity and mortality from drug-induced respiratory diseases, healthcare providers should be familiar with the possible adverse effects of the medications they prescribe. (medscape.com)
• Drug-induced pulmonary toxicity is a diagnosis of exclusion. (medscape.com)
• Radiologic patterns observed in drug-induced pulmonary toxicity are highly variable and depend on the type of adverse reaction the patient is experiencing. (medscape.com)
• Most drug-induced pulmonary toxicities involve the parenchyma, thus, interstitial infiltrates may be demonstrated on radiographs. (medscape.com)
• If the drug-induced pulmonary toxicity causes airway obstruction, then the FEV 1 /FVC ratio and FEV 1 will be reduced. (medscape.com)
• In general, bronchoscopy with transbronchial biopsy is not helpful in establishing the diagnosis of drug-induced pulmonary toxicity. (medscape.com)
• Bronchoalveolar lavage (BAL) can contribute to the expected clinicopathologic pattern of a given drug-induced lung disease such as identifying eosinophils in a drug-induced eosinophilic pneumonia. (medscape.com)
• The aim of this study was to evaluate the prevalence of drug-induced gingival overgrowth (DIGO) in Brazilian users of nifedipine and/or phenytoin and to determine the presence of predisposing/modifying factors. (bvsalud.org)
• Risk factors for drug-induced gingival overgrowth. (bvsalud.org)
• Several causes of gingival hyperplasia are known, and the most recognized is drug-induced gingival enlargement. (medscape.com)
• Currently, the etiology of drug-induced gingival overgrowth is not entirely understood but is clearly multifactorial. (medscape.com)
• Debate is ongoing regarding whether drug-induced gingival overgrowth is due to hyperplasia of the gingival epithelium or of submucosal connective tissue, and/or both. (medscape.com)

Acquired Immune D1

• Covid-19 Vaccine Induced Acquired Immune Deficiency Syndrome, or VAIDS, appears to be one of the more serious long-term adverse effects caused by the injections. (naturalnews.com)

Alcohol-induced deaths2

• Rates of alcohol-induced deaths for persons aged 45-64 years increased from 17.3 per 100,000 population in 1999 to 26.0 in 2017. (cdc.gov)
• The age-adjusted rate of alcohol-induced deaths in 2020 was 13.1 per 100,000 standard population. (cdc.gov)

20201

• In 2020, Emma McDougall and Kaitlin Webber explored transit-induced gentrification in the Map the System competition. (altmetric.com)

Inflammation4

• The pathophysiology of sepsis includes inflammation, immune dysfunction, and dysfunction of coagulation, while sepsis-induced cardiomyopathy ( SIC ), defined as a global but reversible dysfunction of both sides of the heart induced by sepsis, plays a significant role in all of the aspects above in the pathogenesis of sepsis. (frontiersin.org)
• Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: Reconciling inflammatory and cholinergic hypotheses of delirium. (atsbio.com)
• New research in mice shows that two commonly used gout medications, which target uric acid and adenosine triphosphate, may offer protection from alcohol-induced liver disease and inflammation . (medicalnewstoday.com)
• The link between alcohol induced tissue damage and sensing by the immune system through the inflammasome opens the door for new therapeutics targeting this type of inflammation in liver diseases. (medicalnewstoday.com)

Degeneration1

• The Al deposition in the brain caused neural degeneration and decreased cell density inducing a state of anxiety, depression, and a deficit of learning and memory. (researchgate.net)

Acute1

• Cyclosporine and tacrolimus cause acute kidney injury (AKI) by inducing afferent and efferent arteriolar vasoconstriction. (medscape.com)

Multiple system4

• Multiple system atrophy (MSA) is a rare atypical parkinsonian disorder characterized by a rapidly progressing clinical course and at present without any efficient therapy. (uni-regensburg.de)
• Multiple system atrophy is a relentlessly progressive neurodegenerative disorder causing pyramidal, cerebellar, and autonomic dysfunction. (msdmanuals.com)
• Multiple system atrophy affects men and women equally. (msdmanuals.com)
• Although multiple system atrophy begins as one type, symptoms of the other type eventually develop. (msdmanuals.com)

Liver5

• A genetically diverse mouse population model in combination with a systems biology approach was utilized to identify transcriptional changes, INH-responsive metabolites, and gene variants that contribute to the liver response in genetically sensitive individuals. (nih.gov)
• Those associated with INH treatment and susceptibility to INH-induced steatosis in the liver included apolipoprotein A-IV, lysosomal-associated membrane protein 1, and choline phosphotransferase 1. (nih.gov)
• In vivo , Pts treatment effectively protected against APAP-induced severe liver injury by decreasing the lethality rate, the serum alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, liver histological injury, liver malondialdehyde (MDA) formation and myeloperoxidase (MPO) levels and by increasing liver glutathione (GSH) and superoxide dismutase (SOD) levels. (karger.com)
• Meanwhile, three human digestive system xenograft tumor models (colorectal cancer colo320, gastric cancer MKN-45 and liver cancer SSMC-7721) and a breast cancer (MDA-MB-231) model were employed to validate the universality of BF-rTK + GCV in solid tumor gene therapy. (biomedcentral.com)
• Liver damage induced by alcohol was associated with increases in the circulating levels of sterile danger molecules, uric acid and ATP. (medicalnewstoday.com)

Cardiac2

• however, the septic shock in the early onset of sepsis, which induced by cytokine storm and cardiac dysfunction, is also an important cause of death for septic patients, especially for the young patients with toxic shock syndrome or meningococcemia ( 2 ). (frontiersin.org)
• Other TLR-related genes (TLR2, 3, and 9) were demonstrated to be involved in sepsis-induced cardiac dysfunction from recent studies. (frontiersin.org)

Rats5

• Animal experiments were designed to study the alterations in the fibrinolysin system as a result of insulin-induced hypoglycemia in rats. (aspetjournals.org)
• To contrast modafinil-induced wakefulness with spontaneous wakefulness, we administered modafinil at midnight, during the normal waking period of rats. (jneurosci.org)
• Rats underwent 5/6 nephrectomy for 8 weeks, which induced CKD and hypertension . (bvsalud.org)
• RD may improve CKD-induced hypertension by modulating the baroreflex response, improving GABA system dysfunction and preventing the development and reducing the severity of cardiorenal syndrome type 4 in CKD rats . (bvsalud.org)
• Here, we evaluate if a unilateral traumatic brain injury induces hindlimb postural asymmetry, a model of postural deficits, and if this asymmetry is spinally encoded and mediated by the endogenous opioid system in rats. (lu.se)

Colitis1

• Results from animal studies suggest that vitamin D may modulate the immune system and protect against inflammatory bowel diseases such as ulcerative colitis and Crohn disease. (medscape.com)

Pluripotent2

• The advent of the human induced pluripotent stem cells (hiPSCs) technology offers unprecedented opportunities for disease modeling, personalized medicine, and the development of new therapeutic interventions. (frontiersin.org)
• At Thermo Fisher Scientific, we have developed Gibco Cell Therapy Systems (CTS) products across the pluripotent stem cell therapy workflow to ease the transition from discovery to commercial manufacturing. (thermofisher.com)

Mice1

• In this study, we investigated the effects of Tribulus terrestris fruit (Leguminosae, Tribuli Fructus, TF) extract on oxazolone-induced atopic dermatitis in mice. (hindawi.com)

Protein2

• With each subsequent injection, of course, vaccine victims are being exposed to blood clot-inducing spike protein nanoparticles . (naturalnews.com)
• This sheds light upon the role of the Smad7 protein in this system. (lu.se)

Endogenous4

• Our model postulates that adolescent exposure to Delta9-tetrahydrocannabinol THC, the primary psychoactive substance in cannabis, transiently disturbs physiological control of the endogenous cannabinoid system over glutamate and GABA release. (erowid.org)
• Exogenous melatonin can entrain circadian rhythms in physiology and behavior, but the role of endogenous melatonin and the two membrane-bound melatonin receptor types, MT1 and MT2, in reentrainment of daily rhythms to light-induced phase shifts is not understood. (nih.gov)
• These data suggest the endogenous melatonin signal facilitates reentrainment of the circadian system to phase advances on the level of the SCN molecular clockwork by acting upon MT2 receptors. (nih.gov)
• We also readily detected off-target alterations induced by four out of six RGNs targeted to endogenous loci in human cells by examination of partially mismatched sites. (nature.com)

Sepsis1

• Sepsis is a lethal syndrome induced by infection, which has a reported annual death of 200,000 in the United States ( 1 ). (frontiersin.org)

Nifedipine2

• Demographic, pharmacological, and periodontal data were obtained from 100 users of the Brazilian Primary Health Care System in Diamantina, Jequitinhonha Valley, Minas Gerais state, Brazil, who were taking nifedipine and/or phenytoin. (bvsalud.org)
• 4. Farias BC, Cabral PA, Gusmão ES, Jamelli SR, Cimões R. Non-surgical treatment of gingival overgrowth induced by nifedipine: a case report on an elderly patient. (bvsalud.org)

Apoptosis4

• The results suggested that BF-rTK + GCV induced tumor apoptosis without autophagy and necroptosis occurrence. (biomedcentral.com)
• However, BF + GCV only induced apoptosis via Fas/FasL signal pathway accompanied with increased P53 expression. (biomedcentral.com)
• BF-rTK + GCV induced tumor apoptosis mediated by FasL and TNFR2 through the mitochondrial control of apoptosis via Bid and Bim without inducing necroptosis and autophagy. (biomedcentral.com)
• Specify the components and their interactions and set up cluding proliferation, differentiation, apoptosis, embryonic the system of equations. (lu.se)

Responses1

• Bi-stable responses and shock-induced persistent forward rubbing were observed in an experimental AMB-flexible rotor facility and its numerical model. (bath.ac.uk)

Dysfunction3

• The complex pathogenesis of SIC involves a combination of dysregulation of inflammatory mediators, mitochondrial dysfunction, oxidative stress, disorder of calcium regulation, autonomic nervous system dysregulation, and endothelial dysfunction. (frontiersin.org)
• The endotoxin-induced myocardial dysfunction probably depends on the toll-like receptor (TLR) 4-induced cytokines release as a delay in onset of myocardial depression after endotoxin administration ( 10 ). (frontiersin.org)
• Both types involve autonomic nervous system dysfunction. (msdmanuals.com)

Autonomic nervou1

• Overview of the Autonomic Nervous System The autonomic nervous system regulates physiologic processes. (msdmanuals.com)

Pulmonary2

• Bleeding from the lungs, or exercise-induced pulmonary hemorrhage (EIPH), as it is more correctly known, is a very common condition in racehorses. (ivis.org)
• Exercise-induced pulmonary hemorrhage (EIPH), also known as "bleeding" or a "bleeding attack", refers to the presence of blood in the airways of the lung in association with exercise. (wikipedia.org)

Nervous2

• The effect that accounts for the popularity on journeys and by students preparing for of khat is its central nervous system stimu- examinations and to counteract fatigue. (who.int)
• Early clinical observation suggested that the central nervous system. (who.int)

Hypertension2

• Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension. (bvsalud.org)
• The objective of the present study was to investigate how RD improves CKD-induced hypertension . (bvsalud.org)

Patterns3

• For a binary Cu-Au alloy, a miscible system, the model results clearly demonstrate the formation of compositional patterns under high-temperature particle irradiation, with characteristic wavelengths that depend on the irradiation temperature and the strength of cascades. (purdue.edu)
• The majority of burn scars with significant fire-induced ETa reductions experienced conversion patterns typical of the western United States following stand-replacing disturbance, with forests converting to shrub/scrub and/or grassland/herbaceous cover through at least the end of the study period (eight to 15 years depending on date of the fire event). (usgs.gov)
• ARBS is designed to help with selecting the proper roof bolt system from the great variety of available bolt types and patterns. (cdc.gov)

Mechanisms2

• Given the lack of effective treatments, we constructed a bifidobacterial recombinant thymidine kinase (BF-rTK) -ganciclovir (GCV) targeting system (BKV) to meet this requirement and to explore antitumor mechanisms. (biomedcentral.com)
• There are several hypotheses about the mechanisms by which calcium antagonists induce gingival hyperplasia, but further investigation is still needed. (medscape.com)

Alpha-synuclein1

• Additionally, benztropine restored the alpha-synuclein-induced myelination deficit of stem cell-derived oligodendrocytes. (uni-regensburg.de)

Deaths3

• Alcohol-induced causes exclude unintentional injuries, homicides, and other causes indirectly related to alcohol use, as well as newborn deaths associated with maternal alcohol use. (cdc.gov)
• The VAERS system run by HHS is now reporting over 23,000 deaths following covid-19 vaccinations. (naturalnews.com)
• As bad as the one million deaths already are, that number is going to explode over the next several years as vaccine-induced "AIDS" explodes. (naturalnews.com)

Alterations1

• These alterations were accompanied by metabolomic changes including reduced levels of glutathione and the choline metabolites betaine and phosphocholine, suggesting that oxidative stress and reduced lipid export may additionally contribute to INH-induced steatosis. (nih.gov)

Facilitates1

• Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression. (nih.gov)

Renal3

• Occupational cohort studies have suggested possible associations between chronic exposure to cadmium, particularly cadmium oxide, and cancers of the lung, prostate, and genitourinary system such as renal carcinoma. (cdc.gov)
• RD was induced by applying phenol to surround the renal artery in CKD. (bvsalud.org)
• Although the pathogenesis of contrast-induced nephropathy (CIN) remains incompletely understood, it is most likely the result of renal vasoconstriction and direct renal tubular epithelial cell toxicity. (medscape.com)

Insulin2

• The rat with its fibrinolysin system suppressed by insulin can be adopted as an experimental model for the study of the ability of nonenzymatic pharmacologic agents to enhance or induce fibrinolytic activity. (aspetjournals.org)
• Conclusion: Allergic contact dermatitis due to CGM systems and insulin pumps are difficult to investigate and require chemical analysis. (lu.se)

Lungs1

• Cadmium's toxicity primarily affects the lungs and kidneys, with secondary effects on the skeletal system. (cdc.gov)

Implications1

• Finally, numerical results are presented that validate the theoretical analysis and provide useful insights into the implications of the model parameters on the overall system performance. (qub.ac.uk)

Conclusion1

• In conclusion, the PMD-induced differential group delay degrades system performance with penalties more severe at higher bit rates and higher PMD coefficients in fibers. (synopsys.com)

20191

• 2019 ( https://www.who.int/nutrition/publications/UNICEF-WHOlowbirthweight-estimates-2019/en/ ). (who.int)

Hypotheses1

• The review also covers recent hypotheses regarding disturbances in strengthening and pruning of synaptic connections in the prefrontal cortex, and the link with latent psychotic disorders.In the present model, cannabis-induced schizophrenia is considered to be a distortion of normal late postnatal brain maturation. (erowid.org)

Identifies1

• A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase. (nih.gov)

Immune system to recognize2

• Cancer gene therapy approaches include the direct killing of tumor cells by injecting a therapeutic gene into the tumor cell or employing vaccine strategies to deliver an immunomodulatory gene that stimulates the immune system to recognize tumor antigens [ 1 ]. (biomedcentral.com)
• This enhances the ability of the immune system to recognize and attack cancer cells. (medscape.com)

Investigate2

• This study aims to investigate the protective effects and mechanism of Pts against acetaminophen (APAP)-induced hepatotoxicity in vivo . (karger.com)
• The first two reactions populating the same compound nucleus were investigated for possible entrance channel effects, whereas for the last system, $^{40}Ar\,+\,^{208}Pb$, two different bombarding energies have been provided to investigate the effect of excitation energy of the compound system. (unina.it)

Calcium2

• Circulating Pneumolysin, another common PAMP produced by Streptococcus pneumoniae , induced cardiomyocyte injury through triggering profound calcium influx during pneumococcal infection ( 11 ). (frontiersin.org)
• Based upon type, chemotherapy induced peripheral neuropathy treatment market is segmented into Calcium Channel a2-delta Ligands, Antidepressants, Opioids, and Others. (medgadget.com)

Article1

• Article: The design and development of a real-time compensation controller of thermally-induced errors for CNC machine tools Journal: International Journal of Manufacturing Research (IJMR) 2017 Vol.12 No.1 pp.118 - 130 Abstract: Thermal deformation of the machine tool structure is one of critical factors affecting the machining accuracy level. (inderscience.com)

Lipid2

• Finally, genome-wide association mapping revealed that polymorphisms in perilipin 2 were linked to increased triglyceride levels following INH treatment, implicating a role for inter-individual differences in lipid packaging in the susceptibility to INH-induced steatosis. (nih.gov)
• Taken together, our data suggest that INH-induced steatosis is caused by not one, but multiple events involving lipid retention in the livers of genetically sensitive individuals. (nih.gov)

Vital Statistics System1

• National Vital Statistics System, Mortality Data, 1999-2017. (cdc.gov)

Context1

• Examining complex systems thinking from a planning perspective on the context of transit-induced gentrification. (altmetric.com)

Vaccines1

• The very same vaccine manufacturers who caused this problem are at the ready, rolling out new "AIDS vaccines" using mRNA technology, supposedly to "treat" those who have suppressed immune systems caused by the first vaccines. (naturalnews.com)

Evaluate1

• A commercially-available computational fluid dynamics (CFD) tool was used to evaluate the operative temperature as well as air velocity distribution inside an office-setting equipped with induced-air supply unit for both heating and cooling cases. (purdue.edu)

Model5

• This review reports the results of a literature search comprising various neurobiological disciplines, ultimately converging into a model that might explain the neurobiology of cannabis-induced schizophrenia. (erowid.org)
• We propose the inverse Gaussian distribution, as a less complex alternative to the classical log-normal model, to describe turbulence-induced fading in free-space optical (FSO) systems operating in weak turbulence conditions and/or in the presence of aperture averaging effects. (qub.ac.uk)
• Now, we extend our previous work of COBI model to the multi-electron systems, and calculate the multiple ionization of Ne and CO molecule collided by very high-q fast projectiles in a strong coupling regime. (scirp.org)
• A unilateral right-sided controlled cortical impact, a model of clinical focal traumatic brain injury was centred over the sensorimotor cortex and was observed to induce hindlimb postural asymmetry with contralateral limb flexion. (lu.se)
• The model successfully describes the kinetics of experimental data and also correctly predicts the behavior in experiments where the system is perturbed. (lu.se)