ImmunityIron-Sulfur PKinaseAPOPTOSISFunctionallyVivoAntibodiesAntibodyMechanismsPathogensBioactiveVaccineBindsAntigenInteractionFunctionalImmune systemMatrix Gla-proMechanisticCompoundsGeneDefectsOligomerizationBindTargetsCellularHomeostasisTherapeuticCellsCharacteristicsImportantSimilarFamilyMutantFactorRoleExpressionFunctionsClassAdditionCellShownActivityLargePatientsChemicalVitaminStructureResponseIncludeStudiesMajority
Immunity7
- a) Vaccine: A suspension of live (usually attenuated) or inactivated microorganisms (e.g., bacteria, viruses, or rickettsiae) or fractions thereof administered to induce immunity and prevent infectious disease or its sequelae. (cdc.gov)
- Immunization is a more inclusive term denoting the process of inducing or providing immunity artificially by administering an immunobiologic. (cdc.gov)
- Most vaccines require several immunizations to induce robust immunity, and indeed, most SARS-CoV-2 vaccines require an initial two-shot regimen followed by several boosters to maintain efficacy. (uw.edu)
- By age, ≥90% had protective sero-immunity through age 69 years but prevalence of sero-immunity declined thereafter, with 75.8% of those aged ≥80 years having protective sero-immunity. (cdc.gov)
- CONCLUSION: The majority of the U.S. population has vaccine-induced sero-immunity to tetanus, demonstrating the success of the vaccination program. (cdc.gov)
- Our study not only supports observations of infection-induced immunity and current recommendations for vaccination postinfection to maximize protection against COVID-19, but also provides a large data set of pre-COVID-19 vaccination anti-SARS-CoV-2 antibody concentrations that will serve as an important comparator in the current setting of vaccine-induced and hybrid immunity. (cdc.gov)
- People who have low TP stood a 1.624-times and the higher chances (95%CI A single gut immunity .008-2.617) of building Medical professional compared to those along with typical full health proteins (P = 0.046). (npyreceptor.com)
Iron-Sulfur P1
- Low-temperature magnetic circular dichroism studies of iron-sulfur proteins. (uga.edu)
Kinase4
- Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
- The Parkinson's disease genes pink1 and parkin , which encode a mitochondrially targeted protein kinase, and an E3 ubiquitin ligase, respectively, participate in a key mitochondrial quality-control pathway that eliminates damaged mitochondria. (sdbonline.org)
- Phosphorylation of PINK1 is not only required for the PINK1-mediated mitochondrial recruitment of Parkin but also induces its kinase activity toward Parkin. (sdbonline.org)
- They have also been shown to induce expression of tumor necrosis factor (TNF), induce F-actin depolymerization, and activate a Src kinase. (listlabs.com)
APOPTOSIS2
- If the damage is extensive, it can induce APOPTOSIS. (lookformedical.com)
- However, they have both been shown to induce apoptosis in several different cell types. (listlabs.com)
Functionally2
- However, cancer cells can become multidrug resistant, a phenomenon due to cells expressing mechanisms that cause simultaneous resistance to many different, structurally and functionally, unrelated drugs [6]. (savedelicious.com)
- As such they constitute one of the most ancient, ubiquitous and structurally and functionally diverse classes of biological prosthetic groups. (uga.edu)
Vivo5
- The generation of an in vivo model of SCA35 can be of use to better understand the molecular mechanisms induced by TG6 loss of function and find new therapeutic avenues for this disease. (ataxia.org)
- Here, we describe further development of an in vivo library selection platform based on self-assembling protein nanoparticles encapsulating their own mRNA genomes (synthetic nucleocapsids or synNCs). (uw.edu)
- This study established an in vivo PINK1 / Parkin -induced photoreceptor neuron degeneration model in Drosophila with the aim of dissecting the PINK1/Parkin pathway in detail. (sdbonline.org)
- In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
- HP-228, a structurally related heptapeptide, is a significantly more effective in vivo protective agent. (severnbiotech.com)
Antibodies4
- V116 was well tolerated, with a safety profile similar to PPSV23, and induced functional antibodies against all 21 serotypes. (bvsalud.org)
- Antibodies are heavy (~150 k Da ) proteins of about 10 nm in size, [7] arranged in three globular regions that roughly form a Y shape. (wikipedia.org)
- However, the characteristics of protective and functional Vi antibodies are unknown. (ox.ac.uk)
- We identified antibodies induced by prime and boost vaccines that recognized subdominant epitopes, indicated by binding to the de-O-acetylated Vi backbone. (ox.ac.uk)
Antibody5
- An antibody ( Ab ), also known as an immunoglobulin ( Ig ), [1] is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses . (wikipedia.org)
- Structurally an antibody is also partitioned into two antigen-binding fragments (Fab), containing one V L , V H , C L , and C H 1 domain each, as well as the crystallisable fragment (Fc), forming the trunk of the Y shape. (wikipedia.org)
- As new SARS-CoV-2 variants emerge and displace circulating virus strains, we recommend that standardized binding antibody assays that include spike protein-based antigens be utilized to estimate antibody concentrations correlated with protection from COVID-19. (cdc.gov)
- Salmonella Typhi Vi capsule prime-boost vaccination induces convergent and functional antibody responses. (ox.ac.uk)
- The Vi-TT prime induced an IgG1-dominant response, whereas the Vi-TT prime followed by the Vi-PS boost induced IgG1 and IgG2 antibody production. (ox.ac.uk)
Mechanisms2
- In the last years several new mutations have been reported as associated to SCA35 but the mechanisms inducing neuronal degeneration are still uncovered. (ataxia.org)
- Research on Fe-S cluster biosynthesis in the Johnson group currently involves investigating the molecular mechanisms of Fe-S cluster assembly on scaffold proteins and the subsequent intact cluster transfer to acceptor or carrier proteins. (uga.edu)
Pathogens2
- This optimism is built on recently published studies demonstrating the efficacy of mRNA vaccines in combatting several types of cancer and infectious pathogens where conventional vaccine platforms may fail to induce protective immune responses. (researchgate.net)
- Ornithodoros erraticus saliva contains bioactive proteins that play essential functions in tick feeding and host defence modulation, which may contribute to host infection by tick-borne pathogens. (biomedcentral.com)
Bioactive1
- Actinobacteria are known to be prolific producers of a wide range of bioactive NPs, and scientific evidence highlights their important protective role against CRC. (frontiersin.org)
Vaccine4
- The present invention relates to a combination of 2 or more S. pneumoniae proteins, their manufacture and use in medicine as a vaccine. (allindianpatents.com)
- In yet another related aspect is a method for making the vaccine of the invention by selecting and isolating 2 different S. pneumoniae proteins and mixing both proteins with a pharmaceutically acceptable carrier. (allindianpatents.com)
- In general, immunobiologists have developed an integrated method for vaccine development based on analyzing protein sequences and structures of target viruses [ 10 ]. (biomedcentral.com)
- Vaccine development to prevent Salmonella Typhi infections has accelerated over the past decade, resulting in licensure of new vaccines, which use the Vi polysaccharide (Vi PS) of the bacterium conjugated to an unrelated carrier protein as the active component. (ox.ac.uk)
Binds1
- Lipoate protein ligase B primarily recognizes the C8-phosphopantetheine arm of its donor substrate and weakly binds the acyl carrier protein. (du.ac.in)
Antigen3
- Recent observations raise the hypothesis that not only the drug/chemical, but also parts of the haptenated protein or peptides may constitute the important structural determinants for antigen recognition by the TCR. (frontiersin.org)
- Strategies, which have been designed to overcome this lack of immunogenicity in infants, include the linking of the polysaccharide to large immunogenic proteins, which provide bystander T-cell help and which induce immunological memory against the polysaccharide antigen to which it is conjugated. (allindianpatents.com)
- Hence, these proteins could be candidate antigen targets for the development of vaccines aimed at the control and prevention of O. erraticus infestations and the diseases this tick transmits. (biomedcentral.com)
Interaction3
- Instead of a simple one-gene locus controlling the onset of myopia, a complex interaction of many mutated proteins acting in concert may be the cause. (wikipedia.org)
- FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
- Identification of a peptide that disrupts hADA3-E6 interaction with implications in HPV induced cancer therapy. (du.ac.in)
Functional1
- Quantified proteins were classified into 23 functional categories and their abundance compared between sexes. (biomedcentral.com)
Immune system1
- Furthermore, a series of important implications on inflammation and the immune system that are induced by the activity of cannabinoid receptors stimulated by the delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) have been noticed. (encyclopedia.pub)
Matrix Gla-pro1
- even in all healthy humans tested, a significant percentage of the extra-hepatic VKD proteins, which are activated by vitamin K2, e.g., osteocalcin and matrix Gla-protein, are only partly carboxylated and therefore inactive. (vitamindwiki.com)
Mechanistic1
- This perspective focuses on two areas that have yielded new useful information during the last 20 years: (i) structure-activity relationship (SAR) studies of contact allergy based on the concept of hapten-protein binding and (ii) mechanistic investigations regarding activation of nonsensitizing compounds to contact allergens by air oxidation or skin metabolism. (cdc.gov)
Compounds2
- Similar to "Vitamin E," "Vitamin K" is not a single substance, but a family of structurally similar, fat-soluble compounds that share a naphthoquinone ring structure with a methyl group at position 2 and an aliphatic side chain at position 3. (vitamindwiki.com)
- CWO primarily consist of a mixture of structurally related terpenes, a class of chemical compounds composed of isoprene units with distinct aromatic qualities that plants generate for defensive purposes. (biorxiv.org)
Gene3
- Aberrant genetic recombination and gene splicing in the OPNLW1 and OPNMW1 genes that code for two retinal cone photopigment proteins can produce high myopia by interfering with refractive development of the eye. (wikipedia.org)
- Spinocerebellar ataxia type 35 (SCA35) is a rare, autosomal dominant neurodegenerative disorder associated with mutations in TGM6 gene that encode the protein transglutaminase 6 (TG6). (ataxia.org)
- This focuses on the expression of the human tdp1 mutant gene in brain tissue of flies lacking the endogenous Gkt protein. (ataxia.org)
Defects2
- Instead of myopia being caused by a defect in a structural protein, defects in the control of these structural proteins might be the actual cause of myopia. (wikipedia.org)
- Moreover, a molecular-level understanding of iron-sulfur cluster biogenesis is crucial for understanding a variety of human diseases involving anemias, myopathies and ataxias that arise from defects in Fe-S cluster biogenesis proteins. (uga.edu)
Oligomerization2
- Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)
- MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
Bind2
- Not only that, but this protein can also bind to the external surface of the cell membrane, through non-specific adsorption, and provide cell protection preventing physical damage of the cells caused by the hydrodynamic stress generated in culture 11 . (albumedix.com)
- To cause sensitization, a chemical must bind to macromolecules (proteins) in the skin. (cdc.gov)
Targets1
- Iron-sulfur protein maturation in Helicobacter pylori:Identifying a Nfu-type cluster carrier protein and its iron-sulfur protein targets. (uga.edu)
Cellular2
- however, DHCer induces autophagy and may be important in the regulation of this important cellular process. (sphingolipidclub.com)
- MDR1 codes for P-glycoprotein (P-gp), a member of the ABC transporter superfamily of proteins that promote cellular efflux of chemotherapeutic agents. (sphingolipidclub.com)
Homeostasis1
- Colchicine may impair vitamin A absorption and can interfere with retinol homeostasis by blocking release of retinol--retinol binding protein (RBP). (interactionsguide.com)
Therapeutic1
- Controlling the biodistribution of protein- and nanoparticle-based therapeutic formulations remains challenging. (uw.edu)
Cells2
- DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
- Some viruses possess an outer envelope, and the outer capsid is composed of major capsid protein (MCP), which appears to be highly conserved among the family and possesses surface binding sites interacting with the surfaces of host's cells [ 2 ]. (biomedcentral.com)
Characteristics1
- 23. What are distinct characteristics of only protein-mediated transport? (fsu.edu)
Important2
- In addition, they act as carriers for important fat-soluble vitamins A, D, E and K. Dietary fats are needed for the conversion of carotene to vitamin A, for mineral absorption and for a host of other processes. (coconutoil.com)
- These findings confirm important quantitative differences between sexes in the O. erraticus saliva proteome, unveil novel salivary proteins and functions at the tick-host feeding interface and improve our understanding of the physiology of feeding in O. erraticus ticks. (biomedcentral.com)
Similar1
- factors could induce similar patient symptoms? (fsu.edu)
Family4
- An immunogenic composition comprising 2 S. pneumoniae recombinant proteins wherein one of the proteins is selected from the Poly Histidine Triad family (PhtX) at a dose of between 1-100 µg and optionally comprising an adjuvant. (allindianpatents.com)
- In a preferred embodiment, one of the proteins is from the Poly Histidine Triad family (PhtX). (allindianpatents.com)
- In another preferred embodiment, one of the proteins is from the Choline Binding Protein family (CbpX), or CbpX truncates, or CbpX truncate-LytX truncate chimeric proteins. (allindianpatents.com)
- Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
Mutant1
- We previously showed that the toxicity is both linked to a loss and a gain of function of the mutant protein but the neuronal role of the TG6 is still not known. (ataxia.org)
Factor1
- 2022). Novel Variant Identified in the Enhancer Region of Host Transcription Factor, BRN3A, is a Significant Risk Factor for HPV-Induced Uterine Cervix Cancer. (du.ac.in)
Role2
- Transcriptomic analysis of the two recombinant strains in comparison with the control strain showed that the correct folding of proteins assisted by molecular chaperones played a key role in the improvement of FumDM expression and its enzyme activity. (inra.fr)
- Beyond this protective role, Mrr can inflict chromosomal DNA damage that elicits the SOS response in the host cell upon heterologous expression of specific methyltransferases such as M.HhaII, or after exposure to high pressure (HP). (uci.edu)
Expression1
- and Applied Neurobiology36, 265-274 Immunohistological intensity measurements as a tool to assess sarcolemma-associated protein expression Aims: The quantification of protein levels in muscle biopsies is of particular relevance in the diagnostic process of neuromuscular diseases, but is difficult to assess in cases of partial protein deficiency, particularly when information on protein localization is required. (dehydrogenase-signal.com)
Functions1
- 9. Identity and functions of specialized proteins in the latticework? (fsu.edu)
Class2
- Which class is protective again brain damage? (fsu.edu)
- This article is about the class of proteins. (wikipedia.org)
Addition1
- In addition to inhibiting protein synthesis, Shiga toxins induce cytokines such as interleukin-1, interleukin-6, and interleukin-8. (listlabs.com)
Cell1
- Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
Shown1
- Increasing vitamin K intake has been shown to increase carboxylation of extra-hepatic VKD proteins in apparently healthy adults, as well as those with osteoporosis and atherosclerosis. (vitamindwiki.com)
Activity1
- This activity renders the 28S rRNA unable to interact with the elongation factors EF-1 and EF-2, thus inhibiting protein synthesis. (listlabs.com)
Large1
- It is obtained by cold ethanol fractionation of large pools of blood plasma and contains 15%-18% protein. (cdc.gov)
Patients2
- Methods: To validate our relative quantification method, we labelled dystrophin and other sarcolemmal proteins in transverse sections of muscle biopsies taken from Duchenne muscular dystrophy and Becker muscular dystrophy patients, a manifesting carrier of Duchenne muscular dystrophy and normal controls. (dehydrogenase-signal.com)
- These bits of information are most likely useful pertaining to Medical professional verification and also early analysis within patients along with T2DM.Ropivacaine-induced myotoxicity in operatively incised muscle tissue hasn't been entirely investigated. (npyreceptor.com)
Chemical1
- Expert systems containing information about the relationship between the chemical structure and the ability of chemicals to haptenate proteins are available. (cdc.gov)
Vitamin1
- This indicates that current intake (and RDA) values for vitamin K are too low to support proper function of extra-hepatic Gla-proteins. (vitamindwiki.com)
Structure1
- 14. What is the structure of proteins? (fsu.edu)
Response1
- An oligomeric switch controls the Mrr-induced SOS response in E. coli. (uci.edu)
Include1
- These include electron paramagnetic resonance (EPR), resonance Raman, FTIR, and UV/visible/near-IR absorption and natural and magnetically induced circular dichroism (CD and MCD). (uga.edu)
Studies1
- We also collaborate with other groups for Mossbauer, electron-nuclear double resonance (ENDOR), X-ray absorption and X-ray crystallography studies of proteins prepared in our laboratory. (uga.edu)
Majority1
- Upon routine examination of the eyes, the vast majority of myopic eyes appear structurally identical to nonmyopic eyes. (wikipedia.org)