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  • side effects of c
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow , digestive tract and hair follicles . (wikipedia.org)
  • It was obvious that it would be meaningful to verify the new function of Retn and that it might lead directly to a potential candidate or target for relieving the bone marrow suppression by chemotherapeutic agents, which is one of the main clinical side effects of chemotherapy. (biomedcentral.com)
  • systemic
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (wikipedia.org)
  • ovarian
  • EGCG could have a protective role in reducing DOX-mediated inflammatory responses in human ovarian tissue. (bioscirep.org)
  • However, these treatments are gonadotoxic and can severely compromise or totally destroy the reproductive potential of women by inducing premature ovarian failure (POF) [ 1 , 2 ]. (bioscirep.org)
  • tissues
  • Specifically, certain triterpenoids (CDDO and derivatives thereof) have been shown to selectively protect normal mouse tissues against the deleterious effects of ionizing radiation ( 11 ). (aacrjournals.org)
  • The process of inducing the immune system to selectively destroy tumor tissues in vivo faces numerous conceptual as well as practical hurdles. (frontiersin.org)
  • Consequently, this meant Retn may play a critical role in bone marrow regeneration after damage, and eventually protect the impaired tissues. (biomedcentral.com)
  • murine
  • The discovery demonstrated a new function of murine Retn and suggested that it could potentially accelerate bone marrow regeneration post chemotherapy. (biomedcentral.com)
  • humoral
  • Although leishmanial infections induce strong humoral responses, antibodies appear to play no role in protection and in fact are associated with nonhealing forms of leishmaniasis. (wiley.com)
  • lymphocytes
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity ). (wikipedia.org)
  • proteins
  • Endocytosis of biotinylated plasma membrane proteins is induced by incubation at 37 ºC. (jove.com)
  • At this point, only proteins that were endocytosed remain protected from L-glutathione and thus remain biotinylated. (jove.com)
  • The biotinylated proteins protected from L-glutathione are those that did not recycle to the plasma membrane. (jove.com)
  • epithelial
  • Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4," The Journal of Biological Chemistry , vol. 279, no. 4, pp. 2712-2718, 2004. (hindawi.com)
  • significantly
  • EGCG significantly reduced DOX-induced inflammatory responses and improved the preservation of follicles. (bioscirep.org)
  • DA-9401 administration to ADR-treated rats significantly decreased serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels, interleukin-6, TNF-α, MDA level, ROS/RNS level, ER stress response protein levels, tunnel positive cells, cleaved caspase-3, and Bax/Bcl2 ratio. (springer.com)
  • Vesicles
  • Studies of this phenomenon using cultured tumor cells showed that these vesicles were produced in abundance and induced a variety of functional alterations in immune cells. (jci.org)
  • expression
  • Although RT induces DNA damage, it also upregulates the expression of various interleukins (IL), including IL-1, IL-6, IL-8, transforming growth factor-beta (TGF-β), and tumor necrosis factor (TNF) ( 6 ), which, through the activity of the transcription factor nuclear factor κB (NF- κB), further increases the expression of IL-6 and IL-8 ( 7 ). (frontiersin.org)
  • Radiation-induced gamma-H2AX expression was observed immediately following exposure to 4 Gy of X-rays and gradually decreased during the culture period. (jove.com)
  • selectively
  • By common usage, the term chemotherapy has come to connote the use of rather non-specific intracellular poisons , especially related to inhibiting the process of cell division known as mitosis , and generally excludes agents that more selectively block extracellular growth signals (i.e. blockers of signal transduction ). (wikipedia.org)
  • human
  • Findings were confirmed in a preclinical model of human chemotherapy-induced intestinal mucositis using duodenal biopsies by demonstrating that TLR2 activation limited the toxic-inflammatory reaction and maintained assembly of the drug transporter p-gp. (jimmunol.org)
  • simple tools to protect your personal information and of Ketone focus by cryopreserved synthesis with mountaineering and populations in areas with supplementation control: a human folate Table. (greggandjenny.com)
  • treatments
  • Other limited research that suggests AHCC might provide other benefits for people receiving chemotherapy treatments. (webmd.com)
  • In conclusion, PDT mediated by Lipo-AlClPc is capable of activating an inflammatory response, providing support to be used at least as an adjunct therapy to surgical treatments, allowing greater tumor control for long periods and, possibly, greater control of metastatic foci. (omicsonline.org)
  • tissue
  • Inflammatory changes are a major component of the normal tissue response to ionizing radiation, and increased nuclear factor κB (NF-κB) activity is an important mediator of inflammatory responses. (aacrjournals.org)
  • This circumstance highlights the necessity to use animal models to investigate the relative contribution of inflammatory changes to the overall response to radiation-induced cell and tissue injury in a multicellular organism. (aacrjournals.org)
  • In contrast, administration of HMGB1 after myocardial infarction induced by permanent coronary artery ligation ameliorates cardiac performance by promoting tissue regeneration. (springer.com)
  • simple tools to protect your personal information and your and work of riling two dietary intense trial studies with the tissue of type accommodation for valley problem in oil emergency amounts. (greggandjenny.com)
  • With tissue damage or pathogen invasion, neutrophils are the first line of defense, playing a major role in mediating the acute inflammatory response. (jove.com)