Induces osteoblast differentiation. Medical search. Frequent questions

GDF2 activate JNK in osteogenic differentiation of mesenchymal progenitor cells (MPCs). (wikipedia.org)
In this study, we verified that exosomes derived from osteogenically differentiated ADSCs can promote osteogenic differentiation of ADSCs. (hindawi.com)
Moreover, we found that these differentially expressed exosomal miRNAs connect osteogenic differentiation to processes such as axon guidance, MAPK signaling, and Wnt signaling. (hindawi.com)
This study confirms that alterations in the expression of exosomal miRNAs can promote osteogenic differentiation of ADSCs, which also provides the foundation for further research on the regulatory functions of exosomal miRNAs in the context of ADSC osteogenesis. (hindawi.com)
In their previous study, the researchers found that epimedin C could induce endothelial-like (but not osteogenic) differentiation of C3H/10T1/2 cells in vitro. (naturalnews.com)
This study was therefore aimed at establishing the dose-response effect of EPO stimulation on rat BMSCs and investigating the effects of mechanical stretch combined with EPO on the proliferation and osteogenic differentiation of BMSCs. (hindawi.com)
The proliferation and osteogenic differentiation of rat BMSCs were examined and compared using EPO with different concentrations. (hindawi.com)
The osteogenic differentiation of BMSCs was detected by alkaline phosphatase (ALP) staining, and the mRNA expression levels of ALP, OCN, COL, and Runx2 were detected by qPCR. (hindawi.com)
Mechanical stretch combined with 20 IU/ml EPO promoted proliferation and osteogenic differentiation of BMSCs. (hindawi.com)
EPO was able to promote the proliferation and osteogenic differentiation of BMSCs, and these effects were enhanced when combined with mechanical stretch. (hindawi.com)
Notably, it promotes the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) [ 15 - 17 ]. (hindawi.com)
This study was therefore aimed at addressing three key issues: First, is there a dose-dependent effect of EPO on the proliferation and osteogenic differentiation of BMSCs? (hindawi.com)
We show that TMEM53 acts as an inhibitor of BMP-SMAD signaling by preventing SMAD accumulation in the cell nucleus and that its deficiency enhances osteogenic differentiation by overactivating the BMP signaling pathway. (nature.com)
However, the primary mechanisms regulating osteogenic differentiation are controversial. (nature.com)
As primary sources of osteoblasts, MSCs show osteogenic functions that are closely associated with bone homeostasis and development. (nature.com)
The results showed that MSC did not alter their osteogenic differentiation capacity, surface marker profile, and the expression profiles of MSC during expansion. (biomedcentral.com)
Microarray analysis of MSC during osteogenic differentiation identified three candidate genes for further examination and functional analysis: ID4, CRYAB, and SORT1. (biomedcentral.com)
Finally we analyzed the gene expression profiles of MSC during osteogenic differentiation. (biomedcentral.com)
Altering the dimensions of nanotubular-shaped titanium oxide surface structures independently allowed either augmented human mesenchymal stem cell (hMSC) adhesion or a specific differentiation of hMSCs into osteoblasts by using only the geometric cues, absent of osteogenic inducing media. (ca.gov)
Various osteogenic stimulators and transcription factors can induce the protein expression of Dlx3. (molcells.org)
This monocyte-induced osteogenic effect was mediated by cell contact with MSCs leading to the production of soluble factor(s) by the monocytes. (ox.ac.uk)
This study establishes a role for monocyte/macrophages as critical regulators of osteogenic differentiation via OSM production and the induction of STAT3 signalling in MSCs. (ox.ac.uk)
The expression of osteogenesis-related gene was increased, which demonstrated that released BMP-2 could effectively induce the cell sheet osteogenic differentiation in vitro. (dovepress.com)
In this work, for the first time, we adopt a multidisciplinary approach to characterize the morphological, biochemical, and molecular changes underlying the response of human bone marrow stromal cells to long-term simulated microgravity exposure during osteogenic differentiation. (lu.se)
Our results show that osteogenic differentiation is reduced while energy metabolism is promoted. (lu.se)

The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(L-lactic acid) scaffolds in vitro and in vivo. (scielo.br)
Compelling $\textit{in vitro}$ data demonstrated that strontium hydroxyapatite nanoparticles exert a dual action, by promoting osteoblasts-driven matrix secretion and inhibiting osteoclasts-driven matrix resorption. (researchgate.net)
Jönsson S, Hjorth-Hansen H, Olsson B, Wadenvik H, Sundan A and Standal T. Second-generation TKI dasatinib inhibits proliferation of mesenchymal stem cells and osteoblast differentiation in vitro . (ntnu.edu)
besides, Mg could promote osteoblast differentiation in vitro and induce the formation of new bone in vivo. (cheric.org)
This investigation evaluates the effects of mechanical deformation on in vitro osteoblasts by assessing changes in MMP gene expression and enzyme activity. (allenpress.com)
To date, various studies have reported that cells isolated from the dental pulp of various animals can be induced to differentiate into cells of the odontoblastic phenotype by means of various chemicals, growth factors and signaling molecules both in vitro and in vivo ( reviewed in Nakashima and Akamine, 2005). (ispub.com)
WDR5, also known as BIG-3, is expressed in the developing growth plate, accelerates chondrocyte and osteoblast differentiation in vitro, and regulates osteoblast differentiation during embryonic bone development. (thermofisher.com)
In vitro they are required for the differentiation of osteoblasts but in excess can cause suppression of the mature osteoblast phenotype by reducing proliferation and inducing apoptosis. (endocrine-abstracts.org)
Using in vitro cell cultures of human bone marrow-derived mesenchymal stem cells (MSC), it was shown that monocytes/macrophages potently induced MSC differentiation into OBs. (ox.ac.uk)
METHODS: Umbilical cord mesenchymal stem cells (UCMSCs) were cultured in vitro and apoptosis was induced. (bvsalud.org)
Thus, tissue loading in vivo resulted in increased TNFa, which increased PLF, which then induced anabolic bone formation, the latter results confirmed in vitro. (cdc.gov)

GDF2 induces the differentiation of mesenchymal stem cells (MSCs) to an osteoblast lineage. (wikipedia.org)
With the in-depth researches of MSCs, an increasing number of studies have indicated that the therapeutic effects of MSCs can be attributed not only to their differentiation capacity but also to their paracrine action [ 21 ]. (hindawi.com)
We found that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and affects their differentiation into osteoblasts. (nih.gov)
Mesenchymal stem cells (MSCs) show trilineage differentiation because these cells differentiate into osteocytes, chondrocytes and adipocytes. (nature.com)
Mesenchymal stem cells (MSCs) and induced pluripotent stem (iPS) cells have great potential as cell sources for tissue engineering and regenerative medicine. (go.jp)

Dovitinib enhanced the BMP-2-induced alkaline phosphatase (ALP) induction, which is a representative marker of osteoblast differentiation. (molcells.org)
Recombinant Human Wnt-3a (Catalog # 5036-WN) induces alkaline phosphatase production by the MC3T3-E1 mouse preosteoblast cell line. (novusbio.com)
Measured by its ability to induce alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. (novusbio.com)

They have a higher odontogenic differentiation capacity compared to other cell groups due to their content of specific progenitor cells. (scielo.br)
Vascularization or vasculogenesis is defined as the differentiation of epithelial progenitor cells (EPCs) into mature epithelial cells to enable the formation of new blood vessels. (naturalnews.com)

Numerous harmful factors that affect the human body from birth to old age cause many disturbances, e.g., in the structure of the genome, inducing cell apoptosis and their degeneration, which leads to the development of many diseases, including cancer. (mdpi.com)
Oppositely, expression of mutated myocilin sensitizes cells to apoptosis induced by oxidative stress. (nih.gov)

Using various cell lines, including normal and WRN mutant fibroblast lines, Dr. Maity's previous research showed that WRN mutant cells respond weakly to different stress-induced autophagy in addition to basal levels. (nih.gov)
During his postdoc, he carried out research to determine the role of Kruppel-like factor 2 (KLF2) during osteoblast (OB) differentiation of dental pulp-derived stem cells (DPSC). (nih.gov)
Simultaneous measurements of glycolysis and oxidative phosphorylation in live cells revealed that OB differentiation decreased the oxygen consumption rate, which indicates reduced ATP production and mitochondrial respiration. (nih.gov)
Expression of IFN-induced transmembrane protein 1 in glomerular endothelial cells. (nih.gov)
The transcriptional factor p38 activation induced by GDF2 has been documented in other cell types such as osteosarcoma cells, human osteoclasts derived from cord blood monocytes, and dental follicle stem cells. (wikipedia.org)
This study was designed to determine the in vivo performance of three different materials as scaffolds for dental pulp stem cells (DPSC) undergoing induced odontogenic differentiation. (scielo.br)
Recently, a number of studies have confirmed that ADSCs possess the ability to differentiate into adipocytes, osteoblasts, and chondrocytes [ 16 - 18 ], suggesting that a broader source of stem cells is available for application in tissue engineering. (hindawi.com)
C3H/10T1/2 cells can be induced to differentiate into multiple stem cell lineages. (naturalnews.com)
Since the researchers already knew that vasculogenesis plays a pivotal role in bone formation, they used a bone morphogenetic protein 2 (BMP2)-induced ectopic bone formation model and mice 4T1 breast cancer cells co-implanted with luciferase-labeled C3H/10T1/2 cells (4T1 + C3H/10T1/2-Luc) model for their study. (naturalnews.com)
Our research is centered on identifying infectious and inflammatory factors present in the bone marrow microenvironment that influence plasma cell survival and differentiation and function of bone and immune cells. (ntnu.edu)
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids. (tocris.com)
Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. (tocris.com)
Analyses of the molecular pathophysiology using the primary cells from the Tmem53 -/- mice and the TMEM53 knock-out cell lines indicates that TMEM53 inhibits BMP signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of BMP2-activated Smad proteins. (nature.com)
However, tartrate-resistant acid phosphatase (TRAP) activity and the number of osteoclast cells (TRAP-positive multinucleated cells) were not changed by nSP treatment in the presence of receptor activator of nuclear factor κB ligand (RANKL) at doses that did not induce cytotoxicity by silica particles. (springer.com)
Collectively, the results suggested that nanosilica exerts no effect on RANKL-induced osteoclast differentiation of RAW264.7 cells, although a detailed mechanistic examination of the nSP70-mediated cytotoxic effect is needed. (springer.com)
Furthermore, it is possible that nSP circulating in the blood can reach the alveolar bone, which is presented in the submucosal layer, as well as various cells such as macrophages and osteoblasts. (springer.com)
Studies employ a transgenic animal model of spondyloarthritis and cells from human subjects including induced pluripotent stem cells (iPSC), to evaluate effects of HLA-B27 expression and misfolding on ER stress and its consequences for cytokine production and cellular function. (nih.gov)
Differentiation of induced pluripotent stem cells (iPSCs) into stromal cells and hematopoietic precursors. (nih.gov)
We also show that loss of USP15 expression from mouse myoblast cells inhibits BMP-induced osteoblast differentiation. (crick.ac.uk)
Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
We monitored these cells during their expansion ex vivo with respect to proliferation kinetics, surface marker profile and differentiation potential. (biomedcentral.com)
Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. (novusbio.com)
To date, various studies have reported that BMP-family growth factors can induce cells isolated from dental pulp tissues to differentiate into odontoblasts. (ispub.com)
In this study, we assayed the effect of exogenous mouse recombinant GDF-5 on cell proliferation of dental pulp cells and determined the expression levels of odontoblast differentiation marker genes in the cells of isolated mouse dental pulp tissues in the presence of GDF-5. (ispub.com)
Yet it remains poorly understood how these factors can induce the various types of cells in the dental pulp to engage in a harmonized and coordinated process of dentin regeneration. (ispub.com)
Here, we investigated the effect of GDF-5 on the proliferation of dental pulp cells and their differentiation into odontoblasts by assaying the expression levels of odontoblast marker genes. (ispub.com)
Z100095BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. (topsan.org)
It primes CD4+ T-cells for IL2 and IL15 responsiveness, induces. (topsan.org)
WDR5 interacts with the pluripotency factor Oct4/POU5F1 and is required for the efficient formation of induced pluripotent stem (iPS) cells. (thermofisher.com)
Small (approximately 30-nm diameter) nanotubes promoted adhesion without noticeable differentiation, whereas larger (approximately 70- to 100-nm diameter) nanotubes elicited a dramatic stem cell elongation (approximately 10-fold increased), which induced cytoskeletal stress and selective differentiation into osteoblast-like cells, offering a promising nanotechnology-based route for unique orthopedics-related hMSC treatments. (ca.gov)
Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation. (ox.ac.uk)
Cells and cytokines of the immune system are known to regulate bone turnover by controlling the differentiation and activity of osteoclasts, the bone resorbing cells. (ox.ac.uk)
However, less is known about the regulation of osteoblasts (OB), the bone forming cells. (ox.ac.uk)
This study aimed to investigate whether immune cells also regulate OB differentiation. (ox.ac.uk)
Inducing the local activation of STAT3 in bone cells may be a valuable tool to increase bone formation in osteoporosis and arthritis, and in localised bone remodelling during fracture repair. (ox.ac.uk)
It is a complex and dynamic process to form a continuous construct via the cells' adhesion, proliferation, differentiation, and extracellular matrix (ECM) deposition on a scaffold. (dovepress.com)
Osteoblasts (cells that make the organic matrix of bone and then mineralize bone) and osteoclasts (cells that resorb bone) are regulated by parathyroid hormone (PTH), calcitonin , estrogen , vitamin D, various cytokines, and other local factors such as prostaglandins. (msdmanuals.com)

These results provide evidence that the involvement of mitophagy is crucial during OB differentiation, and KLF2 critically regulates it. (nih.gov)
These results indicate that Dlx3 is a novel target of ER-α, and that ER-α regulates the osteoblast differentiation through modulation of Dlx3 expression and/or interaction with Dlx3. (molcells.org)
However, the molecular mechanisms by which ER-α regulates osteoblast differentiation remain to be elucidated. (molcells.org)

The increase in ALP, mineral deposition, and osteoblastic genes induced by the mechanical stretch-EPO combination was inhibited by U0126, an ERK1/2 inhibitor. (hindawi.com)
Binding of BMP2/4 to their receptors initiates the signal transduction cascade by inducing phosphorylation of SMAD1/5/9, which can then form hetero-complexes with SMAD4 followed by translocation into the nucleus to upregulate osteogenesis-related genes. (nature.com)
Composed of multiple constituent enhancers, super enhancers (SEs) are powerful cis-regulatory elements that identify genes that ensure sequential differentiation. (nature.com)
RNAi-mediated depletion of USP15 increases ALK3 K48-linked polyubiquitylation, and reduces both BMP-induced SMAD1 phosphorylation and transcription of BMP target genes. (crick.ac.uk)

The present study investigates the effects of nSP on osteoclast differentiation and the relationship between particle size and these effects. (springer.com)
Our studies revealed that nSP induced high ROS and pro-inflammatory cytokine production, and these cellular responses may induce excess osteoclast differentiation. (springer.com)
Therefore, we consider that it is necessary to estimate nSP-induced effects on osteoclast differentiation. (springer.com)
Furthermore, because we indicated previously that nSP induced different cellular responses from submicron-sized silica particles, such as those described above, it was of interest to analyse the effects of particle size on osteoclast differentiation. (springer.com)
Degradation of matrix extracellular phosphoglycoprotein (MEPE) and DMP-1 and release of acidic serine-rich and aspartate-rich MEPE-associated motif (ASARM) peptides are chiefly responsible for the hypophosphatemic rickets mineralization defect and changes in osteoblast-osteoclast differentiation. (medscape.com)

We show that USP15 enhances BMP-induced phosphorylation of SMAD1 by interacting with and deubiquitylating ALK3. (crick.ac.uk)
Furthermore, USP15 modulates BMP-induced phosphorylation of SMAD1 and transcription during Xenopus embryogenesis. (crick.ac.uk)

Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)

Additionally, we were able to reconstruct the three developmental phases during osteoblast differentiation: proliferation, matrix maturation, and mineralization, and illustrate the activation of the SMAD signaling pathways by TGF-β2 and BMPs. (biomedcentral.com)

P253R fibroblast growth factor receptor-2 mutation induces RUNX2 transcript variants and calvarial osteoblast differentiation « Dott. (carinci.org)

We seeded mouse neonatal calvarial osteoblasts onto flexible 6-well plates and subjected to continuous cyclic mechanical stretching. (allenpress.com)

Standal T, Abildgaard N, Fagerli UM, Stordal B, Hjertner O, Borset M and Sundan A. HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma . (ntnu.edu)

Increased PLF also promoted cell adhesion in MC3T3-E1 osteoblast-like cell cultures. (cdc.gov)

PPM-3 influences tumor development by affecting the differentiation of macrophages. (bvsalud.org)

The researchers found that epimedin C treatment significantly increased the bone weight and blood perfusion of mice in the BMP2-induced ectopic osteogenesis model. (naturalnews.com)

Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)

The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)

Consequently, PLDL and PDL seemed to be promising scaffold candidates for odontogenic regeneration at least as HA-TCP, when they were applied with the DPSC induced for odontogenic differentiation. (scielo.br)

Prior studies of acute phosphate restriction during the endochondral phase of fracture healing showed delayed chondrocyte differentiation was mechanistically linked to decreased bone morphogenetic protein signaling. (researchgate.net)

GDF2 is one of the most potent BMPs to induce orthotopic bone formation in vivo. (wikipedia.org)
Based on these results, the researchers concluded that epimedin C effectively promotes vascularization both in the BMP2-dependent bone formation model and in the 4T1 mammary tumor-bearing model by inducing the endothelial-like differentiation of C3H/10T1/2 in vivo. (naturalnews.com)
In vivo, glucocorticoids are anabolic at physiological concentrations, but in excess have an adverse effect on the skeleton most clearly seen in steroid-induced osteoporosis. (endocrine-abstracts.org)

Two important goals in stem cell research are to control the cell proliferation without differentiation and to direct the differentiation into a specific cell lineage when desired. (ca.gov)

Herein, we investigated the effect of dovitinib on human recombinant bone morphogenetic protein (BMP)-2-induced osteoblast differentiation in a cell culture model. (molcells.org)
Interferon-induced transmembrane protein 1 (IFITM1) is essential for progression of laryngeal squamous cell carcinoma in an Osteopontin/NF-κB-dependent manner. (nih.gov)
Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is encoded by the GDF2 gene. (wikipedia.org)
An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. (scielo.br)
Growth/differentiation factor-5 (GDF-5) belongs to the bone morphogenetic protein (BMP) family, which is expressed in dental pulp tissues. (ispub.com)
Growth/differentiation factor-5 (GDF-5) is a member of the bone morphogenetic protein (BMP) family, which is a subgroup of the transforming growth factor- (TGF-) superfamily. (ispub.com)
Z101967UP1 is a non-glycosylated secretoglobin family member protein which induces anti-inflammatory and anti-tumorigenic responses. (topsan.org)
We found novel proteins were dysregulated under simulated microgravity, including CSC1-like protein, involved in the mechanotransduction of pressure signals, and PTPN11, SLC44A1 and MME which are involved in osteoblast differentiation pathways and which may become the focus of future translational projects. (lu.se)

During the cellular differentiation process, cellular metabolism alters as the cell prepares for ongoing changes. (nih.gov)
C3H/10T1/2 is a clonal mouse embryo line used in the developmental determination of vertebrate stem cell lineages and their subsequent differentiation. (naturalnews.com)
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. (tocris.com)
This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. (tocris.com)
Despite growing experience and knowledge concerning human MSC and their use in cell-based strategies, the molecular mechanisms that govern MSC self-renewal, expansion and multilineage differentiation are not well understood and remain an active area of investigation. (biomedcentral.com)
The DNA synthesis capacity, the cell viability, and the tube formation capacity of HUVECs could be significantly induced by 6.25% Mg alloy extract. (cheric.org)
These results indicate that, although GDF-5 may have no effect on cell proliferation in isolated dental pulp tissue, it could promote odontoblast differentiation. (ispub.com)

Aim: To investigate the acute effects of oral glucocorticoids in doses used in clinical practice on biochemical indices of function of osteoclasts, osteoblasts and osteocytes.Methods: In 17 adult patients suffering from various medical pathologies requiring systemic steroid therapy that were never before treated with glucocorticoids, the glucocorticoid treatment was initiated (mean prednisolone equivalent dose of 23.1±12.7 mg/day, range 10 50 m. (bone-abstracts.org)

Dlx3 is essential for the skeletal development and plays an important role in osteoblast differentiation. (molcells.org)

A specially formulated aqueous extract of propolis (PWE) has been prepared in such a way to preclude the inclusion of flavonoids but contain mostly organic aromatic acids to study whether it would still protect against radiation-induced intestinal mucositis and to study the possible involvement of apoptotic pathways. (blogspot.com)

Collectively, our results indicate that ER-α-induced Dlx3 activity may induce the osteoblast differentiation in a ligand independent manner. (molcells.org)

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. (nih.gov)
Bone morphogenetic proteins (BMP), known as active components of odontogenic differentiation and tooth development, have been used as a growth factor in an appropriate medium. (scielo.br)

BMP2 is a cytokine and growth factor that stimulates the differentiation of myoblasts to osteoblasts. (naturalnews.com)

BMP2 also induces the formation of cartilage and bones. (naturalnews.com)

This factor is known to be essential for osteoblastic differentiation. (wikipedia.org)

The HRHF task decreased grip strength and induced forepaw mechanical hypersensitivity in both trained control and 6-week HRHF animals. (cdc.gov)

To address this question we first developed human oligonucleotide microarrays with 30.000 elements and then performed large-scale expression profiling of long-term expanded MSC and MSC during differentiation into osteoblasts. (biomedcentral.com)
Previous studies have demonstrated changes in the RNA expression in cyclically stressed osteoblasts obtained from mouse calvaria. (allenpress.com)
The expression of Uteroglobin is induced by steroid hormones such as. (topsan.org)

Nevertheless, the effect of GDF-5 on odontoblast differentiation from dental pulp tissues remains unknown. (ispub.com)

However, each differentiation method has a different impact on cellular metabolic changes. (nih.gov)
Accordingly, there is a compelling need to clarify the biological and cellular responses induced by different particle sizes. (springer.com)

Therefore, a metabolic shift from mitochondrial respiration to the glycolytic pathway occurs during OB differentiation. (nih.gov)
The Smad signaling pathway of GDF2 target HEY1 inducing the differentiation by up regulating it. (wikipedia.org)
Another pathway for GDF2 is the induced non-canonical one. (wikipedia.org)
In conclusion, these data indicate that 6.25% Mg-Zn-Mn alloy extract induces the angiogenesis of HUVECs via FGF signaling pathway. (cheric.org)

We found that ER-α increases BMP-2-induced osteoblast differentiation. (molcells.org)

By applying classical OB differentiation methods and a phytoestrogen ferutinin stimulated OB differentiation procedure, Dr. Maity showed that the levels of KLF2 and autophagy-related molecules increase during osteoblast differentiation. (nih.gov)

Interestingly, the CE extract also induced changes in the gut microbiota after weight loss in POP-exposed mice, including blooming of Parvibacter, a member of the Coriobacteriaceae family which has been predicted to play a role in xenobiotic metabolism. (cranberryinstitute.org)

Anatomy43

Organisms7

Diseases13

Chemicals and Drugs111

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes54

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Osteogenic25

Vitro11

MSCs5

Alkaline phosphatase3

Progenitor cells2

Apoptosis2

Cells38

Regulates3

Genes4

Osteoclast differentiation5

Smad12

Proliferation and differentiation1

Mineralization1

RUNX21

Calvarial1

Inhibits1

Adhesion1

Macrophages1

Osteogenesis1

Migration1

Signal transduction1

Regeneration1

Chondrocyte1

Vivo3

Lineage1

Protein8

Cell7

Osteocytes1

Skeletal1

Pathways1

Ligand1

Proteins2

Growth1

Formation1

Osteoblastic1

Mechanical1

Expression3

Dental pulp1

Cellular2

Pathway4

Increases1

Molecules1

Extract1