Induces mesangial cells. Medical search. Frequent questions

The relationship between cell proliferation, protein tyrosine phosphorylation, phosphotyrosine kinase activity and bradykinin receptor activation in rat mesangial cells was investigated. (nih.gov)
We demonstrated that bradykinin (BK), through the B2 receptor, induced a dose-dependent inhibition of mesangial cell proliferation stimulated by fetal calf serum. (nih.gov)
Taken together, these data suggest for the first time that, in proliferating rat mesangial cells, B2 receptor stimulation is able to induce, via a pertussis insensitive pathway, the inhibition of tyrosine kinase activity and mesangial cell proliferation. (nih.gov)
To assess the therapeutic potential of naringin and the mechanisms involved, we cultured rat glomerular mesangial cells and grouped them according to different glucose concentrations, different action times, different concentrations of MCC950, and different concentrations of naringin.The cell proliferation was measured by MTT assay. (biomedcentral.com)
Naringin also inhibited the proliferation of cells. (biomedcentral.com)
Naringin inhibited the proliferation of cells that were induced by high glucose. (biomedcentral.com)
Mesangial expansion caused by cell proliferation and glomerular extracellular matrix accumulation is one of the earliest renal abnormalities observed at the onset of hyperglycemia in diabetes mellitus. (dsmc.or.kr)
Transcription factor Sp1 is implicated in the transcriptional regulation of a wide range of genes participating in cell proliferation, and is assumed to play an essential role in mesangial expansion. (dsmc.or.kr)
The Sp1-decoy oligodeoxynucleotide suppressed transcription of these cytokines and proliferation of primary rat mesangial cells in response to high glucose. (dsmc.or.kr)
This can be explained in part by their intrinsically low telomerase activity, eradicating the risk of tumorigenesis through unbridled cell proliferation. (wikipedia.org)
This suggests the possibility that strictly regulated self-renewal mediated by Wnt signaling in cancer cells may be disturbed by the SUMOylation pathway to allow more malignant proliferation. (frontiersin.org)
Involved in positive regulation of biosynthetic process and positive regulation of glomerular mesangial cell proliferation. (mcw.edu)
MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
In renal pathophysiological conditions, it is also responsible for growth and profibrogenic actions, cell proliferation, production of cytokines and extracellular matrix proteins, and renal inflammatory cell infiltration. (vin.com)
MicroRNAs (miRNAs) are small endogenous RNAs that are associated with tumourigenesis, cell proliferation and apoptosis ( 4 , 5 ). (spandidos-publications.com)
Along with his mentor, he demonstrated that nitric oxide and cyclic GMP inhibit smooth muscle and mesangial cell growth and proliferation induced by serum and various growth factors, such as platelet-derived growth factor, epidermal growth factor, insulin-like growth factor, and fibroblast growth factor. (aacc.org)
The CCK-8 method measures cell proliferation, and the Transwell method detects migration and invasion. (researchsquare.com)
In terms of mechanism, the functional gain and loss experiments of human LEC show that TLR3 regulates the proliferation, migration, invasion of LEC and EMT induced by TGF-β2 by targeting the Jagged-1/Notch signaling pathway to affect the development of fibrotic cataract. (researchsquare.com)
These findings indicate that TLR3 prevents the progression of lens fibrosis by targeting the Jagged-1/Notch signaling pathway to regulate LEC proliferation, migration, invasion and TGF-β2-induced EMT. (researchsquare.com)
Excessive proliferation and migration of lens epithelial cells and transformation into mesenchymal cells (ie EMT) are common causes of cataracts. (researchsquare.com)
Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. (bvsalud.org)

Apoptosis is a distinct form of cell death that is observed under various physiologic and pathologic conditions, and it is thought to be important in regulating the number of glomerular cells. (elsevierpure.com)
This study investigated the possible role of reactive oxygen species in the induction of apoptosis in cultured human mesangial cells. (elsevierpure.com)
Fragmented nuclei with condensed chromatin, a morphologic characteristic of apoptosis, were observed by electron microscopy in mesangial cells exposed to 0.02 mM hydrogen peroxide for 4 h. (elsevierpure.com)
Nuclear DNA extracted from mesangial cells that had been incubated with hydrogen peroxide (2 to 20 mM) or with xanthine (0.05 mM) and xanthine oxidase (5 to 100 mU/mL) showed the ladder pattern on electrophoresis that is a biochemical marker for apoptosis. (elsevierpure.com)
Furthermore, apoptosis of mesangial cells induced by reactive oxygen species may contribute to the loss of such cells observed in glomerular disease. (elsevierpure.com)
Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis resistance, increased activity of senescence-associated β -galactosidase (SA- β -gal), and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16 INK4A , ARF proteins, and p21 [ 13 - 16 ]. (hindawi.com)
Rhamnaceae) on cisplatin-induced damage to kidney epithelial LLC-PK1 cells via mitogen-activated protein kinase (MAPK) and apoptosis pathways. (mdpi.com)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
Sirt1 mediates light-induced damage mitigation by HRS through inhibition of apoptosis and oxidant-stress. (arvojournals.org)
Myocardial I/R injury may induce cell apoptosis and autophagy by activating oxidative stress and upregulating inflammatory mediators, ultimately resulting in irreversible fibrotic damage ( 3 ). (spandidos-publications.com)
In both cases there is enhancement of mesangial cell apoptosis and the altered mesangium has a marked decrease of mesangial cells, most undergoing apoptosis. (heraldopenaccess.us)

In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
1 Although the pathogenesis of light-induced retinal damage remains unclear, oxidative stress is likely involved. (arvojournals.org)
Zinc is also an antioxidant and can directly protect cell membrane lipids and proteins and mercaptan-dependent macromolecules (tubulin and enzyme) from oxidative damage [ 6 ]. (nature.com)
Our previous cell and animal experiments confirmed that zinc supplementation could activate Nrf2 and up-regulate its downstream antioxidant factors, thus reducing oxidative damage to renal tubular epithelial cells and kidney tissues [ 11 ]. (nature.com)
In addition, it is an important fat-soluble antioxidant tasked with protecting lipoproteins and cell membranes against oxidative damage. (fusabil.org)
[ 18 ] Loss of DKC1 has been reported to induce oxidative stress independent of telomere shortening. (medscape.com)

Mechanical stretch induces vascular permeability factor in human mesangial cells: mechanisms of signal transduction. (unito.it)
We studied the effect of stretch on VPF production by human mesangial cells and the intracellular signaling pathways involved. (unito.it)
Stretch induces VPF gene expression and protein secretion in human mesangial cells via PKC- and PTK-dependent mechanisms. (unito.it)

The expressions of NLRP3, ASC, caspase-1, IL-1β, and IL-18 in rat glomerular mesangial cells were significantly higher in the high glucose (HG) group than in the control normal glucose (NG) group and exhibited time-dependence activity. (biomedcentral.com)
The NLRP3-inflammasome potentially plays a role in the process of activation and inflammation of glomerular mesangial cells as induced by high-glucose conditions. (biomedcentral.com)
Resveratrol treatment alleviated the hyperpermeability and the overexpression of cav-1 induced by high glucose in a dose-dependent manner. (springer.com)
Resveratrol also down-regulated the increased expressions of vascular endothelial growth factor (VEGF) and kinase insert domain receptor (KDR, or VEGF receptor-2) induced by high glucose. (springer.com)
Inhibition of VEGF/KDR pathway by using SU5416, a selective inhibitor of KDR, alleviated the hyperpermeability and the cav-1 overexpression induced by high glucose. (springer.com)
The above results demonstrate that RSV ameliorates caveolae-mediated hyperpermeability induced by high glucose via VEGF/KDR pathway. (springer.com)
As the first layer of renal filtration barrier, whether high glucose triggers glomerular endothelial cells (GECs) pyroptosis in the pathogenesis of diabetic nephropathy (DN) is unclear. (diabetesjournals.org)
Previous research showed that the gut microbiota metabolites-butyrate, reversed high glucose induced IL-1β release in mesangial cells. (diabetesjournals.org)
Therefore, we hypothesized that high glucose may induce GECs pyroptosis and then trigger inflammatory, but sodium butyrate may alleviate it. (diabetesjournals.org)
In this study, human renal glomerular endothelial cells (HRGECs) were exposed to high glucose in vitro, exogenous sodium butyrate was used as an intervention reagent, and then caspase 1 inhibitor Ac-YVAD-CMK pre-treated or silencing GSDMD by siRNA on HRGECs. (diabetesjournals.org)
Our results showed that high glucose increased the protein level of GSDMD, GSDMD-N and cleaved-caspase-1, and induced the release of IL-1β and LDH, PI positive staining cells also increased synchronously. (diabetesjournals.org)
Sodium butyrate co-treated, pretreatment with caspase-1 inhibitor or GSDMD siRNA alleviated high glucose-induced pyroptosis in HRGECs, respectively. (diabetesjournals.org)
Overall, this is the first observation of the potential relationship between sodium butyrate and pyroptosis in the pathogenesis of DN, proved that sodium butyrate could inhibit high glucose-induced Caspase1-GSDMD canonical pyroptosis pathway, which may act as new therapeutic targets of DN. (diabetesjournals.org)
found that high glucose in mesangial cells induced sumoylation (by SUMO 2/3) of smad4, the co-smad essential for TGF- β -induced signal transduction, and such sumoylation would be important for enhanced TGF- β signal transduction in the cells exposed to high glucose condition and diabetic kidney. (hindawi.com)
Our preliminary data show markedly reduced levels of PTEN-Long along with increased Akt kinase activity in the kidney cortex of type 1 and type 2 diabetic mice and in high glucose- or TGFb-treated mesangial and PTE cells. (grantome.com)
In specific aim 3, we will study the contribution of Akt-2 isotype to hypertrophy and fibronectin/PAI-1 expression in response to high glucose and TGFb in mesangial and PTE cells and in diabetic mice kidneys. (grantome.com)

They found that gremlin induced early activation of smad2/3 signal transduction via TGF- β independent manner in human tubular epithelial cells and long-term exposure of gremlin induced epithelial mesenchymal transition (EMT). (hindawi.com)

Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)

They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)
Reactive oxygen species (ROS), such as the superoxide radical, the hydroxyl radical, and H 2 O 2 , are continuously produced in most cells under physiological conditions, and their levels are regulated by a number of enzymes and physiological antioxidants such as superoxide dismutase, glutathione peroxidase, and catalase as well as by other nonenzymatic antioxidants. (diabetesjournals.org)
In addition, reactive oxygen species have an important role in DXR-induced cardiotoxicity. (fusabil.org)

Treatments with pertussis-toxin, inhibition of phospholipase C and protein kinase C inhibitors and chelation of free cytosolic calcium did not change the bradykinin-induced inhibition of phosphotyrosine kinase. (nih.gov)
Stretch-induced activation of the mitogen-activated protein kinase Erk has been linked to matrix production. (mcmaster.ca)
Results: Western blotting demonstrated that mesangial cells produced a kallikrein protein, which was of a different molecular weight to urinary kallikrein from rats of the same species. (le.ac.uk)
AS101 treatment decreased IL-10 and TGF-β expression in plasma and kidney tissues and results in 25% reduction in the fresh and fractional kidney weight and decreased hypertrophy of tubular cells (protein/DNA ratio, morphometric analysis). (biu.ac.il)
Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
Fatty acid-binding protein 3 (FABP3) located in renal mesangial and distal tubular cells, and had been shown to be a sensitive marker of renal injury, potentially be a mediator in pathogenesis of chronic kidney disease (CKD). (medsci.org)
High-mobility group box 1 protein (HMGB1) has been reported to be a potent proangiogenic factor induced by inflammatory stress. (molvis.org)
The VEGF-A protein and mRNA levels in conditioned medium of RGC-5 cells incubated with AGE-modified BSA (AGE-BSA) were examined with real-time PCR and enzyme-linked immunosorbent assay (ELISA), and BSA-treated cells were used as controls. (molvis.org)
Compared with the BSA controls, the RGC-5 cells incubated with AGE-BSA showed a dose- and time-dependent increase in VEGF-A mRNA and VEGF-A protein secretion in the supernatant, with the highest levels achieved at 24 h. (molvis.org)
Simultaneously, I am working to identify underlying mechanisms contributing to anthracycline-induced muscle protein degradation. (mdanderson.org)
Besides, it plays an important role in many other mechanisms such as mitochondrial dysfunction, a disruption in iron regulatory protein, nitric oxide release,inflammatory mediators, calcium dysregulation, autophagy and cell death. (fusabil.org)
In the second aim, how PTEN-Long forces activation of PDGFRb to regulate mesangial and PTE cell hypertrophy, and matrix protein expression will be investigated. (grantome.com)
Serum protein electrophoresis only showed hypoalbuminaemia, and bone marrow and splenic aspirates showed no abnormal cell clones. (who.int)

Muse cells do not express CD34 (markers for hematopoietic stem cells, adipose stem cells, VSELs) and CD117 (hematopoietic stem cells markers), Snai1 and Slug (skin-derived precursors markers), CD271 and Sox10 (neural crest-derived stem cells markers), NG2 and CD146 (perivascular cells) or CD31 and von Willebrand factor (endothelial progenitor markers). (wikipedia.org)
Other reports also show that DN is highly associated with accelerated aging in various types of cells such as tubular cells, podocytes, mesangial cells, and endothelial cells [ 21 - 23 ]. (hindawi.com)
Endothelial hyperpermeability induced by hyperglycemia is the initial step in the development of atherosclerosis, one of the most serious cardiovascular complications in diabetes. (springer.com)
Permeability was assessed by the efflux of fluorescein isothiocyanate (FITC)-dextran permeated through the monolayer endothelial cells (ECs). (springer.com)
In this study, we explore the role of HMGB1 in advanced glycation end products (AGEs)-induced vascular endothelial growth factor A (VEGF-A) production in rat retinal ganglion cell line 5 (RGC-5) cells. (molvis.org)
It may also invade and proliferate within heart and coronary artery endothelial cells, and, along with Streptococcus sanguis, it may also induce platelet aggregation associated with thrombus formation. (medscape.com)

We next found that BK induced a dose-dependent inhibition of phospho-tyrosine kinase activity. (nih.gov)
A single oral benazepril administration at a dose of 0.5 mg/kg induces a rapid decrease in plasma ACE activity with maximal, and nearly total, inhibition observed one hour after dosing. (vin.com)
Cytokine inhibition preserves renal hemodynamic function following mesangial cell immune injury. (mcw.edu)

We propose the outline of such a mechanism based on following aspects: (1) The glomerulus is a complex structure, the stability of which depends on the cooperative function of the basement membrane, mesangial cells and podocytes, counteracting the distending forces originating from the high glomerular hydrostatic pressures. (scienceopen.com)
when podocytes are lost for any reason they cannot be replaced by new cells. (scienceopen.com)

AS101, by inhibiting the activity of IL-10, decreases TGF-β production by mesangial cells, thus limiting compensatory tubular cell hypertrophy. (biu.ac.il)
We have reported that Akt kinase/mTORC1 (mechanistic target of rapamycin complex 1) axis contributes to renal hypertrophy and fibronectin expression in mesangial and proximal tubular epithelial (PTE) cells, and in kidneys of type 1 and type 2 diabetic mice. (grantome.com)
In this proposal, using cultured mesangial and PTE cells and renal tissues from diabetic OVE26 and db/db mice, we will test the hypothesis that hyperglycemia/TGFb-induced inappropriate downregulation of PTEN-Long results in PDGFRb/Akt-2 activation that contributes to renal hypertrophy and matrix expansion in diabetic kidney disease. (grantome.com)

abstract = "The present study investigated the role of IL-10 produced by the mesangial cells in postnephrectomy compensatory renal growth and the effect of the immunomodulator AS101 on this process. (biu.ac.il)

Diabetes causes retinal microvasculopathy associated with pericyte cell death, microaneurysms, abnormal vascular permeability, and macular edema. (molvis.org)

Angrem52 cDNA downstream of the putative matrix gene, as human genes expressed in kidney mesangial cells. (cdc.gov)
These a putative fusion peptide is readily identifiable based on genes' expression in human kidney mesangial cells was homology to those of other paramyxoviruses (Figure 1B). (cdc.gov)
The understanding of the pathways and cells that are involved in the fibrosis will guide the future therapies to combat the kidney fibrosis. (hindawi.com)
Published kidney RNA and ATAC sequencing databases were used to evaluate LRP1 transcription levels in different renal cell types. (asn-online.org)
Furthermore, in the kidney and in mesangial and PTE cells, we identify Akt-2 as the predominant isotype of Akt kinase that acts downstream of PTEN-Long/PDGFRb. (grantome.com)
Active cell division can promote kidney recovery. (drprincetta.com)

Although in all diabetic patients, GFR is initially normal or mildly elevated with no histological alterations, it progresses to produce thick glomerular basement membrane and expand to mesangial, followed by high glomerular capillary pressure and microalbuminuria. (scialert.net)
Results from chemically induced insulinopenic ( 2 ) as well as in genetically predisposed insulin-resistant ( 3 ) rodent models ( 4 ) and human histological ( 5 ) and clinical observations ( 6 ) provide support for this concept of a specific diabetic cardiomyopathy, although its mechanism remains poorly understood. (diabetesjournals.org)
Mesenchymal stem cells (MSCs) have been demonstrated to be protective in diabetic nephropathy (DN) by reducing albuminuria and attenuating glomerular injury. (thestemcellfoundation.com)
Streptozotocin-induced diabetic rats received no treatment or treatment with MSCs (2 × 10 6 , via tail vein) for two continuous weeks. (thestemcellfoundation.com)

Kallikrein gene 'knock-down' by small interfering RNA transfection induces a profibriotic phenotype in rat mesangial cells. (le.ac.uk)
Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
introduced a new concept of CKD-associated secretory phenotype (CASP), which indicates that senescent renal cells could secrete SASP components of various cytokines such as IL-1, IL-6, and TNF- α [ 19 , 20 ]. (hindawi.com)

They are collectable from commercially obtainable mesenchymal cells such as human fibroblasts, bone marrow-mesenchymal stem cells and adipose-derived stem cells. (wikipedia.org)
Comprise ~0.03% of bone marrow transplantation and several % of mesenchymal stem cell transplantation. (wikipedia.org)
They are also positive for general mesenchymal stem cell markers such as CD105, CD90 and CD29. (wikipedia.org)
Therefore, Muse cells are double positive for pluripotent and mesenchymal stem cell markers. (wikipedia.org)
Introducing exogenous mesenchymal stem cells represents a novel therapeutic avenue that has been experimentally tested with promising results. (heraldopenaccess.us)
The article addresses how mesangial injury occurs in LCDD and AL-amyloidosis as examples of generic mesangiopathies and summarizes existing data regarding the experimental use of exogenous mesenchymal stem cells in mesangial healing. (heraldopenaccess.us)

Furthermore, the Wnt/β-catenin can crosstalk with other signaling pathways including Notch, FGF, Hedgehog, and TGF-β/BMP signaling cascades to form a signaling network to regulate the survival and progression of cancer cells ( 14 - 16 ). (frontiersin.org)
The glomerulopathic light chains interact with mesangial cells where purported receptors regulate the downstream cellular mechanisms that will be activated and result in glomerular alterations. (heraldopenaccess.us)

Hydrogen peroxide (2 mM) also significantly increased the number of mesangial cells with fragmented DNA as detected by in situ nick end-labeling. (elsevierpure.com)
The results show that secretion of IL-10 and TGF-β by mesangial cells isolated from the remaining kidneys was increased significantly, compared with those of control and sham animals. (biu.ac.il)
Cisplatin-induced LLC-PK1 cell death was most significantly reduced following treatment with 3-dehydroxyceanothetric acid 2-methyl ester (3DC2ME). (mdpi.com)
The ethanol extract of Paeonia lactiflora Pall (Paeoniceae) significantly increased the differentiation of MC3T3-E1 preosteoblastic cells determined by alkaline phosphatase assay. (ijpsonline.com)
Furthermore, 4-O-methylbenzoyloxypaeoniflorin (2) significantly inhibited the osteoclastic differentiation of Raw264.7 cells. (ijpsonline.com)
Blocking with GZ, NAC, and JNK significantly suppressed AGE-induced VEGF-A production. (molvis.org)

In this context, the parietal epithelial cells (PECs) of the glomerulus have attracted increasing attention in recent years. (scienceopen.com)
Lens epithelial cells are distributed under the anterior capsule of the lens and under the capsule of the equator of the lens. (researchsquare.com)
The lens epithelial cells proliferate, differentiate and migrate inward to form lens fibers. (researchsquare.com)

Moreover, TGF-β secretion by mesangial cells was increased after the addition of exogenous recombinant IL-10 and inhibited in the presence of neutralizing anti-IL-10 antibodies. (biu.ac.il)

Abnormally activated Wnt/β-catenin signaling pathway plays a crucial role in promoting malignant tumor occurrence, development, recurrence, and metastasis, particularly in cancer stem cells. (frontiersin.org)
Studies have shown that the Wnt/β-catenin signaling pathway controls cell fate and function through the transcriptional and post-translational regulation of omics networks. (frontiersin.org)
Currently approved therapies are neither pathway nor cell specific in nature, due to which these therapies became ineffective in reducing the fibrosis and are associated with side effects. (hindawi.com)
Focusing on TGF- β -induced profibrotic signaling pathway on the ligand-receptor complex level, there are two exciting papers included in the special issue. (hindawi.com)

Mesangial injury represents a crucial event in the pathogenesis of light chain-associated glomerulopathies in patients with plasma cell dyscrasias. (heraldopenaccess.us)

The in vitro I/R model was established by the hypoxia/reoxygenation method using H9C2 cells. (spandidos-publications.com)
Glomerular mesangial cells were cultured for the in vitro experiment. (thestemcellfoundation.com)

Adding exogenous HA to unstimulated cells that had undetectable pericellular coats of HA selectively reduced perlecan and versican turnover, whereas other proteoglycans were unaffected. (cardiff.ac.uk)

The existence of specific receptors for plant-derived molecules in mammalian cells initiated a search for specific endogenous ligands. (degruyter.com)

In the present study, we investigated whether Sirtuin Type 1 (Sirt1), a class III histone deacetylase, mediates the retinal protective effect of HRS in rats with light-induced retinal damage. (arvojournals.org)

This was shown in human Muse cells infused into animal models with fulminant hepatitis, partial hepatectomy, muscle degeneration, epidermolysis bullosa, skin injury, stroke and spinal cord injury. (wikipedia.org)
Schistosomal antigens induce immunological responses which could provoke several forms of glomerular injury known as schistosomal glomerulopathy and that affect 10-15% of infected individuals. (who.int)

Mesangial cells, at the center of the glomerular tuft, produce extracellular matrix components when exposed to mechanical stretch, thus providing a model system simulating in vivo pathology. (mcmaster.ca)
Mesangial cells (MCs) are essential for normal renal function through the synthesis of their own extracellular matrix, which forms the structural support of the renal glomerulus. (cardiff.ac.uk)

A decline in renal function is related to the accumulation of inflammatory cells in the kidneys, which suggests a causative link. (biomedcentral.com)

tubular cell degeneration and nephrosis are the most commonly reported effects in laboratory animals. (cdc.gov)

Hela cells and human fibroblast-derived iPS cells showed high telomerase activity while Muse was at nearly the same level as that in somatic cells such as fibroblasts (these data are shown without running control for the telomerase activity, the comparison is not scientific thought). (wikipedia.org)
RNA and ATAC sequencing database analysis indicated preferential transcription of LRP1 in mesangial cells and fibroblasts. (asn-online.org)
In addition, he developed several methods for clinical use, including a molecular assay for the diagnosis of hereditary hemochromatosis, an assay for cystathionine ß-synthase in cultured fibroblasts, a methionine loading test for the diagnosis of heterozygosity of homocystinuria, and a method for molecular diagnosis of sickle cell disease using microextracted DNA from Guthrie cards. (aacc.org)

Overexpressing MT prevented these defects induced by diabetes. (diabetesjournals.org)
These data show that diabetes induces damage at the level of individual myocyte. (diabetesjournals.org)
Clitorea ternatea exhibits antidiabetic and antioxidant activities, offers the protection against diabetes-induced cognitive decline, and warrants the need for further studies to elucidate its mode of action. (jcimjournal.com)

Methods: Rat mesangial cells were treated with 12, 60, 120 nmol/l kallikrein-specific siRNAs. (le.ac.uk)
Using these methods, it could be established that the proliferating cells in Bowman's space, which are characteristically found in RPGN, are derived almost exclusively from the glomerular epithelium - primarily PECs. (scienceopen.com)

Targeting activated Gα subunits to specific cells in vivo permits identification of downstream effector pathways independent of receptor activation, and thus permits insight into disease mechanisms otherwise impossible to study in vivo . (medscape.com)

Infection of renal cells with HIV may contribute. (msdmanuals.com)

These results suggest that high levels of HA in the mesangium in disease is a mechanism controlling the accumulation of specific mesangial matrix components. (cardiff.ac.uk)
Different light chains are responsible for two diseases with diametrically opposite mesangial alterations: Light chain deposition disease which results in the expansion of the mesangium due to accumulation of matrix proteins not present in the normal mesangium and AL (light chain-associated) amyloidosis where the native mesangial matrix is replaced by fibrils (amyloid). (heraldopenaccess.us)

HMGB1 is implicated in the production of VEGF-A in retinal ganglion cell line-5 (RGC-5). (molvis.org)
3 - 5 Therefore, antioxidants capable of easily passing the blood-retinal barrier could be a promising treatment for light-induced damage. (arvojournals.org)

Treatment of cells with siRNA resulted in a dose-dependent decrease in kallikrein mRNA levels, which impacted on other components of the kallikrein-kinin system, dose-dependently reducing bradykinin B2 receptor mRNA expression. (le.ac.uk)

Hydrogen peroxide (0.02 to 20 mM) decreased the number of viable cells, as determined by trypan blue exclusion, in a dose-dependent manner. (elsevierpure.com)

Donor-Muse cells can be directly used for treatment without HLA-matching test or immunosuppressant treatment due to the specific immune privilege. (wikipedia.org)
My study aims to target immune suppressive cells with a specific goal to promote anti-tumor immunity. (mdanderson.org)
Interstitial immune cell infiltrate, fibrosis, and edema are common. (msdmanuals.com)

In light-damaged retinas, 5 days of HRS treatment increased Sirt1 expression, mitigated a- and b-wave amplitude reduction, and decreased the reduction of outer nuclear cell layers. (arvojournals.org)

Elevated Pgc, leading to the transmission of abnormal mechanical stress to resident renal glomerular cells, is a major pathogenic factor in progressive glomerular fibrosis and the ultimate loss of renal function. (mcmaster.ca)

The investigation of the effects of mechanical stretch on mesangial cells can provide important insights into glomerular pathophysiology related to increased intraglomerular pressure (Pgc). (mcmaster.ca)

NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)

Long-term effect of glomerular hypertension is deleterious as stretching of capillaries and mesangial cells leads to glomerular damage and consequently to progression of CKD. (vin.com)

Muse cells are shown to home into the damage site by S1P-S1P recptor 2 axis and spontaneously differentiate into tissue-compatible cells according to the microenvironment to contribute to tissue regeneration when infused into the blood stream. (wikipedia.org)
We previously reported mitigation of light-induced damage in the rat retina by intraperitoneal injection of hydrogen-rich saline (HRS). (arvojournals.org)
2 , 3 Antioxidants have been used to prevent light-induced damage. (arvojournals.org)
The repair of the damaged mesangium is difficult due to the absence of enough mesangial cells that can participate in the process and also the damage can be so extensive that the intrinsic processes that are available for repair (i.e. recruitment of stem cells from bone marrow and precursor stem cells in renal niches) cannot effectively carry out the recovery. (heraldopenaccess.us)
The findings that have been elucidated have paved the way for the design of novel therapeutic interventions aimed at stopping, slowing down or avoiding renal damage in patients with plasma cell dyscrasias. (heraldopenaccess.us)

Replenish new functional cells through spontaneous differentiation into tissue-compatible cells after homing to damaged tissue. (wikipedia.org)

Anatomy17

Organisms9

Diseases23

Chemicals and Drugs162

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes28

Disciplines and Occupations1

Information Science2

Proliferation21

Apoptosis11

Oxidative6

Human mesangial cells3

High glucose16

Signal Transduction1

Glucose1

Reactive Oxygen3

Protein13

Endothelial6

Inhibition3

Podocytes2

Hypertrophy3

Abstract1

Vascular permeability1

Kidney6

Diabetic4

Phenotype3

Mesenchymal6

Regulate2

Significantly6

Epithelial cells3

Secretion1

Pathway4

Pathogenesis1

Vitro2

Exogenous1

Receptors1

Rats1

Injury2

Extracellular2

Inflammatory1

Tubular cell1

Fibroblasts3

Diabetes3

Methods2

Mechanisms1

Renal cells1

Accumulation2

Retinal2

Decrease1

Dose-dependent1

Immune3

Sirt11

Fibrosis1

Mechanical stretch1

Inflammation1

Progression1

Damage5

Differentiation1