• TP53 is an important transcriptional activator of genes involved in the regulation of the G1 checkpoint of the cell cycle as well as certain genes responsible for programmed-cell death (apoptosis). (wikipedia.org)
  • Generally, prolymphocyte proportion exceeds 90% Minimal or absence of lymphadenopathy - abnormalities in size, number or consistency of lymph nodes Splenomegaly - Abnormal enlargement of the spleen High white blood cell count B-symptoms - Fever, night sweats and/or weight loss Similar to other leukemias, B-cell prolymphocytic leukemia is often asymptomatic. (wikipedia.org)
  • This is the highest incidence among all sub-types of B-cell malignancies. (wikipedia.org)
  • B-prolymphocytes are characterized by: Large size - approximately twice the size of a normal small lymphocyte Round or oval-shaped nuclei Single prominent nucleolus Moderately condensed nuclear chromatin High nuclear-cytoplasmic ratio - indicates more abundant cytoplasm This technique is used to study proteins expressed in cells using immunologic markers. (wikipedia.org)
  • Immunophenotyping helps distinguish B-PLL from similar diseases, one of its key identifiers is the absence in expression of the surface antigens CD10, CD11c, CD25, CD103 and cyclin D1 - an important regulator of cell-cycle progression. (wikipedia.org)
  • B-PLL represents less than 1% of all leukemia cases worldwide, mainly affecting the elderly population with a mean age of presentation between 65-70 years. (wikipedia.org)
  • High white blood cell counts - greater than 100 x 109/L - are also indicative of B-PLL. (wikipedia.org)