Induces jun transcription. Medical search. Frequent questions

Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in inducing cancer cell apoptosis. (hindawi.com)
First, we found that GS-002 significantly inhibited cell proliferation and induced cell apoptosis in dose-dependent manners. (hindawi.com)
Furthermore, we found that GS-002 induced more cell apoptosis in ATF-3-overexpressing cells. (hindawi.com)
Recent research demonstrated that the potential to induce apoptosis through endoplasmic reticular (ER) stresses can be a target for cancer therapy. (hindawi.com)
In both rat lens organ culture and mouse lens epithelial cells (MLECs), CREB promotes oxidative stress-induced apoptosis. (aging-us.com)
To confirm that CREB is a major player mediating the above stress response, we established stable lines of MLECs stably expressing CREB and found that they are also very sensitive to oxidative stress-induced apoptosis. (aging-us.com)
It was found that CREB significantly suppressed expression of the αB-crystallin gene to sensitize CREB-expressing cells undergoing oxidative stress-induced apoptosis. (aging-us.com)
CREB knockdown via CRISPR/CAS9 technology led to upregulation of αB-crystallin and enhanced resistance against oxidative stress-induced apoptosis. (aging-us.com)
Moreover, overexpression of exogenous human αB-crystallin can restore the resistance against oxidative stress-induced apoptosis. (aging-us.com)
Together, our results demonstrate that CREB is an important transcription factor mediating stress response, and it promotes oxidative stress-induced apoptosis by suppressing αB-crystallin expression. (aging-us.com)
Apoptosis can be induced in response to hypoxia. (bmj.com)
Cells adapt to this environmental stress, so that after repeated periods of hypoxia, selection for resistance to hypoxia induced apoptosis occurs. (bmj.com)
The key regulator of this process, hypoxia inducible factor 1 (HIF-1), can initiate apoptosis by inducing high concentrations of proapoptotic proteins, such as BNIP3, and can cause stabilisation of p53. (bmj.com)
During hypoxia, an intricate balance exists between factors that induce or counteract apoptosis, or even stimulate proliferation. (bmj.com)
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. (hmdb.ca)
Previous research has reported that CXCL1 contributes to the ingress of neutrophils into the RA joint (15) and induce hypertrophy and apoptosis of chondrocytes (16). (researchsquare.com)
Inhibition of autophagy via bafilomycin A1 aggravated H 2 O 2 -induced reactive oxygen species (ROS) accumulation and apoptosis in MAC-T cells. (biomedcentral.com)
Furthermore, TFEB overexpression attenuated H 2 O 2 -induced apoptosis by downregulating the caspase apoptotic pathway. (biomedcentral.com)
Our results indicate that activation of TFEB mediated autophagy alleviates H 2 O 2 -induced oxidative damage by reducing ROS accumulation and inhibiting caspase-dependent apoptosis. (biomedcentral.com)

Surprisingly, we found that inactivation of c-Jun, or mutation of its JNK phosphorylation sites, actually increased lung tumor burden. (figshare.com)
In c-Jun-deficient cells, JunD phosphorylation was increased, and expression of a dominant-active JNKK2-JNK1 transgene further increased lung tumor formation. (figshare.com)
The mRNA and protein levels of α smooth muscle actin (α-SMA) and Snail and the phosphorylation levels of Smad2/3, p38 mitogen-activated protein kinase (p38MAPK), and extracellular signal-regulated kinase ½ (ERK1/2) were determined by quantitative reverse transcription polymerase chain reaction (RT-PCR), western blot, and immunofluorescence staining. (molvis.org)
Mechanistically, we revealed that nintedanib reduces the TGF-β1-induced phosphorylation of Smad2/3, p38MAPK, and ERK1/2, suggesting that nintedanib acts through both classic and nonclassic signaling pathways of TGF-β1 to prevent HTF activation. (molvis.org)
UVB-induced phosphorylation of c-Jun N-terminal kinase, p38 kinase and Akt was inhibited by delphinidin. (oregonstate.edu)
Our results showed that ATP induces the phosphorylation of MAPKs in a time and dose-dependent manner, peaking at 5 min at 10 M ATP. (conicet.gov.ar)
In addition, western blot analysis revealed that ATP-induced phosphorylation of MAPKs in Caco-2 cells was dependent on calcium influx and intracellular calcium release, Src-family tyrosine kinases, and partially dependent on the cAMP/PKA and PKC pathways. (conicet.gov.ar)
We demonstrate, by confocal microscopy, that stimulation of Caco-2 cells with ATP results in the translocation of active MAPKs to the nucleous where they induce the expression of c-Fos and Jun family proteins, the phosphorylation of ATF-1, ATF-2 and JunD transcription factors and stimulate Caco-2 cell proliferation. (conicet.gov.ar)
however differences between benign and cancer samples were not statistically significant (Fig. 7and and and and Fig. S5and Fig. S5 B ). Collectively these results point toward a strong possibility that MLK3-induced phosphorylation of Pin1 could promote oncogenesis. (bioskinrevive.com)
These results suggest that MLK3-induced phosphorylation of Pin1 could be an early event in oncogenesis a notion that was also suggested Ceftobiprole medocaril previously for Pin1 (3). (bioskinrevive.com)
Predicated on our current data and released outcomes we propose a model for MLK3-induced Pin1 phosphorylation and its own impact on mobile homeostasis (Fig. 8). (bioskinrevive.com)
In this study, we show that Tip60 is required for the early DNA damage response (DDR) to UV, including the phosphorylation of histone 2AX, c-Jun N-terminal kinases (JNKs), and ataxia telangiectasia-related substrates. (rupress.org)

It was discovered that while GH induces the transcription of genes such as c-fos, c-jun, insulin-like growth factor-I, and serine protease inhibitor 2.1, it resulted in the acute inhibition of insulin-like growth factor binding protein-1 and albumin gene expression. (aacc.org)
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. (cancerindex.org)
The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. (cancerindex.org)

JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer. (figshare.com)
The AP-1 transcription factor c-Jun is required for Ras-driven tumorigenesis in many tissues and is considered as a classical proto-oncogene. (figshare.com)
SNAI1/Snail 1, SNAI2/Snail 2 (also known as Slug), ZEB1, ZEB2, TCF3 and KLF8 (Kruppel-like factor 8) can bind to the E-cadherin promoter and repress its transcription, whereas factors such as Twist, Goosecoid, TCF4 (also known as E2.2), homeobox protein SIX1 and FOXC2 (fork-head box protein C2) repress E-cadherin indirectly. (wikipedia.org)
Snail and Slug are known to regulate the expression of p63 isoforms, another transcription factor that is required for proper development of epithelial structures. (wikipedia.org)
The phosphatidylinositol 3' kinase (PI3K)/AKT axis, Hedgehog signaling pathway, nuclear factor-kappaB and Activating Transcription Factor 2 have also been implicated to be involved in EMT. (wikipedia.org)
GS-002 also induced endoplasmic reticular (ER) stress as evidenced by increases in ER stress-responsive proteins including glucose-regulated protein 78 (GRP78), growth arrest- and DNA damage-inducible gene 153 (GADD153), phosphorylated eukaryotic initiation factor 2 α (eIF2 α ), phosphorylated protein endoplasmic-reticular-resident kinase (PERK), and ATF-3. (hindawi.com)
We recently reported that genetic or pharmacological inhibition of insulin-like growth factor receptor (IGF-1R) slows DNA replication and induces replication stress by downregulating the regulatory subunit RRM2 of ribonucleotide reductase, perturbing deoxynucleotide triphosphate (dNTP) supply. (nature.com)
Protein expression was investigated by ELISA and immunofluorescence, transcription factor-DNA binding by ELISA, gene expression by real-time PCR, prostaglandin E 2 (PGE 2 ) by radioimmunoassay, and matrix metalloproteinase (MMP) activity and nitric oxide (NO) production by fluorometry. (karger.com)
c-Jun is one of three Jun family proteins making up the activator protein-1 (AP-1) transcription factor group. (rndsystems.com)
The general transcription factor, CREB has been shown to play an essential role in promoting cell proliferation, neuronal survival and synaptic plasticity in the nervous system. (aging-us.com)
Activator protein-1 and nuclear factor-kappaB, crucial transcription factors involved in COX-2 expression, were activated by UVB and delphinidin abolished this activation. (oregonstate.edu)
Instead, TWHF partially inhibited DNA binding capacity of cytokine-stimulated activating protein-1 (AP-1) and nuclear factor-κB (NF-κB) transcription factors. (aspetjournals.org)
Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding. (nature.com)
This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. (cancerindex.org)
The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. (cancerindex.org)
Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) drive NK cell responses against viral infection and tumors in vivo. (cancerindex.org)
Glucose and GLP-1 also synergistically activated NFAT (nuclear factor of activated T-cells)-mediated transcription from a minimal promoter construct containing tandem NFAT consensus sequences. (diabetesjournals.org)
We have previously identified NFAT (nuclear factor of activated T-cells) as a key regulator of insulin gene transcription in pancreatic β-cells that is activated by the calcium/calmodulin-dependent protein phosphatase 2B (calcineurin) in response to increased [Ca 2+ ] i ( 10 ). (diabetesjournals.org)
Secretion of tumor necrosis factor (TNF)-α and interleukin (IL)-1 could induce obesity- and diabetes mellitus (DM)-related inflammation, however its association with SG procedure has not been elucidated well. (researchgate.net)
Transcription factor EB (TFEB)-mediated autophagy is an important cytoprotective mechanism against oxidative stress. (biomedcentral.com)
Induction of autophagy is tightly regulated at the transcriptional level and involves the master regulator, transcription factor EB (TFEB). (biomedcentral.com)
Transcription factor 7-like 2 ( TCF7L2 ) variants have been associated with type 2 diabetes mellitus (T2DM) in multiple ethnic groups. (medscape.com)
The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)
Translocation of EWSR1 (Ewing sarcoma breakpoint region 1) with an ETS (E26 transformation-specific) transcription factor gene occurs in more than 95% of Ewing sarcomas. (medscape.com)

2018 Jun 6;9(1):2192. (nih.gov)

Activation of Wnt pathway in breast cancer cells induces the EMT regulator SNAIL and upregulates the mesenchymal marker, vimentin. (wikipedia.org)
c-Jun acts as a positive regulator of cell proliferation and can induce oncogenic transformation. (rndsystems.com)

Our lab's interest involves the use of human induced neurons to model Alzheimer's disease, specifically modeling changes in calcium homeostasis. (rosalindfranklin.edu)

Mechanistically, we found that protein levels of the Jun family member JunD were increased in the absence of c-Jun. (figshare.com)
On the other hand, transcription factors such as grainyhead-like protein 2 homologue (GRHL2), and ETS-related transcription factors ELF3 and ELF5 are downregulated during EMT and are found to actively drive MET when overexpressed in mesenchymal cells. (wikipedia.org)
Mechanistic studies revealed no impact on the activation of extracellular signal-regulated kinase, p38, and c-Jun N-terminal kinase mitogen-activated protein kinases. (aspetjournals.org)
Furthermore, studies using cycloheximide indicate that these GH-induced changes in mRNA expression do not require protein synthesis and hence are primary, not secondary events. (aacc.org)
Western blot indicates that metallic nickel nanoparticles induced a higher level of protein expressions for R-Ras, cmyc, C-Jun, p65, and p50 in a time-dependent manner. (cdc.gov)

ATF-3 induces DNA synthesis and expression of cyclin D1 in hepatocytes [ 21 ] and is involved in serum-induced cell proliferation as a target gene of c-myc [ 10 ]. (hindawi.com)
Exogenous RRM2 expression rescued hallmarks of replication stress induced by co-inhibiting IGF with CHK1 or WEE1, identifying RRM2 as a critical target of the functional IGF:CHK1 and IGF:WEE1 interactions. (nature.com)
Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase. (oregonstate.edu)
We found that delphinidin suppressed UVB-induced COX-2 expression in JB6 P+ mouse epidermal cells. (oregonstate.edu)
Moreover, in vivo investigations using mouse skin revealed that the upregulation of COX-2 expression, MAPKK4 activity and PI-3K activity induced by UVB was abolished with delphinidin treatment. (oregonstate.edu)
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. (nature.com)
It also increases insulin production by enhancing glucose-induced insulin gene expression. (diabetesjournals.org)
Our results showed that exposure to Pteridium aquilinum induces histomorphological modifications including increased expression of acidic glycoconjugates in the gastric mucosa. (pasteur.fr)
CXCR2, c-Raf and MAPKs was found to regulate CXCL1-induced IL-6 expression in OASFs and RASFs. (researchsquare.com)
Finally, CXCL1 triggered the transcriptional activities of c-Jun (which regulates the expression of proinflammatory proteins) in OASFs and RASFs. (researchsquare.com)
Consequent abnormal expression of the cardiac and limb-specific T-box transcription factors lead to the malformations described in HOS. (medscape.com)

EBF3 bound directly to p21 cip1/waf1 promoter and regulated transcription from both p21 cip1/waf1 and p27 kip1 promoters in reporter assays. (aacrjournals.org)
These turned on transcription elements could act in the cyclin D1 promoter to induce its transcription. (bioskinrevive.com)
In this study, GLP-1 (100 nmol/l), in the presence of glucose (11 mmol/l), induced a ∼71-fold increase in insulin gene promoter activity in INS-1 pancreatic β-cells, an effect that was an order of magnitude larger than with either stimulant alone. (diabetesjournals.org)
NFAT binds to three distinct NFAT elements within the rat I insulin promoter and activates insulin gene transcription. (diabetesjournals.org)

First, given evidence that IGFs regulate the response to IR, we also found evidence that IGF-1R depletion induced endogenous DNA lesions marked by γH2AX foci in prostate cancer cells [ 10 ]. (nature.com)

In summary, this work unveils a SETBP1 function that directly affects gene transcription and clarifies the mechanism operating in myeloid malignancies and in the Schinzel-Giedion syndrome caused by SETBP1 mutations. (nih.gov)
3- 5 Therefore, during severe hypoxia or anoxia, the cell initiates a cascade of events that leads to apoptotic cell death, thereby preventing the accumulation of cells with hypoxia induced mutations. (bmj.com)

Low ATP concentrations in hypoxic tumour cells disable the apoptotic cascade and induce cell death by necrosis. (bmj.com)

One pathway results from the direct effect of increased [Ca 2+ ] i , which activates calcineurin, and in turn, it upregulates insulin gene transcription via NFAT. (diabetesjournals.org)
The second pathway also involves glucose metabolism but appears to be driven by glucose-derived factors that target insulin gene transcription independently of [Ca 2+ ] i . (diabetesjournals.org)

Currently there is intense interest to define the mechanism of action of glucagon-like peptide-1 (GLP-1) in regulating β-cell function, including insulin gene transcription. (diabetesjournals.org)
These data suggest that the synergistic action of glucose and GLP-1 to promote insulin gene transcription is mediated through NFAT via PKA- and calcineurin-dependent pathways in pancreatic β-cells. (diabetesjournals.org)
The rate of insulin gene transcription in pancreatic β-cells is regulated by a complex integration of signals derived from nutrients, hormones, and neurotransmitters ( 1 - 5 ). (diabetesjournals.org)
Two signaling pathways arising from glucose metabolism converge to activate NFAT-mediated insulin gene transcription. (diabetesjournals.org)
The gene transcription alterations and the induced glycophenotypic changes observed in the gastric mucosa contribute for the understanding of the molecular mechanisms underlying the role of Pteridium aquilinum in the gastric carcinogenesis process. (pasteur.fr)

this family of proteins is hereafter called EBF) are a group of DNA-binding transcription factors with the basic helix-loop-helix (bHLH) domain. (aacrjournals.org)
Afterward, molecular docking was used to analyze the binding force of the top 10 active compounds with target proteins of VCAM1, CTNNB1, and JUN. (hindawi.com)
The molecular docking results revealed that the top 10 active compounds of HGWD had a strong binding to the target proteins of VCAM1, CTNNB1, and JUN. (hindawi.com)

Many transcription factors (TFs) that can repress E-cadherin directly or indirectly can be considered as EMT-TF (EMT inducing TFs). (wikipedia.org)
On the other hand, ATF-3 is rapidly induced in cells treated with growth stimulators such as serum and growth factors [ 20 ]. (hindawi.com)
Transcriptome wide identification and characterization of NO-responsive WRKY transcription factors in Arabidopsis thaliana L. (umu.se)
8000 Bahía Blanca, Argentina In the present work, we examined the role of ATP in the activation of the MAP kinases (MAPKs) ERK1/2, JNK1/2 and p38 and their involvement in the modulation of transcription factors and proliferation of human colon cancer Caco-2 cells. (conicet.gov.ar)
Utilizing the cell-reprogramming technology we induce neuronal differentiation of OPCs with proneural transcription factors. (rosalindfranklin.edu)
Mycobacterium tuberculosis (MTB) induced tuberculosis has been known as one of the risk factors for lung carcinogenesis. (lidsen.com)
In addition, myocardial transcription factors, non-coding RNAs, cyclins, and cell cycle-dependent kinases are involved in the multimodal regulation of pre-existing cardiomyocyte proliferation. (bvsalud.org)
Biochemical studies suggest that in one case this transcription factors to implement particular genetic programs. (lu.se)
In occurs through the inhibition of DNA binding of cognate cis- hematopoiesis there exist several lineage branch points with regulatory motif while in the other case DNA binding is unaffected identified key transcription factors and external signals [3-5]. (lu.se)

We conclude that Tip60 enables UV-induced DDR signaling even in the absence of p53, whereas preaccumulated p53 suppresses UV-induced DDR by reducing the levels of BRCA1. (rupress.org)

Nitric oxide-induced AtAO3 differentially regulates plant defense against Pseudomonas syringae pv. (umu.se)

Rather, p53 accumulation by either knockdown of Mdm2 or addition of an Mdm2 inhibitor, Nutlin-3, before irradiation strongly attenuated the UV-induced DDR and increased cell survival. (rupress.org)
Overexpression of TFEB activated autophagy and attenuated H 2 O 2 -induced ROS accumulation. (biomedcentral.com)

Several signaling pathways (TGF-β, FGF, EGF, HGF, Wnt/beta-catenin and Notch) and hypoxia may induce EMT. (wikipedia.org)
2 In addition, hypoxia induces genetic instability by the induction of fragile sites causing gene amplification. (bmj.com)

Previous studies reported that ATF-3 was induced by treating cells with antitumorigenic compounds [ 14 - 18 ] and a phosphoinositide 3-kinase inhibitor [ 19 ]. (hindawi.com)
Recently, gene-editing techniques, including programmable nucleases such as restriction endonuclease, zinc finger nuclease, transcription activator-like effector nuclease, clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeats-associated 9 and base editors, have provided new tools for editing mtDNA in mammalian cells. (bvsalud.org)

Spectrofluorimetric measurements showed that cell stimulation with ATP induced transient elevations in intracellular calcium concentration. (conicet.gov.ar)

This work identifies JunD, not c-Jun, as the crucial substrate of JNK signaling and oncogene required for Ras-induced lung cancer. (figshare.com)

the latter samples were confirmed by reverse transcription PCR molecular testing ( 7 ) to contain PV strains. (cdc.gov)
Here, we investigated the effects of delphinidin, an abundant dietary anthocyanin, on UVB-induced COX-2 upregulation and the underlying molecular mechanism. (oregonstate.edu)

A three-dimensional (3D) collagen gel contraction assay demonstrated that nintedanib effectively inhibits myofibroblast contraction induced by TGF-β1. (molvis.org)

Similar phenotypes were induced by IGF:WEE1 co-inhibition, also via exacerbation of RRM2 downregulation. (nature.com)

In January 2016 Jon received a second stent and in June he was diagnosed with an anoxic brain injury. (cornnation.com)

Characterization of the zinc-induced Shank3 interactome of mouse synaptosome. (nih.gov)

Orthologous to human TASOR2 (transcription activation suppressor family member 2). (nih.gov)
Our results demonstrate that metallic nickel nanoparticles caused higher activation of AP-1 and NF-kB, and a greater decrease of p53 transcription activity than fine particles. (cdc.gov)

Kounis NG, Frangides C, Papadaki PJ, Zavras GM, Goudevenos J. Dose-dependent appearance and disappearance of amiodarone-induced skin pigmentation. (medscape.com)

The specific changes on the DNA upon UV exposure are different from those induced by γ irradiation, mostly resulting in chemical modifications of single DNA strands such as cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts ( Balajee and Bohr, 2000 ). (rupress.org)

Triptolide lowers the arthritic scores, delays the onset of collagen induced arthritis and reduces the expressions of TNF-α, IL-6, NF-κB and COX-2 in paw cartilage in arthritic rats. (biomedcentral.com)

A previously suggested mechanism for this regulation consists of the ability of Tip60 to coactivate transcription by the tumor suppressor p53. (rupress.org)

2022, Jun 1, 24(6):888-900. (hopkinsmedicine.org)

Here, we review recent insights into the biogenesis of eRNAs and the mechanisms underlying their multifaceted functions and consider how these findings could inform future investigations into enhancer transcription and eRNA function. (nature.com)

Anatomy11

Organisms7

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes68

Information Science3

Apoptosis19

Phosphorylation12

Genes3

Factor24

20181

Regulator2

Neurons1

Protein5

Expression11

Promoter4

Endogenous1

Mutations2

Apoptotic1

Pathway2

Gene transcription5

Proteins3

Factors9

Suppresses1

Regulates1

Accumulation2

Hypoxia2

Cells2

Intracellular1

Oncogene1

Molecular2

Inhibits1

Inhibition1

20161

Characterization1

Activation2

Dose-dependent1

Modifications1

Reduces1

Mechanism1

20221

Enhancer1