Pancreatic acinar cell injury triggers the synthesis and release of pro-inflammatory cytokines and chemokines (32, 36, 39, 41, 82). (pancreapedia.org)
This review aims to describe the roles of key cytokines and chemokines in commonly used experimental models of pancreatitis and how the cytokine profile is affected by the choice of a specific model. (pancreapedia.org)
S. lappa decreased the immunoglobulin E, cytokines and chemokines with the reduction in histopatholgical features of atopic dermatitis (AD) lesion. (molcells.org)
Subfamily2
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. (cancerindex.org)
We performed a prospective study to associate hepatic expression of the CXC subfamily of chemokines with histology findings and prognosis of patients with AH. (statsignaling.com)
Cytokine3
Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. (wikipedia.org)
In the context of AP, the most extensively investigated chemokines are CC-ligand 2 (CCL2, also known as monocyte chemoattractant protein-1 or MCP-1), CXC-ligand 1 (CXCL1, also known as cytokine-induced neutrophil chemoattractant or CINC in rat and keratinocyte cytokine or KC in mouse), and CXC-ligand 2 (CXCL2, also known as macrophage inflammatory protein 2-alpha or MIP2a). (pancreapedia.org)
There were some differences between bone marrow- and adipose tissue-derived MSCs for several secreted proteins, such as cytokine (interferon-γ), growth factors (basic fibroblast growth factor, hepatocyte growth factor, and insulin-like growth factor-1), and chemokine (stem cell-derived factor-1). (biomedcentral.com)
Tumor2
In particular, Guadecitabine greatly enhanced the efficacy of combined ICBs by increasing effector memory CD8+ T cells, inducing effector NK cells in the spleen and reducing tumor infiltrating regulatory T cells and myeloid derived suppressor cells (MDSC), in the tumor microenvironment (TME). (biomedcentral.com)
Recent studies in mouse tumor models have shown that T RM cells are induced by cancer vaccines delivered in peripheral tissue sites, or by the depletion of regulatory T cells. (frontiersin.org)
Metastasis2
Furthermore, we identified that FOXO1, a key molecule controlling cellular energy metabolism, mediated the effect of IFN-γ induced IL-27 expression, and that NR4A1, a key molecule controlling PMo differentiation and inhibiting cancer metastasis, inhibited the pro-NK cell and anti-metastasis activity of IFN-IMo by suppressing CXCL9 expression. (bmj.com)
Human CEA isolated from hepatic metastasis of colon adenocarcinoma. (samatashkhis.com)
Full-length CCL21 is bound to glycosaminoglycans, and endothelial cells and it induces the chemotactic migration of T cells and the cell adhesion caused by integrin activation. (wikipedia.org)
This multi-step process is enabled by inflammatory receptors and molecules expressed by the endothelial cells which capture the neutrophils and support their extravasation, alongside gradients of chemokines that guide the neutrophils through the ECM. (nature.com)
Similarly, hepatic sinusoidal endothelial E-selectin expression is up regulated by highly metastatic cells entering the liver [ 10 ]. (biomedcentral.com)
Receptor1
CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7. (wikipedia.org)
Chemotactic1
Chemokines (chemotactic cytokines) are positively charged polypeptides with highly conserved cysteine (C) residues within the N-terminal sequence, classifying them as 'C', 'CC', 'CXC' or 'CX3C' types (102, 143). (pancreapedia.org)
Ligand1
Chemokine CCL21 contains an extended C-terminus which is not found in CCL19, another ligand of CCR7. (wikipedia.org)
Chemotaxis1
The presence or absence of a glutamate-leucine-arginine sequence further divides chemokines into 'ELR' and 'non-ELR' chemokines, with ELR-chemokines exhibiting highest activity in chemotaxis assays (65, 130). (pancreapedia.org)
Upregulation2
In vitro, PBM induced VEGF upregulation, improved dental pulp cells proliferation and migration, and favored their mineralization potential. (bvsalud.org)
Another mechanism whereby injured pancreatic acinar cells trigger the inflammatory response is through synthesis and release of cytokines (36) and chemokines (11), and upregulation of adhesion molecules such as the intercellular adhesion molecule-1 (ICAM-1) (136), which together promote neutrophil and monocyte infiltration (27, 71) and exacerbate tissue injury (10, 27, 37). (pancreapedia.org)
Alcohol-induced2
Adenoviral delivery of superoxide dismutase has been shown to produce beneficial effects in warm ischemia reperfusion (18), alcohol-induced liver injury (19), and reduced-size liver grafts (20). (ectrx.org)
Abukhadir SS, Mohamed N, Mohamed N. Pathogenesis of alcohol-induced osteoporosis and its treatment: a review. (springer.com)
Expression1
Methods We screened multiple inflammatory cytokines/chemokines activity of modulating PMo/IMo associated cell markers expression using human monocyte in vitro culture system. (bmj.com)
Acute1
Acetaminophen (APAP) poisoning is one of the leading causes of acute hepatic failure and liver transplantation is often the only lifesaving alternative. (mdpi.com)
Inflammatory1
The following review considers recent advances in the understanding of hepatic ischemia-reperfusion injury and focuses on inflammatory mediators of significance. (ectrx.org)
Peripheral1
They use CCL21 chemokine gradient for the migration to the lymph nodes even when there is no inflammation in the body, and they contribute to peripheral tolerance. (wikipedia.org)
Activity1
Guadecitabine in association with ICBs increased serum levels of IFN-γ and IFN-γ-induced chemokines with anti-angiogenic activity. (biomedcentral.com)
Recruitment1
CCL21 is a chemokine involved in the recruitment of T cells into secondary lymphoid organs. (wikipedia.org)
Cells2
Then they migrate along the chemokine gradient to the lymph node where they present the antigen to T cells. (wikipedia.org)
This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC). (wikipedia.org)
Cell1
We also found that IFN-IMos induced by short-term IFN-γ treatment robustly boosted NK cell expansion for threefold and promoted NK differentiation and function through IL-27 and CXCL9. (bmj.com)
Effects1
In this discussion of antioxidant molecules, it is also important to include melatonin, which exerts multiple protective effects in hepatic ischemia and reperfusion (33-36). (ectrx.org)
Treatment2
Conclusion: T Stage was a significant prognostic determinant, and gastrectomy plus hepatic resection could be a promising treatment for patients with LMGC. (statsignaling.com)
Our in vivo data demonstrated that IMo expansion was induced by short-term (3 days) IFN-γ treatment through increasing CMo-IMo differentiation and blocking IMo-PMo differentiation. (bmj.com)
Shown1
In the multivariate analysis, T stage was shown to be an independent prognostic determinant, while gastrectomy plus hepatic resection was of marginal significance compared with chemotherapy alone. (statsignaling.com)