Induces granulocyte colony stimulating factor. Medical search. Frequent questions

Granulocyte macrophage-colony-stimulating factor (GM-CSF), released from alveolar macrophages (AM), is an important regulator of eosinophil, T cell, and macrophage function and survival. (nih.gov)
Intradermal transgenic expression of granulocyte-macrophage colony-stimulating factor induces neutrophilia, epidermal hyperplasia, Langerhans' cell/macrophage accumulation, and dermal fibrosis. (mcmaster.ca)
Granulocyte-macrophage colony stimulating factor induces both HLA-DR expression and cytokine production by human monocytes. (ox.ac.uk)
The effect of recombinant human granulocyte-macrophage colony stimulating factor (GM-CSF) on the expression of HLA-DR, and the production of the cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) by human peripheral blood monocyte-enriched populations was investigated. (ox.ac.uk)
Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. (ox.ac.uk)
IL-18 has been reported to induce interferon-gamma (IFN-gamma) and granulocyte/macrophage colony-stimulating factor (GM-CSF) production in T cells, and both agents also inhibit OCL formation in vitro. (ox.ac.uk)
No notable changes in either phase were seen for IL-1RA, IL-2, IL-5, IL-10, IL-12p70, IL-17, granulocyte colony-stimulating factor, monocyte chemotactic protein 1, and platelet-derived growth factor β polypeptide levels (data not shown), and macrophage inflammatory protein 1β concentrations. (cdc.gov)
Treatment of HCEpiC with 1 ng/ml IL-1β for 18 h significantly increased release of the cytokines/chemokines granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1), while hyperosmolarity-induced release of IL-6 and MCP-1. (molvis.org)
Increases in the relative fold change in messenger RNA expression of the inflammatory mediators, interleukin (IL)-6, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor alpha (TNF-a) were identified following exposure to diacetyl, 4-OPA, glyoxal, glutaraldehyde , and methyl glyoxal when compared to a clean air control. (cdc.gov)
Regulation of immunomodulatory functions by granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in vivo. (nwbio.com)
Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor. (nwbio.com)
Granulocyte macrophage colony‐stimulating factor releasing tough cryogels recruit four times more DCs than blank gels by day 7 in vivo. (nsf.gov)

We analyzed serum cytokine, chemokine, and growth factor levels in travelers returning to Germany from Australia. (cdc.gov)
Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues. (wikipedia.org)
The cytokine granulocyte-colony stimulating factor (G-CSF) is known to have trophic and neuroprotective properties in the brain, and we recently identified it as a modulator of neuronal and behavioral plasticity. (jneurosci.org)
Here, we report that granulocyte-colony stimulating factor (G-CSF), a pleiotropic cytokine with known trophic and neuroprotective properties in the brain, acts directly on dopaminergic circuits to enhance their function. (jneurosci.org)
The granulopoietic cytokine granulocyte colony-stimulating factor (G-CSF) induces pain: analgesia by rutin. (harvard.edu)
Secondary endpoints were systemic cytokine concentrations, leukocyte counts, and the phagocytic activity of granulocytes and monocytes. (asahq.org)
Luminex technology was used to determine the effects of EGCG (0.3 - 30 µM) on IL-1β- or hyperosmolar-induced cytokine release into the medium. (molvis.org)
The VitroCell module was used to determine whether these dicarbonyls were capable of inducing inflammatory cytokine expression by exposed pulmonary epithelial cells (A549). (cdc.gov)

Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor that is widely used to treat neutropenia. (elsevierpure.com)
We describe a patient who was admitted with uncontrolled thyrotoxicosis and carbimazole induced neutropenia. (edu.pl)
G-CSF was first trialled as a therapy for neutropenia induced by chemotherapy in 1988. (wikipedia.org)
Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative? (hindawi.com)
We report a case of clopidogrel-induced bone marrow toxicity manifesting with severe neutropenia in a patient treated with multiple coronary stents and provide suggestions for an alternative treatment. (hindawi.com)

GM-CSF was shown to induce both the expression of HLA-DR and the cytokines IL-1 and TNF alpha in a dose-dependent manner. (ox.ac.uk)
Northern blotting showed that mRNA levels of IL-1 and TNF alpha were transiently induced, similar to other cytokines. (ox.ac.uk)
Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO-cGMP-PKG-KATP Channel Signaling Pathway. (harvard.edu)
The association of exogenous granulocyte colony-stimulating factors (G-CSF) with the development of Sweet syndrome also supports the importance of neutrophils and related endogenous cytokines in the underlying process. (medscape.com)
Growth factors and cytokines involved in their migration, development and survival could be absent in this tissue and need further investigations. (bvsalud.org)

4] F. Joseph, N. Younis and D. Bowen Jones: "Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor", Int. J. Clin. (edu.pl)
The authors studied the effects of mild hypothermia on the outcome in a rat model of intraabdominal sepsis and tested whether granulocyte colony-stimulating factor (G-CSF) augments the host response and improves outcome during mild hypothermia. (asahq.org)

The defective chemotactic response to IL-8 does not appear to be due to impaired chemoattractant receptor function, as the number of IL-8 receptors and chemoattractant-induced calcium influx, actin polymerization, and release of gelatinase B were comparable to those of wild- type PMNs. (elsevierpure.com)
Reinforcement effect of histamine on the differentiation of murine myeloblasts and promyelocytes: externalization of granulocyte colony-stimulating factor receptors induced by histamine. (aspetjournals.org)

The development of bone changes induced in rats by recombinant human granulocyte colony-stimulating factor is suppressed by bisphosphonate. (uchicago.edu)

Because G-CSF receptor (G-CSFR)-deficient mice do not have the expected neutrophilia after administration of human interleukin- 8 (IL-8), we examined the effect of the loss of G-CSFR on IL-8-stimulated PMN function. (elsevierpure.com)
White blood cells The G-CSF-receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates proliferation and differentiation into mature granulocytes. (wikipedia.org)
Using in vivo high-resolution single HSC divisional tracking, we directly demonstrate that clinically applied thrombopoietin receptor but not granulocyte colony-stimulating factor (G-CSF) receptor agonists drive HSCs into self-renewing divisions leading to quantitative expansion of functional HSC as defined by their in vivo serial multilineage and long-term repopulating potential. (uzh.ch)
Cannabinoid type-2 (CB 2 ) receptor activation was shown to reduce the production of the monocyte chemotactic protein-2 (MCP-2) chemokine in polyinosinic-polycytidylic acid [poly-(I:C)]-stimulated human keratinocyte (HaCaT) cells, an in vitro model of allergic contact dermatitis (ACD). (aspetjournals.org)

Neutrophils isolated from the cancer-induced inflammatory microenvironment contain β-endorphin protein and are identified by the Ly6G + immune marker. (frontiersin.org)
These effects seem to be a result of the ability of G-CSF to alter local inflammatory signaling cascades, particularly tumor necrosis factor α. (jneurosci.org)
Tofacitinib inhibits IFN-γ and the STAT1-dependent acute lipopolysaccharide-induced inflammatory response. (aad.org)

Fluorescent histograms were derived from gated events with the side and forward light-scatter characteristics of viable lymphocytes (left panel), monocytes (center panel) and granulocytes (right panel). (bdbiosciences.com)
CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes. (thermofisher.com)

LPS induced an increase in NF-kappaB activation as examined by p50 translocation assay without suppression by PD 098059 or by SB 203580. (nih.gov)
18 Pisciotta A V, Konings S A. 51Cr release assay of clozapine-induced cytotoxicity: evidence for immunogenic mechanism. (thieme-connect.de)
In this assay hematopoietic cells are cultured in MyeloCult™ medium with supportive human or mouse stromal cell layers and tested for their ability to generate myeloid clonogenic progenitors for several weeks as assayed by replating the cells in a colony-forming unit (CFU) assay using MethoCult™ medium. (stemcell.com)
Effects of EGCG on nuclear factor kappa B (NFκB) and activator protein-1 (AP-1) transcriptional activity were assessed by reporter gene assay. (molvis.org)
function of proliferative responses provoked in the induction cell products favor immediate type hypersensitivity reactions, phase of contact allergy, the murine local lymph node assay serving as growth and differentiation factors for mast cells and (LLNA), has been accepted as a stand-alone method for skin eosinophils, the cellular effectors of the clinical manifestations of sensitization testing (NIH, 1999). (cdc.gov)

G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. (wikipedia.org)
CCN1 also induced Jag1 expression in hepatic stellate cells, whereupon they interacted with hepatic progenitor cells to promote their differentiation into cholangiocytes. (jci.org)

3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)

Administration of CCN1 protein or soluble JAG1 induced cholangiocyte proliferation in mice, which was blocked by inhibitors of NF-κB or NOTCH signaling. (jci.org)
These findings demonstrate that CCN1 induces cholangiocyte proliferation and ductular reaction and identify CCN1/α v β 5 /NF-κB/JAG1 as a critical axis for biliary injury repair. (jci.org)

In addition to stimulating polymorphonuclear neutrophil (PMN) production, G-CSF may have significant effects on PMN function. (elsevierpure.com)
She received four doses of filgrastim (Granulocyte-colony stimulating factor) which maintained the neutrophil count within a reasonable level while she continued to receive carbimazole to prepare her for surgery. (edu.pl)

In contrast, interferon-gamma (IFN-gamma), which induced major histocompatibility complex (MHC) class II expression, did not induce IL-1 or TNF alpha production. (ox.ac.uk)

5 Alvir J MJ, Lieberman J A. Agranulocytosis: Incidence and risk factors. (thieme-connect.de)
6 Gerson S L. G-CSF and the management of clozapine-induced agranulocytosis. (thieme-connect.de)
13 Claas F H, Abbott P A, Witvliet M D, D'Amaro J, Barnes P M, Krupp P. No direct clinical relevance of the human leucocyte antigen (HLA) system in clozapine-induced agranulocytosis. (thieme-connect.de)
14 Amar A, Segman R H, Shtrussberg S, Sherman L, Safirman C, Lerer B, Brautbar C. An association between clozapine-induced agranulocytosis in schizophrenics and HLA-DQB1*0201. (thieme-connect.de)
16 Guest I, Sokoluk B, MacCrimmon J, Utrecht J. Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis. (thieme-connect.de)

However, IFN-gamma enhanced the cell surface expression of HLA-DR and the production of IL-1 and TNF alpha on monocyte-enriched cells stimulated by GM-CSF. (ox.ac.uk)

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)

15 Buchmann N, Strous R D, Ulman A M, Lerner M, Kotler M. Olanzapine-induced leukopenia with human leukocyte antigen profiling. (thieme-connect.de)
The tough cryogel vaccine induces strong antigen‐specific cytotoxic T‐lymphocyte and humoral responses. (nsf.gov)

Stief, T. (2018) Granulocyte Colony-Stimulating Factor Multiplies Normal Blood ROS Generation at Less than 1 µg/l. (scirp.org)

Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans. (harvard.edu)

Upon enhanced hematopoietic demand, HSCs can be induced to divide and self-renew or differentiate. (uzh.ch)
This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)

Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. (wikipedia.org)
The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)

Previous studies suggest that oxidative stress, via free radical production, is involved in MPTP-induced neurotoxicity. (researchgate.net)

1998. Protection by extracellular glutathione against sulfur mustard induced toxicity in vitro. (cdc.gov)

We previously demonstrated that male mice with carcinogen-induced oral SCC exhibit less nociceptive behavior and a higher concentration of neutrophils in the cancer microenvironment compared to female mice with oral SCC. (frontiersin.org)
Oral cancer cells secrete granulocyte colony stimulating factor (G-CSF), a growth factor that recruits neutrophils from bone marrow to the cancer microenvironment. (frontiersin.org)
We infer that rG-CSF-induced Ly6G + neutrophils drive an endogenous analgesic mechanism. (frontiersin.org)
In addition to G-CSF, the use of ATRA in the context of acute promyelocytic leukemia has shown the propagation of aberrant neutrophils as seen in drug-induced Sweet syndrome. (medscape.com)

Trisomy 8+ cells showed a significant positive correlation with apoptotic CD34+ cells and capacity for colony formation. (who.int)

Sweet syndrome (acute febrile neutrophilic dermatosis) is a hypersensitivity reaction that occurs in response to systemic factors, such as hematologic disease, infection, inflammation, vaccination, or drug exposure. (medscape.com)
Ocular surface inflammation can be induced by numerous insults including the presence of pathogens, allergic reaction, and dry eye disease. (molvis.org)

During the Middle of December 2019, a virus-induced pneumonia emerged in Wuhan, China, which ultimately resulted in the current global pandemic ( 1 ). (spandidos-publications.com)

Saline-treated male mice with HSC-3 tumors exhibited less oral cancer-induced nociceptive behavior and had more β-endorphin protein in the cancer microenvironment than saline-treated female mice with HSC-3 tumors. (frontiersin.org)

We determined the mechanisms of GM-CSF regulation in AM from normal volunteers activated by lipopolysaccharide (LPS) by examining the role of nuclear factor-kappaB (NF-kappaB), and of p38 mitogen-activated protein (MAP) kinase and MAP kinase kinase (MKK-1). (nih.gov)
For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)

We then evaluated the efficacy of chronic rG-CSF administration to attenuate oral cancer-induced nociception using a tongue xenograft cancer model with the HSC-3 human oral cancer cell line. (frontiersin.org)
By itself, GM-CSF did not induce surface class II expression on the human monocytic tumour cell line THP-1, whereas it synergized with IFN-gamma to induce surface expression. (ox.ac.uk)
Mouse granulocyte-colony stimulating factor (G-CSF) was first recognised and purified in Walter and Eliza Hall Institute, Australia in 1983, and the human form was cloned by groups from Japan and Germany/United States in 1986. (wikipedia.org)

Granulocyte-Colony Stimulating Factor Therapy to Induce Neovascularization in Ischemic Heart Disease: Doktordisputats. (ku.dk)

Neurons G-CSF can also act on neuronal cells as a neurotrophic factor. (wikipedia.org)
To investigate whether tenascin-C and tenascin-R may play important functional roles in the lesioned central nervous system, we have analysed their expression in the olivocerebellar system of the adult rat after 3-acetylpyridine-induced degeneration of nerve cells in the inferior olivary nucleus. (researchgate.net)
RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
The cellular levels of endocannabinoids [anandamide (AEA), 2-arachidonoylglycerol] and related molecules (palmitoylethanolamide, oleoylethanolamide) were quantified in poly-(I:C)-stimulated HaCaT cells treated with CBD. (aspetjournals.org)
We show that in poly-(I:C)-stimulated HaCaT cells, CBD elevates the levels of AEA and dose-dependently inhibits poly-(I:C)-induced release of MCP-2, interleukin-6 (IL-6), IL-8, and tumor necrosis factor- α in a manner reversed by CB 2 and TRPV1 antagonists 6-iodopravadoline (AM630) and 5′-iodio-resiniferatoxin (I-RTX), respectively, with no cytotoxic effect. (aspetjournals.org)
In addition, some studies have suggested a role for tumor necrosis factor, and others have suggested an imbalance of type 1 helper T cells. (medscape.com)

10 microM), also prevented GM-CSF expression and release induced by LPS, indicating that GM-CSF release is NF-kappaB-dependent. (nih.gov)

this is known as drug-induced Sweet syndrome. (rarediseases.org)
Familial AN, drug-induced AN, AN occurring in hyperinsulinemic states (eg, diabetes, obesity), AN associated with polycystic ovary disease, and AN associated with a spectrum of autoimmune disease in women should be considered before AN is determined to represent a paraneoplastic syndrome. (medscape.com)
A drug-induced variant due to the administration of various medications has been recognized, and a pregnancy-associated form has also been reported. (medscape.com)

G-CSF stimulates the production of granulocytes, a type of white blood cell. (wikipedia.org)
Additionally, IFN-γ signaling inhibition by the blockade of JAK1 decreases the production of tumor necrosis factor and IL-6. (aad.org)
The effects of EGCG on glucose oxidase (GO)-induced reactive oxygen species (ROS) production was determined using the ROS probe CM-H 2 DCFDA. (molvis.org)

RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)

Local naloxone treatment restored the cancer mediator-induced nociceptive behavior. (frontiersin.org)
9 Pollmächer T, Fenzel T, Mullington J, Hinze-Selch D. The influence of clozapine treatment on plasma granulocyte colony stimulating (G-CSF) levels. (thieme-connect.de)
Objective To assess whether granulocyte colony-stimulating factor (G-CSF) treatment induces a sustained benefit on adverse remodelling in patients with large anterior ST-elevation myocardial infarction (STEMI) and left ventricular (LV) dysfunction after successful reperfusion. (bmj.com)
There was a significant dose-dependent decrease in GO-induced ROS levels after treatment of HCEpiC with EGCG. (molvis.org)

Together, these results suggest that targeting immune factors may provide a new avenue for therapeutic intervention in the multiple psychiatric disorders that are characterized by motivational and cognitive deficits. (jneurosci.org)

Chemoattractant-induced adhesion of G-CSFR-deficient PMNs was significantly impaired, suggesting a defect in β2-integrin activation. (elsevierpure.com)

The action of G-CSF in the central nervous system is to induce neurogenesis, to increase the neuroplasticity and to counteract apoptosis. (wikipedia.org)

7 Hummer M, Kurz M, Barnas C, Saria A, Fleischhacker W W. Clozapine-induced transient white blood count disorders. (thieme-connect.de)

G-CSF plasma concentrations of 0.1 - 1 μ g/l might favor singlet oxygen generation without immunosuppression or cell fragment-induced thrombin generation. (scirp.org)

The patient was free from previous cardiovascular events, with untreated hypertension and smoker status as risk factors. (hindawi.com)
Identification of individuals with risk factors for the development of severe alcoholic hepatitis may provide insight to the diverse clinical spectrum and prognosis of the disease. (wjgnet.com)

Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses. (nwbio.com)

Recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines. (nwbio.com)

6] D. Usha, D.M. Thatte and S.A. Dahanukar: "Therapeutic potential of the haematopoietic growth factors", J. Postgrad. (edu.pl)

and vascular endothelial growth factor (VEGF). (cdc.gov)
it is one of the most common growth factors in the blood. (iasp-pain.org)

Direct activation of PVA neurons using optogenetics and pharmacological approaches were sufficient to induce persistent mechanical hyperalgesia in naive animals. (iasp-pain.org)
In contrast, optogenetic manipulations of VTA DA neurons revealed their roles in sustaining recurrent scratching episodes through signaling scratching-induced reward. (iasp-pain.org)

As a result, activation of right central nucleus of amygdala with blue light was enough to induce persistent mechanical hyperalgesia. (iasp-pain.org)

The nitroxyl donor, Angeli's salt, reduces chronic constriction injury-induced neuropathic pain. (harvard.edu)

Anatomy23

Organisms5

Diseases8

Chemicals and Drugs27

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Psychiatry and Psychology1

Phenomena and Processes24

Information Science2

Macrophage12

Cytokine8

Neutropenia5

Cytokines5

Sepsis2

Receptors2

Recombinant human1

Receptor4

Inflammatory3

Monocytes2

Assay5

Differentiation2

Chemotherapy1

Proliferation2

Neutrophil2

Interferon-gamma1

Agranulocytosis5

Monocyte1

Dendritic1

Antigen2

20181

Gene Expression1

HSCs2

Stem cells2

Oxidative Stress1

Toxicity1

Neutrophils4

Apoptotic1

Inflammation2

20191

Microenvironment1

Protein2

Human3

Therapy1

Cells7

Expression1

Drug3

Production3

Mechanisms1

Treatment4

Immune1

Significantly1

Apoptosis1

Disorders1

Concentrations1

Risk Factors2

Responses1

Clinical1

Haematopoietic1

Growth2

Neurons2

Activation1

Chronic1