AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Transcription FactorsMEF2 Transcription FactorsTranscription, GeneticDNA-Binding ProteinsPromoter Regions, GeneticSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceTranscriptional ActivationBinding SitesTrans-ActivatorsMyogenic Regulatory FactorsBasic Helix-Loop-Helix Transcription FactorsRNA, MessengerProtein BindingNuclear ProteinsTranscription Factor AP-1Repressor ProteinsCell LineGene Expression Regulation, DevelopmentalForkhead Transcription FactorsHomeodomain ProteinsSignal TransductionAmino Acid SequenceDNABasic-Leucine Zipper Transcription FactorsMutationTranscription Factor AP-2Cell NucleusCell DifferentiationTransfectionKruppel-Like Transcription FactorsTranscription Factors, TFIIGenes, ReporterChromatin ImmunoprecipitationGATA4 Transcription FactorHeLa CellsCells, CulturedYY1 Transcription FactorSTAT3 Transcription FactorTranscription Factor TFIIDNFATC Transcription FactorsActivating Transcription Factor 3Reverse Transcriptase Polymerase Chain ReactionElectrophoretic Mobility Shift AssaySp3 Transcription FactorNF-kappa BEnhancer Elements, GeneticTranscription Initiation SiteZinc FingersPaired Box Transcription FactorsActivating Transcription Factor 2Transcription Factor TFIIBRegulatory Sequences, Nucleic AcidGene Expression ProfilingE2F1 Transcription FactorRecombinant Fusion ProteinsCloning, MolecularRNA Polymerase IIPlasmidsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsGene ExpressionGATA3 Transcription FactorGATA1 Transcription FactorGATA2 Transcription FactorGene Expression Regulation, FungalTCF Transcription FactorsGATA Transcription FactorsLuciferasesProtein Structure, TertiaryMicrophthalmia-Associated Transcription FactorMADS Domain ProteinsPhosphorylationSTAT1 Transcription FactorActivating Transcription FactorsCell Line, TumorHelix-Loop-Helix MotifsTranscription Factor RelAE2F Transcription FactorsChromatinOligonucleotide Array Sequence AnalysisSaccharomyces cerevisiaeModels, BiologicalSequence Homology, Amino AcidSaccharomyces cerevisiae ProteinsGene Expression Regulation, PlantMice, KnockoutCyclic AMP Response Element-Binding ProteinGATA6 Transcription FactorActivating Transcription Factor 4Transcription Factor 7-Like 1 ProteinActivating Transcription Factor 1Blotting, WesternProto-Oncogene ProteinsTranscription Factor TFIIIAProto-Oncogene Proteins c-junMice, TransgenicDown-RegulationDrosophila Proteins
EnhancerMyocyteProteinsApoptosisPathwaySuppressesMyogenesisMRNARegulationSkeletal muscleDifferentially expressedRegulatesMiceMechanismsMEF2AChromatin structureRegulatorsMutationsAssayNitric oxide syHematopoietic cellsDifferentiationAtrophy2000SynapseHypertrophySarcomereProgenitor cellsProtein encoded by this geneRepressionRANKLNeuronsPromotesKnockdownDrosophilaPhosphorylationGenomicPluripotentAdultPromotersPathological geneRisk factor for schizophreniaEnrichmentEpigenetic modulatorsReporter geneCardiomyocyteDevelopmentalModulatorsQuantitativeTissue-specificActivatesActivityTumorPolymeraseRegulate gene
Enhancer8
  • We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity- and calcineurin-dependent manner as hippocampal neurons formed synapses. (elsevierpure.com)
  • Additionally, we show that CHD7 reduces accessibility of enhancers with corresponding reduction in enhancer activity and proximal gene expression. (wustl.edu)
  • Myocyte enhancer factor-2 (MEF2) family activation is reported to be involved in pitavastatin-dependent KLF4 induction. (soken.ac.jp)
  • By applying whole genome and quantitative chromatin conformation analysis {chromatin interaction analysis with paired end tag sequencing (ChIA-PET), and real time chromosome conformation capture (3C) assay}, we observed that the MEF2C-bound enhancer and transcription start site (TSS) of KLF4 came into closer spatial proximity by pitavastatin treatment. (soken.ac.jp)
  • Analysis of this network identified serum response factor (SRF) and myocyte enhancer factor-2 (MEF2) as critical TFs in regulating longitudinal stretch-induced gene changes whose activity is modulated by protein kinase C (PKC). (escholarship.org)
  • Of particular importance has been the identification of two families of transcription factors: the myogenic regulatory factors (MRFs) and the myocyte enhancer factors (MEFs). (biologists.com)
  • The activities of transcription factors nuclear factor of activated T cells (NFAT) and myocyte enhancer-binding factor (MEF)2, were also enhanced in an IGF-1 signaling-dependent manner. (ox.ac.uk)
  • We have characterized a model of synapse elimination in CA1 neurons of organotypic hippocampal slice cultures that is induced by expression of the active transcription factor Myocyte Enhancer Factor 2 (MEF2) and relies on postsynaptic FMRP. (bvsalud.org)
Myocyte1
  • The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner. (ox.ac.uk)
Proteins11
  • TGEKP(Y/F)X. The zinc fingers enable all KLF proteins to bind to CACCC gene promoters, so although they may complete varied functions (due to lack of homology away from the zinc fingers), they all recognize similar binding domains. (wikipedia.org)
  • Analysis of the proteins that activate and repress different enhancers is combined with genetic studies to accurately position these factors within complex signalling networks. (ox.ac.uk)
  • Chemically induced gene expression changes were characterized by qRT-PCR, global run-on sequencing (GRO-seq) and immunoblotting, and the network of cooperative proteins of GATA4 and NKX2-5 were further explored by the examination of the GATA4 and NKX2-5 interactome by BioID. (biomedcentral.com)
  • MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
  • Tamir, Y., and Bengal E . (2000) Phosphoinositide 3-kinase induces the transcriptional activity of MEF2 proteins during muscle differentiation . (technion.ac.il)
  • Interestingly, EPS of differentiated myotubes to induce Z-disc assembly and maturation resulted in increased levels of proteins involved in ATP synthesis, presumably to fulfill the higher energy demand of contracting myotubes. (omicsdi.org)
  • these multidomain guanine nucleotide exchange factors (GEFs) contain additional domains known to interact with phosphatidylinositides as well as with a number of different proteins. (biomedcentral.com)
  • RNA binding proteins (RBPs) act as critical facilitators of spatially regulated gene expression. (bvsalud.org)
  • Our results suggest a model where MEF2 regulates posttranslational modifications of FMRP via APC/Cdh1 to regulate translation of proteins necessary for synapse elimination. (bvsalud.org)
  • Deficiency in ClpP induces an overload of mitochondrial misfolded/unfolded proteins, suppresses mitochondrial respiratory activity, increases mitochondrial oxidative damage and causes cell death. (springer.com)
  • This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)
Apoptosis7
  • Parvin overexpression uncovers tissue-specific genetic pathways and disrupts F-actin to induce apoptosis in the developing epithelia in Drosophila. (uiowa.edu)
  • There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)
  • Jolkinolide B induces apoptosis in cancer cells. (targetmol.jp)
  • The Fas FasL technique as an essential pathway inducing cell apoptosis participates in occurrence and improvement of leukemia. (microrna21.com)
  • Leukemia cells frequently are not sensitive or are resistant to Fas FasL mediated apoptosis, though it's considered one of im portant factors leading to immunoescape and unsensi tivity of leukemia cells to chemotherapy. (microrna21.com)
  • Lately research connected to mechanisms of leukemia cell resistance to Fas FasL mediated apoptosis selleck chemical such as Fas and FasL mutation and expression abnormality, Fas signaling transduction pathway abnormality, and regulatory have an impact on of apoptotic regulatory genes on Fas FasL process, as well as tactics replying to antiapoptosis of leukemia cells including NF kappa B, XIAP, membrane receptor CD28 and matrix metalloproteinase 7 obtained some pro gresses. (microrna21.com)
  • HDACs one is vital in en hancing cytarabine induced apoptosis in pediatric AML, not less than partly mediated by Bim. (microrna21.com)
Pathway8
  • FGF pathway is not necessary for Gata4 -induced liver specification in animal cap explants but is required for prolonged period in sandwiches of AE and AC. (xenbase.org)
  • In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. (spandidos-publications.com)
  • Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway. (uiowa.edu)
  • PTH regulates myleoid ELF-1-like factor (MEF)-induced MAB-21-like-1 (MAB21L1) expression through the JNK1 pathway. (univ-paris5.fr)
  • Reuveny, M., Heller, H., and Bengal, E . (2004) RhoA controls myoblast survival by inducing the phosphatidylinositol 3-kinase-Akt signaling pathway . (technion.ac.il)
  • recently demonstrated that the developmental VEGFA-MEF2 pathway, which was thought to be involved, is in fact impaired in adult ischaemic hearts. (elifesciences.org)
  • Here, employing an inducible B cell expression system, we have determined that M2 activates the NFAT pathway in a Src kinase-dependent manner - leading to induction of the plasma cell-associated transcription factor, Interferon Regulatory Factor-4 (IRF4). (prelekara.sk)
  • In primary murine B cells, addition of cyclosporine (CsA) resulted in a significant decrease in M2-induced IL-10 levels as well as IRF4 expression, emphasizing the importance of the NFAT pathway in M2- mediated induction of IL-10. (prelekara.sk)
Suppresses2
  • 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human en. (targetmol.jp)
  • Overexpression of ClpP reduces αSyn-induced mitochondrial oxidative stress through enhancing the level of Superoxide Dismutase-2 (SOD2), and suppresses the accumulation of αSyn S129 phosphorylation and promotes neuronal morphology in neurons derived from PD patient iPS cells carrying αSyn A53T mutant. (springer.com)
Myogenesis1
  • Fasting also induced muscle atrophy marker genes Murf1 and Fbxo32 and reduced myogenesis factor Mef2 expression without muscle fibre or gender differences. (hku.hk)
MRNA6
  • This is in contrast to (B), where injection of cer1 or hhex MOs in AE leads to downregulation of both cardiac and liver marker gene mRNA levels in conjugates. (xenbase.org)
  • MicroRNAs regulate gene expression at the post-transcriptional level by binding to 3′- or less often to 5′-untranslated regions of target messenger RNAs (mRNAs), which in consequence leads to inhibited translation and/or induces degradation of targeted mRNA [ 1 ]. (archivesofmedicalscience.com)
  • A microRNA strand is transferred to the Argonaute complex (AGO), forming an RNA-induced silencing complex (RISC), and guides it to pair with the target mRNA through binding of the microRNA seed sequence with the microRNA recognition site on the mRNA. (archivesofmedicalscience.com)
  • Identification of an RNA-binding protein that is phosphorylated by PTH and potentially mediates PTH-induced destabilization of Npt2a mRNA. (univ-paris5.fr)
  • A high frequency of BCL2 mRNA over expression plus a reasonably minimal frequency of BAX mRNA above expression detected in each analyzed leukemia within this research, indicate that altered transcription of those genes may very well be involved in leukemogenesis. (microrna21.com)
  • Evaluated the mRNA gene expression profile of 12 HDAC genes by quantitative serious time polymerase chain reaction in 94 consecutive childhood acute lymphoblastic leukaemia samples and its association with clinical biological functions and survival. (microrna21.com)
Regulation13
  • The goal of my laboratory is to understand how blood vessels grow, differentiate and regress through studying the transcriptional regulation of vascular genes. (ox.ac.uk)
  • To study vessel regulation, my laboratory primarily focuses on the identification, characterisation and delineation of enhancers ( cis -regulatory elements) directing gene expression within the vasculature. (ox.ac.uk)
  • SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. (ox.ac.uk)
  • To better understand these mechanisms involved in gene regulation, we pursue two questions: 1) what are the roles of the chromatin remodeler CHD7 in cerebellar development and 2) what are the roles of the MEF2 TF family in cerebellar function. (wustl.edu)
  • Thus, TFs also play a vital role in proper gene regulation. (wustl.edu)
  • Finally, motor activity induces a switch from non-compensatory to compensatory MEF2-dependent gene regulation. (wustl.edu)
  • In endothelial cells, statin-dependent atheroprotective gene up-regulation is mediated by Kruppel-like factor (KLF) family transcription factors. (soken.ac.jp)
  • To dissect the mechanism of gene regulation, we sought to determine molecular targets by performing microarray analyses of human umbilical vein endothelial cells (HUVECs) treated with pitavastatin, and KLF4 was determined to be the most highly induced gene. (soken.ac.jp)
  • This indicated the involvement of epigenetic modulators in the regulation of GATA-dependent transcription. (biomedcentral.com)
  • We find that during normal lifespan of CMs gene regulation is mainly orchestrated by dynamic mCpG and canonical histone marks at distal regulatory and genic regions. (nature.com)
  • In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
  • Kolpakova A*, Katz S*, Keren A, Rojtblat A, Bengal E . (2013) Transcriptional Regulation of Mesoderm Genes by MEF2D during Early Xenopus Development . (technion.ac.il)
  • p38 MAPK is involved in regulation of HSP27, MAPKAPK-2 (MK2), MAPKAPK-3 (MK3), and several transcription factors including ATF-2, Stat1, the Max/Myc complex, MEF-2, Elk-1, and indirectly CREB via activation of MSK1. (targetmol.jp)
Skeletal muscle6
  • In this study, we used gastrocnemius skeletal muscle RNA sequencing data from fasting male mice in the Gene Expression Omnibus (GEO) database. (hku.hk)
  • The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). (biomedcentral.com)
  • Furthermore, forced expression of Akt in adult skeletal muscle induced MSY3 phosphorylation and myogenin derepression. (biomedcentral.com)
  • Basic helix-loop-helix (bHLH) myogenic regulatory factors coordinate the correct function and organization of many skeletal muscle functions. (biomedcentral.com)
  • Zetser, A., Gredinger, E., and Bengal, E. (1999) p38 mitogen-activated protein kinase promotes skeletal muscle differentiation: participation of the MEF2C transcription factor . (technion.ac.il)
  • Using genetic mouse models, we found that mutations of two different molecular clock genes, Clock and Bmal1, dramatically disrupt skeletal muscle structure and function. (ufl.edu)
Differentially expressed1
  • After 30 minutes of stretch, 53 and 168 genes were considered differentially expressed (DE) from transverse and longitudinal stretch, respectively. (escholarship.org)
Regulates2
  • Proteoglycan 4, a novel immunomodulatory factor, regulates parathyroid hormone actions on hematopoietic cells. (univ-paris5.fr)
  • Furthermore, we show that expression of IRF4 alone in a B cell line up-regulates IL-10 expression in culture supernatants, revealing a novel role for IRF4 in B cell induced IL-10. (prelekara.sk)
Mice3
  • However, expression of embryonic hemoglobin and fetal hemoglobin genes is normal in EKLF-deficient mice, and since all genes on the human β-globin locus exhibit the CACCC elements, researchers began searching for other Krüppel-like factors. (wikipedia.org)
  • Fasting reduced Fndc5 and Igf1 gene expression in soleus and TA muscles in both male and female mice without muscle phenotype or gender differences, but Il6, Mstn and Erfe expression was influenced by fasting with fibre type- and gender-dependent effects. (hku.hk)
  • These mice express tamoxifen-induced Cre recombinase (Mer-cre-Mer) that enzymatically removes a stop codon flanked by lox sequences (floxed) on a reporter gene such as green fluorescent protein or yellow fluorescent protein, thus resulting in traceable fluorescence on the cells of interest. (musculoskeletalkey.com)
Mechanisms5
  • This network model was used in conjunction with the RNA-Seq data to identify the mechanisms regulating gene expression changes due to longitudinal and transverse stretch. (escholarship.org)
  • Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. (nature.com)
  • In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
  • Abstract Objective To investigate the incidence, mechanisms, types of injury, most affected anatomical regions, and factors leading to injuries in trail bikers. (bvsalud.org)
  • Derepression is induced by posttranslational mechanisms downstream of metabotropic glutamate receptor signaling. (bvsalud.org)
MEF2A3
  • The latter part of this dissertation will address the roles of paralogous transcription factors, MEF2A and MEF2D, and their roles in cerebellar function. (wustl.edu)
  • Using single and double conditional knockout of MEF2 family TFs, we find that MEF2A and MEF2D play functionally redundant roles in cerebellar-dependent motor learning. (wustl.edu)
  • Importantly, sites experiencing compensatory MEF2A occupancy are concentrated within open chromatin and undergo functional compensation for genomic activation and gene expression. (wustl.edu)
Chromatin structure2
  • item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells. (soken.ac.jp)
  • It is believed that loss of acetylation could compact the chromatin structure, leading to the transcriptional repression of specific genes [ 3 ]. (biomedcentral.com)
Regulators4
  • Enhancers are densely clustered groups of transcription factor binding motifs and are the principal regulators of spatio-temporal patterns of gene transcription. (ox.ac.uk)
  • MEF2 transcription factors are key regulators of sprouting angiogenesis. (ox.ac.uk)
  • Collectively, our studies on CHD7 and MEF2 provide further understanding of the roles of two critical classes of gene regulators in cerebellar development and function. (wustl.edu)
  • By altering the major axis of biaxial, mechanical stretch, I hypothesized that different signaling pathways and transcription regulators would be activated and lead to divergent gene expression profiles in cardiac myocytes. (escholarship.org)
Mutations3
  • Recent studies have revealed numerous mutations in the FLNC gene causing familial and sporadic myopathies and cardiomyopathies with marked clinical variability. (omicsdi.org)
  • The discovery that mutations in sarcomere protein genes cause HCM has enabled the development of mouse models that recapitulate clinical manifestations of disease. (rupress.org)
  • New disease genes and pathogenic mutations often seem far afield from the overt manifestations of human pathology, in particular when the gene is expressed life long, but the disease emerges only after years or decades. (rupress.org)
Assay4
  • By transactivation assay in mouse fibroblasts, KLF2 was also noticed to bind to the β-globin gene promoter containing the CACCC sequence shown to be the binding site for EKLF, confirming KLF2 as a member of the Krüppel-like Factor family. (wikipedia.org)
  • We focused on MEF2C among the MEF2 family members and identified a novel functional MEF2C binding site 148 kb upstream of the KLF4 gene by chromatin immunoprecipitation along with deep sequencing (ChIP-seq) followed by luciferase assay. (soken.ac.jp)
  • Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
  • Using a bimolecular ubiquitin-mediated fluorescence complementation (UbFC) assay, we demonstrate that MEF2 promotes ubiquitination of FMRP in CA1 neurons that relies on activity and interaction with APC/Cdh1. (bvsalud.org)
Nitric oxide sy1
  • In addition, it was revealed that the atheroprotective genes induced with pitavastatin, such as nitric oxide synthase 3 (NOS3) and thrombomodulin (THBD), were suppressed by KLF4 knockdown. (soken.ac.jp)
Hematopoietic cells1
  • The administration of nonlethal irradiation to induce death of hematopoietic cells and their precursors followed by administration of donor bone marrow (radiation chimeras) revealed populations of macrophages, including synovial macrophages, Langerhans cells, and microglia, that were resistant to irradiation and remained host origin, whereas the monocyte population was derived from donor hematopoietic cells. (musculoskeletalkey.com)
Differentiation8
  • To understand the development of adiposity, it is crucial to identify the genes which expression is associated with adipogenic differentiation. (biomedcentral.com)
  • Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
  • On the other hand, the terminal differentiation phase was enriched with genes involved in energy production, lipid and carbohydrate metabolism. (biomedcentral.com)
  • Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
  • Alter J, Bengal E. (2011) Stress-Induced C/EBP Homology Protein (CHOP) Represses MyoD Transcription to Delay Myoblast Differentiation . (technion.ac.il)
  • Alter, J., Rozentzweig, D., and Bengal, E. (2008) Inhibition of myoblast differentiation by tumor necrosis factor alpha is mediated by c-Jun N-terminal kinase 1 and leukemia inhibitory factor . (technion.ac.il)
  • Tamir, Y., and Bengal, E. (1998) p53 protein is activated during muscle differentiation and participates with MyoD in the transcription of muscle creatine kinase gene . (technion.ac.il)
  • 3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone. (targetmol.jp)
Atrophy1
  • Odeh M, Tamir-Livne Y, Haas T, Bengal E (2019) P38α MAPK coordinates the activities of several metabolic pathways that together induce atrophy of denervated muscles . (technion.ac.il)
20001
Synapse2
  • When activated, MEF2 promoted the transcription of a set of genes, including ore and synGAP, that restrict synapse number. (elsevierpure.com)
  • MEF2-induced synapse elimination is deficient in Fmr1 KO CA1 neurons, and is rescued by acute (24 h), postsynaptic and cell autonomous reexpression of FMRP in CA1 neurons. (bvsalud.org)
Hypertrophy1
Sarcomere1
  • whereas longitudinal but not transverse stretch induced expression of genes involved in sarcomere organization and cytoskeletal protein binding. (escholarship.org)
Progenitor cells1
  • Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
Protein encoded by this gene2
  • The protein encoded by this gene is a DNA-binding transcription factor that activates many muscme-specific, growth factor-induced, and stress-induced genes. (chip-atlas.org)
  • FASLG, the protein encoded by this gene would be the ligand for FAS. (microrna21.com)
Repression2
  • We further explored that the reduction of HDAC4 level led to a significant repression of proinflammation cytokines induced up-regulated expressions of matrix-degrading enzymes (MMP1 (Matrix metalloproteinase 1), MMP3 (Matrix metalloproteinase 3) , MMP13 (Matrix metalloproteinase 13), ADAMTS4 (aggrecanase 1) and ADAMTS5 (aggrecanase 2)) in SW1353 in vitro. (biomedcentral.com)
  • A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)
RANKL1
  • Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes. (univ-paris5.fr)
Neurons2
  • In response to increased neuronal activity, calcium influx into neurons induced the activation of the calcium/calmodulin-regulated phosphatase calcineurin, which dephosphorylated and activated MEF2. (elsevierpure.com)
  • Although both TFs are highly expressed in granule neurons, transcriptomic analyses show MEF2D is the predominant genomic regulator of gene expression in vivo. (wustl.edu)
Promotes1
  • Z16078526 induces endogenous Ucp1 expression, promotes p38 MAPK phosphorylation and lipolysis in primary mouse brown adipocytes. (targetmol.jp)
Knockdown1
  • Moreover, knockdown of HDAC4 inhibited the expression of some anabolic genes (such as aggrecan). (biomedcentral.com)
Drosophila1
  • Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila. (uiowa.edu)
Phosphorylation1
  • These molecular signatures were supported by analysis of oxidative phosphorylation protein complex expression in mouse brain and assays of mitochondrial function in engineered cell lines, which revealed a lack of metabolic flexibility and a contribution of the 3q29 gene PAK2. (bvsalud.org)
Genomic1
  • Depending on the organism and availability, mt-tRNA Val or mt-tRNA Phe are incorporated, most likely due to their genomic proximity to mt-rRNA genes and consequent near stoichiometric presence of their transcripts 4 , 8 . (nature.com)
Pluripotent1
  • To address some of the limitations of these models, here we used two complementary ex vivo models based on Xenopus embryos: pluripotent animal cap explants expressing Gata4 transcription factor and conjugates of gastrula -stage AE with animal caps (AC). (xenbase.org)
Adult4
  • It is vital for embryonic erythropoiesis in promoting the switch from fetal hemoglobin (Hemoglobin F) to adult hemoglobin (Hemoglobin A) gene expression by binding to highly conserved CACCC domains. (wikipedia.org)
  • KLF2, initially called lung Krüppel-like Factor due to its high expression in the adult mouse lung, was first isolated in 1995 by using the zinc finger domain of EKLF as a hybridization probe. (wikipedia.org)
  • In a murine KLF2-deficient embryo, expression of β-like globin genes normally expressed in primitive erythroid cells was significantly decreased, although adult β-globin gene expression was unaffected. (wikipedia.org)
  • Furthermore, it is unknown whether endogenous progenitors/stromal cells in the adult human heart could be chemically induced to generate functional atrial or ventricular heart muscle to treat adult heart diseases. (biomedcentral.com)
Promoters1
Pathological gene2
  • In contrast, pathological gene expression in terminal heart failure is accompanied by changes in active histone marks without major alterations in CpG methylation and repressive chromatin marks. (nature.com)
  • In contrast to previous findings in heart tissue, expression of the pathological gene program in heart failure was not accompanied by changes in the CM DNA methylome but by active histone marks. (nature.com)
Risk factor for schizophrenia1
  • The 1.6-megabase deletion at chromosome 3q29 (3q29Del) is the strongest identified genetic risk factor for schizophrenia, but the effects of this variant on neurodevelopment are not well understood. (bvsalud.org)
Enrichment2
  • Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
  • Moreover, during this phase an enrichment in genes involved in the formation of the lipid droplets was evidenced as well as the activation of the thyroid-receptor/retinoic X receptor (TR/RXR) and the peroxisome proliferator activated receptors (PPARs) signalling pathways. (biomedcentral.com)
Epigenetic modulators1
Reporter gene2
  • Reporter gene assays were conducted to examine combinatorial effects of GATA-targeted compounds and bromodomain and extraterminal domain (BET) inhibition on chamber-specific gene expression. (biomedcentral.com)
  • In this line, reporter gene assays with combinatorial treatment of 3i-1000 and the BET bromodomain inhibitor (+)-JQ1 demonstrated the cooperative role of GATA4 and BRD4 in the modulation of chamber-specific cardiac gene expression. (biomedcentral.com)
Cardiomyocyte2
  • Examination of gene expression in st. 43 AC/AE explants by RT-PCR reveals expression of liver (fabp1), intestine (fabp2), pancreas (pdia2 and pdx1 , but not ins and amy2a), thyroid/lung (nkx2-1) as well as ventricular cardiomyocyte (myl3) markers. (xenbase.org)
  • Due to cellular heterogeneity in the heart, the activation of gene programs representing specific atrial and ventricular cardiomyocyte subtypes would be highly desirable. (biomedcentral.com)
Developmental1
Modulators2
  • GATA4-targeted compounds 3i-1000 and 3i-1103 were identified as differential modulators of atrial and ventricular gene expression. (biomedcentral.com)
  • The thorough expression of every Inhibitors,Modulators,Libraries up regulated gene in pediatric AML was presented in Figure two along with the expression of down regulated genes was presented in Figure three. (microrna21.com)
Quantitative1
  • To assess the potential roles of HDAC4, HDAC4 expression in human chondrosarcoma cells (SW1353) was down-regulated by transfecting small interference RNA (siRNA), thereafter, cells were treated with IL-1β or TNF-α, and the expressions of several matrix-degrading enzymes and anabolic factors were examined by using quantitative PCR. (biomedcentral.com)
Tissue-specific2
  • Compounds that target tissue-specific transcription factors could overcome non-specific effects of small molecules and lead to the regeneration of heart muscle following myocardial infarction. (biomedcentral.com)
  • e.g. they bind selectively to DNA, stimulate transcription resulting in tissue-specific RNA synthesis and undergo specific changes in response to various hormones or phytomitogens. (lookformedical.com)
Activates1
  • Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription. (univ-paris5.fr)
Activity2
  • The dynamic cytoskeletal localization of Csl and its dominant effects on cell shape and behavior and transcription factor activity suggest that Csl plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. (ox.ac.uk)
  • Ectopic expression of PML recruits HDAC7 to PML NBs and leads to activation of MEF2 reporter activity. (microrna21.com)
Tumor1
  • showed the Wilms tumor gene is in excess of expressed in sufferers with most varieties of acute leukemia. (microrna21.com)
Polymerase2
Regulate gene1
  • Upon assessing transcriptomic and epigenomic functions of CHD7, we find CHD7 to regulate gene programs implicated in human disorders of brain folding. (wustl.edu)