Induces expression of leukemia inhibitory factor. Medical search. Frequent questions

[ 45 , 46 ] LIF was initially discovered by Metcalf and colleagues as a protein that induced murine myeloid leukemic M1 cell differentiation into macrophages. (medscape.com)
Subsequent to adhesion, the blastocyst, now capable of independent LIF mRNA expression, increases trophoblast cell proliferation while initiating differentiation processes (into cytotrophoblast and syncytiotrophoblast cells) which ultimately result in an augmentation of trophoblast invasion. (medscape.com)
Retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells is potentiated by leukemia inhibitory factor. (muni.cz)
Neural differentiation of pluripotent mouse embryonal carcinoma cells by retinoic acid - inhibitory effect of serum. (muni.cz)
The ease of inducing stable genetic modifications in ES cells allows for in vitro manipulations to enhance differentiation into specific cell types and to optimize in vivo function of differentiated progeny in animal models of disease. (jneurosci.org)
In vitro differentiation of Bcl-XL overexpressing ES (Bcl-ES) cells resulted in higher expression of genes related to midbrain dopamine (DA) neuron development and increased the number of ES-derived neurons expressing midbrain DA markers compared with differentiation of wild-type ES cells. (jneurosci.org)
Here, we report that Bcl-ES cells show enhanced DA and serotonin neuron differentiation with an associated increase in the expression of genes specific to midbrain and hindbrain development compared with wild-type ES cells. (jneurosci.org)
To induce differentiation toward hematopoietic stem cells (HSCs) in vitro, ESCs were cultured in methylcellulose with stem cell factor, interleukin (IL)-3, and IL-6. (rupress.org)
Introduction Myeloid progenitors derived from multipotential hematopoietic stem cells can be differentiated into myeloid cells including neutrophils monocytes and macrophages which act as important mediators of innate immunity and play a central role in host defense against infections and to tissue damage.1-3 Conversely defective regulation of myeloid differentiation has devastating consequences leading to myeloid diseases and disorders such as myeloid aplasia dysplasia and leukemia. (academicediting.org)
Therefore an improved understanding of the molecular mechanisms that control myeloid differentiation will not only provide new insights into fundamental developmental processes but also improve our abilities to treat leukemia and other myeloid disorders. (academicediting.org)
The cAMP-PKA-CREB signaling cascade cross talks with the Notch pathway, acting synergistically by reducing progenitor markers and inducing astrocytic differentiation. (intechopen.com)
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. (nih.gov)
Furthermore, enforced expression of DLL4 partially reversed the effects of miR-124 on NSCs proliferation and differentiation. (biomedcentral.com)
My lab group has been studying pigment epithelium derived factor (PEDF), a protein that acts in neuronal differentiation and survival in cells derived from the retina and CNS. (nih.gov)

Growth factors injected into and around the injured site to stimulate tendon stem/progenitor cells (TSPC) proliferation may offer an alternative option for promoting tendon repair. (biomedcentral.com)
To maintain these cells as well as various types of related induced stem cells and progenitor cells in culture, Mouse Embryonic Fibroblasts (MEFs) are routinely used as feeder cells, largely to serve as a source of Leukemia Inhibitory Factor (LIF). (nih.gov)

Per 56 is made by a receptor on exon 9 of the peripherin gene transcript which induces a frameshift and replacement of a 21 amino acid sequence in the C-terminal found on the dominant 57 form with a new 8 amino acid sequence. (wikipedia.org)
For each growth factor there is a receptor, signal transducers, and responsive genetic elements. (nih.gov)
In addition, androgen and its receptor ( Ar ) could modulate uterine growth, antagonize the expression of estrogen-regulated genes, and also helps in the decidualization of the uterine stroma [ 8 ]. (biomedcentral.com)
Previous work from our group found that leukemia inhibitory factor receptor (LIFR) promotes tumor dormancy when expressed on bone-disseminated tumor cells and that loss of LIFR enables otherwise dormant tumor cells to colonize the bone. (ectsoc.org)
Aryl Hydrocarbon Receptor-Activating Polychlorinated Biphenyls and Their Hydroxylated Metabolites Induce Cell Proliferation in Contact-Inhibited Rat Liver Epithelial Cells. (muni.cz)
Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia. (muni.cz)
Here, we showed that leukemia inhibitory factor (LIF) was predominantly expressed in developing endothelium, while its receptor was expressed in surrounding cells such as retinal astrocytes. (elsevierpure.com)
Using EL4 cell-derived transfectants with differential expression levels of exogenous human CC chemokine receptor 4 or human CD20 as target cells, ADCC of fucose variants of chimeric IgG1 antibodies specific for these antigens were measured. (aacrjournals.org)
In RG cells and astrocytes enwrapping glutamatergic synapses, EAAT1 transcriptional regulation is mediated by PKC, increasing Notch expression and its receptor intracellular traffic. (intechopen.com)
Cloning and expression of the human interleukin-6 (BSF-2/IFN β2) receptor. (nature.com)
Receptor for Ciliary Neurotrophic Factor. (nature.com)
Accelerated Nerve Regeneration in Mice by upregulated expression of Interleukin (IL) 6 and IL-6 Receptor. (nature.com)
This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. (nih.gov)
Evaluating the effect of 3 glucocorticoid receptor gene polymorphisms on risk of relapse in 100 Iranian children with acute lymphoblastic leukemia: a case-control study. (cdc.gov)
It is now known that type II relates to a mutation in a different gene, the gene for the leukemia inhibitory factor receptor ( LIFR ). (medscape.com)
2 Experimental studies have shown that angiotensin receptor blockers and an ACE inhibitor can increase ACE-2 expression in the cardiovascular and renal systems. (ectrx.org)

Our lab has therefore examined how LIFR expression is regulated in breast cancer cells, with the hope that understanding its regulation might provide novel avenues to therapeutically target dormant disseminated tumor cells. (ectsoc.org)
Through these efforts we have found that LIFR is epigenetically regulated, and that histone deacetylase (HDAC) inhibitors, which are FDA-approved for several blood cancers, stimulate LIFR expression on breast cancer cells from all subtypes. (ectsoc.org)

3. Progesterone enhances HLA-G gene expression in JEG-3 choriocarcinoma cells and human cytotrophoblasts in vitro. (nih.gov)
8. Effect of progesterone on HLA-E gene expression in JEG-3 choriocarcinoma cell line. (nih.gov)
11. Progesterone regulates HLA-G gene expression through a novel progesterone response element. (nih.gov)
We demonstrate that MiDAC functions as a modulator of a neurodevelopmental gene expression program and binds to important regulators of neurite outgrowth. (elifesciences.org)
MiDAC upregulates gene expression of pro-neural genes such as those encoding the secreted ligands SLIT3 and NETRIN1 (NTN1) by a mechanism suggestive of H4K20ac removal on promoters and enhancers. (elifesciences.org)
Conversely, MiDAC inhibits gene expression by reducing H3K27ac on promoter-proximal and -distal elements of negative regulators of neurogenesis. (elifesciences.org)
Epigenetic regulators often constitute chromatin-modifying enzymes which catalyze the addition and removal of posttranslational modifications on histones and are involved in the control of gene expression by modulating chromatin structure and function. (elifesciences.org)
HDAC1 and HDAC2 belong to the family of class I HDACs, are highly similar (83% identity) and are involved in the control of gene expression by modulating chromatin structure and function. (elifesciences.org)
To interrogate and characterize gene expression differences resulting from BPA exposure, we also generated RNA-seq libraries from RNA extracted from FACS-purified PGCLCs and performed transcriptome analysis using bioinformatics-based approaches. (nih.gov)
Differential gene expression analysis also revealed the deregulation of genes associated with lipid metabolism as well as deregulated expression of genes associated with later stages of gametogenesis. (nih.gov)
Altered gene expression of the steroid receptors and reduced expression of Hox10a , integrins, Mmp9, Timp1/3 , Gp130 & Stat3 was observed in the implanted region of the uterus of PCOS animals. (biomedcentral.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Both of these enzymes play a key role in the epigenetic regulation of gene expression during development, and the gene coding for MLL is frequently rearranged in infant and secondary therapy-related acute leukemias. (embl.de)
In addition, the CRISPR/Cas9 system has been successfully repurposed to promote or repress gene expression, facilitate endogenous imaging or induce epigenome DNA editing among others. (cancer.gov)
AEDK decreased gene expression and the secretion of the pro-inflammatory cytokines, TNF-α and IL-1β by inhibiting nuclear factor-κB. (spandidos-publications.com)

The inhibition of myocyte hypertrophy by CIP4 small interfering oligonucleotides (siRNA) was rescued by expression of a recombinant CIP4 protein, but not by a mutant lacking the N-terminal FCH domain responsible for CIP4 intracellular localization. (biomedcentral.com)
were as explained previously.5 Briefly EBs were induced from ESC and cultivated for 8 days trypsinized to single cells and coated onto semiconfluent OP9 cells in medium made up of 25 ng/mL oncostatin M 10 ng/mL basic fibroblast growth factor 5 ng/mL IL-6 20 ng/mL SCF 5 ng/mL IL-11 and 1 ng/mL recombinant mouse leukemia inhibitory factor. (academicediting.org)
ESCs can also be cultured without feeders if the medium is supplemented with recombinant LIF and other factors. (nih.gov)
Much of our progress in understanding PEDF relied on our development of overexpression systems that yielded recombinant proteins as functionally active neurotrophic factors identical to the native protein and ideal for biochemical, biophysical, and biological studies. (nih.gov)

We now show using RNA interference that CIP4 expression in neonatal rat ventricular myocytes is required for the induction of non-mitotic, hypertrophic growth by the α-adrenergic agonist phenylephrine, the IL-6 cytokine leukemia inhibitor factor, and fetal bovine serum, as assayed using morphometry, immunocytochemistry for the hypertrophic marker atrial natriuretic factor and [ 3 H]leucine incorporation for de novo protein synthesis. (biomedcentral.com)
Conventional ES cells can be derived and maintained in vitro with media containing the cytokine leukemia inhibitory factor (LIF), which propagates the pluripotent state by activating STAT3 signaling, and simultaneous inhibition of glycogen synthase kinase-3 (GSK3) and MAP kinase/ERK kinase signaling. (nih.gov)

In an in vitro study, LIF inhibited hypoxia-induced VEGF expression and proliferation in cultured astrocytes. (elsevierpure.com)
NIH investigators have developed an in-vitro system using CHO cells stably expressing a TET-On expression vector regulating RORgamma and a RORE-Luciferase reporter. (nih.gov)
SPD induces cytoprotective autophagy in FGSCs in vitro and ameliorates cellular senescence of FGSCs induced by H 2 O 2 . (biomedcentral.com)

15. PreImplantation factor (PIF*) regulates systemic immunity and targets protective regulatory and cytoskeleton proteins. (nih.gov)
CIP4 is a scaffold protein that regulates membrane deformation and tubulation, organization of the actin cytoskeleton, endocytosis of growth factor receptors, and vesicle trafficking. (biomedcentral.com)
IL-10 regulates LIF and MMP expressions and evolves in the control of invasion and proliferation processes of trophoblast cells. (4science.ge)
Physiologic secretion of IL-6 by thymic epithelial cells up-regulates virus expression in chronically infected cells. (aai.org)

Basic fibroblast growth factor and its receptors in human embryonic stem cells. (muni.cz)
Soluble receptors for cytokines and growth factors: generation and biological function. (nature.com)
Specifically, we found that CD8+ T cells at progression were characterized by an increasing terminally exhausted effector phenotype (T-betdim/- Eomeshi PD1hi) with high co-expression of inhibitory receptors (PD1, CD244 and CD160). (ega-archive.org)

Derivation of bona fide porcine pluripotent stem cells is still a critical issue because porcine embryonic stem cells (ESCs) are not available yet, and most of the culture conditions to maintain porcine induced pluripotent stem cells (piPSCs) are based on conditions for mouse and human iPS cells. (nature.com)
Although mouse ESCs (mESCs) are routinely cultured by the use of a combination of leukemia inhibitory factor (LIF) and serum, it has been shown that MEK inhibition in combination with a glycogen synthase kinase-3 (GSK3b) inhibitor, referred as the 2i condition, was sufficient to favor pluripotency in mESCs. (cancer.gov)
In contrast, induction of MERVL expression in KAP1, HP1α and HP1β KO ESCs may occur predominantly as a consequence of indirect effects, in association with activation of a subset of 2C-specific genes. (biomedcentral.com)

17. PreImplantation factor (PIF*) promotes embryotrophic and neuroprotective decidual genes: effect negated by epidermal growth factor. (nih.gov)
PGCLC transcriptome analysis revealed an aberrant program with significant deregulation of X-linked genes and retrotransposon expression. (nih.gov)
Additionally, pPSC cell line isolated from 5.5 days blastocysts could be sustained in 3i medium and the expression of endogenous pluripotent genes OCT4 , ESRRB , and STELLA was significantly increased. (nature.com)
FCCM has an autosomal dominant transmission with incomplete penetrance and variable clinical expression that is associated with germline mutations in the CCM1/KRIT1, CCM2/MGC4607, and CCM3/PDCD10 genes. (cancerindex.org)
It is clear that Notch represents an activity-dependent molecular key in RG cells that enable them to shape glutamatergic transmission through the expression of genes involved in glial/neuronal interactions. (intechopen.com)
The ETS transcription factor (TF) family is one of the largest families of TFs including 29 genes in humans and 28 in mouse and has been widely involved in cancer. (cancer.gov)
Her PhD research, in Molecular Pathology, focused on the role of homeobox genes in the development of acute leukemia. (nih.gov)
Moreover, SPD significantly changed the expression of autophagy-related genes and pathways in FGSCs, as shown by bioinformatics analysis of RNA sequencing data. (biomedcentral.com)
Intriguingly, as recently shown for KAP1, RYBP, LSD1 and G9a-deficient mESCs, many genes normally expressed in the 2C embryo are also induced in HP1 KO mESCs, revealing that aberrant expression of a subset of 2C-specific genes is a common feature in each of these KO lines. (biomedcentral.com)
Expression of FOXP3 and cytokine genes, and the concentration of cytokines associated with Tregs, were assessed before and after treatment with MSC-Exo. (medworm.com)
Consistent with our goal of elucidating the mechanisms of action of PEDF, we are interested in signal transduction and the expression of genes affected by PEDF s stimuli. (nih.gov)

In 3i condition, the doxycycline-inducible iPSCs could be passaged for a long term without the addition of doxycycline, and the flattened morphology of intermediate state piPSCs could convert to the naïve-like morphology with the increase in endogenous pluripotent gene expressions. (nature.com)
Genetic individuality indicates that the resultant induced pluripotent stem cells (iPSCs) reserved from precursor cells enable personalized cell therapy and regenerative medicine 3 . (nature.com)

Here, we demonstrate that the macrophage-secreted protein RELMα critically protects females against high-fat diet (HFD)-induced obesity. (bvsalud.org)
Polymorphism and expression of macrophage migration inhibitory factor does not contribute to glucocorticoid resistance in idiopathic thrombocytopenic purpura. (cdc.gov)
Macrophage migration inhibitory factor -173G/C gene polymorphism increases the risk of renal disease: a meta-analysis. (cdc.gov)
The therapeutic potential of these cells was mediated by the secretion of prostaglandin E2, granulocyte-macrophage colony-stimulating factor, IL-6, and IL-13. (ectrx.org)
The paracrine effects of granulocyte-macrophage colony-stimulating factor that were mediated by increases in number of alveolar macrophages improved the host defense. (ectrx.org)
Interleukin 6 was considered as a key player during inflammatory responses, which can promote the survival of CD 11b+ peripheral blood mononuclear cells and induce M2 macrophage polarization. (ectrx.org)

Consistent with increased inhibitory innervation, POMC neurons in the Fmr1-/y mice exhibit lower activity, based on cFOS expression. (bvsalud.org)
PCOS was induced in mice by oral administration of letrozole daily for 21 days. (biomedcentral.com)
The retinas of Lif-/- mice displayed increased microvessel density accompanied by sustained tip cell activity, due to increased VEGF expression by astrocytes in the vascularized area. (elsevierpure.com)
Lif-/- mice resisted hyperoxygen insult in the oxygen-induced retinopathy model, whereas they paradoxically had increased numbers of neovascular tufts. (elsevierpure.com)
ESC-derived, cytokine-induced HSCs (c-kit + /CD45 + ) were isolated by flow cytometry and injected either intra bone marrow or intravenously into lethally irradiated MHC-mismatched recipient mice. (rupress.org)

Ectopic expression of miR-124 or knockdown of DLL4 promoted the proliferation and the formation of NSCs to neurospheres. (biomedcentral.com)

Each of these complex hematopoietic pathways is under the influence of one or more hematopoietic growth factors (colony stimulating factors) or cytokines that enhance cellular proliferation and maturation and other substances that exert negative or inhibitory effects on the process. (nih.gov)
Exogenous growth factors that activate TSPC proliferation have emerged as a promising approach for treatment. (biomedcentral.com)
Connective tissue growth factor (CTGF) can promote tendon wound healing by stimulating proliferation of a TSPC population marked by CD146. (biomedcentral.com)
Ibrutinib downregulates a subset of miRNA leading to upregulation of tumor suppressors and inhibition of cell proliferation in Chronic Lymphocytic Leukemia. (nih.gov)
To address this gap, we recently devised a mouse model of trigeminal neuropathic pain, using a partial ligation of infraorbital nerve (pIONL) that induces allodynic response to tactile stimuli within the area innervated by infraorbital nerve (ION), with substantial changes in glial proliferation and neuropeptide expression in the trigeminal ganglion and caudal medulla [ 2 ]. (biomedcentral.com)

For example, some cytokines used to ameliorate chemotherapy-induced neutropenia may have the undesirable effect of stimulating the growth of tumor cells or of activating mature neutrophils. (nih.gov)
Dimitriadis E, White CA, et al: Cytokines, chemokines and growth factors in endometrium related to implantation. (4science.ge)
We also measured the expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β. (spandidos-publications.com)
Mast cell activation is initiated by the phosphorylation of tyrosine kinase which leads to the activation of protein kinase C, nuclear factor (NF)-κB and the expression of pro-inflammatory cytokines ( 4 , 8 ). (spandidos-publications.com)
Activated mast cells can release histamine and other inflammatory mediators, such as eicosanoids, proteoglycans and a number of pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and IL-13 ( 5 , 9 ). (spandidos-publications.com)

Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin+ dendritic cells, lymphoid tissue-resident langerin+ dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)

LIF expression levels have been found to be both diminished or increased in uterine flushings, endometrial cell cultures or decidual cells from infertile (human) women with repeated abortions or unexplained infertility. (medscape.com)
7. Endometrial HLA-F expression is influenced by genotypes and correlates differently with immune cell infiltration in IVF and recurrent implantation failure patients. (nih.gov)
During the adhesion phase of early pregnancy, integrins (e.g., α4, αv, β1, β3) are considered to be endometrial markers, and their expression is synchronized with the blastocyst attachment to the endometrium [ 9 ]. (biomedcentral.com)
Hambartsoumian E. Endometrial leukemia inhibitory factor (LIF) as a possible cause of unexplained infertility and multiple failures of implantation. (4science.ge)

Chronic myeloid leukemia (CML) is a malignant hematopoietic stem cell disorder caused by the oncogenic BCR-ABL1 fusion protein. (oncotarget.com)

9. Molecular studies of trophoblast HLA-G: polymorphism, isoforms, imprinting and expression in preimplantation embryo. (nih.gov)
13. PreImplantation Factor (PIF*) endogenously prevents preeclampsia: Promotes trophoblast invasion and reduces oxidative stress. (nih.gov)
IL-10 is a suppressor of hyperglycemia-induced trophoblast cell dysfunction and LIF, MMP-9, and NO may be critical players in it. (4science.ge)

Pyrvinium is effective in inducing apoptosis, inhibiting colony formation and self-renewal capacity of CD34 + cells from TKI-resistant BP-CML patients, while cord blood CD34 + are largely unaffected. (oncotarget.com)
Instead, we show that pyrvinium localizes to mitochondria and induces apoptosis by inhibiting mitochondrial respiration. (oncotarget.com)
Expression of bcl-2 in vivo does not prevent apoptosis. (aai.org)

The expression of the TSPC markers CD146, Oct4, and nestin, induced by the 29-mer, was examined by immunostaining and western blotting. (biomedcentral.com)
The cells were stimulated by IL-10, TNF-alpha and LIF, and the effect of glucose concentration on their functional activity and expression ability of several markers were determined. (4science.ge)
We found that Spermidine (SPD) significantly increased protein expression of autophagy markers microtubule-associated protein 1 light chain 3 beta-II (MAP1LC3B-II/LC3B-II) and sequestosome-1/p62 (SQSTM1/p62), and evoked autophagic flux in FGSCs. (biomedcentral.com)
Further, we found that SPD significantly reduced basal or hydrogen peroxide (H 2 O 2 )-induced up-regulated protein expression of the aging markers, cyclin dependent kinase inhibitor 2A (p16/CDKN2A) and tumor protein 53 (p53). (biomedcentral.com)
We studied the expression of SSEA-4 surface protein and the various ESC and MSC markers in the ex vivo cultured limbal stromal cells. (molvis.org)
Expression of MSC and ESC markers on these cells were also analyzed by FACS. (molvis.org)
After passaged, a subpopulation of these cells showed low expression of SSEA-4 but were negative for other important ESC surface markers such as Tra-1-60, Tra-1-81, and transcription factors like octamer-binding transcription factor 4 (Oct4), SRY(sex determining region Y)-box 2 (Sox2), and Nanog. (molvis.org)
However, despite the expression of SSEA-4, these cells did not express any other markers of ESC. (molvis.org)

The use of BCR-ABL1 tyrosine kinase inhibitors (TKI) has led to excellent clinical responses in patients with chronic phase chronic myeloid leukemia (CML). (oncotarget.com)
Leukemia cell lines that can be induced to myeloid cells in the presence of chemical inducers such as DMSO and retinoid acid are karyotypically abnormal and thus may not recapitulate the normal myeloid cells. (academicediting.org)

This exhausted status in CD8+ T cells was induced by progressing leukemic cells mainly through a mechanism dependent on soluble factors, including IL-10. (ega-archive.org)

A number of ERV subfamilies are particularly active early in embryogenesis [ 3 ], likely due to selection for expression and in turn retrotransposition at those stages in development that maximize the likelihood of germline transmission. (biomedcentral.com)

1. Preimplantation Factor (PIF) Promotes HLA-G, -E, -F, -C Expression in JEG-3 Choriocarcinoma Cells and Endogenous Progesterone Activity. (nih.gov)
This technology allows the RNA-guided localization of the nuclease Cas9 at specific DNA sequences to induce double strand brakes (DBSs) and thus, using endogenous repair mechanisms, perform precise genome editing in cells. (cancer.gov)

Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia. (ega-archive.org)
Also it is essential to note the influence of severe male factor and its impact on genetic and morphological state of the embryo. (jri.ir)

In addition, expression of limbal epithelial and corneal stromal proteins such as ATP-binding cassette sub-family G member 2 (ABCG2), tumour protein p63 (p63), paired box 6 (Pax6), cytokeratin 3 (AE5), cytokeratin 10, and keratocan sulfate were evaluated either by immunofluorecence staining or reverse transcription polymerase chain reaction. (molvis.org)
Our study confirmed the expression of SSEA-4 by a subpopulation of cultured limbal stromal cells. (molvis.org)

The most important and discussed ones in the literature are maternal age, the causes of infertility, the ovarian response to stimulation, the influence of the male factor and sperm quality, embryo quality and the various uterine pathologies. (jri.ir)

[ 47 ] LIF is a recognized expression product of numerous cell types such as neurons, hepatocytes and kidney and breast epithelial cells. (medscape.com)
6. Cytokine stimulation of the choriocarcinoma cell line JEG-3 leads to alterations in the HLA-G expression profile. (nih.gov)
10. Endoplasmic reticulum aminopeptidase-1 mediates leukemia inhibitory factor-induced cell surface human leukocyte antigen-G expression in JEG-3 choriocarcinoma cells. (nih.gov)
The mechanisms that regulate tumor cell entry and exit from dormancy in the bone are not well understood, but several factors have been identified. (ectsoc.org)
We further investigated IgG1 binding to natural killer (NK) cells and NK cell activation during ADCC induction to elucidate the mechanism by which low-fucose IgG1 induces ADCC upon target cells with low antigen expression. (aacrjournals.org)
These include activation of the tumor suppressor, protein phosphatase 2A or inhibition of leukemia stem cell self-renewal by targeting the Wnt/β-catenin pathway through inhibition of MAP kinase interacting serine/threonine kinase (MNK)-eukaryotic translation initiation factor 4E (eIF4E) axis [ 3 , 4 ]. (oncotarget.com)
Skeletal muscle stem cell-derived myoblasts are mainly responsible for postnatal muscle growth and injury-induced muscle regeneration. (rupress.org)
Methods Cell culture W4/129S6 mESCs (Taconic) were plated on γ-irradiated mouse embryonic fibroblasts or 0.1% gelatin-coated 6-well plates and managed in DMEM (high glucose Invitrogen) with 15% FBS 1000 U/mL leukemia inhibitory factor (Chemicon) 0.1 nonessential amino acids 2 l-glutamine 1 sodium pyruvate 10 2 100 Empagliflozin U/mL penicillin and 100 U/mL streptomycin. (academicediting.org)
Interleukin-6 (IL-6) was discovered in 1986 as a B cell stimulatory factor initiating IgG production ( 1 ). (frontiersin.org)
However, since glutamate is a major participant in cell metabolism, even for the synthesis of the inhibitory neurotransmitter GABA [ 7 , 20 ], and not always the visualization of associated molecules guarantees the glutamatergic nature of neurons, an ideal marker was still sought. (hindawi.com)
This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. (nih.gov)
T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. (nih.gov)
However, little is known about the expression of stage-specific embryonic antigen 4 (SSEA-4) and the embryonic stem cell (ESC)-like properties of these cells. (molvis.org)
Finally, we have isolated a low molecular weigh fraction of Schwann cell conditioned medium that contains DA neuron survival and growth-promoting activity, referred to in this application as dopamine neurotrophic factor (DNTF). (neurotree.org)

This review will highlight fundamental mechanisms of glucocorticoid signaling and detail the mechanisms of glucocorticoid-induced muscle atrophy. (frontiersin.org)
While at UCSD she authored multiple papers on the molecular mechanisms of leukemia involving HoxA9, E2A-PBX1 and Nup98-HoxA9. (nih.gov)

To isolate the active component of AEDK, activity-guided fractionation was performed, based on the inhibitory effects on systemic anaphylaxis. (spandidos-publications.com)

Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)

In this study, we, therefore, induced obesity and established an obese asthma mouse model using ovalbumin (OVA) stimulation and applied treatment with Vit D (100 ng/kg). (medworm.com)

We concluded that PEDF s neurotrophic activity must be mediated by a mechanism independent of serine protease inhibition, and we proposed that during evolution this serpin might have lost its inhibitory activity and gained its neurotrophic function. (nih.gov)

Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a BIM deletion polymorphism in pediatric acute lymphoblastic leukemia. (cdc.gov)

[ 45 ] Nonetheless, faulty LIF protein expression is not responsible for negative (LIF-related) pregnancy outcome alone. (medscape.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

Evidence of domain swapping within the jumonji family of transcription factors. (embl.de)

The past decade has witnessed the cloning and characterization of several hematopoietic growth factors. (nih.gov)
Hence, growth factors alone provide insufficiently precise control of the hematopoietic system. (nih.gov)
Growth factors are only a part of a complex system regulating hematopoiesis. (nih.gov)
The anatomical analysis of TSPC populations in the wound healing process supports the hypothesis that substantial expansion of resident TSPC by exogenous growth factor is beneficial for tendon healing. (biomedcentral.com)
Platelet-rich plasma (PRP) that harbors platelet-derived growth factor (PDGF) is another means of treating tendon injury, although the effect is limited, possibly because of a low concentration of PDGF in the preparation [ 5 ]. (biomedcentral.com)
They are also found in transforming growth factor beta regulator 1 (TBRG1), a growth inhibitory protein induced in cells undergoing arrest in response to DNA damage and transforming growth factor (TGF)-beta1. (embl.de)
13,14 Release of paracrine factors, including keratinocyte growth factor, angiopoietin 1, and tumor necrosis factor alpha-stimulated gene 6, attenuated epithelial and endothelial damage in lung injury. (ectrx.org)

The obtained outer membrane preparations inhibitor expert were then subjected to SDS Page to analyze the expression from the lipase fusion protein. (ras-signal.com)

Exome sequencing data from patient with Chronic Lymphocytic Leukemia. (ega-archive.org)
NIEHS grantees have uncovered the key molecular pathway involved in chronic obstructive pulmonary disease (COPD) induced by air pollution exposure. (nih.gov)

While MMERVK10C and IAP ERVs are bound by SETDB1 and KAP1 and are induced following their deletion, MERVL ERVs show relatively low levels of SETDB1 and KAP1 binding and are upregulated exclusively following KAP1 depletion, indicating that KAP1 influences MERVL expression independent of SETDB1. (biomedcentral.com)

Here, we characterized the roles of these chromatin factors in MERVL silencing in mESCs. (biomedcentral.com)

Low-fucose IgG1s showed potent ADCC at low antigen densities at which their corresponding high-fucose counterparts could not induce measurable ADCC. (aacrjournals.org)

This interesting factor is secreted by retinal pigment epithelial cells into the interphotoreceptor matrix, where it acts on photoreceptor cells. (nih.gov)

This requirement was consistent with the induction of CIP4 expression by hypertrophic stimulation. (biomedcentral.com)

We also observed that upon complete RAS depletion or MEK inhibition, ERF, a transcriptional repressor from the ETS (E26-Transformation Specific)-domain family, translocates to the nucleus where it binds to the enhancers of pluripotency factors and key RAS targets. (cancer.gov)

Early passaged cells when induced were able to differentiate into adipocytes, osteocytes and chondrocytes. (molvis.org)

[ 68 ] A matter of interest is that women bearing a copper T380A intrauterine device as an effective contraceptive, also maintain a lower uterine expression of LIF in comparison to control. (medscape.com)
The causes of implantation failure are diverse and especially due to different maternal factors as uterine abnormalities, hormonal or metabolic disorders, infections, immunological factors, thrombophilias as well as other less common ones. (jri.ir)

Leukemia inhibitory factor is often perceived as an important modulator of human pregnancy for a number of reasons. (medscape.com)
[ 64-67 ] Women with higher LIF levels during the implantation window may have a better chance of establishing pregnancy than women with low LIF expression. (medscape.com)
Also, pregnancy is a complex process with overlapping expression patterns making it challenging to mimic their stage-specific role. (biomedcentral.com)
Therefore, the motive of the current study was to investigate the probable molecular cascade to decipher the early pregnancy loss in the letrozole-induced PCOS mouse model. (biomedcentral.com)
Sepashvili A., Iobadze M. The key molecules in diabetes-induced pregnancy loss. (4science.ge)

Anatomy20

Organisms10

Diseases15

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes25

Disciplines and Occupations1

Information Science3

Differentiation14

Progenitor2

Receptor16

LIFR2

Gene expression15

Recombinant4

Cytokine leukemia2

Vitro3

Regulates4

Receptors3

ESCs3

Genes11

Pluripotent2

Macrophage6

Mice5

Ectopic1

Proliferation5

Cytokines5

Stimuli1

Endometrial4

Hematopoietic stem1

Trophoblast3

Apoptosis3

Markers8

Myeloid2

Leukemic1

Germline1

Endogenous2

Genetic2

Stromal2

Embryo1

Cell14

Mechanisms2

Systemic1

Cellular1

Obesity1

Neurotrophic1

Polymorphism1

Protein expression2

Transcription factors1

Growth7

Inhibitor1

Chronic2

Deletion1

MESCs1

Antigen1

Epithelial1

Induction1

Inhibition1

Differentiate1

Uterine2

Pregnancy5