• We have previously demonstrated that Ganoderma lucidum down-regulated the expression of NF-kappaB-regulated urokinase plasminogen activator (uPA) and uPA receptor (uPAR), which resulted in suppression of cell migration of highly invasive human breast and prostate cancer cells. (greenmedinfo.com)
  • DNA methylation, a form of epigenetic control of gene transcription, refers to cytosine methylation at position 5 in the pyrimidine ring, which can result in inappropriate silencing of genes involved in diverse biological processes, including cell proliferation, apoptosis, migration and cell cycle arrest ( 5 ). (spandidos-publications.com)
  • HP75 cells treated with overexpressed miR-543 exhibited increased cell proliferation, migration and invasion, while decreased cell apoptosis as well as expression of Cleaved caspase-3 and Cleaved caspase-8 were observed. (cancerindex.org)
  • Cell proliferation was reduced in a time-dependent manner of drug exposure as revealed from BrdU incorporation and migration studies. (jcimjournal.com)
  • Effects of Thuja occidentalis ethanolic extract on A549 cell migration (Light microscopy, ×20) Wound-healing assays were performed to assess cell migration. (jcimjournal.com)
  • Overexpression of JAM3 or recombinant JAM3 protein enhanced trophoblast adhesion and migration, which were inhibited by JAM3 knockdown. (bioone.org)
  • Chinese Propolis Suppressed Pancreatic Cancer Panc-1 Cells Proliferation and Migration via Hippo-YAP Pathway. (sorentt.ir)
  • The amount of penetrated cells symbolized the migration activity. (mindunwindart.com)
  • This research is the initial PH-797804 survey of DP not merely MGC5276 inhibiting TMEM16A CaCC currents but also considerably blocking the development, migration and invasion of SW620 cells. (mindunwindart.com)
  • In normal human tissues, hSulf-1 is stably expressed, and it plays important roles in cell proliferation and differentiation [ 1 , 2 ]. (oncotarget.com)
  • The following methods were applied: at first proliferation assays with photometric analysis were conducted, then an annexin-V-detection was applied for differentiation of the treated cells in vital, necrotic and apoptotic groups. (uni-marburg.de)
  • 3. Buhrmann C, Mobasheri A, Matis U, Shakibaei M. Curcumin mediated suppression of nuclear factor-kappaB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment. (arjunanatural.com)
  • This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
  • Xanthoxyletin significantly inhibited the proliferation of oral cancer cells (IC₅₀, 10-30 µM) with lower cytotoxicity for normal cells. (medscimonit.com)
  • Pretreatment with PD98059 increased Cd-induced cytotoxicity suggesting that ERK activation may be a survival response in the present cell system. (cdc.gov)
  • Cycloheximide, an inhibitor of protein synthesis, did not alter Cd-induced cytotoxicity indicating that J774A.1 cell death by Cd is independent of de novo protein synthesis including p53. (cdc.gov)
  • ERK activation by Cd is not related to decreased proliferation of macrophages but may play a protective role against Cd-induced cytotoxicity. (cdc.gov)
  • The results demonstrated that curcumin induced cytotoxicity and apoptosis dose- and time-depedently. (iiarjournals.org)
  • Exploring the anticancer effects of standardized extracts of poplar-type propolis: In vitro cytotoxicity toward cancer and normal cell lines. (sorentt.ir)
  • Antagonistic Effects of CAPE (a Component of Propolis) on the Cytotoxicity and Genotoxicity of Irinotecan and SN38 in Human Gastrointestinal Cancer Cells In Vitro. (sorentt.ir)
  • Adding lunasin to IL-12- or IL-2-stimulated NK cells demonstrated synergistic effects in the induction of IFNG and GZMB involved in cytotoxicity. (weeksmd.com)
  • BAY 293 We looked into the cytotoxicity of leucine deprivation on regular cells further, including major hepatocytes, brownish adipose cells (BAT) and MCF-10A cells. (racetab.org)
  • A cytotoxicity assay indicated that NQ preferentially killed cancer cells, compared to normal cells. (molcells.org)
  • Functional analysis revealed that knockdown of PTGR1 significantly inhibited proliferation and colony formation by PC cells. (go.jp)
  • Furthermore, the supernatant of THP-1 DCs significantly inhibited the proliferation of gastric cancer cells by inducing apoptosis and G1/S cell cycle arrest. (hindawi.com)
  • There was a significantly higher apoptosis in si-Prok1 group. (ajol.info)
  • Animal study confirmed that β-peltatin significantly suppressed the growth of subcutaneously-implanted BxPC-3 cell xenografts. (biomedcentral.com)
  • Results: DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors. (iiarjournals.org)
  • The growth rate of the cells was reduced when grown in ( significantly? (racetab.org)
  • Importantly, Alizarin had a significantly lower inhibitory activity on normal cells (IC50 for MSC, 828.6 µg/ml), thereby revealing a selective activity towards malignant cells. (moestuininfo.com)
  • Both curcumin and AKBA inhibited cellular proliferation, induced apoptosis and cell-cycle arrest in colorectal cancer cell lines, and these effects were significantly enhanced with combined treatment. (arjunanatural.com)
  • In patients with relapsing or unresponsive disease, hematopoietic stem-cell transplantation significantly prolongs disease-free survival. (medscape.com)
  • These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)
  • The THP-1 human monocytic cell line was used as a source of monocytic effector cells for analyzing proliferation and dendritic cell (DC) induction. (hindawi.com)
  • The results demonstrated that JIB extract combined with cisplatin enhanced the inhibition of cell growth, proliferation, and survival through the obstruction of cell cycle progression and AKT/mTOR and MAPK signaling as well as the induction of cell apoptosis. (medsci.org)
  • Treatment of the MM cell line with the DNA methylation inhibitor 5‑Aza‑2'‑deoxycytidine (5‑Aza‑CdR) resulted in tumor cell proliferation inhibition, apoptosis induction and G0/G1 cell cycle arrest. (spandidos-publications.com)
  • β-peltatin initially arrested PAC cells at G2/M phase, followed by apoptosis induction. (biomedcentral.com)
  • End points are proliferation, cell cycle allocation, induction of apoptosis and necrosis. (uni-marburg.de)
  • si-Prok1 arrests cell cycle, induces apoptotic changes, and inhibits the proliferation of ovarian granulosa cells through a mechanism related to the regulation of Pi3k/Akt signaling pathway. (ajol.info)
  • Ethanolic leaf extract of TO demonstrated apoptotic and antiproliferative potentials against A549 cell line. (jcimjournal.com)
  • Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death. (lktlabs.com)
  • EESR-induced apoptosis was associated with the upregulation of p53, a death receptor Fas, and a pro-apoptotic protein Bax and the activation of caspase 3, 8, and 9, resulting in the degradation of PARP. (jcpjournal.org)
  • In the present study, cytotoxic and apoptotic effects of melatonin were investigated on H-ras oncogene transformed rat embryo fibroblast 5RP7 cells. (tubitak.gov.tr)
  • The percentages of early/late apoptotic cells to which melatonin (IC50: 380 μM) was administered were increased 6.2-fold in 5RP7 cells compared to controls for 48 h. (tubitak.gov.tr)
  • Li L , Jiang H , Li Y , Xiang X , Chu Y , Tang J , Liu K , Huo D , Zhang X , . Chaetocin exhibits anticancer effects in esophageal squamous cell carcinoma via activation of Hippo pathway. (aging-us.com)
  • The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. (mdpi.com)
  • In addition to the balance between tumors and the immune system, there is also a balance between tumors and the nonimmune cells that surround them [ 10 ]. (hindawi.com)
  • We further confirmed that hSulf-1 overexpression can inhibit AKT phosphorylation and CDK4 nuclear localization and retard the growth of melanoma xenograft tumors in nude mice. (oncotarget.com)
  • Curcumin can slow the growth of these tumors by inhibiting angiogenesis. (beatcancer.org)
  • Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. (foodtolive.com)
  • Cell-division rates vary for different tumors. (medscape.com)
  • This study aimed to investigate the effects of xanthoxyletin, a plant-derived coumarin, on human oral squamous cancer cells in vitro and in mouse xenografts in vivo . (medscimonit.com)
  • It is immunotoxic in vivo and induces apoptosis in many cultured cells. (cdc.gov)
  • Tubeimoside I inhibits LPS-stimulated production of TNF-α, IL-1β, and IL-6, preventing the development of pulmonary edema and infiltration of inflammatory cells in vivo. (lktlabs.com)
  • The in vivo effects of β-peltatin and podophyllotoxin were evaluated on a subcutaneously-xenografted BxPC-3 cell nude mice model. (biomedcentral.com)
  • Background/Aim: Demethoxycurcumin (DMC), a derivate of curcumin from natural plants, exerts antitumor effects on various human cancer cells in vitro and in vivo. (iiarjournals.org)
  • Nevertheless, no reports have disclosed whether DMC can affect the growth of human cervical cancer cells in vivo. (iiarjournals.org)
  • In addition, NK cells stimulated with lunasin plus cytokines displayed higher tumoricidal activity than those stimulated with cytokines alone using in vitro and in vivo tumor models. (weeksmd.com)
  • Therefore, we aimed to investigate the effects of oleandrin on cancer cell proliferation , viability and apoptosis in vitro and in vivo . (phoenixbiotechnology.com)
  • Here, we investigated the antitumorigenic effects of curcumin and 3 acetyl-11-keto-β-boswellic acid (AKBA) on modulation of specific cancer-related miRNAs in colorectal cancer cells and validated their protective effects in vivo using a xenograft mouse model. (arjunanatural.com)
  • The MTT assay assessed cell viability, and autophagy was detected by electron microscopy. (medscimonit.com)
  • Cell viability was detected by the Cell Counting Kit-8 (CCK-8) assay. (hindawi.com)
  • Cell viability was ascertained through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay after deployment of TO in different doses. (jcimjournal.com)
  • TO demonstrated a dose-dependent decrease in viability of A549 cells after 24 h of exposure. (jcimjournal.com)
  • Effects of Thuja occidentalis ethanolic extract on viability of A549 cell line (A) and L-132 cell line (B) Cells were exposed to Thuja occidentalis ethanolic extract for 24 h at different concentrations and the cell viability was determined by MTT assay. (jcimjournal.com)
  • Cell viability was determined using Cell Counting Kit-8 assay. (biomedcentral.com)
  • Outcomes Leucine deprivation decreases viability of tumor cells We 1st determined the result of leucine deprivation on viability of tumor cells. (racetab.org)
  • Open up in another window Shape 1 The result of leucine deprivation on cell viability(A and B) Cells had been incubated in charge BAY 293 (+leu) or leucine-deficient (?leu) moderate for indicated period, accompanied by MTT assay. (racetab.org)
  • We extracted information about the effects of oleandrin on cell proliferation, cell viability , apoptosis and/or cell cycle arrest in in vitro studies, and the effects on tumor size and volume in animal experimental models. (phoenixbiotechnology.com)
  • Overall, in vitro studies demonstrated that oleandrin was able to inhibit cell proliferation, decrease cell viability, and induce apoptosis and/or cell cycle arrest. (phoenixbiotechnology.com)
  • Cell number and viability were assessed on harvested cells using the trypan blue dye exclusion assay. (moestuininfo.com)
  • Furthermore, H 2 O 2 -induced oxidative stress reduced JAM3 expression in trophoblasts and cell culture supernatants. (bioone.org)
  • It also protects against oxidative damage induced by tributyltin, reducing reactive oxygen species production and DNA damage. (thewomensmag.com)
  • Consumption of broccoli sprouts was found to help reduce Helicobacter pylori induced gastritis (6) (7) , protect against oxidative stress-induced upper airway disease (8) and against oxidative DNA damage (9) . (foodtolive.com)
  • Herb-partitioned moxibustion may inhibit excessively activated autophagy and modulate the expression of immune-related factors by regulating the LKB1-mTOR-PI3KC signal transduction networks, thereby alleviating intestinal inflammation in CD rats. (hindawi.com)
  • Tubeimoside-1 attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models. (lktlabs.com)
  • These pro- has been implicated as contributing apoptosis, inflammation, and several liferating cel s replace dead cel s to the cancer phenotype, through pleiotropic responses. (who.int)
  • Effects of Thuja occidentalis ethanolic extract on cellular proliferation tested by BrdU incorporation assay Cells were exposed to three different concentration of Thuja occidentalis ethanolic extract for 6, 12 and 24 h along with incorporation of BrdU. (jcimjournal.com)
  • Effects of Propolis and Phenolic Acids on Triple-Negative Breast Cancer Cell Lines: Potential Involvement of Epigenetic Mechanisms. (sorentt.ir)
  • The underlying mechanism responsible for the effects of lunasin on NK cells is likely due to epigenetic modulation on target gene loci. (weeksmd.com)
  • We determined by circular dichroism spectroscopy that NQ effectively caused conformational changes in DNA and modulated different proteins related to epigenetic modifications and c ell cycle control. (molcells.org)
  • NQ induced apoptosis in HepG2 cells by activating p53-ROS crosstalk and induces epigenetic modifications leading to inhibited proliferation and cell cycle arrest. (molcells.org)
  • Activating mutations upstream may also underlie some epigenetic or within the ERK1/2 cascade are events that change cell signalling. (who.int)
  • The inhibition of cell growth was also demonstrated by cell cycle arrest at G2/M phase. (greenmedinfo.com)
  • 10 mg/mL) of Nidus Vespae decoction (NVD) inhibited SGC-7901 gastric cancer cell growth by inducing G2/M cell cycle arrest and apoptosis. (hindawi.com)
  • Our findings suggest that NVD not only directly inhibits the growth of gastric cancer cells but also exerts indirect antitumor effects by enhancing immune function. (hindawi.com)
  • In addition, AKT/mTOR signaling and MAPK signaling were inhibited by JIB extract to suppress melanoma cell growth and proliferation. (medsci.org)
  • in other, similar cellular and animal models, this compound inhibits cell and tumor growth. (lktlabs.com)
  • It can reduce the sulfation of cell surface heparan sulfate proteoglycan (HSPG) and inhibit various growth factor receptor-mediated signaling pathways. (oncotarget.com)
  • hSulf-1 reduces the sulfation of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix and inhibits binding between various cell growth factors and their receptors. (oncotarget.com)
  • Curcumin can help protect against cancer initiation, slow its growth when it occurs, and even sensitize cancer cells to treatment. (beatcancer.org)
  • Inhibit Angiogenesis - Curcumin slows new blood vessel growth by blocking vascular growth factors. (beatcancer.org)
  • Normalize Cell Growth - Curcumin restores normal growth controls, reverses uncontrolled reproduction of malignant cells, blocks access of cancer cells to growth factors, turns on genes that prevent cell growth and turns off genes that promote cancer growth. (beatcancer.org)
  • Inhibitory effect of EESR on cancer cell growth and proliferation was determined by water-soluble tetrazolium salt assay. (jcpjournal.org)
  • EESR showed significant antioxidant activity and inhibitory effect on HT29 cell growth in a dose-dependent manner. (jcpjournal.org)
  • The abnormal cell growth is one of the critical characteristics of cancer for invasion or spreading out to other parts of the body. (jcpjournal.org)
  • Melatonin inhibited cell growth and induced apoptosis in 5RP7 cells. (tubitak.gov.tr)
  • As there is a substantial growth-inhibitory aftereffect of leucine deprivation, we explored whether leucine deprivation got any inhibitory influence on cell routine development. (racetab.org)
  • Cancer is a complex and multifaceted disease characterized by the uncontrolled growth and spread of abnormal cells. (greenteaadvice.com)
  • Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
  • The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
  • Cancer chemotherapy is based on an understanding of tumor cell growth and of how drugs affect this growth. (medscape.com)
  • After cells divide, they enter a period of growth (ie, phase G1), followed by DNA synthesis (ie, phase S). The next phase is a premitotic phase (ie, G2), then finally a mitotic cell division (ie, phase M). (medscape.com)
  • Podophyllotoxin derivative antineoplastic agents have cytotoxic effects on cell growth. (medscape.com)
  • Open up in another window Shape 3 Leucine deprivation induces apoptosis of human being breast tumor BAY 293 cell(A and B) MDA-MB-231 or MCF-7 cells had been incubated in charge (+leu) or leucine-deficient (?leu) moderate for 48h, accompanied by dedication of cleaved caspases inside a and annexin-V assay in B. (C and D) Nude mice. (racetab.org)
  • In a prior study, we discovered that TMEM16A is certainly amplified and extremely expressed in extremely metastatic SW620 cells and knockdown of TMEM16A in SW620 cells reduced metastasis [16]. (mindunwindart.com)
  • MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7. (cancerindex.org)
  • Inhibit Local Cancer Invasion - Curcumin blocks protein-melting enzymes and fibroblasts that allow cancer to penetrate and invade local sites. (beatcancer.org)
  • Apis mellifera propolis enhances apoptosis and invasion inhibition in head and neck cancer cells. (sorentt.ir)
  • To investigate cell invasion, the transwell put in chambers had been covered with Matrigel. (mindunwindart.com)
  • Cd inhibited cell proliferation via cell cycle arrest and induced apoptosis in a dose-dependent manner. (cdc.gov)
  • In-vitro-treatment with Lonafarnib leads to a dose-dependent G2-arrest of glioblastomacells, lungcancer- and fibrosarcomacells. (uni-marburg.de)
  • EESR induced cell cycle arrest at G2/M phase in a dose-dependent manner by modulating cyclin B, cyclin-dependent kinase 1 (CDK1), and CDK inhibitor p21 expression. (jcpjournal.org)
  • We showed inhibition of cell proliferation that was time- and dose-dependent in 5RP7 cells for 24 and 48 h. (tubitak.gov.tr)
  • It induces G 2 /M cell cycle arrest suppressing proliferation via cyclin-dependent kinases (CDKs) and triggers dose-dependent apoptosis via death-receptor caspase cascades or the mitochondrial caspase cascades. (foodtolive.com)
  • Targeted therapy drugs are used to target specific genes and proteins of cancer cells to precisely identify and attack specific types of cancer cells. (medsci.org)
  • miRNAs regulate proteins expressions by arresting or degrading the mRNAs. (cancerindex.org)
  • We further revealed that chaetocin triggered the activation of Hippo pathway in ESCC cells, which is characterized by elevated phosphorylation levels of almost all core proteins in Hippo pathway, such as MST1 (Thr183), MST2 (Thr180), MOB1 (Thr35), LAST1 (Thr1079 and Ser909) and YAP (Ser127), ultimately leading to decreased nuclear translocation of YAP. (aging-us.com)
  • Diverse models show that Flavoprirol inhbitis the TNF-mediated NF-κB-activation and the AP-1-activation, suppresses the expression of a multiplicity of antiapoptotic proteins and the TNF-induced AKT-activation. (uni-marburg.de)
  • Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
  • consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
  • American blotting Proteins through the cell lysates had been ready from cell lines as previously referred to [16]. (mindunwindart.com)
  • Inhibition of ERK suppressed DNA synthesis and had an additive effect with Cd-inhibited proliferation suggesting that Cd-induced ERK activity is not responsible for the G2/M arrest and subsequent inhibition of cell proliferation. (cdc.gov)
  • Icariin can inhibit the proliferation and colony forming ability of medulloblastoma cells, induce cell arrest in synthesis phase by inhibiting the expression of cyclin A, cyclin-dependent kinase 2 and cyclin B1, and induce cell apoptosis by regulating the expression of B-cell lymphoma 2, cleaved caspase-3, cleaved caspase-9 and cleaved poly (ADP-ribose) polymerase protein. (ijpsonline.com)
  • Dacarbazine is an alkylating agent that inhibits DNA, RNA, and protein synthesis. (medscape.com)
  • This agent requires activation in the liver to form its active intermediaries, which in turn modify and cross-link DNA, thereby inhibiting DNA, RNA, and protein synthesis. (medscape.com)
  • Effect of cadmium on P53 and mitogen-activated protein kinases in a murine macrophage cell line: relation to apoptosis. (cdc.gov)
  • Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. (springer.com)
  • The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
  • Present study was designed to determine the impact of cadmium on cell proliferation, cell cycle and apoptosis, and to investigate the possible involvement of p53 and MAPKs signaling pathways in J774A.1 murine macrophages. (cdc.gov)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Effects of propolis and its bioactive components on breast cancer cell pathways and the molecular mechanisms involved. (sorentt.ir)
  • Gene-expression arrays revealed that curcumin and AKBA regulated distinct cancer signaling pathways, including key cell-cycle regulatory genes. (arjunanatural.com)
  • Combined bioinformatics and in silico analysis identified apoptosis, proliferation, and cell-cycle regulatory signaling pathways as key modulators of curcumin and AKBA-induced anticancer effects. (arjunanatural.com)
  • With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
  • Curcumin-induced apoptosis mainly involves the activation of caspase-3 and mitochondria-mediated pathway in various cancer cells of different tissue origin. (iiarjournals.org)
  • Here, we demonstrated that chaetocin dramatically inhibited the proliferation in ESCC cells by causing cycle arrest in the M phase and activating the caspase-dependent apoptosis signaling pathway in vitro , and we also found that chaetocin induced the accumulation cellular reactive oxygen species (ROS). (aging-us.com)
  • An important anti-tumor mechanism of hSulf-1 operates by decreasing downstream AKT signaling pathway activity and inhibiting the nuclear import of CDK4. (oncotarget.com)
  • To study the possible anticancer and antiproliferative activities of ethanolic leaf extract of Thuja occidentalis (TO) on A549 non-small lung carcinoma cells in vitro . (jcimjournal.com)
  • Additionally, this compound inhibits production of HIV core protein p24 and infectivity of HIV-1 in vitro. (lktlabs.com)
  • Flavopiriol blocks the ATP-binding site of cyclin-dependent cinases and leads to a G1- respectively G2-cellcycle arrest in vitro. (uni-marburg.de)
  • The aim of this study is to investigate potential synergistic effects of Flavopiridol and Lonfarnib inhibiting the proliferation of human ovarian cancer cells in vitro. (uni-marburg.de)
  • This study supports evidence in literature pointing to a certain activity of these drugs and at the same time emphasizes the different sensibility of human ovarian cancer cell lines to targeted therapeutics in vitro. (uni-marburg.de)
  • In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines. (xcessbio.com)
  • Also, sulforaphane inhibits histone deacetylase (HDAC) by its metabolites in vitro (13) . (foodtolive.com)
  • The Cuban Propolis Component Nemorosone Inhibits Proliferation and Metastatic Properties of Human Colorectal Cancer Cells. (sorentt.ir)
  • We discovered that curcumin and AKBA induced upregulation of tumor-suppressive miR-34a and downregulation of miR-27a in colorectal cancer cells. (arjunanatural.com)
  • TRPV6 expression mainly confines on the apical membrane of epithelial cells. (wikipedia.org)
  • Our data demonstrate that Ganoderma lucidum inhibits cell proliferation in a dose- and time-dependent manner by the down-regulation of expression of cyclin B and Cdc2 and by the up-regulation of p21 expression. (greenmedinfo.com)
  • Treatment with Cd at 20 and 50 microM induced phosphorylation of extracellular signal-regulated kinase (ERK), but did not alter p53 mRNA expression or the activation of p38 MAPK and c-Jun N-terminal MAPK. (cdc.gov)
  • Two PTGR1-specific short hairpin RNA (shRNA) sequences were used to block the expression of PTGR1 via a lentivirus-mediated system in the androgen-independent PC cell lines DU145 and PC 3. (go.jp)
  • Vitamin D ameliorates stress ligand expression elicited by free fatty acids in the hepatic stellate cell line LX-2. (springer.com)
  • Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats. (springer.com)
  • In the present study, MEG3 upregulation was negatively associated with the International Staging System (ISS) status of the bone marrow samples of 39 patients with MM. MEG3 overexpression in an MM cell line resulted in elevated p53 expression. (spandidos-publications.com)
  • Expression of this gene is induced by TGFBR1. (cancerindex.org)
  • Curcumin also promoted the expression of Bax, cytochrome C, p53 and p21 but inhibited the expression of Bcl-2. (iiarjournals.org)
  • JAM3 expression in cell-cell junctions decreased with the formation of syncytiotrophoblasts. (bioone.org)
  • JAM3 knockdown induced reactive oxygen species and syncytin 2 expression in trophoblasts. (bioone.org)
  • Western blotting was used for protein expression analysis of the collected cell masses (spheroids), and H-E staining was used for structural observation. (medsci.org)
  • Cisplatin showed concentration-dependent antitumor effects due to loss of cell adhesion and spheroid disruption in each cell line, while cetuximab exhibited antitumor effects that correlated with EGFR expression in each cell line. (medsci.org)
  • In most cancer cell lines and tumor tissues, hSulf-1 expression levels are markedly decreased. (oncotarget.com)
  • The decreased expression of hSulf-1 is closely related to cancer cell proliferation, increased metastatic activity, inhibition of apoptosis, and reduced sensitivity to radio- and chemotherapy [ 3 - 5 ]. (oncotarget.com)
  • Lonafarnib is also able to induce apoptosis via a CHOP-dependent upregulation of the DR-5-expression and a following caspase-8-activation. (uni-marburg.de)
  • Effect of Turkish Propolis on miRNA Expression, Cell Cycle, and Apoptosis in Human Breast Cancer (MCF-7) Cells. (sorentt.ir)
  • Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
  • JIB extract induced cell cycle arrest at the G 0 /G 1 phase and decreased cyclin and cdk protein expressions. (medsci.org)
  • In this study, we found that hSulf-1 overexpression in melanoma cells can inhibit cell proliferation and induce cell cycle arrest and apoptosis by decreasing the protein kinase B (AKT) phosphorylation and limiting CDK4 nuclear import. (oncotarget.com)
  • Studies characterising the immune response in patients with COVID-19 show that the correlates of protection in infected individuals are T-cell responses against the SARSCoV-2 spike protein and neutralising titres of immunoglobin G and immunoglobin A antibodies. (bvsalud.org)
  • Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. (arjunanatural.com)
  • DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)
  • Garlic oil, along with its major components DADS and DATS, effectively inhibits various pathogens, including Helicobacter pylori and Staphylococcus aureus. (thewomensmag.com)
  • It effectively inhibits the proliferation of cancer cells by inducing cell cycle arres. (targetmol.com)
  • MBM-17S effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. (targetmol.com)
  • MBM-55 effectively inhibits the proliferation of cancer cells by inducing. (targetmol.com)
  • Thus, Ganoderma lucidum exerts its effect on cancer cells by multiple mechanisms and may have potential therapeutic use for the prevention and treatment of cancer. (greenmedinfo.com)
  • The underlying molecular mechanisms by which androgen-independent PC cells acquire the capacity to proliferate remain largely unclear. (go.jp)
  • The mechanisms influenced by Flaoprirol and Lonafarnib are relevant on ovarian cancer cells. (uni-marburg.de)
  • Metabolomic Identification of Anticancer Metabolites of Australian Propolis and Proteomic Elucidation of Its Synergistic Mechanisms with Doxorubicin in the MCF7 Cells. (sorentt.ir)
  • The purpose of BAY 293 our current research would be to investigate the result of leucine deprivation on breast tumor cells and also to elucidate the root mechanisms. (racetab.org)
  • Macrophages and dendritic cells can produce 1,25-dihydroxyvitamin D within the microenvironment. (springer.com)
  • Polish Propolis-Chemical Composition and Biological Effects in Tongue Cancer Cells and Macrophages. (sorentt.ir)
  • Cuban Brown Propolis Interferes in the Crosstalk between Colorectal Cancer Cells and M2 Macrophages. (sorentt.ir)
  • Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
  • Reishi inhibits proliferation and induces programmed cell death in human prostate cancer cells. (greenmedinfo.com)
  • Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. (greenmedinfo.com)
  • In this study, we investigated the effects of Ganoderma lucidum on cell proliferation, cell cycle, and apoptosis in human prostate cancer cells PC-3. (greenmedinfo.com)
  • The osteosarcoma cells appeared to be the most sensitive, whereas the prostate cancer cells was substantially unaffected. (moestuininfo.com)
  • Consistent with this hypothesis, prostate cancer cells appeared to be resistant to Alizarin treatment. (moestuininfo.com)
  • Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells. (foodtolive.com)
  • Additionally, JIB extract induced B16/F10 cell apoptosis via the caspase cascade. (medsci.org)
  • Curcumin induced the production of reactive oxygen species (ROS) and Ca +2 , decreased the levels of mitochondria membrane potential and induced caspase-3 activity. (iiarjournals.org)
  • The melatonin treatment resulted in increased caspase-3 activity and reduced the mitochondrial membrane potential in the 5RP7 cells for 48 h. (tubitak.gov.tr)
  • These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)
  • In most cancers, hSulf-1 is inactivated, which endows cancer cells with increasesed cell proliferation and metastatic activities, inhibition of apoptosis, and decreased sensitivity to radio- and chemotherapy. (oncotarget.com)
  • One important mechanism of carcinogenesis is uncontrolled cell proliferation caused by the excessive activation of cell proliferation signals. (oncotarget.com)
  • Sulforaphane blocks the initiation stage in carcinogenesis by inhibiting enzymes that convert procarcinogens to carcinogens and by inducing phase 2 enzymes that detoxify carcinogens and facilitate their excretion from the body. (foodtolive.com)
  • extract (JIB extract) for melanoma cells. (medsci.org)
  • Overall, hSulf-1 function in melanoma cells provides an ideal molecular treatment target. (oncotarget.com)
  • JAM3 knockdown additionally inhibited trophoblast proliferation and increased the number of trophoblasts in the sub-G1 and G2/M phases, indicating cell-cycle disturbance and apoptosis. (bioone.org)
  • One such peptide, Lunasin , has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. (weeksmd.com)
  • It exerts cytotoxic effect by inhibiting rapid proliferation of cancer cells. (medscape.com)
  • MPP + can cause severe damage to mitochondrial morphology and the function in SH-SY5Y cells, and echinacoside selectively reverse mitochondrial function and cell apoptosis, yet there is no effect on mitochondrial morphology. (jcimjournal.com)
  • Drugs of the so-called targeted therapy operate selectively by either inhibiting receptors and ligands or molecules of the signaltransduction. (uni-marburg.de)
  • Surface functionalization of gold nanoparticles (AuNPs) is essential for biomedical applications that target them to specific disease areas and allow them to selectively interact with cells or biomolecules. (molcells.org)
  • The goal of specific molecular targets in cancer therapy is to create a "magic bullet" that selectively kills cancer cells. (medscape.com)
  • The goal of gene therapy is to introduce new genetic material into cancer cells that selectively kills them without causing toxicity to the surrounding cells. (medscape.com)
  • This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)
  • Moreover, the MST1/2 inhibitor XMU-MP-1 not only partially rescued the inhibitory effect chaetocin-induced proliferation, but also rescued the chaetocin-induced apoptosis in ESCC cells. (aging-us.com)
  • However, the mechanism(s) responsible for the effects of Ganoderma lucidum on cancer cells remain to be elucidated. (greenmedinfo.com)
  • The study included SCC-1 human oral cancer cells and EBTr normal embryonic bovine tracheal epithelial cells, which were treated with 0 µM, 5 µM, 10 µM, and 20 µM of xanthoxyletin for 24 hours. (medscimonit.com)
  • Curcumin (diferuloylmethane), the yellow pigment in turmeric (Curcuma longa), is known to inhibit proliferation of cancer cells by arresting them at various phases of the cell cycle and to induce apoptosis in tumor cells. (iiarjournals.org)
  • Enhance Immune Surveillance - Curcumin prevents cancer cells from evading normal immune system detection and improves the body's ability to detect and destroy malignant cells. (beatcancer.org)
  • Reduce Production of Adhesion Molecules - Curcumin keeps malignant tissue from sticking to vessel walls and reduces cancer cells' ability to form distant metastases. (beatcancer.org)
  • Cancer cells can grow unusually via limitless number of cell division and can avoid apoptosis. (jcpjournal.org)
  • Melatonin may be an anticancer agent against H-ras oncogene activated cancer cells. (tubitak.gov.tr)
  • Algerian propolis: between protection of normal cells and potentialisation of the anticancer effects of doxorubicin against breast cancer cells via P-glycoprotein inhibition and cell cycle arrest in the S phase. (sorentt.ir)
  • Chinese Propolis Inhibits the Proliferation of Human Gastric Cancer Cells by Inducing Apoptosis and Cell Cycle Arrest. (sorentt.ir)
  • Gene therapy has attracted attention for its potential to specifically and efficiently target cancer cells with minimal toxicity to normal cells. (weeksmd.com)
  • Numerous vectors have been engineered for the sole purpose of killing cancer cells, and some have successfully suppressed malignant tumours. (weeksmd.com)
  • As our understanding of the molecular biology of HNSCC continues to develop, we can target the specific components of cancer cells that are not found in normal cells. (medscape.com)
  • Ideal targets should be both specific to cancer cells and commonly found in cancer cells. (medscape.com)
  • Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
  • Melatonin induces antiproliferative activity through modulation of apo" by AYŞE KAPLAN, GÜLŞEN AKALIN ÇİFTÇİ et al. (tubitak.gov.tr)
  • Analysing the results of the proliferation assays synergistic effects when combining Flavorpiridol and Lonafarnib could not be shown in SKOV3-cells but in BG1-cells. (uni-marburg.de)
  • The objective of this study is to evaluate the antioxidant and anticancer effects of ethanol extract of S. rufopilosa (EESR) and to determine the molecular mechanism of its anticancer activity in human colon carcinoma HT29 cells. (jcpjournal.org)
  • As a haematological cancer that originates from the malignant transformation of plasma cells, MM maintains pathophysiologic heterogeneity due to its complex genetic background ( 2 ). (spandidos-publications.com)
  • Four varieties of tumor cells were examined: malignant melanoma A375, lung caner A549, ovarian carcinoma breast and A2780 cancer MCF-7 and MDA-MB-231 cells. (racetab.org)
  • Although the intended target is the malignant cells of Hodgkin lymphoma, the effects of chemotherapy on normal cells of the body are considerable and account for the adverse effects observed with these agents. (medscape.com)
  • This difference allows normal cells to recover more quickly than malignant ones after chemotherapy and is the rationale behind current cyclic dosage schedules. (medscape.com)