Induces cardiac gene transcription and protein. Medical search. Frequent questions

CARP was originally identified as a YB-1-associating, cardiac-restricted transcription co-repressor in the homeobox NKX2-5 pathway that is involved in cardiac ventricular chamber specification, maturation and morphogenesis, and whose mRNA levels are exquisitely sensitive to Doxorubicin, mediated through a hydrogen peroxide/ERK/p38MAP kinase-dependent as well as M-CAT cis-element-dependent mechanism. (wikipedia.org)
Liver Specification in the Absence of Cardiac Differentiation Revealed by Differential Sensitivity to Wnt/β Catenin Pathway Activation. (xenbase.org)
FGF pathway is not necessary for Gata4 -induced liver specification in animal cap explants but is required for prolonged period in sandwiches of AE and AC. (xenbase.org)
Therefore, the aim of the present study was to identify a regulatory signaling pathway in cardiac inflammation based on the hypothesis that a distinct subset of inflammation-related activated fibroblasts plays crucial roles in the recruitment of inflammatory cells, especially monocytes/macrophages, and in the pathology of heart failure. (kcl.ac.uk)
Pulsatile shear stress induces ubiquitin-proteasome-mediated degradation of PDCD4 via a PI3K/Akt pathway in HUVECs. (plos.org)
In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. (spandidos-publications.com)
Interestingly, NPM interacts with Toll-like receptor (TLR)4 in these cells and activates an NF-kB-dependent inflammatory pathway upregulating interleukin IL-6 and COX-2 gene expression. (frontiersin.org)
Nucleolar nucleolin has a role in chromatin remodeling and gene transcription, and interestingly enough, Wnt pathway genes were differentially expressed in the RNA-seq data following iSN04 suppression. (shinshu-u.ac.jp)
Chaperonin Containing Tailless Complex Polypeptide 1 (CCT-1) is one of the important elements of protein folding pathway in cells and proteasome is an important component of Adenosine Triphosphate (ATP) dependent protein degradation pathway in cells. (ijpsonline.com)
They are involved in the formation of protein folding/degradation signalling pathway, maintaining the normal spatial structure and normal biological function of protein [ 3 ]. (ijpsonline.com)
The integration of this new information with previous findings has allowed us to draw a more complete pathway of regulatory events during cardiac induction and differentiation in Drosophila . (biologists.com)
We identified a significant induction of epithelial alarmin (thymic stromal lymphopoietin-TSLP)-dependent interleukin-13 pathway after co-exposure, associated with increased mucin and interferon gene expression. (cdc.gov)

An additional study showed that beta-adrenergic signaling via protein kinase A and CaM kinase induces the expression of CARP, and that CARP may have a negative effect on contractile function. (wikipedia.org)
Analysis of this network identified serum response factor (SRF) and myocyte enhancer factor-2 (MEF2) as critical TFs in regulating longitudinal stretch-induced gene changes whose activity is modulated by protein kinase C (PKC). (escholarship.org)
Zhu H, Dai Z, Liu X, Zhou H, Wang Y. Serine/threonine kinase 3 promotes oxidative stress and mitochondrial damage in septic cardiomyopathy through inducing Kelch-like ECH-associated protein 1 phosphorylation and nuclear factor erythroid 2-related factor 2 degradation. (ijbs.com)
13. Pseudolaric acid B induces apoptosis via activation of c-Jun N-terminal kinase and caspase-3 in HeLa cells. (whocc.org.cn)
Lactate dehydrogenase (LDH) and creatine kinase‑MB (CK‑MB) release, infarct size, cardiac function, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities, malondialdehyde (MDA), intracellular reactive oxygen species (ROS), and DJ‑1 protein expression levels were assessed. (spandidos-publications.com)
PTEN also dephosphorylates Src homology 2-containing protein (Shc) directly, and inhibits the activation of Shc/Raf/ERK1/2 (extracellular signal-regulated kinase) signaling cascade. (biomedcentral.com)
Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. (nature.com)
Protein kinase D1 (PKD1), together with PKD2 and PKD3, constitute a family classified within the calcium/calmodulin-dependent protein kinase superfamily 7 . (nature.com)
Excitotoxic production of ROS elevates death-associated protein kinase (DAPK) activity, which provokes neuronal apoptosis in cerebral ischemia and seizure models 8 . (nature.com)

Decreased expression of CARP in cardiac cells within the ischemic region was detected in a rat model of ischemic injury, and was thought to be linked to the induction of GADD153, an apoptosis-related gene. (wikipedia.org)
Another study demonstrated that adenoviral overexpression of CARP in cardiomyocytes enhances cardiac hypertrophy induced by Angiotensin II or pressure-overload and promotes cardiomyocyte apoptosis via p53 activation and mitochondrial dysfunction. (wikipedia.org)
In cardiac conditional Ezh2-knockout mice, cardiomyocyte proliferation was repressed, and the apoptosis process was induced [ 10 ]. (hindawi.com)
In LPS-challenged HL-1 cardiomyocytes, shRNA-mediated STK3 knockdown normalized mitochondrial membrane potential and ATP production, attenuated apoptosis, and rescued antioxidant gene expression by preventing Nrf2 downregulation. (ijbs.com)
Gain of function and loss of function experiments showed that PDCD4 induced turnover (proliferation and apoptosis) of HUVECs. (plos.org)
PDCD4 induces turnover (proliferation and apoptosis) of HUVECs. (plos.org)
Hypoxia/reoxygenation (H/R)-induced cardiomyocyte cell apoptosis is critical in developing myocardial infarction. (biomedcentral.com)

Cardiac myocytes are striated muscle cells with myofilaments running along their length and Z-discs in a transverse direction. (escholarship.org)
By altering the major axis of biaxial, mechanical stretch, I hypothesized that different signaling pathways and transcription regulators would be activated and lead to divergent gene expression profiles in cardiac myocytes. (escholarship.org)
To investigate the effect of stretch axis, cardiac myocytes were cultured on a micropatterned substrate, and the primary stretch axis was applied either parallel or transverse to the myofibril direction. (escholarship.org)
The network model provides evidence that cardiac myocytes engage different transcriptional regulators in response to different principal orientations of biaxial stretch. (escholarship.org)
In addition, studies are pursued related to diabetic cardiomyopathy and the effects of excessive enzymatic protein glycosylation in cardiac myocytes and their influence on heart function. (ucsd.edu)
In addition, matrine and oxymatrine significantly shortened the prolonged action potential duration induced by probucol in neonatal cardiac myocytes. (current-pharmaceutical-design.com)

Retinoid Receptor-Mediated Signaling in Cardiac Redecorating Cardiac remodeling includes a main role within the development to HF, that is associated with modifications within the ventricular framework and function, caused by myocardial damage, pressure or quantity overload. (researchassistantresume.com)
Myocardial ischemia, also called cardiac ischemia or hypoxia/reoxygenation (H/R)-induced heart damage, is caused by decreased blood flow [ 1 ]. (biomedcentral.com)
Given that MMP-9 is an AP-1 target gene involved in cardiac remodeling, myocardial dysfunction and progression of heart failure, these findings suggest that miR-146a might be a new and promising therapeutic tool for treating cardiac disorders associated with enhanced inflammation in the heart. (jefferson.edu)
Compounds that target tissue-specific transcription factors could overcome non-specific effects of small molecules and lead to the regeneration of heart muscle following myocardial infarction. (biomedcentral.com)
In addition, IPC reduced LDH and CK‑MB release, attenuated myocardial infarct size, improved cardiac function following I/R, and inhibited the elevation of ROS and MDA and the decrease in activities of the antioxidant enzymes SOD, CAT and GPx. (spandidos-publications.com)
Prolonged oxygen deprivation due to reduced blood flow to cardiac or peripheral tissues can lead to myocardial infarction and peripheral vascular disease, respectively. (umn.edu)
The team, led by Associate Professor Tomohide Takaya from the Department of Agricultural and Life Sciences at Shinshu University, recently discovered that an anti-nucleolin aptamer, myogenetic oligodeoxynucleotide iSN04, induced myocardial differentiation in embryonic stem cells (ESCs). (shinshu-u.ac.jp)
In Drosophila , the primordial cells generating myocardial cells(cardioblasts) and pericardial cells are induced within mesodermal areas receiving a combination of Dpp (i.e. (biologists.com)

In a transgenic mouse model of cardiac-specific overexpression of CARP, mice exhibited normal physiology at baseline, but were protected against pathological cardiac hypertrophy induced via pressure-overload or isoproterenol, which could be attributed to the downregulation of the ERK1/2, MEK and TGFbeta-1 pathways. (wikipedia.org)
Our hypothesis is that activation of nuclear-localised RSK1 in addition to RSK2 promotes changes in gene expression that are not compatible with compensated hypertrophy induced by α1ARs. (bmj.com)

Furthermore, the decreased expression of the EZH2 gene is crucial for stem cell differentiation into specific cell lineages involved in myogenesis, adipogenesis, osteogenesis, neurogenesis, and haematopoiesis [ 9 ]. (hindawi.com)
Histamine and its receptors represent a complex system of immunoregulation with distinct effects mediated by four GPCRs (G protein-coupled receptors HRs 1-4) and their differential expression, which changes according to the stage of cell differentiation and microenvironmental influences. (hindawi.com)
Chemical compounds that modulate atrial and ventricular cell fate could be used to improve subtype-specific differentiation of endogenous or exogenously delivered progenitor cells in order to promote cardiac regeneration. (biomedcentral.com)
4. 5-azacytidine induces cardiac differentiation of P19 embryonic stem cells. (whocc.org.cn)
Aptamers are single-stranded pieces of DNA that bind to target proteins and are able to modulate signaling cascades during cell differentiation when a stem cell commits to a specific functional role or phenotype. (shinshu-u.ac.jp)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. (nih.gov)
The germline mutations of cardiac specific transcription factors are the major causes of CHD. (city-made.com)
[ 2 , 3 , 4 ] A full list of the described mutations is available at the TBX5 Gene Mutation Database , an online locus-specific database that contains germline and somatic mutations of the TBX5 gene. (medscape.com)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)
Antigenic drift involves small mutations in the genes of influenza viruses that lead to changes in HA and NA that accumulate over time, resulting in the emergence of novel strains that the human immune system may not recognize. (cdc.gov)

After 30 minutes of stretch, 53 and 168 genes were considered differentially expressed (DE) from transverse and longitudinal stretch, respectively. (escholarship.org)
Therefore, in this study, tensor decomposition (TD)-based unsupervised feature extraction (FE)-which is the extension of a recently proposed principal component analysis-based unsupervised FE that has been successfully applied to various bioinformatics problems [ 5 - 22 ]-was used for various gene expression profiles of murine tissues with the aim to find genes coexpressive or differentially expressed between stressful and unstressful conditions in the brain and heart. (biomedcentral.com)

Subsequent studies showed that CARP expression in cardiomyocytes is regulated by alpha-adrenergic signaling, in part via the transcription factor GATA4. (wikipedia.org)
RNA sequencing (RNA-Seq) was conducted to study whole genomic expression changes after acute cardiac myocyte stretch. (escholarship.org)
whereas longitudinal but not transverse stretch induced expression of genes involved in sarcomere organization and cytoskeletal protein binding. (escholarship.org)
This network model was used in conjunction with the RNA-Seq data to identify the mechanisms regulating gene expression changes due to longitudinal and transverse stretch. (escholarship.org)
Here, we identified the coding sequence of the EZH2 gene and characterized its expression pattern in fetal tissues of Duroc pigs at 65- and 90-day postcoitus (dpc). (hindawi.com)
Polycomb Group (PcG) proteins are a family of protein complex that regulate gene expression, especially repressing gene transcription [ 1 ]. (hindawi.com)
Since identification of EZH2 in the research of protooncogene product Vav [ 3 ], studies have shown that EZH2 is highly expressed in tumorigenesis, which regulates the expression of tumor suppressor genes, such as in breast cancer, prostate cancer, and lung cancer [ 4 - 6 ]. (hindawi.com)
Thus, the appropriate expression level of the EZH2 gene is important for embryonic development. (hindawi.com)
However, the transcript and expression status of the EZH2 gene during porcine embryonic development remains unknown. (hindawi.com)
Subsequently, we detected the expression of EZH2 on mRNA level and protein level in two different embryonic development stages (65-dpc and 90-dpc) via qRT-PCR and western blots. (hindawi.com)
ERK1/2 and RSKs phosphorylate transcription factors producing changes in gene expression. (bmj.com)
Lesser ERK1/2 activation by PE causes nuclear activation of only RSK2, and this signalling is associated with a different gene expression profile. (bmj.com)
Our aim was to investigate if expression of nuclear-localised RSK1 is detrimental to the hypertrophic response induced in vivo by PE. (bmj.com)
A) RT-PCR showing expression of cardiac fate marker myl7 , liver fate marker nr1h5 and control marker odc1 in Gata4 mRNA-injected ACs , control ACs and stage 33 sibling control embryo . (xenbase.org)
Examination of gene expression in st. 43 AC/AE explants by RT-PCR reveals expression of liver (fabp1), intestine (fabp2), pancreas (pdia2 and pdx1 , but not ins and amy2a), thyroid/lung (nkx2-1) as well as ventricular cardiomyocyte (myl3) markers. (xenbase.org)
LPS treatment upregulated cardiac STK3 expression. (ijbs.com)
Accordingly, transfection of phosphodefective KEAP1 mutant protein in cardiomyocyte restored Nrf2 expression and mitochondrial performance upon LPS, while expression of a phosphomimetic KEAP1 mutant abolished the mitochondria-protective and pro-survival effects of STK3 deletion. (ijbs.com)
They then examined the mRNA expression pattern at a single cell level using so-called single-cell RNA sequencing analysis and found a subset of cardiac fibroblasts highly expressed genes activated by the transcription factor NF-kB and CCL2 mRNA. (kcl.ac.uk)
Thanks to advancements in gene expression profiling, it is now possible to search for disease biomarkers on an unprecedented scale.Here we applied a selection of five machine learning (ML) approaches to identify blood-based biomarkers for Alzheimer's (AD) and Parkinson's disease (PD) with the application of multiple feature selection methods. (bvsalud.org)
We demonstrated that convolutional neural networks perform consistently well across both the Alzheimer's (ROC AUC = 0.810) and Parkinson's (ROC AUC = 0.715) datasets, suggesting its potential in gene expression biomarker detection with increased tuning of their architecture. (bvsalud.org)
Also, studies are conducted related to the expression of specific heat shock proteins and protection of the heart against cardiac ischemia. (ucsd.edu)
Immunoprecipitation revealed that pulsatile shear stress induced the coupling of ubiquitin with PDCD4 expression. (plos.org)
In addition, STA enhanced SIRT1, Nrf2, and HO-1 protein expression in H/R-stimulated H9c2 cells. (biomedcentral.com)
The expression of the antioxidant protein is stimulated to perform an antioxidant function after Nrf2 has been triggered, whereas the amounts of ROS are restrained [ 13 ]. (biomedcentral.com)
miR-146a targets Fos expression in human cardiac cells. (jefferson.edu)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
Chemically induced gene expression changes were characterized by qRT-PCR, global run-on sequencing (GRO-seq) and immunoblotting, and the network of cooperative proteins of GATA4 and NKX2-5 were further explored by the examination of the GATA4 and NKX2-5 interactome by BioID. (biomedcentral.com)
Reporter gene assays were conducted to examine combinatorial effects of GATA-targeted compounds and bromodomain and extraterminal domain (BET) inhibition on chamber-specific gene expression. (biomedcentral.com)
GATA4-targeted compounds 3i-1000 and 3i-1103 were identified as differential modulators of atrial and ventricular gene expression. (biomedcentral.com)
In this line, reporter gene assays with combinatorial treatment of 3i-1000 and the BET bromodomain inhibitor (+)-JQ1 demonstrated the cooperative role of GATA4 and BRD4 in the modulation of chamber-specific cardiac gene expression. (biomedcentral.com)
2. Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-gamma. (whocc.org.cn)
7. Transgenic expression of Korean type hepatitis C virus core protein and related mutants in mice. (whocc.org.cn)
IPC caused a significant increase in the expression levels of DJ‑1 protein. (spandidos-publications.com)
Probucol, a cholesterol-lowering drug, induces LQTs by inhibiting the expression of the hERG channel. (current-pharmaceutical-design.com)
Western blot was performed to measure the expression levels of proteins. (current-pharmaceutical-design.com)
We proposed a novel mechanism underlying the probucol induced decrease in the expression of transcription factor Specificity protein 1 (Sp1), which is an established transactivator of the hERG gene. (current-pharmaceutical-design.com)
We also demonstrated that matrine and oxymatrine were able to upregulate Sp1 expression which may be one of the possible mechanisms by which matrine and oxymatrine rescued probucol-induced hERG channel deficiency. (current-pharmaceutical-design.com)
Moreover, NPM is crucial for inflammatory gene expression induced by tumor necrosis factor alpha (TNF-α) and lipopolysaccharides (LPS) in fibroblasts and macrophages ( 6 ). (frontiersin.org)
Recently, noncoding RNAs (ncRNAs) have been reported to regulate protein expression, and it is definite that PTEN expression is controlled by ncRNAs epigenetically or posttranscriptionally as well. (biomedcentral.com)
The team postulates that the iSN04-anchored nucleolin alters gene expression and Wnt signaling. (shinshu-u.ac.jp)
In this study, gene expression profiles of various murine tissues observed under various types of stress or without stress were analyzed in an integrated manner using tensor decomposition (TD). (biomedcentral.com)
Furthermore, the top 10 genes encoding protein-, DNA-, or mRNA-interacting proteins were identified as those governing expression of these ∼ 400 genes and are possible therapeutic targets in PTSD-mediated heart diseases according to other reports. (biomedcentral.com)
The gene expression profiles used in this study were downloaded from the Gene Expression Omnibus (GEO) database (GEO ID GSE68077). (biomedcentral.com)
The gene expression profile was standardized (i.e., means and variances in each sample are 0 and 1, respectively). (biomedcentral.com)
To perform gene selection using gene singular value vectors, \(x_{\ell _{1},i_{1}}\) for synthetic data and \(x_{\ell _{5},i}\) for real gene expression profiles, we have to decide which singular value vectors are used for the selection. (biomedcentral.com)
Resistance (IR) by affecting the expression of skeletal muscle related genes [ 1 ]. (ijpsonline.com)
As the expression vector of life information, the specific spatial structure formed by protein folding is the basis of its biological function. (ijpsonline.com)
In an early step, the Dorsocross genes act in parallel with tinman to activate the expression of pannier , a cardiogenic gene encoding a Gata factor. (biologists.com)
Our loss- and gain-of-function studies, as well as the observed genetic interactions among Dorsocross, tinman and pannier , suggest that co-expression of these three genes in the cardiac mesoderm, which also involves cross-regulation, plays a major role in the specification of cardiac progenitors. (biologists.com)
Consequent abnormal expression of the cardiac and limb-specific T-box transcription factors lead to the malformations described in HOS. (medscape.com)
Compared with individual exposures, co-exposure aerosols produced greater acellular and cellular oxidants detected by electron paramagnetic resonance (EPR) spectroscopy, and in vivo immune-spin trapping (IST), as well as synergistically increased lavage neutrophils, lavage proteins and inflammation related gene/protein expression. (cdc.gov)

The binding sites of T-box transcription factor TBX5 and NK-2 transcription factor-related locus 5 Nkx2.5, which were expressed at higher levels in aortic smooth muscle cells than in T cells, were located within the −387 to +97 NFAT3 promoter region, exhibiting the maximum enhancer activity. (aai.org)
It has been reported that NKX2-5, GATA-4 and TBX5 are the key genes associated with the occurrence of simple CHD. (city-made.com)
The research reveals multiple subpopulations of cardiomyocytes expressing specific transcription factors (NR2F2, TBX5 and HEY2) - with different spatial and biological functions as observed in the heart. (azbio.org)
The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)

Importantly, the transition from hypertrophy to heart failure is associated with a decrease in cardiac contractility, ventricular remodeling and fibrosis, and myocyte loss. (bmj.com)
Our results demonstrate that miR-146a transcript levels were sharply increased in cardiac ventricular tissue of transgenic mice with specific overexpression of TNF-α in the heart, and also in a cardiomyocyte cell line of human origin (AC16) exposed to TNF-α. (jefferson.edu)
Due to cellular heterogeneity in the heart, the activation of gene programs representing specific atrial and ventricular cardiomyocyte subtypes would be highly desirable. (biomedcentral.com)
Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
Furthermore, it is unknown whether endogenous progenitors/stromal cells in the adult human heart could be chemically induced to generate functional atrial or ventricular heart muscle to treat adult heart diseases. (biomedcentral.com)
A research team led by Jared Churko, PhD, director of the University of Arizona iPSC Core in the UA Sarver Heart Center, used a transcriptomic approach - studying what genes are expressed - to identify gene signatures of cell subpopulations identified as atrial-like or ventricular-like. (azbio.org)

A team of researchers, led by Professor Kinya Otsu, showcase how a distinct subset of cardiac fibroblasts become activated by pressure overload and attract monocytes to the heart. (kcl.ac.uk)
They found that cardiac fibroblasts can produce CCL2 and name the cells inflammatory fibroblasts. (kcl.ac.uk)
In the mouse which did not express the NF-kB activator IKKb in cardiac fibroblasts, pressure overload induced less monocyte recruitment and did not induce heart failure. (kcl.ac.uk)
The adult heart contains many resident cardiac fibroblasts, which play important roles in maintaining tissue architecture. (kcl.ac.uk)
In response to tissue injury or stress, the resident cardiac fibroblasts undergo a transition to activated myofibroblasts, a highly synthetic cell type that induces the genes encoding smooth muscle α actin (ACTA2) and collagen. (kcl.ac.uk)
To conclude, we found that a subset of cardiac fibroblasts involved in cardiac inflammation under stress. (kcl.ac.uk)
Here, we provide evidence that exposure of human skin fibroblasts to a Radio Electric Asymmetric Conveyer (REAC), an innovative device delivering radio electric conveyed fields at a radiofrequency of 2.4 GHz, afforded remarkable commitment toward cardiac, neuronal, and skeletal muscle lineages. (nih.gov)
Both the innate stimuli, such as lipopolysaccharides and Poly inositol-cytosine and adaptive stimuli, that is, cytokine mix, were able to induce the extracellular release of NPM in immortalized keratinocytes and human skin fibroblasts in the absence of cytotoxicity. (frontiersin.org)

in offering the impetus for producing novel therapeutic methods for the avoidance and treatment of diabetes-induced cardiac problems and heart failing. (researchassistantresume.com)

Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
Cardiac mitochondrial function is altered in a variety of inherited and acquired cardiovascular diseases. (jci.org)

We uncovered two mechanisms of nucleolin interference with iSN04 at play whereby early treatment inhibits cardiomyogenesis, while treatment at a later stage enhances the generation of cardiac progenitors. (shinshu-u.ac.jp)
hence,the cardiac progenitors are generated in bilateral, segmentally repeated areas of the dorsal mesoderm of the early embryo. (biologists.com)

CARP is highly expressed in cardiac and skeletal muscle, and is a transcription factor involved in development and under conditions of stress. (wikipedia.org)
To address some of the limitations of these models, here we used two complementary ex vivo models based on Xenopus embryos: pluripotent animal cap explants expressing Gata4 transcription factor and conjugates of gastrula -stage AE with animal caps (AC). (xenbase.org)
STK3-mediated phosphorylation of Kelch-like ECH-associated protein 1 (KEAP1) was shown to suppress antioxidant gene transcription controlled by nuclear factor erythroid 2-related factor 2 (Nrf2) in macrophages. (ijbs.com)
Elevated intracellular calcium levels activate calcineurin, which in turn then dephosphorylates the transcription factor nuclear factor of activated T cells (NFAT) in the cytoplasm. (bmj.com)
Sirt1 has the ability to control crucial transcription factors like nucleus erythroid factor 2-related factor 2 (Nrf2), which is crucial for cytoprotection, the anti-inflammatory response, and the antioxidant response [ 11 ]. (biomedcentral.com)
In the leucine zipper transcription factor family [ 12 ], Nrf2 is an antioxidant sensor and regulator of intracellular ROS preparation. (biomedcentral.com)
miR-146a is a microRNA whose transcript levels are induced in the heart upon activation of NF-κB, a transcription factor induced by pro-inflammatory molecules (such as TNF-α) that is strongly related to the pathogenesis of cardiac disorders. (jefferson.edu)
These changes correlated with a diminution in the DNA-binding activity of AP-1, the Fos-containing transcription factor complex. (jefferson.edu)
NKX2-5 is a gene which encodes a homeobox-containing transcription factor. (city-made.com)
Mammalian cells respond to hypoxia by modulating oxygen-sensing transducers that stabilize the transcription factor hypoxia-inducible factor 1α (HIF-1α), which transactivates genes governing angiogenesis and metabolic pathways. (umn.edu)
The Nature Communications article is titled, "Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis. (azbio.org)
We previously showed that genotoxic stress induced an active extracellular release of nucleophosmin (NPM) in human cardiac mesenchymal progenitor cells, and that serum deprivation provokes NPM secretion from human endothelial cells, eliciting inflammation via nuclear factor kappa B (NF-kB) transcriptional activation. (frontiersin.org)
It also regulates the stability and activity of transcription factors including p53 and nuclear factor kappa B (NF-κB) ( 5 , 6 ). (frontiersin.org)
Epidermal growth factor (EGF) and fibroblast growth factor 2 (FGF-2) induce the proliferation of neural precursor cells isolated from specific regions of the embryonic and adult brain. (beauty104.com.tw)
In this study we used phosphorylation of the transcription factor cAMP response element-binding protein as a functional readout to identify cells responding to EGF and FGF-2. (beauty104.com.tw)
A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)

Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine. (shinshu-u.ac.jp)
The T-box gene family is a group of related genes that play a critical role in human embryonic development. (medscape.com)

Our results provide insight into the mechanisms underlying cardiac inflammation and fibroblast-mediated inflammatory responses that could be therapeutically targeted to treat heart failure. (kcl.ac.uk)
Ample evidence shows that pro-atherosclerotic disturbed flow induces sustained activation of atherogenic genes in endothelial cells to promote their oxidation, inflammation, cell cycle progression and proliferation, whereas pulsatile shear stress tends to maintain endothelial cells in a quiescent and less proliferative state with a low level of oxidation and inflammation [16] , [17] . (plos.org)
C diphtheriae infection typically is characterized by a local inflammation, usually in the upper respiratory tract, associated with toxin-mediated cardiac and neural disease. (medscape.com)
In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. (hindawi.com)

The cardiac fibroblast might therefore be a therapeutic target to treat patients with heart failure. (kcl.ac.uk)
Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
Unfortunately, there is currently no effective therapeutic method to rescue probucol-induced LQTs. (current-pharmaceutical-design.com)
Conclusion: Our current results demonstrate that matrine and oxymatrine could rescue probucol-induced hERG deficiency in vitro, which may lead to potentially effective therapeutic drugs for treating acquired LQT2 by probucol in the future. (current-pharmaceutical-design.com)

His son presented with cardiac conduction disturbance with no congenital heart or skeletal defect. (medscape.com)

In cardiomyocytes treated with doxorubicin, a model of anthracycline-induced cardiomyopathy, CARP mRNA and protein levels were depleted, myofilament gene transcription was attenuated and sarcomeres showed significant disarray. (wikipedia.org)
To explore whether STK3 induces KEAP1-mediated suppression of Nrf2 in septic cardiomyopathy, wild-type and global STK3 knockout (STK3 -/- ) mice were treated with LPS. (ijbs.com)
Mice homozygous for a knock-out allele exhibit impaired cardiac muscle contractility, wider Z-lines, and dilated cardiomyopathy. (jax.org)

DJ‑1 protein, as a multifunctional intracellular protein, has been demonstrated to serve a critical role in regulating cell survival and oxidative stress. (spandidos-publications.com)
To provide in vivo evidence that DJ‑1 is involved in the delayed cardioprotection induced by ischemic preconditioning (IPC) against oxidative stress caused by ischemia/reperfusion (I/R), the present study subjected male Sprague‑Dawley rats to IPC (3 cycles of 5‑min coronary occlusion/5‑min reperfusion) 24 h prior to I/R (30‑min coronary occlusion/120‑min reperfusion). (spandidos-publications.com)
However, in situ knockdown of DJ‑1 attenuated the IPC‑induced delayed cardioprotection, and reversed the inhibitory effect of IPC on I/R‑induced oxidative stress. (spandidos-publications.com)
Notably, DJ‑1 is required for IPC to inhibit I/R‑induced oxidative stress. (spandidos-publications.com)
Previous studies have revealed that the delayed cardioprotective mechanisms underlying IPC are complex and involve upregulation of endogenous cardioprotective proteins and oxidative stress inhibition ( 5 - 7 ). (spandidos-publications.com)
Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. (nature.com)

In contrast, BMP signaling is shown to be essential for Gata4 -induced liver specification. (xenbase.org)
A,B) Marker gene analysis in Gata4 -expressing animal caps. (xenbase.org)
A′) Western blotting shows efficient translation of exogenous Gata4 protein. (xenbase.org)
Additionally, BioID analysis indicated broad interaction between GATA4 and BET family of proteins, such as BRD4. (biomedcentral.com)

CARP has been localized to nuclei and Z-discs in animal and human muscle cells, and at intercalated discs in human cardiac muscle cells. (wikipedia.org)
In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells. (intechopen.com)
These cells acquire the capability to contract, migrate, proliferate, elaborate extracellular matrix and mediate the development of cardiac fibrosis. (kcl.ac.uk)
Can recapitulate that phenomenon by growing skin cells with 3 transcription factors (gene regulators). (oneradionetwork.com)
Induced pluripotent stem cells can be persuaded to become a specific tissue type. (oneradionetwork.com)
En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
Application of unidirectional pulsatile shear stress to human umbilical vein endothelial cells (HUVECs) decreased PDCD4 protein but not mRNA level. (plos.org)
Interestingly, AP-1 inhibition was accompanied by a reduction in matrix metalloproteinase (MMP)-9 mRNA levels in human cardiac cells. (jefferson.edu)
Researchers believe that human-induced pluripotent stem cells (hiPSC) are the key to unlocking this regenerative ability. (azbio.org)
Understanding the gene signatures of different populations of hiPSC-CMs will impact our understanding of how to use such cells to discover drugs, model heart disease and repair a damaged heart," Dr. Churko explained. (azbio.org)
Priming of striatal cells for 24 hr with FGF-2 but not with EGF was sufficient to induce the appearance of EGF- and FGF-2 responsive cells after only 2 d in vitro. (beauty104.com.tw)
Self-renewal and pluripotency-the capacity to form any cell lineage-are inherent characteristics of induced pluripotent stem cells (iPSCs). (shinshu-u.ac.jp)
However, when these pluripotent stem cells were treated after experiencing differentiating conditions for five days, specific marker genes were upregulated, and the cells committed to forming beating cardiomyocytes. (shinshu-u.ac.jp)

Programmed cell death 4 (PDCD4) is an important tumor suppressor in the development of various human cancers [1] and inhibits translation rather than transcription. (plos.org)

Advances in molecular biology and genome analysis now also allow for detailed descriptions of DNA-binding transcription factors and transcriptional regulatory networks. (medscape.com)
Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. (biomedcentral.com)
Whole genome and transcriptome sequencing of post-mortem cardiac tissues from sudden cardiac death victims identifies a gene regulatory variant in NEXN. (nih.gov)
Regulatory mechanism of human vascular smooth muscle cell phenotypic transformation induced by NELIN. (nih.gov)
The protein-centered research could not uncover all the gene regulatory and signaling pathways to sustain the healthy heart. (amegroups.org)
The emergence of non-protein-coding RNAs (ncRNAs), especially microRNAs (miRNAs) and more recent long non-coding RNAs (lncRNAs), has shed a light on further dissecting the gene regulatory networks of the heart ( 3 , 4 ). (amegroups.org)
Yet, the deaths related to cardiovascular disease still ranks the top among all causes of deaths in industrialized countries ( 5 ), calling for further understanding of cardiac gene regulatory networks. (amegroups.org)
Studies in several vertebrate models and Drosophila have uncovered a surprising degree of evolutionary conservation of regulatory mechanisms and genes that control early cardiogenesis. (biologists.com)

DJ-1, a novel oncogene product identified in 1997, is a ubiquitously expressed and highly conserved intracellular protein ( 11 ). (spandidos-publications.com)

Echocardiography was used to assess cardiac function/dimensions at baseline and following treatment. (bmj.com)
Echocardiography is considered the most reliable noninvasive test to establish the diagnosis, assess cardiac function, and exclude associated structural heart disease. (medscape.com)

Although researchers have identified sensors, pathways, and TFs involved in cardiac mechanotransduction, I, for the first time, integrated this information into a logic-based network model of cardiac myocyte stretch signaling. (escholarship.org)
The pathways related to cell protein folding and degradation need to be elucidated because of training was set. (ijpsonline.com)

RAR and RXR modulate gene manifestation by performing as ligand-dependent transcription elements. (researchassistantresume.com)

On the mobile level, cardiac redecorating is seen as a cardiomyocyte hypertrophy, fibroblast hyperplasia associated with a rise in collagen deposition inside the interstitial matrix (fibrosis) and cell loss of life. (researchassistantresume.com)

mice displayed normal cardiac function at baseline and in response to pressure overload-induced cardiac hypertrophy, suggesting that these proteins are not essential. (wikipedia.org)

Conversely, REAC treatment elicited a biphasic effect on a number of stemness-related genes, leading to early transcriptional increase of Oct4, Sox2, cMyc, Nanog, and Klf4 within 6-20 h, followed by a downregulation at later times. (nih.gov)
The REAC action bypassed a persistent reprogramming toward an induced pluripotent stem cell-like state and involved the transcriptional induction of the NADPH oxidase subunit Nox4. (nih.gov)

This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. (cusabio.com)

The NFAT family transcription factors play crucial roles in immunological and other biological activities. (aai.org)
Proteins that act both at the cell surface and intracellularly will be discussed in this thesis, with particular emphasis on the fibroblast growth factors. (beauty104.com.tw)
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
In all these organisms, cardiac induction in the lateral mesoderm involves the concerted action of signals mediated by Bmp, Wnt and Fgf family members, which act upon cardiogenic genes encoding NK homeodomain, Gata and T-box transcription factors (reviewed by Zaffran and Frasch, 2002 ). (biologists.com)

Mice heterozygous for a gene trap allele exhibit impaired response to methamphetamine. (jax.org)

Our present study identifies the Dorsocross T-box genes as key mediators of combined Dpp and Wg signals during this process. (biologists.com)

Conclusions Increased nuclear-localised RSK1 in cardiomyocytes promotes cardiac hypertrophy, but compromises the compensated hypertrophic response to PE. (bmj.com)
After binding to mobile retinoic acidity binding Necrostatin-1 IC50 protein (CRABP), ATRA is usually transported in to the nucleus and binds to nuclear receptors to modify gene transcription or sent to cytochrome (CYP) enzymes for degradation [66,67]. (researchassistantresume.com)
Activation of PPARγ nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism. (globalrph.com)
Activation of PPARγ nuclear receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. (globalrph.com)
11. The nuclear 16-kD protein methylation increases in the early period of liver regeneration in a hepatectomized rat. (whocc.org.cn)

Background: The human ether-a-go-go-related gene (hERG) potassium channel is the rapidly activating component of cardiac delayed rectifier potassium current (IKr), which is a crucial determinant of cardiac repolarization. (current-pharmaceutical-design.com)

NT-proBNP and BNP are potential early biomarkers for 2-DG-induced cardiac toxicity that can be useful to monitor 2-DG therapy in clinical trials. (cusabio.com)
The combination of the exposure chamber and the ALI-based model is promising for assessing 3-D printer emission-induced toxicity. (cdc.gov)

therefore, as yet unidentified antioxidant proteins may additionally be involved. (spandidos-publications.com)
Cardioprotective effects of rutin via alteration in TNF-alpha, CRP, and BNP levels coupled with antioxidant effect in STZ-induced diabetic rats. (cusabio.com)

This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. (nih.gov)

Alternative splicing of gene can generate multiple transcripts and proteins to regulate tissue and organ development [ 17 ]. (hindawi.com)
Takes 7 days to grow cardiac tissue, 21 days for brain tissue. (oneradionetwork.com)
Proteomics is the study of proteomes, the proteins expressed by a cell, tissue or organism. (azbio.org)

During gastrulation anterior endoderm (AE) provides cardiogenic signals that act on adjacent mesoderm , resulting in induction of cardiac precursors. (xenbase.org)
Subsequently cardiogenic mesoderm generates a FGF signal that acts on adjacent AE to induce foregut organ specification. (xenbase.org)

Our results indicate that PKD1 inactivation underlies excitotoxicity-induced neuronal death and suggest that PKD1 inactivation may be critical for the accumulation of oxidation-induced neuronal damage during aging and in neurodegenerative disorders. (nature.com)

Sugar coats proteins, and the protein loses its function. (oneradionetwork.com)
To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. (spandidos-publications.com)
Co-exposure induced a significantly greater respiratory function decline compared to individual exposure. (cdc.gov)

The macrophage produces inflammatory cytokines, which is a small protein that influences the immune systems and damages to the heart. (kcl.ac.uk)
The main goal of this study consisted of studying new roles of miR-146a in cardiac pathological processes caused by the pro-inflammatory cytokine TNF-α. (jefferson.edu)

In addition, PPARγ-responsive genes also participate in the regulation of fatty acid metabolism. (globalrph.com)
This indicated the involvement of epigenetic modulators in the regulation of GATA-dependent transcription. (biomedcentral.com)

Human cardiac ankyrin repeat protein is a 36.2kDa protein composed of 319 amino acids. (wikipedia.org)
Improved induction of antibodies against key neutralizing epitopes by human immunodeficiency virus type 1 gp120 DNA prime-protein boost vaccination compared to gp120 protein-only vaccination. (southernbiotech.com)
6. Zbytek B, Wortsman J, Slominski A. Characterization of a ultraviolet B-induced corticotropin-releasing hormone-proopiomelanocortin system in human melanocytes. (southernbiotech.com)

Research have shown a reduced plasma degree of retinol in type 1 diabetics and in streptozotocin-induced diabetic pet versions [92,93] which eating supplementation of supplement A inhibits the introduction of type 1 diabetes [94]. (researchassistantresume.com)

This is in contrast to (B), where injection of cer1 or hhex MOs in AE leads to downregulation of both cardiac and liver marker gene mRNA levels in conjugates. (xenbase.org)

Research interests in the laboratory include thyroid hormone action in the heart, especially, thyroid hormone-induced alterations in the transcription of the gene coding for the Ca2+ ATPase and the role which specific thyroid hormone receptor isoforms play in the heart. (ucsd.edu)
Our purpose was to identify genes linking PTSD and heart diseases. (biomedcentral.com)
Based upon the obtained features, ∼ 400 genes were identified as candidate genes that may mediate heart diseases associated with PTSD. (biomedcentral.com)
TD-based unsupervised feature extraction turned out to be a useful method for gene selection and successfully identified possible genes causing PTSD-mediated heart diseases. (biomedcentral.com)
After cardioblast specification, the Dorsocross genes are re-expressed in a segmental subset of cardioblasts, which in the heart region develop into inflow valves (ostia). (biologists.com)
Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures. (bvsalud.org)

Diagnosis was based on reverse transcription polymerase chain reac- tion, and patients were classified as mild, moderate or critical. (who.int)

The results showed that chaperonin containing tailless complex polypeptide the large number of proteins involved, the complex relationship between proteins and the lack of research on the effects of movement and cell protein folding and degradation. (ijpsonline.com)

Our previous study revealed that hypoxia preconditioning of H9c2 cardiomyocytes significantly increased the de novo synthesis of DJ-1 and induced cardioprotection against prolonged hypoxic injury 24 h later ( 17 ). (spandidos-publications.com)
Hypoxia-induced miR-424 was regulated by PU.1-dependent transactivation. (umn.edu)

Anatomy20

Organisms12

Diseases12

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes77

Disciplines and Occupations2

Information Science3

Pathway12

Kinase9

Apoptosis7

Myocytes6

Myocardial8

Hypertrophy induced2

Differentiation5

Mutations6

Differentially expressed2

Expression51

Tbx54

Ventricular6

Fibroblasts8

Diabetes-induced cardiac1

Mitochondrial2

Progenitors2

Factor16

Embryonic2

Inflammation4

Therapeutic4

Skeletal1

Cardiomyopathy3

Oxidative stress6

GATA44

Cells13

Tumor1

Regulatory8

Intracellular1

Assess cardiac function2

Pathways2

Modulate1

Fibrosis1

Pressure-overload1

Transcriptional2

Vivo1

Factors4

Mice1

Identifies1

Nuclear5

Crucial1

Toxicity2

Antioxidant2

Encodes1

Tissue3

Cardiogenic2

Underlies1

Function3

Inflammatory2

Regulation2

Human3

Diabetic1

Downregulation1

Heart6

Diagnosis1

Degradation1

Hypoxia2