Induces apoptosis of hepatocytes. Medical search. Frequent questions

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Anatomy30

Hepatocytes Liver Cells, Cultured Cell Line, Tumor Mitochondria Tumor Cells, Cultured Cell Line Jurkat Cells HL-60 Cells Hep G2 Cells Cell Nucleus Mitochondria, Liver Epithelial Cells HeLa Cells Cytosol Kupffer Cells Fibroblasts Cell Membrane Endoplasmic Reticulum Bile Canaliculi Cell Line, Transformed U937 Cells Bile Ducts T-Lymphocytes Microsomes, Liver Mitochondrial Membranes Subcellular Fractions Intracellular Membranes Cytoplasm Macrophages

Organisms10

Rats, Inbred Strains Rats, Sprague-Dawley Rats, Wistar Mice, Inbred C57BL Mice, Knockout Rats, Inbred F344 Mice, Transgenic Adenoviridae Mice, Nude Mice, Inbred BALB C

Diseases9

Necrosis Liver Neoplasms, Experimental Carcinoma, Hepatocellular Liver Neoplasms Disease Models, Animal Drug-Induced Liver Injury Liver Diseases Colonic Neoplasms Cell Transformation, Neoplastic

Chemicals and Drugs131

Caspases Apoptosis Regulatory Proteins Caspase 3 Proto-Oncogene Proteins c-bcl-2 Inhibitor of Apoptosis Proteins bcl-2-Associated X Protein X-Linked Inhibitor of Apoptosis Protein Apoptosis Inducing Factor CASP8 and FADD-Like Apoptosis Regulating Protein Caspase 9 Caspase Inhibitors Caspase 8 Fas Ligand Protein Tumor Suppressor Protein p53 RNA, Messenger Cytochromes c bcl-X Protein Annexin A5 Proto-Oncogene Proteins Cysteine Proteinase Inhibitors Enzyme Inhibitors Amino Acid Chloromethyl Ketones Reactive Oxygen Species Antineoplastic Agents Poly(ADP-ribose) Polymerases Tumor Necrosis Factor-alpha RNA, Small Interfering TNF-Related Apoptosis-Inducing Ligand Membrane Glycoproteins Glucagon Caspase 7 Carrier Proteins NF-kappa B Proto-Oncogene Proteins c-akt Cytochrome c Group BH3 Interacting Domain Death Agonist Protein Albumins Myeloid Cell Leukemia Sequence 1 Protein bcl-2 Homologous Antagonist-Killer Protein Glutathione Protein-Serine-Threonine Kinases Asialoglycoproteins Membrane Proteins Staurosporine DNA-Binding Proteins Transcription Factors Ceramides Proteins DNA Receptors, TNF-Related Apoptosis-Inducing Ligand Antineoplastic Agents, Phytogenic Mitogen-Activated Protein Kinases bcl-Associated Death Protein Cycloheximide Neoplasm Proteins Fas-Associated Death Domain Protein Asialoglycoprotein Receptor Liver Glycogen Recombinant Proteins Cysteine Endopeptidases Phenobarbital Caspase 2 Cytochrome P-450 Enzyme System 2-Acetylaminofluorene p38 Mitogen-Activated Protein Kinases Receptors, Tumor Necrosis Factor Intracellular Signaling Peptides and Proteins Phosphatidylinositol 3-Kinases Calcium Apoptotic Protease-Activating Factor 1 Nuclear Proteins Phosphorylase a Cyclin-Dependent Kinase Inhibitor p21 Culture Media, Serum-Free Hydrogen Peroxide Insulin Glucose Caspase 1 Dihydroxyacetone L-Lactate Dehydrogenase DNA Primers MAP Kinase Kinase Kinase 5 Tumor Suppressor Proteins Antioxidants Dexamethasone Nafenopin Carbon Tetrachloride Glycochenodeoxycholic Acid Protein Synthesis Inhibitors Cytochrome P-450 CYP3A Oligopeptides Phosphorylases Etoposide Propidium Isoenzymes Carcinogens Orosomucoid Acetylcysteine Vasopressins Galactosamine Cell Cycle Proteins MAP Kinase Kinase 4 Transcription Factor CHOP Taurocholic Acid Proto-Oncogene Proteins c-myc alpha-Fetoproteins Microtubule-Associated Proteins Phosphatidylserines Oligonucleotides, Antisense Mitochondrial Proteins Receptors, Cytoplasmic and Nuclear Glucokinase Receptors, Death Domain Flavonoids Diethylnitrosamine Adaptor Proteins, Signal Transducing Recombinant Fusion Proteins Pyrrolizidine Alkaloids Hepatocyte Growth Factor Doxorubicin Imidazoles Nucleic Acid Synthesis Inhibitors Sphingomyelin Phosphodiesterase Dactinomycin Trans-Activators Tetrazolium Salts Sulfonamides Adenosine Triphosphate Extracellular Signal-Regulated MAP Kinases Plant Extracts Receptors, Tumor Necrosis Factor, Type I

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

In Situ Nick-End Labeling Blotting, Western Transfection Flow Cytometry Reverse Transcriptase Polymerase Chain Reaction Immunohistochemistry Liver Neoplasms, Experimental Models, Biological Disease Models, Animal Immunoblotting Microscopy, Electron Microscopy, Fluorescence Cell Culture Techniques Hepatectomy Liver, Artificial Culture Media, Serum-Free Cell Separation Xenograft Model Antitumor Assays Fluorescent Antibody Technique Gene Knockdown Techniques Microscopy, Confocal Drug Screening Assays, Antitumor Gene Expression Profiling Blotting, Northern

Phenomena and Processes51

Apoptosis DNA Fragmentation Cell Survival Signal Transduction Enzyme Activation Cell Proliferation Dose-Response Relationship, Drug Liver Regeneration Transfection Cell Division Cell Cycle Time Factors Phosphorylation Down-Regulation Gene Expression Regulation Necrosis Cell Death Up-Regulation Membrane Potential, Mitochondrial Gene Expression Kinetics Oxidative Stress DNA Damage Genes, bcl-2 Enzyme Induction Drug Synergism Gene Expression Regulation, Neoplastic Cell Differentiation RNA Interference Gluconeogenesis Transcription, Genetic Protein Binding Base Sequence Mutation Gene Expression Regulation, Enzymologic Cytoprotection Autophagy Biological Transport Drug Resistance, Neoplasm Protein Transport Amino Acid Sequence Promoter Regions, Genetic MAP Kinase Signaling System Genetic Vectors Endoplasmic Reticulum Stress Oxidation-Reduction Genes, p53 Gamma Rays Cell Cycle Checkpoints G1 Phase Gene Silencing

Disciplines and Occupations1

Immunohistochemistry

Information Science3

Molecular Sequence Data Base Sequence Amino Acid Sequence

Anatomy Organisms Diseases Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Disciplines and Occupations Information Science

Hepatocytes Apoptosis Liver Caspases Apoptosis Regulatory Proteins Caspase 3 Cells, Cultured Proto-Oncogene Proteins c-bcl-2 Inhibitor of Apoptosis Proteins DNA Fragmentation Cell Survival In Situ Nick-End Labeling Cell Line, Tumor bcl-2-Associated X Protein X-Linked Inhibitor of Apoptosis Protein Signal Transduction Apoptosis Inducing Factor CASP8 and FADD-Like Apoptosis Regulating Protein Caspase 9 Enzyme Activation Caspase Inhibitors Mitochondria Caspase 8 Fas Ligand Protein Tumor Cells, Cultured Tumor Suppressor Protein p53 Cell Line RNA, Messenger Blotting, Western Cytochromes c bcl-X Protein Cell Proliferation Dose-Response Relationship, Drug Annexin A5 Rats, Inbred Strains Liver Regeneration Rats, Sprague-Dawley Transfection Cell Division Rats, Wistar Flow Cytometry Proto-Oncogene Proteins Cysteine Proteinase Inhibitors Enzyme Inhibitors Cell Cycle Amino Acid Chloromethyl Ketones Mice, Inbred C57BL Time Factors Reactive Oxygen Species Antineoplastic Agents Phosphorylation Poly(ADP-ribose) Polymerases Down-Regulation Tumor Necrosis Factor-alpha Gene Expression Regulation RNA, Small Interfering Necrosis Reverse Transcriptase Polymerase Chain Reaction TNF-Related Apoptosis-Inducing Ligand Cell Death Mice, Knockout Up-Regulation Jurkat Cells Membrane Potential, Mitochondrial Immunohistochemistry Membrane Glycoproteins Gene Expression Glucagon Rats, Inbred F344 Caspase 7 Carrier Proteins Liver Neoplasms, Experimental NF-kappa B Proto-Oncogene Proteins c-akt HL-60 Cells Kinetics Cytochrome c Group Oxidative Stress Hep G2 Cells Carcinoma, Hepatocellular DNA Damage Genes, bcl-2 Liver Neoplasms BH3 Interacting Domain Death Agonist Protein Albumins Cell Nucleus Myeloid Cell Leukemia Sequence 1 Protein bcl-2 Homologous Antagonist-Killer Protein Glutathione Protein-Serine-Threonine Kinases Enzyme Induction Asialoglycoproteins Models, Biological Membrane Proteins Staurosporine Mice, Transgenic Drug Synergism Gene Expression Regulation, Neoplastic DNA-Binding Proteins Cell Differentiation

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