• Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. (greenmedinfo.com)
  • The copper (II) complex of salicylate phenanthroline inhibits proliferation and induces apoptosis of hepatocellular carcinoma cells. (bvsalud.org)
  • Histone deacetylase inhibitor valproic acid inhibits proliferation and induces apoptosis in KM3 cells via downregulating VEGF receptor. (nel.edu)
  • Dong X, Song Q, Li L, Zhao C, Wang L. Histone deacetylase inhibitor valproic acid inhibits proliferation and induces apoptosis in KM3 cells via downregulating VEGF receptor. (nel.edu)
  • Lee SO, Jeong YJ, Yu MH, et al: Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells. (spandidos-publications.com)
  • UV-B-induced DNA damage can trigger cell signaling pathways to activate defense systems, leading to DNA repair and/or apoptosis ( 6 ). (spandidos-publications.com)
  • These previous results indicated that the ROS-p38-p53 pathways are involved in UV-induced cell damage. (spandidos-publications.com)
  • CONCLUSIONS: Statins inhibit proliferation and induce apoptosis in EAC cells via inhibition of Ras farnesylation and inhibition of the ERK and Akt signaling pathways. (uea.ac.uk)
  • Effects of regorafenib on cell viability, apoptosis pathways, metastatic potential, and expression of metastatic and anti-apoptotic proteins were evaluated with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay, flow cytometry, cell migration and invasion assay, and western blotting. (tmu.edu.tw)
  • 191.20 μg/mL). cCN also induced apoptotic cell death in the treated cells via the intrinsic and extrinsic apoptosis pathways by affecting the mRNA expression levels of Bad, Bax, Bcl-2, Bcl-xL , and FasL . (phcog.com)
  • Conclusion Our findings have suggested that resveratrol induces cell cycle arrest, apoptosis, and autophagy in T-ALL cells through inhibiting Akt/mTOR/p70S6K/4E-BP1 and activating p38-MAPK signaling pathways. (besjournal.com)
  • inhibited MST2 relationships with Raf-1 but improved binding to RASSF1A leading to higher activation of downstream tension signalling pathways (JNK FK866 and p38 MAPK) and apoptosis. (biomasswars.com)
  • In addition, FN has been shown to inhibit apoptosis via various intracellular pathways 20 . (nature.com)
  • Present study was designed to determine the impact of cadmium on cell proliferation, cell cycle and apoptosis, and to investigate the possible involvement of p53 and MAPKs signaling pathways in J774A.1 murine macrophages. (cdc.gov)
  • At high concentrations, NSAIDs have anticarcinogenic properties operating through cyclooxygenase-2-dependent and -independent pathways to inhibit cellular proliferation, inhibit angiogenesis, and induce apoptosis. (medscape.com)
  • Loss of mitochondrial membrane potential, upregulation of proapoptotic proteins, activation of MCL-1, PARP-1 and Caspase 9 suggest that MESF treatment leads to activation of mitochondrial pathway of apoptosis. (nature.com)
  • Green husk extract generates an antiproliferative effect in HL-60 cells, which is related to an induction of the early stages of apoptosis and a loss of mitochondrial membrane potential. (ejbiotechnology.info)
  • In addition, regorafenib significantly induced accumulation of sub-G1 phase cells, loss of mitochondrial membrane potential, and expression of active caspase-3 and caspase-8. (tmu.edu.tw)
  • Results of the present study revealed that luteolin decreased viability of JAR and JEG-3 cells, which are valuable placental models, in a dose-dependent manner, and it induced apoptosis and loss of mitochondrial membrane potential in JAR and JEG-3 cells. (ewha.ac.kr)
  • PCA treatment induced cell cycle arrest in G 2 /M phase, the activation of poly (ADP-ribose) polymerase (PARP) and caspase-3, the upregulation of Bax and downregulation of Bcl-2 in OVCAR-3 cells. (nih.gov)
  • It also induced cell cycle arrest at G0/G1 phase via up regulating cyclin-dependent kinase (CDK) inhibitors p21 and p27 and down regulating cyclin A and cyclin D1. (besjournal.com)
  • We previously reported that treatment of human T-cell leukemia virus type 1 (HTLV-1)-associated adult T-cell leukemia-lymphoma cells either with arsenic trioxide (As) combined to interferon-α (IFN-α) or with the bortezomib (PS-341) proteasome inhibitor induces cell cycle arrest and apoptosis, partly due to the reversal of the constitutive nuclear factor-κB (NF-κB) activation. (edu.lb)
  • Cd inhibited cell proliferation via cell cycle arrest and induced apoptosis in a dose-dependent manner. (cdc.gov)
  • Inhibition of ERK suppressed DNA synthesis and had an additive effect with Cd-inhibited proliferation suggesting that Cd-induced ERK activity is not responsible for the G2/M arrest and subsequent inhibition of cell proliferation. (cdc.gov)
  • Results suggested that p53 is not involved in Cd-induced cell cycle arrest and apoptosis in J774A.1 cells. (cdc.gov)
  • We also observed that PCA treatment significantly caused upregulation of autophagy-related protein LC3-II and induced GFP-LC3 puncta formation. (nih.gov)
  • Xanthoxyletin significantly inhibited the proliferation of oral cancer cells (IC₅₀, 10-30 µM) with lower cytotoxicity for normal cells. (medscimonit.com)
  • Finally, MTE significantly inhibited the proliferation and promoted the apoptosis of lymphocytes from T-ALL patients, compared with lymphocytes from healthy peoples. (oncotarget.com)
  • Pretreatment of cells with pifithrin-α or U0126, specific inhibitors of p53 or MEK-1/2, significantly attenuated Triphala-induced apoptosis. (biomedcentral.com)
  • Moreover, NAC or U0126 pretreatment significantly attenuated Triphala-induced p53 transcriptional activity. (biomedcentral.com)
  • In the present study, we demonstrate that Triphala significantly inhibit the proliferation of Capan-2 and BxPC-3 human pancreatic cancer cells. (biomedcentral.com)
  • Pre-administration of acteoside at 10 or 50 mg/kg subcutaneously at 12 and 1 h prior to D-GalN/LPS intoxication significantly inhibited hepatic apoptosis, hepatitis and lethality. (elsevierpure.com)
  • The results show that downregulation of Rab21 can significantly inhibit cell growth and remarkably induce cell apoptosis in T98G and U87 cell lines. (biomedcentral.com)
  • We found that a significant increase occurred in Rab21 expression in T98G and U87 glioma cell lines and that downregulation of Rab21 using specific-siRNA transfected with two glioma cell lines (T98G and U87) significantly inhibits cell growth and remarkably induces cell apoptosis. (biomedcentral.com)
  • SK228 significantly inhibited growth of different lung and esophageal cancer cell lines at sub-micromolar range, but not normal lung cells. (ntnu.edu.tw)
  • Diclofenac significantly suppressed SH-SY5Y cell death induced by two types of ER-stress-inducing agents: thapsigargin, an inhibitor of Ca 2+ -ATPase on the endoplasmic reticulum membrane, and tunicamycin, a glycosylation blocker. (elsevierpure.com)
  • The present study evaluated the protective effects of PF on UV‑induced skin damage in vitro, and demonstrated that the effects were mediated via the ROS‑p38‑p53 pathway. (spandidos-publications.com)
  • Acteoside showed no apparent effect on the marked elevation of serum TNF-α, but it partially prevented in vitro TNF-α (100 ng/ml)-induced cell death in D-GalN (0.5 mM)-sensitized hepatocytes at the concentrations of 50, 100 and 200 μM. (elsevierpure.com)
  • The aim of the present study was to verify the effects of regorafenib on apoptosis and metastatic potential in TSGH 8301 human bladder carcinoma cells in vitro. (tmu.edu.tw)
  • These results show that regorafenib not only induces apoptosis, but also inhibits metastatic potential in bladder cancer TSGH 8301 cells in vitro. (tmu.edu.tw)
  • It was found that the growth of leukemia cells in vitro was inhibited by the various extracts of TF. (upm.edu.my)
  • Inhibits proliferation of MOLT4 cells in vitro . (rndsystems.com)
  • [ 17-20 ] In vitro and in vivo research suggests that NSAIDs and selective cyclooxygenase-2 inhibitors hinder growth and survival of bladder cancer cells and nitrosamine-induced tumors. (medscape.com)
  • TUNEL and western blot assay showed that KTC could induce apoptosis of endometriotic tissues, accompanied with the increased protein expression of caspases 8 and 9, activated caspase-3, and cytochrome c in a dose-dependent manner. (hindawi.com)
  • Western blot analysis and real-time PCR showed that celastrol dose-dependently suppressed TNF-α-induced MMP-9 gene expression at both the mRNA and protein levels in MDA-MB-231 cells. (spandidos-publications.com)
  • Thus the inhibitory effects of SLTM on gene expression appear to result from generalized down-regulation of mRNA synthesis and initiation of apoptosis consequent upon overexpressing the protein. (bris.ac.uk)
  • Simvastatin inhibited activation of extracellular signal-regulated kinase (ERK) and protein kinase B (Akt) but not c-Jun NH2-terminal kinase or p38 mitogen-activated protein (MAP) kinase. (uea.ac.uk)
  • High dose of ATRA induced morphologic change in GIST-T1 cells, rounded-up cells, and activated the caspase-3 protein. (biomedcentral.com)
  • In further examination, we found that the ATRA-induced apoptosis in GIST-T1 cells was accompanied by the down-regulated expression of survivin and up-regulated expression of Bax protein. (biomedcentral.com)
  • Fibrinogen-like protein 2 (Fgl2) is involved in apoptosis, angiogenesis and inflammatory response. (silverchair.com)
  • We found that Fgl2 gene silencing inhibits apoptosis and improves heart function of streptozotocin (STZ)-induced diabetes rats, the possible mechanism maybe that Fgl2 gene silencing reduces the tumour necrosis factor (TNF)±levels, decreases the expression of B-cell lymphoma-2 (bcl2), bcl-2-associated X (bax), toll-like receptors 4 (TLR4) and p38 mitogen-activated protein kinase (MAPK). (silverchair.com)
  • Our study found that fibrinogen-like protein 2 (Fgl2) gene silencing activates angiopoietin/Tie system and induces myocardial microvascular endothelial Cells proliferation and cell migration, we also found that serum Fgl2 levels elevated in patients with acute coronary syndrome (ACS), these results are preliminary, but very meaningful [ 1 , 2 ]. (silverchair.com)
  • Shiga toxins (Stx) are potent AB 5 cytotoxins that inhibit eukaryotic protein synthesis, eventually leading to host cell death ( 1 ). (cdc.gov)
  • Thus a thorough understanding of both mechanical and chemical stimulation separately, as well as coupled together, is integral to gain insight into FN synthesis, function and the effects of various pathology-induced abnormalities that can perturb this multi-functional protein. (nature.com)
  • Effect of cadmium on P53 and mitogen-activated protein kinases in a murine macrophage cell line: relation to apoptosis. (cdc.gov)
  • Cycloheximide, an inhibitor of protein synthesis, did not alter Cd-induced cytotoxicity indicating that J774A.1 cell death by Cd is independent of de novo protein synthesis including p53. (cdc.gov)
  • Trouw L., Nilsson S., Goncalvez I., Landberg G. and Blom A. M. (2005) C4b-binding protein binds to necrotic cells and DNA, which limits DNA release and inhibits complement activation. (lu.se)
  • Here we show that methanolic extracts of Sapota fruit (MESF) induces cytotoxicity in a dose-dependent manner in cancer cell lines. (nature.com)
  • In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)
  • Furthermore, cotreatment with PCA and autophagy inhibitor attenuated the cytotoxicity induced by PCA in OVCAR-3 cells. (nih.gov)
  • Our study provides the first evidence that SK228 exhibits cancer cell-specific cytotoxicity by inducing mitochondria-mediated apoptosis. (ntnu.edu.tw)
  • Pretreatment with PD98059 increased Cd-induced cytotoxicity suggesting that ERK activation may be a survival response in the present cell system. (cdc.gov)
  • ERK activation by Cd is not related to decreased proliferation of macrophages but may play a protective role against Cd-induced cytotoxicity. (cdc.gov)
  • RESULTS: All three statins reduced viable cell number and inhibited proliferation in a similar dose-dependent manner. (uea.ac.uk)
  • Cu(sal)(phen) inhibited the proliferation of HCC cells (HepG2 and HCC-LM9) and induced apoptosis of HCC cells in a dose -dependent manner by upregulating mitochondrial reactive oxygen species (ROS) production . (bvsalud.org)
  • In this work, for the first time we have demonstrated that ATRA affected on cell proliferation of GIST-T1 and GIST-882 cell line through inhibition of cell growth in a dose dependent manner and induced apoptosis. (biomedcentral.com)
  • Open in another home window Fig. 2 Dual mTOR inhibitors inhibit bladder tumor cell growth within a dose-dependent way. (m2cobalt.com)
  • The possibility that cytotoxic effects were due to apoptosis was indicated by significant time- and dose-dependent induction of caspase-3/7 activity in both HepG2 cells and human hepatocytes. (cdc.gov)
  • Our data revealed that PCA could modulate apoptosis and autophagy, suggesting the potential of PCA for chemoprevention and chemotherapy of ovarian cancer. (nih.gov)
  • One cell range exhibited apoptosis in response to mixture medications, whereas the various other 2 cell lines possess increased degrees of autophagy indicative of level of resistance to apoptosis. (m2cobalt.com)
  • Resveratrol Induces Apoptosis and Autophagy in T-cell Acute Lymphoblastic Leukemia Cells by Inhibiting Akt/mTOR and Activating p38-MAPK[J]. Biomedical and Environmental Sciences, 2013, 26(11): 902-911. (besjournal.com)
  • Objective To explore the effects of resveratrol-induced apoptosis and autophagy in T-cell acute lymphoblastic leukemia (T-ALL) cells and potential molecular mechanisms. (besjournal.com)
  • Methods The anti-proliferation effect of resveratrol-induced, apoptosis and autophagy on T-ALL cells were detected by using MTT test, immunofluorescence, electronic microscope, and flow cytometry, respectively. (besjournal.com)
  • Results Resveratrol inhibited the proliferation and induced apoptosis and autophagy in T-ALL cells in a dose and time-dependent manner. (besjournal.com)
  • When autophagy was suppressed by 3-MA, apoptosis in T-ALL cells induced by resveratrol was enhanced. (besjournal.com)
  • Therefore, the reasonable inhibition of autophagy in T-ALL cells may serve as a promising strategy for resveratrol induced apoptosis and can be used as adjuvant chemotherapy for T-ALL. (besjournal.com)
  • These results indicate that Rh4-induced ferroptosis is regulated via the autophagy pathway. (hindawi.com)
  • Therefore, this study proves that Rh4 inhibits cancer cell proliferation by activating the ROS/p53 signaling pathway and activating autophagy to induce ferroptosis, which provides necessary scientific evidence of the great anticancer potential of Rh4. (hindawi.com)
  • Review of literature: the BPs inhibit the osteoclastic activity and induce osteoclast apoptosis. (bvsalud.org)
  • Mechanistically, MTE enhanced PTEN (phosphatases and tensin homolog) level and inactivated PI3K/AKT/mTOR signaling pathway in Jurkat cells, which mediated the inhibition of cell proliferation by MTE and MTE-induced apoptosis. (oncotarget.com)
  • Taken together, these results reveal an unrecognized function of MTE in inhibiting the proliferation and inducing the apoptosis of T-ALL cells, and identify a pathway of PTEN/PI3K/AKT/mTOR for the effects of MTE on leukemia therapy. (oncotarget.com)
  • Mechanically, we address that CD suppressed cell proliferation and induced apoptosis via induction of FOXO3a as well as decreased phosphorylation of Akt, mTOR, MEK/ERK and their downstream molecules, cMyc and hypoxia inducible factor 2α expression in a concentration- and time-dependent trend. (ncku.edu.tw)
  • Collectively, these results showed that luteolin plays an important role in the treatment of human choriocarcinoma cells by inhibiting the PI3K/AKT/mTOR/SREBP cascade and expression of lipogenic genes. (ewha.ac.kr)
  • Dual mTOR inhibitors inhibit Trimethobenzamide hydrochloride cell proliferation We analyzed whether OSI-027 and PP242 would inhibit BC cell development. (m2cobalt.com)
  • Furthermore, resveratrol induced significant dephosphorylation of Akt, mTOR, p70S6K, and 4E-BP1, but enhanced specific phosphorylation of p38-MAPK which could be blocked by SB203580. (besjournal.com)
  • Pretreatment of cells with SB202190, a p38 inhibitor, may inhibit the DNA binding activity of p53 and suppress p53-dependent transcription ( 10 ). (spandidos-publications.com)
  • Statins induced apoptosis and enhanced the antiproliferative effect of NS-398, a selective cyclooxygenase (COX)-2 inhibitor. (uea.ac.uk)
  • ERK inhibitor, PD98059, suppressed Cd-induced ERK activation. (cdc.gov)
  • Triphala-mediated reduced cell survival correlated with induction of apoptosis, which was associated with reactive oxygen species (ROS) generation. (biomedcentral.com)
  • It also exhibited greater suppression on cell proliferation as well as cell migration or invasion capabilities and induction of apoptosis in Hep3B cells than single siRNA simultaneously. (biomedcentral.com)
  • Our outcomes further show how the dissociation from the Raf-1-MST2 complicated can be section of mitogenic signalling therefore linking induction of proliferation with the chance of apoptosis. (biomasswars.com)
  • Researchers discovered that excessive induction of Fgl2 under certain medical conditions (e.g., pathogen invasion) could trigger complement activation, inflammatory response, cellular apoptosis and immune dysfunctions. (silverchair.com)
  • A dramatic inhibition of cell proliferation and induction of apoptosis was observed in PS-341 and in As-IFN-α treated cells. (edu.lb)
  • In a similar manner, CYP3A4 mRNA expression was also induced (10-30-fold), although at the higher doses induction returned to near control levels. (cdc.gov)
  • Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)
  • May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. (lu.se)
  • Specify the components and their interactions and set up cluding proliferation, differentiation, apoptosis, embryonic the system of equations. (lu.se)
  • Treatment with Cd at 20 and 50 microM induced phosphorylation of extracellular signal-regulated kinase (ERK), but did not alter p53 mRNA expression or the activation of p38 MAPK and c-Jun N-terminal MAPK. (cdc.gov)
  • This plant had shown to induce antiproliferative effect as well as apoptosis in cancer cells. (upm.edu.my)
  • Kim JM, Noh EM, Kwon KB, et al: Curcumin suppresses the TPA-induced invasion through inhibition of PKCα-dependent MMP-expression in MCF-7 human breast cancer cells. (spandidos-publications.com)
  • Yu HY, Kim KS, Moon HI, Kim KM, Lee YC and Lee JH: JNP3, a new compound, suppresses PMA-induced tumor cell invasion via NF-κB down regulation in MCF-7 breast cancer cells. (spandidos-publications.com)
  • SPIN1 ablation activates p53, suppresses cell growth, reduces clonogenic ability, and induces apoptosis of human cancer cells. (elifesciences.org)
  • Growth of an A549 tumor cell xenograft was markedly inhibited without significant side effects. (ntnu.edu.tw)
  • Reduced tumor-growth in Triphala fed mice was due to increased apoptosis in the tumors cells, which was associated with increased activation of p53 and ERK. (biomedcentral.com)
  • Osteoclasts do not induce cytotoxic effects in bone cells. (medscape.com)
  • However, fipronil sulfone induced cytotoxic effects at lower doses. (cdc.gov)
  • We assessed the effect of acteoside, a naturally occurring antioxidative phenylethanoid, on hepatic apoptosis and the subsequent liver failure induced by D-Galactosamine (D-GalN) and lipopolysaccharide (LPS). (elsevierpure.com)
  • A co-administration of D-GalN (700 mg/kg) and LPS (35 μg/kg) to mice evoked typical hepatic apoptosis characterized by DNA fragmentation and apoptotic body formation, resulting in fulminant hepatitis and lethality of mice. (elsevierpure.com)
  • Experiments using the MTT assay, cell cycle analysis, apoptosis assay, real-time PCR and western blot were performed to establish the expression levels of related genes. (biomedcentral.com)
  • Park SK, Hwang YS, Park KK, Park HJ, Seo JY and Chung WY: Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. (spandidos-publications.com)
  • The results also suggested that the PI3K/AKT pathway was inhibited by luteolin treatment of JAR and JEG-3 cells in a dose- and time-dependent manner. (ewha.ac.kr)
  • Akt can be a primary downstream effector of PI3K whose pleiotropic features are the inhibition of apoptosis (16-18). (biomasswars.com)
  • The mode of cell death in MDA-MB-231 cells induced by cCN was examined using a luminescence- and fluorescence-based assay and the mechanisms involved were evaluated by comparative analysis of gene expression by reverse transcription-quantitative polymerase chain reaction. (phcog.com)
  • The Drosophila IAP homolog THREAD/DIAP1 (TH/DIAP1), encoded by the thread (th) gene, negatively regulates apoptosis during development. (sns.it)
  • Our preclinical studies demonstrate that Triphala is effective in inhibiting the growth of human pancreatic cancer cells in both cellular and in vivo model. (biomedcentral.com)
  • It is immunotoxic in vivo and induces apoptosis in many cultured cells. (cdc.gov)
  • In addition, cell death analysis indicated that PF treatment markedly reduced UV‑B‑radiation‑induced apoptosis in keratinocytes, which was accompanied by increased procaspase 3 expression and decreased cleaved caspase 3 expression. (spandidos-publications.com)
  • SquamouS cell carcinoma for the viability of the tumour cel s once skin lesions are also mutated in the ultraviolet they have become malignant (Rol ison (UV) radiation-induced skin lesions of A large number of HPV types have et al. (who.int)
  • Our findings suggest that KTC could inhibit the growth of ectopic endometrial tissue through upregulating the level of TNF- α and its downstream signaling, including caspases and cytochrome c. (hindawi.com)
  • However, reports on the growth-inhibitory effect of C. nutans leaf extract on the aggressive triple-negative breast cancer cells and the mechanisms of induced-cell death in these cells are limited. (phcog.com)
  • NSAIDs inhibit cyclooxygenase-1 and cyclooxygenase-2, a rate-limiting enzyme induced by endogenous (growth factors or cytokines) and exogenous (tobacco carcinogens) stimuli, and are involved in prostaglandin synthesis and the inflammatory response. (medscape.com)
  • An integrated network pharmacology and RNA-Seq approach for exploring the preventive effect of Lonicerae japonicae flos on LPS-induced acute lung injury. (greenmedinfo.com)
  • Results CD inhibited both 786-O and A-498 cell proliferation and induced a series apoptotic characteristics expressions, ROS accumulation, caspase-3 activation as well as poly-(ADP-ribose) polymerase cleavage in both ccRCC cells. (ncku.edu.tw)
  • Right here we display that MST2 can be phosphorylated by Akt which inhibits its pro-apoptotic activity nevertheless by a totally different system than MST1. (biomasswars.com)
  • It inhibits inflammatory reactions and pain by decreasing the activity of cyclooxygenase, which is responsible for prostaglandin synthesis. (medscape.com)
  • Akt-induced phosphorylation of MST2 (i) promotes MST2 discussion with Raf-1 (ii) blocks MST2 recruitment by RASSF1A and (iii) straight inhibits MST2 kinase activity. (biomasswars.com)
  • Likewise, activity levels for a CYP1A1-specific substrate, luciferin CEE, demonstrated that CYP1A1 enzyme activities were maximally induced by 1 µM fipronil followed by dramatically declining activity measurements at 10 and 25 µM. (cdc.gov)
  • Kim Y, Kang H, Jang SW and Ko J: Celastrol inhibits breast cancer cell invasion via suppression of NF-κB-mediated matrix metalloproteinase-9 expression. (spandidos-publications.com)
  • Zhang S, Li Z, Wu X, Huang Q, Shen HM and Ong CN: Methyl-3-indolylacetate inhibits cancer cell invasion by targeting the MEK1/2-ERK1/2 signaling pathway. (spandidos-publications.com)
  • In addition, SK228 inhibits cancer cell invasion via FAK/Paxillin disruption at noncytotoxic doses. (ntnu.edu.tw)
  • Experiments using tumors obtained from Apc min/+ mice and cells from human colon cancers showed that this Ino80 defect induced stalled replication forks, the concomitant activation of ATR-Chk1 signaling and an increase in apoptosis, suggesting that Ino80 haploinsufficiency inhibited colon cancer tumorigenesis by activating replication stress-induced ATR-Chk1 signaling to increase apoptosis. (ewha.ac.kr)
  • Furthermore, the cell death mechanism in the spleen tissue of treated mice was found via apoptosis. (upm.edu.my)
  • Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
  • In this study, we investigated whether DIM could improve insulin-dependent diabetes and nephropathy in streptozotocin (STZ)-induced diabetic mice. (researchgate.net)
  • DIM also improved diabetic nephropathy by inhibiting the expression of PKC-α, the marker of albuminuria, and TGF-β1, an indicator of renal hypertrophy, in diabetic mice. (researchgate.net)
  • Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
  • Downregulation of Raf-1 can replacement FK866 for the loss of RASSF1A expression (6) suggesting that Raf-1 binding to MST2 is critical for preventing RASSF1A mediated MST2 activation and apoptosis. (biomasswars.com)
  • The proapoptotic genes reaper (rpr), grim, and head involution defective (hid) are required for virtually all embryonic apoptosis. (sns.it)
  • In addition, that analysis of loss-of-function mutations demonstrates that th is necessary to block apoptosis very early in embryonic development. (sns.it)